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  1. Article ; Online: COVID-19: Challenges of Viral Variants.

    Jacobs, Jana L / Haidar, Ghady / Mellors, John W

    Annual review of medicine

    2022  Volume 74, Page(s) 31–53

    Abstract: The COVID-19 pandemic has been accompanied by SARS-CoV-2 evolution and emergence of viral variants that have far exceeded initial expectations. Five major variants of concern (Alpha, Beta, Gamma, Delta, and Omicron) have emerged, each having both unique ... ...

    Abstract The COVID-19 pandemic has been accompanied by SARS-CoV-2 evolution and emergence of viral variants that have far exceeded initial expectations. Five major variants of concern (Alpha, Beta, Gamma, Delta, and Omicron) have emerged, each having both unique and overlapping amino acid substitutions that have affected transmissibility, disease severity, and susceptibility to natural or vaccine-induced immune responses and monoclonal antibodies. Several of the more recent variants appear to have evolved properties of immune evasion, particularly in cases of prolonged infection. Tracking of existing variants and surveillance for new variants are critical for an effective pandemic response.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Pandemics ; Antibodies, Monoclonal
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-042921-020956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.321: Show issues Location:
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  2. Article ; Online: Coronavirus Disease 2019 Vaccination by Gender and Age in a Sample of Black Adults in Chicago.

    Hirschtick, Jana L / DiFranceisco, Wayne / Hunt, Bijou / Jacobs, Jacquelyn / Valencia, Jesus / Walsh, Jennifer L / Quinn, Katherine

    Health education & behavior : the official publication of the Society for Public Health Education

    2024  , Page(s) 10901981241245060

    Abstract: Although vaccine behaviors differ greatly by gender and age, few studies have examined vaccination at the intersection of gender and age within the Black community. We examined COVID-19 vaccination by gender and age using a survey of over 500 Black ... ...

    Abstract Although vaccine behaviors differ greatly by gender and age, few studies have examined vaccination at the intersection of gender and age within the Black community. We examined COVID-19 vaccination by gender and age using a survey of over 500 Black adults in Chicago, Illinois, fielded from September 2021 to March 2022. Although 54% had received at least one COVID-19 vaccine, the proportion vaccinated was considerably lower for Black men (28%) and women (37%) under 40 years old than Black men (92%) and women (86%) over 40 years (
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1362906-2
    ISSN 1552-6127 ; 1090-1981
    ISSN (online) 1552-6127
    ISSN 1090-1981
    DOI 10.1177/10901981241245060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 523: Show issues Location:
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  3. Article ; Online: Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in Blood of Patients With Coronavirus Disease 2019 (COVID-19): What Does It Mean?

    Jacobs, Jana L / Mellors, John W

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 9, Page(s) e2898–e2900

    MeSH term(s) COVID-19 ; Diagnostic Tests, Routine ; Humans ; RNA ; SARS-CoV-2
    Chemical Substances RNA (63231-63-0)
    Keywords covid19
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1316
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    Zs.A 1505: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  4. Article ; Online: Associations Between Religiosity and Medical Mistrust: An Age-Stratified Analysis of Survey Data from Black Adults in Chicago.

    Jacobs, Jacquelyn / Walsh, Jennifer L / Valencia, Jesus / DiFranceisco, Wayne / Hirschtick, Jana L / Hunt, Bijou R / Quinn, Katherine G / Benjamins, Maureen R

    Journal of racial and ethnic health disparities

    2024  

    Abstract: Medical mistrust is associated with poor health outcomes, ineffective disease management, lower utilization of preventive care, and lack of engagement in research. Mistrust of healthcare systems, providers, and institutions may be driven by previous ... ...

    Abstract Medical mistrust is associated with poor health outcomes, ineffective disease management, lower utilization of preventive care, and lack of engagement in research. Mistrust of healthcare systems, providers, and institutions may be driven by previous negative experiences and discrimination, especially among communities of color, but religiosity may also influence the degree to which individuals develop trust with the healthcare system. The Black community has a particularly deep history of strong religious communities, and has been shown to have a stronger relationship with religion than any other racial or ethnic group. In order to address poor health outcomes in communities of color, it is important to understand the drivers of medical mistrust, which may include one's sense of religiosity. The current study used data from a cross-sectional survey of 537 Black individuals living in Chicago to understand the relationship between religiosity and medical mistrust, and how this differs by age group. Descriptive statistics were used to summarize data for our sample. Adjusted stratified linear regressions, including an interaction variable for age group and religiosity, were used to model the association between religiosity and medical mistrust for younger and older people. The results show a statistically significant relationship for younger individuals. Our findings provide evidence for the central role the faith-based community may play in shaping young peoples' perceptions of medical institutions.
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2760524-3
    ISSN 2196-8837 ; 2197-3792
    ISSN (online) 2196-8837
    ISSN 2197-3792
    DOI 10.1007/s40615-024-01979-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Trusted Sources of Information and COVID-19 Vaccination Among Black Adults in Chicago.

    Hirschtick, Jana L / Walsh, Jennifer L / DiFranceisco, Wayne / Jacobs, Jacquelyn / Hunt, Bijou / Valencia, Jesus / Quinn, Katherine

    American journal of health promotion : AJHP

    2024  , Page(s) 8901171241240529

    Abstract: Purpose: Examine trust in sources of COVID-19 information and vaccination status.: Design: Cross-sectional.: Setting: Chicago, Illinois.: Subjects: Convenience sample of 538 Black adults surveyed between September 2021 and March 2022.: ... ...

    Abstract Purpose: Examine trust in sources of COVID-19 information and vaccination status.
    Design: Cross-sectional.
    Setting: Chicago, Illinois.
    Subjects: Convenience sample of 538 Black adults surveyed between September 2021 and March 2022.
    Measures: Trust in sources of COVID-19 information, COVID-19 vaccination.
    Analysis: Using latent class analysis, we identified classes of trust in sources of COVID-19 information. We considered predictors of class membership using multinomial logistic regression and examined unadjusted and adjusted associations between trust class membership and COVID-19 vaccination while accounting for uncertainty in class assignment.
    Results: Our analytic sample (n = 522) was predominantly aged 18-34 (52%) and female (71%). Results suggested a four-class solution: (1) low trust, (2) high trust in all sources, (3) high trust in doctor and government, and (4) high trust in doctor, faith leader, and family. Unadjusted odds of vaccination were greater in the high trust in all sources (OR 2.0, 95% CI 1.2-3.2), high trust in doctor and government (OR 2.7, 95% CI 1.4-5.3), and high trust in doctor, faith leader, and family classes (OR 2.1, 95% CI 1.2, 3.9) than the low trust class. However, these associations were not significant after adjustment for sociodemographic and health status factors.
    Conclusion: Although COVID-19 vaccination varied across trust classes, our adjusted findings do not suggest a direct association between trust and vaccination, reflecting complexities in the vaccine decision-making process.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645160-3
    ISSN 2168-6602 ; 0890-1171
    ISSN (online) 2168-6602
    ISSN 0890-1171
    DOI 10.1177/08901171241240529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2531: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Community Cohesion, Social Support, and Mental Health among Black Individuals in Chicago: A Cross-Sectional Examination of the Effects on COVID-19 Vaccination.

    Quinn, Katherine G / Hunt, Bijou / Jacobs, Jacquelyn / Valencia, Jesus / Hirschtick, Jana / Walsh, Jennifer L

    Journal of racial and ethnic health disparities

    2023  

    Abstract: The COVID-19 pandemic put a significant strain on communities, social resources, and personal relationships, disproportionately impacting Black and low-income communities in the United States. Community cohesion and social support are positively ... ...

    Abstract The COVID-19 pandemic put a significant strain on communities, social resources, and personal relationships, disproportionately impacting Black and low-income communities in the United States. Community cohesion and social support are positively associated with numerous health outcomes and preventive health measures, yet were strained during the pandemic due to COVID mitigation measures. This study examined the relationships between social cohesion, social support, mental health, and COVID-19 vaccination to understand whether community cohesion and social support were associated with increased likelihood of receiving a COVID-19 vaccination. Data are from a cross-sectional survey of 537 Black Chicagoans that was disseminated between September 2021 and March 2022. Structural equation modeling was used to test associations between community cohesion, social support, loneliness, anxiety, stress, and having received a COVID-19 vaccination. Results demonstrated that social support mediated associations between community cohesion and loneliness, anxiety, and stress, but was not associated with COVID-19 vaccination. These results demonstrate the importance of community cohesion and social support on mental health and suggest there are other potential pathways that may link community cohesion and vaccination.
    Language English
    Publishing date 2023-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2760524-3
    ISSN 2196-8837 ; 2197-3792
    ISSN (online) 2196-8837
    ISSN 2197-3792
    DOI 10.1007/s40615-023-01837-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in Blood of Patients With Coronavirus Disease 2019 (COVID-19)

    Jacobs, Jana L / Mellors, John W

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    What Does It Mean?

    2020  

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/cid/ciaa1316
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Rapid determination of SARS-CoV-2 antibody neutralization titer using Bio-Rad Bio-Plex correlates strongly with pseudovirus-determined neutralization titer.

    Heaps, Amy L / Sobolewski, Michele D / Jacobs, Jana L / Gordon, Kelley C / Haidar, Ghady / Mellors, John W / Parikh, Urvi M

    Journal of virological methods

    2023  Volume 316, Page(s) 114726

    Abstract: Accurate and rapid evaluation of SARS-CoV-2 half-maximal neutralizing antibody (nAb) titer (NT50) is an important research tool for measuring nAb responses after prophylaxis or therapeutics for COVID-19 prevention and management. Compared with ACE2- ... ...

    Abstract Accurate and rapid evaluation of SARS-CoV-2 half-maximal neutralizing antibody (nAb) titer (NT50) is an important research tool for measuring nAb responses after prophylaxis or therapeutics for COVID-19 prevention and management. Compared with ACE2-competitive enzyme immunoassays for nAb detection, pseudovirus assays remain low-throughput and labor intensive. A novel application of the Bio-Rad Bio-Plex Pro Human SARS-CoV-2 D614G S1 Variant nAb Assay was used to determine NT50 from COVID-19-vaccinated individuals and showed strong correlation to a laboratory-developed SARS-CoV-2 pseudovirus nAb assay. The Bio-Plex nAb assay could provide a rapid, high-throughput, culture-free method for NT50 determination in sera.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/diagnosis ; Antibodies, Viral ; Antibodies, Neutralizing ; Angiotensin-Converting Enzyme 2 ; RNA Viruses
    Chemical Substances Antibodies, Viral ; Antibodies, Neutralizing ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2023-03-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2023.114726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: The emerging plasticity of SARS-CoV-2.

    McCormick, Kevin D / Jacobs, Jana L / Mellors, John W

    Science (New York, N.Y.)

    2021  Volume 371, Issue 6536, Page(s) 1306–1308

    MeSH term(s) Amino Acid Substitution ; Angiotensin-Converting Enzyme 2/metabolism ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/virology ; COVID-19 Vaccines/immunology ; Evolution, Molecular ; Genome, Viral ; Humans ; Immune Evasion ; Mutation ; Protein Domains ; Receptors, Coronavirus/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; SARS-CoV-2/physiology ; Selection, Genetic ; Sequence Deletion ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Receptors, Coronavirus ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abg4493
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    Zs.MG 77: Show issues

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