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Article: Severe acute respiratory syndrome coronavirus 2 positivity in neonates born to coronavirus disease 2019-positive mothers: A retrospective data analysis.

Pande, Shailesh / Patel, Vainav / Munne, Kiran

2023 Volume 67, Issue 2, Page(s) 333–334

MeSH term(s)	Pregnancy ; Infant, Newborn ; Female ; Humans ; COVID-19 ; SARS-CoV-2 ; Mothers ; Retrospective Studies ; India/epidemiology ; Pregnancy Complications, Infectious/epidemiology ; Infectious Disease Transmission, Vertical
Language	English
Publishing date	2023-07-17
Publishing country	India
Document type	Letter ; Comment
ZDB-ID	800737-8
ISSN	2229-7693 ; 0019-557X
ISSN (online)	2229-7693
ISSN	0019-557X
DOI	10.4103/ijph.ijph_953_22
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Article: Detection of SARS-CoV-2 infection by RT-PCR test: factors influencing interpretation of results

Munne, Kiran / Bhanothu, Venkanna / Bhor, Vikrant / Patel, Vainav / Mahale, Smita D. / Pande, Shailesh

Virusdisease. 2021 June, v. 32, no. 2

2021

Abstract: In this current pandemic of coronavirus disease 2019 (COVID-19), prompt interventions in terms of early detection and clinical management along with isolation of positive cases is of utmost importance. This helps to limit not only the spread of severe ... ...

Abstract	In this current pandemic of coronavirus disease 2019 (COVID-19), prompt interventions in terms of early detection and clinical management along with isolation of positive cases is of utmost importance. This helps to limit not only the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections but also the morbidity and mortality associated with it. Different strategies for screening of COVID-19 in containment zones and non-containment areas include testing of symptomatic patients and their contacts in fever clinics, hospital-based testing, testing on demand and population-based screening. The choice of tests like reverse-transcription polymerase chain reaction (RT-PCR), rapid antigen testing (RAT) or antibody test depends upon these strategies and also the turnaround time. Currently, RT-PCR is considered the gold standard for COVID-19 detection. This commentary provides the insights and experiences on COVID-19 diagnosis by RT-PCR. The utility of this test is limited by several false positive, false negative and inconclusive results at early stages of infection, scarcity of reagents and lack of well-equipped labs including trained staff. Moreover, appropriate sample collection and transport, standard laboratory protocols, stringent quality control norms, good quality RNA extraction kits, PCR kits with suitable primers can help in improving accuracy of the test results. A careful assessment of clinical, radiological and molecular findings is required for identifying potential cases of COVID-19.
Keywords	COVID-19 infection ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; antibodies ; antigens ; fever ; morbidity ; mortality ; pandemic ; quality control ; reverse transcriptase polymerase chain reaction
Language	English
Dates of publication	2021-06
Size	p. 187-189.
Publishing place	Springer India
Document type	Article
Note	Letter
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-021-00692-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Evaluation of cytokine profile in cervicovaginal lavage specimens of women having asymptomatic reproductive tract infections.

Aranha, Clara / Goriwale, Mayuri / Begum, Shahina / Gawade, Sheetal / Bhor, Vikrant / Patil, Anushree D / Munne, Kiran / Bansal, Vandana / Tandon, Deepti

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

2022 , Page(s) 1–6

Abstract: Reproductive tract infections (RTIs) such as vaginal candidiasis and bacterial vaginosis (BV) are common among sexually active women and can be both symptomatic or asymptomatic. The microbiota of the reproductive tract triggers immune response at the ... ...

Abstract	Reproductive tract infections (RTIs) such as vaginal candidiasis and bacterial vaginosis (BV) are common among sexually active women and can be both symptomatic or asymptomatic. The microbiota of the reproductive tract triggers immune response at the cervicovaginal interface resulting in secretion of cytokines during the course of these RTIs. The objective of this study was to evaluate the cytokine profile in cervicovaginal lavage of women having asymptomatic vaginal infections. Measurement of vaginal cytokines was done for various interleukins including IL-1β, IL-6, IL-8, IL-10, IL-12/IL23p40, IL-17A, tumour necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) by ProcartaPlex™ Multiplex Immunoassay. Women having vaginal
Language	English
Publishing date	2022-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	604639-3
ISSN	1364-6893 ; 0144-3615
ISSN (online)	1364-6893
ISSN	0144-3615
DOI	10.1080/01443615.2022.2106555
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Article: Detection of SARS-CoV-2 infection by RT-PCR test: factors influencing interpretation of results.

Munne, Kiran / Bhanothu, Venkanna / Bhor, Vikrant / Patel, Vainav / Mahale, Smita D / Pande, Shailesh

Virusdisease

2021 Volume 32, Issue 2, Page(s) 187–189

Abstract	In this current pandemic of coronavirus disease 2019 (COVID-19), prompt interventions in terms of early detection and clinical management along with isolation of positive cases is of utmost importance. This helps to limit not only the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections but also the morbidity and mortality associated with it. Different strategies for screening of COVID-19 in containment zones and non-containment areas include testing of symptomatic patients and their contacts in fever clinics, hospital-based testing, testing on demand and population-based screening. The choice of tests like reverse-transcription polymerase chain reaction (RT-PCR), rapid antigen testing (RAT) or antibody test depends upon these strategies and also the turnaround time. Currently, RT-PCR is considered the gold standard for COVID-19 detection. This commentary provides the insights and experiences on COVID-19 diagnosis by RT-PCR. The utility of this test is limited by several false positive, false negative and inconclusive results at early stages of infection, scarcity of reagents and lack of well-equipped labs including trained staff. Moreover, appropriate sample collection and transport, standard laboratory protocols, stringent quality control norms, good quality RNA extraction kits, PCR kits with suitable primers can help in improving accuracy of the test results. A careful assessment of clinical, radiological and molecular findings is required for identifying potential cases of COVID-19.
Language	English
Publishing date	2021-05-03
Publishing country	India
Document type	Journal Article
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-021-00692-5
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Article ; Online: Mapping the vaginal microbiota variations in women from a community clinic in Mumbai, India.

Tandon, Deepti / Shah, Nainisha / Goriwale, Mayuri / Karandikar, Kalyani / Begum, Shahina / Patil, Anushree D / Munne, Kiran / Kamat, Sharmila / Aranha, Clara / Bhor, Vikrant M

Indian journal of medical microbiology

2023 Volume 45, Page(s) 100393

Abstract: Purpose: The vaginal microbiome contributes significantly to women's reproductive health and fluctuates due to various physiological and pathological factors. The study's objective is to map the vaginal microbiome of non-pregnant women and evaluate ... ...

Abstract	Purpose: The vaginal microbiome contributes significantly to women's reproductive health and fluctuates due to various physiological and pathological factors. The study's objective is to map the vaginal microbiome of non-pregnant women and evaluate variations based on various potential factors influencing vaginal milieu. Methods: Fifty-two sexually active, non-pregnant women between 18 and 45 years were recruited from a community clinic and clinical history was recorded. Vaginal swabs were collected to assess the vaginal microbiome by sequencing the V3-V4 region of the 16S rRNA using the Illumina HiSeq platform, followed by data analysis with QIIME 2. Vaginal milieu was assessed by Nugent score and profiling cytokines in the cervico-vaginal lavage. Results: Lactobacillus iners (34.3%) were the most abundant species in all women. Significant changes in abundance of genera (Lactobacillus, Prevotella and Anaerococcus), expression of pro-inflammatory cytokine IFN-γ and changes in alpha and beta diversity was observed in women having asymptomatic bacterial vaginosis (BV). Differences in beta diversity were seen between healthy women and women exhibiting presence of Candida spp. Variations in the abundance of genera (Lactobacillus, Bifidobacterium, Porphyromonas) were observed in women who had delivery less than twelve months back, probably as more of these women (50%, 53.7%) had higher abnormal Nugent score. Conclusion: Lactobacillus iners was the most prevalent vaginal species in women from a Mumbai community clinic. Maximum variations in the vaginal microbiome characterized by a perturbation of the Lactobacillus predominant vaginal microbiota are seen in those women who have asymptomatic BV and childbirth within last twelve months.
MeSH term(s)	Female ; Humans ; RNA, Ribosomal, 16S/genetics ; Vagina/microbiology ; Vaginosis, Bacterial/microbiology ; Microbiota/genetics
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1038798-5
ISSN	1998-3646 ; 0255-0857
ISSN (online)	1998-3646
ISSN	0255-0857
DOI	10.1016/j.ijmmb.2023.100393
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Article: Enablers & challenges of tribal women & health system for implementation of screening of non-communicable diseases & common cancers: A mixed-methods study in Palghar district of Maharashtra, India.

Birje, Shantanu / Patil, Anushree Devashish / Munne, Kiran Ramdas / Chavan, Vidya / Joshi, Beena Nitin / Akula, Anamika / Salvi, Neha / Nair, Smitha / Valawalkar, Shahanara Prabhu / Tandon, Deepti / Chauhan, Sanjay / Patil, Devendra / Babu, Bontha V

The Indian journal of medical research

2023 Volume 156, Issue 2, Page(s) 319–329

Abstract: Background & objectives: Non-communicable diseases (NCDs) and cancers of breast, oral cavity and cervix contribute to around 5.87 million (60%) deaths in India. Despite this, there is limited evidence on preparedness of the tribal health system in ... ...

Abstract	Background & objectives: Non-communicable diseases (NCDs) and cancers of breast, oral cavity and cervix contribute to around 5.87 million (60%) deaths in India. Despite this, there is limited evidence on preparedness of the tribal health system in mitigating these conditions. This mixed-methods study aimed at identifying enablers and challenges using a multistakeholder approach for the screening of NCDs and common cancers in a tribal block of Maharashtra, India. Methods: This study was conducted in a tribal community of Dahanu taluka in Palghar district of Maharashtra. A total of nine focus group discussions (FGDs) among tribal women and accredited social health activists (ASHAs), 13 key informant interviews (KIIs) among auxiliary nurse midwives (ANMs) and community health officers (CHO) and facility surveys of five public health facilities were conducted. The FGDs and KIIs were conducted using guides, recorded digitally, transcribed, analyzed and triangulated to identify emerging themes. Results: The tribal women had limited knowledge about NCDs and common cancers. Paucity of health facilities, out-of-pocket expenditure, misconceptions, belief on traditional healers and inability to prioritize health were identified as major challenges. The ASHAs were recognized as a key connecting link between health system and community while provision of culturally appropriate IEC materials and adequate training were recognized as critical enablers by healthcare providers in implementing screening for NCDs and common cancers. Interpretation & conclusions: The study recommends incorporating socioculturally relevant strategies in the tribal population and strengthening health facilities in terms of infrastructure and training with involvement of ASHAs for successful implementation of the National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS) through health and wellness centres.
MeSH term(s)	Humans ; Female ; Noncommunicable Diseases/epidemiology ; Early Detection of Cancer ; India/epidemiology ; Government Programs ; Neoplasms/diagnosis ; Neoplasms/epidemiology
Language	English
Publishing date	2023-01-09
Publishing country	India
Document type	Journal Article
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
DOI	10.4103/ijmr.ijmr_3240_21
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Article ; Online: An update on prevalence, diagnosis, treatment and emerging issues of genital mycoplasma infection in Indian women: A narrative review.

Tandon, Deepti / Munne, Kiran / Chauhan, Sanjay / Patil, Anushree D

Indian journal of dermatology, venereology and leprology

2019 Volume 85, Issue 5, Page(s) 441–447

Abstract: Despite adequate treatment of reproductive tract infection, there is persistence of symptoms in some patients. This raises the possibility of existence of other silent microbes with pathogenic potential. Apart from the common sexually transmitted ... ...

Abstract	Despite adequate treatment of reproductive tract infection, there is persistence of symptoms in some patients. This raises the possibility of existence of other silent microbes with pathogenic potential. Apart from the common sexually transmitted organisms such as Chlamydia trachomatis and Neisseria gonorrhoeae, there are other silent and emerging pathogens, like genital mycoplasma, which have been associated with cervicitis, pelvic inflammatory disease, infertility, and pregnancy-related complications in women. Although these organisms were identified decades ago, they are still overlooked or ignored. There is a need to understand the role played by these organisms in Asian populations and their susceptibility to the standard line of treatment. Data on genital mycoplasma infections in Indian women is heterogeneous, with limited evidence of pathogenicity. Although known for their wide spectrum of reproductive morbidities in western counterparts, these microorganisms are yet to gain the attention of Indian clinicians and microbiologists. There is paucity of adequate information in India regarding these infections, so Indian literature was compiled to get an overview of these pathogens, their association with reproductive morbidities, and their response to treatment. Thus, there is a need to explore genital mycoplasma infections in Indian women, especially in the arena of antimicrobial resistance among genital mycoplasma, which has the potential to become a major problem. A literature search with keywords focusing on "genital mycoplasma", "sexually transmitted infections India", "sexually transmitted mycoplasma", and "characteristic of mycoplasma" was carried out through computerized databases like PubMed, MEDLINE, Embase, and Google Scholar.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial/drug effects ; Drug Resistance, Bacterial/physiology ; Female ; Genital Diseases, Female/diagnosis ; Genital Diseases, Female/epidemiology ; Genital Diseases, Female/therapy ; Humans ; India/epidemiology ; Mycoplasma Infections/diagnosis ; Mycoplasma Infections/epidemiology ; Mycoplasma Infections/therapy ; Prevalence ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/therapy ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2019-08-25
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	416068-x
ISSN	0973-3922 ; 0019-5162 ; 0378-6323
ISSN (online)	0973-3922
ISSN	0019-5162 ; 0378-6323
DOI	10.4103/ijdvl.IJDVL_915_18
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Article: An Approach to Resolve Uncertainty in COVID-19 Diagnosis due to Inconclusive Results from RT-PCR Test.

Pande, Shailesh / Bhanothu, Venkanna / Mayekar, Anjali / Birje, Shantanu / Bhagat, Sharad / Bhowmick, Shilpa / Kerkar, Shilpa / Gaonkar, Reshma / Aranha, Clara C / Patel, Vainav / Bhor, Vikrant / Mahale, Smita D / Munne, Kiran

The Journal of the Association of Physicians of India

2022 Volume 70, Issue 6, Page(s) 11–12

MeSH term(s)	COVID-19/diagnosis ; COVID-19 Testing ; Humans ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Sensitivity and Specificity ; Uncertainty
Language	English
Publishing date	2022-06-15
Publishing country	India
Document type	Letter
ZDB-ID	800766-4
ISSN	0004-5772
ISSN	0004-5772
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Article ; Online: Cross sectional study to evaluate microbiological spectrum of RTI/STI and co-infections among women with cervicitis or cervico-vaginitis from a community clinic in Mumbai.

Tandon, Deepti / Patil, Anushree D / Pramanik, Jayanti Mania / Kerkar, Shilpa / Munne, Kiran / Begum, Shahina / Tryambake, Varsha / Surve, Suchitra

Indian journal of medical microbiology

2021 Volume 40, Issue 1, Page(s) 144–146

Abstract: Cervicitis is an inflammatory condition of cervix, when presented along with vaginal discharge; it is termed as cervico-vaginitis. These can be infective, hence important to diagnose due to risk of spreading to upper genital tract. This cross-sectional ... ...

Abstract	Cervicitis is an inflammatory condition of cervix, when presented along with vaginal discharge; it is termed as cervico-vaginitis. These can be infective, hence important to diagnose due to risk of spreading to upper genital tract. This cross-sectional study was undertaken to evaluate the microbiological spectrum in cervicitis or cervico-vaginitis among 100 sexually active women by Gram stain and Multiplex Real time polymerase chain reaction. Bacterial vaginosis 21(21%) was the most common RTI. Among STIs, genital mycoplasmas were the predominant infections hence further research is required to understand their pathogenesis.
MeSH term(s)	Cervix Uteri ; Coinfection/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Sexually Transmitted Diseases ; Uterine Cervicitis/epidemiology ; Vaginitis
Language	English
Publishing date	2021-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1038798-5
ISSN	1998-3646 ; 0255-0857
ISSN (online)	1998-3646
ISSN	0255-0857
DOI	10.1016/j.ijmmb.2021.10.003
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Article ; Online: A retrospective analysis of COVID-19 diagnosis results obtained by rapid antigen tests and RT-PCR: Implications for disease management.

Munne, Kiran / Bhanothu, Venkanna / Mayekar, Anjali / Birje, Shantanu / Bhor, Vikrant / Patel, Vainav / Mahale, Smita D / Pande, Shailesh S

Indian journal of medical microbiology

2021 Volume 39, Issue 4, Page(s) 537–539

Abstract: There is a need for understanding and establishment of the most appropriate testing algorithm for COVID-19 diagnosis in asymptomatic high-risk groups. Here, we present a retrospective analysis of RT-PCR results obtained from 412 cases tested negative for ...

Abstract	There is a need for understanding and establishment of the most appropriate testing algorithm for COVID-19 diagnosis in asymptomatic high-risk groups. Here, we present a retrospective analysis of RT-PCR results obtained from 412 cases tested negative for coronavirus disease 2019 (COVID-19) by rapid antigen testing method. Among 178 (43.2%) asymptomatic individuals, 44.9% of the high risk contacts, 12.2% of police custody individuals, 22.22% of the pregnant women and 33.33% of individuals hospitalised for preoperative or other medical conditions showed RT-PCR positivity. Our results suggest a need for focussed and intensive (multi-modality) testing in groups at high risk for SARS-CoV-2 infection.
MeSH term(s)	COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; COVID-19 Testing/methods ; Disease Management ; Female ; Humans ; India ; Pregnancy ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; Sensitivity and Specificity
Language	English
Publishing date	2021-05-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1038798-5
ISSN	1998-3646 ; 0255-0857
ISSN (online)	1998-3646
ISSN	0255-0857
DOI	10.1016/j.ijmmb.2021.05.006
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