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Article: Y-chromosomal STR haplotype in the Japanese population.

Koyama, H / Iwasa, M / Maeno, Y / Tsuchimochi, T / Isobe, I / Yoshimi, S N / Jun, M O / Matsumoto, T / Horii, T / Nagao, M

Forensic science international

2002 Volume 124, Issue 2-3, Page(s) 221–223

Abstract: Allele and haplotype frequencies of seven Y-chromosome STR loci from samples of 108 unrelated ...

Abstract	Allele and haplotype frequencies of seven Y-chromosome STR loci from samples of 108 unrelated Japanese males living in Aichi Prefecture.
MeSH term(s)	Alleles ; Genetics, Population ; Haplotypes ; Humans ; Japan ; Polymerase Chain Reaction ; Tandem Repeat Sequences ; Y Chromosome/genetics
Language	English
Publishing date	2002-01-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/s0379-0738(01)00572-2
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Article ; Online: Evidence for a new resonance and search for the Y(4140) in the gammagamma-->phiJ/psi process.

Shen, C P / Yuan, C Z / Aihara, H / Arinstein, K / Aushev, T / Bakich, A M / Balagura, V / Barberio, E / Bay, A / Belous, K / Bhardwaj, V / Bischofberger, M / Bracko, M / Browder, T E / Chang, M-C / Chang, P / Chen, A / Chen, P / Cheon, B G /

Chiang, C-C / Cho, I-S / Choi, Y / Dalseno, J / Das, A / Dolezal, Z / Drutskoy, A / Eidelman, S / Epifanov, D / Gabyshev, N / Golob, B / Ha, H / Haba, J / Han, B-Y / Hayasaka, K / Hayashii, H / Horii, Y / Hoshi, Y / Hou, W-S / Hsiung, Y B / Hyun, H J / Inami, K / Itoh, R / Iwabuchi, M / Iwasaki, M / Iwasaki, Y / Joshi, N J / Julius, T / Kang, J H / Kawasaki, T / Kiesling, C / Kim, H J / Kim, H O / Kim, J H / Kim, S K / Kim, Y I / Kim, Y J / Ko, B R / Kodys, P / Korpar, S / Kreps, M / Krizan, P / Krokovny, P / Kuhr, T / Kwon, Y-J / Kyeong, S-H / Lange, J S / Lee, M J / Lee, S-H / Li, J / Liu, C / Liu, Y / Liventsev, D / Louvot, R / Matyja, A / McOnie, S / Miyabayashi, K / Miyata, H / Miyazaki, Y / Mori, T / Mussa, R / Nakano, E / Nakao, M / Nakazawa, H / Natkaniec, Z / Neubauer, S / Nishida, S / Nishimura, K / Nitoh, O / Ohshima, T / Okuno, S / Olsen, S L / Pakhlova, G / Park, C W / Park, H / Park, H K / Pestotnik, R / Petric, M / Piilonen, L E / Röhrken, M / Ryu, S / Sahoo, H / Sakai, Y / Schneider, O / Senyo, K / Sevior, M E / Shapkin, M / Shiu, J-G / Shwartz, B / Singh, J B / Smerkol, P / Sokolov, A / Solovieva, E / Staric, M / Teramoto, Y / Trabelsi, K / Uehara, S / Uglov, T / Unno, Y / Uno, S / Urquijo, P / Varner, G / Vervink, K / Wang, C H / Wang, P / Wang, X L / Watanabe, Y / Wedd, R / Won, E / Yabsley, B D / Yamashita, Y / Zhang, C C / Zhang, Z P / Zivko, T / Zyukova, O

Physical review letters

2010 Volume 104, Issue 11, Page(s) 112004

Abstract: ... 2{+}. No signal for the Y(4140)-->phiJ/psi structure reported by the CDF Collaboration in B-->K ... phiJ/psi decays is observed, and limits of Gamma_{gammagamma}(Y(4140))B(Y(4140)-->phiJ/psi)<41 eV for J ... in which the Y(4140) is a D{s}{*+}D{s}{*-} molecule. ...

Abstract	The process gammagamma-->phiJ/psi is measured using a data sample of 825 fb{-1} collected with the Belle detector. A narrow peak of 8.8{-3.2}{+4.2} events, with a significance of 3.2 standard deviations including systematic uncertainty, is observed. The mass and natural width of the structure [named X(4350)] are measured to be [4350.6{-5.1}{+4.6}(stat)+/-0.7(syst)] MeV/c{2} and [13{-9}{+18}(stat)+/-4(syst)] MeV, respectively. The product of its two-photon decay width and branching fraction to phiJ/psi is [6.7{-2.4}{+3.2}(stat)+/-1.1(syst)] eV for J{P}=0{+}, or [1.5{-0.6}{+0.7}(stat)+/-0.3(syst)] eV for J{P}=2{+}. No signal for the Y(4140)-->phiJ/psi structure reported by the CDF Collaboration in B-->K{+}phiJ/psi decays is observed, and limits of Gamma_{gammagamma}(Y(4140))B(Y(4140)-->phiJ/psi)<41 eV for J{P}=0;{+} or <6.0 eV for J{P}=2{+} are determined at the 90% C.L. This disfavors the scenario in which the Y(4140) is a D{s}{+}D{s}{-} molecule.
Language	English
Publishing date	2010-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.104.112004
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Article ; Online: Purinergic inhibitory regulation of esophageal smooth muscle is mediated by P2Y receptors and ATP-dependent potassium channels in rats.

Shiina, Takahiko / Suzuki, Yuji / Horii, Kazuhiro / Sawamura, Tomoya / Yuki, Natsufu / Horii, Yuuki / Shimizu, Yasutake

The journal of physiological sciences : JPS

2024 Volume 74, Issue 1, Page(s) 26

Abstract: Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated segment of the rat esophagus was placed in an ... ...

Abstract	Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated segment of the rat esophagus was placed in an organ bath, and mechanical responses were recorded using a force transducer. Exogenous application of ATP (10-100 μM) evoked relaxation of the esophageal smooth muscle in a longitudinal direction under the condition of carbachol (1 μM) -induced precontraction. Pretreatment with a non-selective P2 receptor antagonist, suramin (500 μM), and a P2Y receptor antagonist, cibacron blue F3GA (200 μM), inhibited the ATP (100 μM) -induced relaxation, but a P2X receptor antagonist, pyridoxal phosphate-6-azophenyl-2,4-disulfonic acid (50 μM), did not affect it. A blocker of ATP-dependent potassium channels (K
MeSH term(s)	Animals ; Rats ; Muscle, Smooth/drug effects ; Muscle, Smooth/physiology ; Muscle, Smooth/metabolism ; Male ; Receptors, Purinergic P2Y/metabolism ; Esophagus/drug effects ; Esophagus/physiology ; Adenosine Triphosphate/metabolism ; Adenosine Triphosphate/pharmacology ; KATP Channels/metabolism ; Muscle Relaxation/drug effects ; Muscle Relaxation/physiology ; Rats, Wistar ; Muscle Contraction/drug effects ; Muscle Contraction/physiology ; Purinergic P2Y Receptor Antagonists/pharmacology ; Gastrointestinal Motility/drug effects ; Gastrointestinal Motility/physiology ; Rats, Sprague-Dawley
Chemical Substances	Receptors, Purinergic P2Y ; Adenosine Triphosphate (8L70Q75FXE) ; KATP Channels ; Purinergic P2Y Receptor Antagonists
Language	English
Publishing date	2024-04-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2234472-X
ISSN	1880-6562 ; 1880-6546
ISSN (online)	1880-6562
ISSN	1880-6546
DOI	10.1186/s12576-024-00916-5
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Article: Computed tomography-guided percutaneous needle biopsy for middle mediastinal tumors with retroaortic paravertebral approach: A case report.

Nakama, Rakuhei / Arai, Yasunori / Horii, Toshihiro / Kobayashi, Tatsushi

Radiology case reports

2024 Volume 19, Issue 4, Page(s) 1440–1444

Abstract: A 74-year-old man was referred to our hospital for a close examination of a mediastinal mass. Contrast-enhanced CT showed a middle mediastinal tumor. We planned to perform a CT-guided percutaneous needle biopsy of the tumor using a retroaortic ... ...

Abstract	A 74-year-old man was referred to our hospital for a close examination of a mediastinal mass. Contrast-enhanced CT showed a middle mediastinal tumor. We planned to perform a CT-guided percutaneous needle biopsy of the tumor using a retroaortic paravertebral approach to avoid transpulmonary puncture. A coaxial blunt-tip needle with a side hole was used to create space in the mediastinum and avoid azygos vein injury. After injecting normal saline, a blunt-tip needle was advanced through the space between the aorta and the vertebral body to the anterior surface of the tumor, and tissue was obtained. The patient was discharged the following day with no complications. For percutaneous middle mediastinal tumor biopsy, the retroaortic paravertebral approach may be a safe, effective route.
Language	English
Publishing date	2024-01-17
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2023.12.062
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Article ; Online: Changes in CT values of wood in the body: pitfalls in detecting a wooden foreign body.

Shiraki, Yuya / Takahashi, Takeshi / Ogi, Manabu / Horii, Arata

BMJ case reports

2024 Volume 17, Issue 2

MeSH term(s)	Humans ; Wood ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Eye Foreign Bodies/diagnosis ; Tomography, X-Ray Computed
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-259348
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Article ; Online: Development of immune cell delivery system using biodegradable injectable polymers for cancer immunotherapy.

Yoshizaki, Yuta / Horii, Kenta / Murase, Nobuo / Kuzuya, Akinori / Ohya, Yuichi

International journal of pharmaceutics

2024 Volume 652, Page(s) 123801

Abstract: Immune cell delivery using injectable hydrogel attracts much attention for improving its therapeutic effect. Specifically, dendritic cells (DCs) are the trigger cells for immune responses, and DC vaccines are studied for improving cancer immunotherapy. ... ...

Abstract	Immune cell delivery using injectable hydrogel attracts much attention for improving its therapeutic effect. Specifically, dendritic cells (DCs) are the trigger cells for immune responses, and DC vaccines are studied for improving cancer immunotherapy. Hydrogel-assisted cell delivery is expected to enhance the viability of the implanted cells. We recently reported temperature-responsive biodegradable injectable polymer (IP) formulation utilizing poly(ε-caprolactone-co-glycolide)-b-poly(ethylene glycol)(PEG)-b-poly(ε-caprolactone-co-glycolide) (tri-PCG). Tri-PCG-based IP was reported to exhibit immediate sol-to-gel transition in response to temperature increase, in vivo biodegradability, and excellent biocompatibility. In this study, tri-PCG-based IP was applied to DC delivery. IP encapsulated live DCs, and the DCs incorporated ovalbumin (OVA) as a model antigen and CpG-DNA (oligo DNA with adjuvant effect) in IP hydrogel. Results suggested that DCs encapsulated in IP hydrogel internalized OVA and CpG-DNA and DCs were maturated to present antigens to T cells. Moreover, subcutaneously injected tri-PCG-based IP prolonged the retention period of cell accumulation at injected sites. Tri-PCG IP hydrogel could release matured DCs as the degradation of the hydrogel progressed. Tri-PCG IP formulation improved treatment efficacy of OVA transfected mouse lymphoma (E.G7-OVA) tumor. Hence, tri-PCG IP is a promising platform for immune cell delivery.
MeSH term(s)	Mice ; Animals ; Polymers/metabolism ; Polyethylene Glycols ; Hydrogels ; Antigens ; DNA ; Dendritic Cells ; Immunotherapy ; Neoplasms/therapy ; Caproates ; Lactones
Chemical Substances	caprolactone (56RE988L1R) ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A) ; Hydrogels ; Antigens ; DNA (9007-49-2) ; Caproates ; Lactones
Language	English
Publishing date	2024-01-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2024.123801
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Article ; Online: Treatment of Renal Anemia in Patients With Hemodialysis Using Hypoxia-inducible Factor (HIF) Stabilizer, Roxadustat: A Short-term Clinical Study.

Mima, Akira / Horii, Yasuhiro

In vivo (Athens, Greece)

2022 Volume 36, Issue 4, Page(s) 1785–1789

Abstract: Background/aim: Renal anemia is a major complication in patients with chronic kidney disease (CKD) and hemodialysis, increasing morbidity and mortality. Roxadustat is a novel oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor (PHI), which ... ...

Abstract	Background/aim: Renal anemia is a major complication in patients with chronic kidney disease (CKD) and hemodialysis, increasing morbidity and mortality. Roxadustat is a novel oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor (PHI), which is administrated for renal anemia. Different from erythropoiesis-stimulating agents (ESAs), Roxadustat could increase erythropoietin physiologically, improving the therapeutic effects. It has not been so long since Roxadustat was approved by the European Commission (EC). Thus, only a few studies have reported on the treatment of renal anemia using Roxadustat. Patients and methods: In this study, we evaluated the efficacy of Roxadustat in patients undergoing hemodialysis (HD). Nine patients under HD (72±10 years old) were enrolled in this study. Patients received Roxadustat first time or changed from ESAs (5-10 mg, 3 times a week after HD). Observation period was 5.3±2.9 months. Results: Roxadustat treatment effectively increased and maintained hemoglobin levels. Levels of ferritin and C-reactive protein tended to decrease, but the difference was not statistically significant. No significant adverse effects were observed in all patients during the study. Conclusion: Roxadustat is effective and relatively tolerant for treating renal anemia in patients subjected to hemodialysis.
MeSH term(s)	Aged ; Aged, 80 and over ; Anemia/drug therapy ; Anemia/etiology ; Glycine/analogs & derivatives ; Hematinics/adverse effects ; Humans ; Hypoxia ; Hypoxia-Inducible Factor-Proline Dioxygenases/therapeutic use ; Isoquinolines ; Middle Aged ; Renal Dialysis/adverse effects
Chemical Substances	Hematinics ; Isoquinolines ; Hypoxia-Inducible Factor-Proline Dioxygenases (EC 1.14.11.29) ; Glycine (TE7660XO1C) ; roxadustat (X3O30D9YMX)
Language	English
Publishing date	2022-06-23
Publishing country	Greece
Document type	Clinical Study ; Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.12892
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Article ; Online: Real-world risk of cardiovascular diseases in patients with type 2 diabetes associated with sodium-glucose cotransporter 2 inhibitors in comparison with metformin: A propensity score-matched model analysis in Japan.

Horii, Takeshi / Oikawa, Yoichi / Shimada, Akira / Mihara, Kiyoshi

Journal of diabetes investigation

2023 Volume 14, Issue 11, Page(s) 1262–1267

Abstract: We aimed to compare the effects of cardiovascular disease risk in Japanese patients with type 2 diabetes on sodium-glucose cotransporter 2 inhibitors (SGLT2Is) or metformin. This retrospective, real-world cohort study was carried out using a claims ... ...

Abstract	We aimed to compare the effects of cardiovascular disease risk in Japanese patients with type 2 diabetes on sodium-glucose cotransporter 2 inhibitors (SGLT2Is) or metformin. This retrospective, real-world cohort study was carried out using a claims database and propensity score matching; 58,402 eligible patients (29,201 per group) were included. The outcomes included nonfatal myocardial infarction, angina pectoris, nonfatal stroke, hospitalization for heart failure and composite end-points. The hazard ratio (HR) for the composite end-point was 0.79, which was lower for SGLT2Is than for metformin. For male patients (HR 0.76), patients aged <65 years (HR 0.94), patients aged ≥75 years (HR 0.78) and patients with body mass index ≥25 kg/m
MeSH term(s)	Humans ; Male ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/chemically induced ; Metformin/therapeutic use ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/chemically induced ; Hypoglycemic Agents/therapeutic use ; Cohort Studies ; Retrospective Studies ; Japan/epidemiology ; Propensity Score ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Glucose ; Sodium
Chemical Substances	Metformin (9100L32L2N) ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2023-07-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2625840-7
ISSN	2040-1124 ; 2040-1116
ISSN (online)	2040-1124
ISSN	2040-1116
DOI	10.1111/jdi.14062
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Book ; Online: Uncertainty Quantification in Heterogeneous Treatment Effect Estimation with Gaussian-Process-Based Partially Linear Model

Horii, Shunsuke / Chikahara, Yoichi

2023

Abstract: Estimating heterogeneous treatment effects across individuals has attracted growing attention as a statistical tool for performing critical decision-making. We propose a Bayesian inference framework that quantifies the uncertainty in treatment effect ... ...

Abstract	Estimating heterogeneous treatment effects across individuals has attracted growing attention as a statistical tool for performing critical decision-making. We propose a Bayesian inference framework that quantifies the uncertainty in treatment effect estimation to support decision-making in a relatively small sample size setting. Our proposed model places Gaussian process priors on the nonparametric components of a semiparametric model called a partially linear model. This model formulation has three advantages. First, we can analytically compute the posterior distribution of a treatment effect without relying on the computationally demanding posterior approximation. Second, we can guarantee that the posterior distribution concentrates around the true one as the sample size goes to infinity. Third, we can incorporate prior knowledge about a treatment effect into the prior distribution, improving the estimation efficiency. Our experimental results show that even in the small sample size setting, our method can accurately estimate the heterogeneous treatment effects and effectively quantify its estimation uncertainty. Comment: 15 pages, 4 figures, accepted at The 38th Annual AAAI Conference on Artificial Intelligence (AAAI-24)
Keywords	Statistics - Methodology ; Computer Science - Artificial Intelligence
Subject code	310
Publishing date	2023-12-16
Publishing country	us
Document type	Book ; Online
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Article ; Online: Active Inference Through Energy Minimization in Multimodal Affective Human-Robot Interaction.

Horii, Takato / Nagai, Yukie

Frontiers in robotics and AI

2021 Volume 8, Page(s) 684401

Abstract: During communication, humans express their emotional states using various modalities (e.g., facial expressions and gestures), and they estimate the emotional states of others by paying attention to multimodal signals. To ensure that a communication robot ...

Abstract	During communication, humans express their emotional states using various modalities (e.g., facial expressions and gestures), and they estimate the emotional states of others by paying attention to multimodal signals. To ensure that a communication robot with limited resources can pay attention to such multimodal signals, the main challenge involves selecting the most effective modalities among those expressed. In this study, we propose an active perception method that involves selecting the most informative modalities using a criterion based on energy minimization. This energy-based model can learn the probability of the network state using energy values, whereby a lower energy value represents a higher probability of the state. A multimodal deep belief network, which is an energy-based model, was employed to represent the relationships between the emotional states and multimodal sensory signals. Compared to other active perception methods, the proposed approach demonstrated improved accuracy using limited information in several contexts associated with affective human-robot interaction. We present the differences and advantages of our method compared to other methods through mathematical formulations using, for example, information gain as a criterion. Further, we evaluate performance of our method, as pertains to active inference, which is based on the free energy principle. Consequently, we establish that our method demonstrated superior performance in tasks associated with mutually correlated multimodal information.
Language	English
Publishing date	2021-11-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781824-X
ISSN	2296-9144 ; 2296-9144
ISSN (online)	2296-9144
ISSN	2296-9144
DOI	10.3389/frobt.2021.684401
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