LIVIVO - Search results -

Search results

Result 1 - 10 of total 16590

Search options

Article ; Online: Association between albumin-bilirubin grade and plasma trough concentrations of regorafenib and its metabolites M-2 and M-5 at steady-state in Japanese patients.

Fujita, Kazuma / Taguchi, Daiki / Fukuda, Koji / Yoshida, Taichi / Shimazu, Kazuhiro / Shinozaki, Hanae / Shibata, Hiroyuki / Miura, Masatomo

Investigational new drugs

2024

Abstract: The aim of the present study was to determine whether the trough plasma concentrations ( ... ...

Abstract	The aim of the present study was to determine whether the trough plasma concentrations (C
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	604895-x
ISSN	1573-0646 ; 0167-6997
ISSN (online)	1573-0646
ISSN	0167-6997
DOI	10.1007/s10637-024-01429-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1823: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Spatiotemporal Design of the Metal-Organic Framework DUT-8(M).

Miura, Hiroki / Bon, Volodymyr / Senkovska, Irena / Ehrling, Sebastian / Bönisch, Nadine / Mäder, Gerrit / Grünzner, Stefan / Khadiev, Azat / Novikov, Dmitri / Maity, Kartik / Richter, Andreas / Kaskel, Stefan

Advanced materials (Deerfield Beach, Fla.)

2022 Volume 35, Issue 8, Page(s) e2207741

Abstract: ... the first example in which an explicit temporal engineering of a switchable MOF (DUT-8, [M ...

Abstract	Switchable metal-organic frameworks (MOFs) change their structure in time and selectively open their pores adsorbing guest molecules, leading to highly selective separation, pressure amplification, sensing, and actuation applications. The 3D engineering of MOFs has reached a high level of maturity, but spatiotemporal evolution opens a new perspective toward engineering materials in the 4th dimension (time) by t-axis design, in essence exploiting the deliberate tuning of activation barriers. This work demonstrates the first example in which an explicit temporal engineering of a switchable MOF (DUT-8, [M
Language	English
Publishing date	2022-12-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202207741
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Rapid and efficient synthesis of a novel cholinergic muscarinic M

Miura, Shotaro / Fukuda, Koichiro / Masada, Shinichi / Usutani, Hirotsugu / Kanematsu, Makoto / Cork, David G / Kawamoto, Tetsuji

Organic & biomolecular chemistry

2019 Volume 17, Issue 35, Page(s) 8166–8174

Abstract: ... of a novel cholinergic muscarinic M ...

Abstract	Continuous flow-flash synthesis of a 2-bromobenzaldehyde derivative 18 as a key intermediate of a novel cholinergic muscarinic M
MeSH term(s)	Allosteric Regulation/drug effects ; Benzaldehydes/chemical synthesis ; Benzaldehydes/chemistry ; Benzaldehydes/pharmacology ; Cholinergic Agents/chemical synthesis ; Cholinergic Agents/chemistry ; Cholinergic Agents/pharmacology ; Humans ; Molecular Structure ; Receptor, Muscarinic M1/metabolism
Chemical Substances	2-bromobenzaldehyde ; Benzaldehydes ; CHRM1 protein, human ; Cholinergic Agents ; Receptor, Muscarinic M1
Language	English
Publishing date	2019-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/c9ob01718f
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from

Tsurumi, Fumika / Miura, Yuta / Nakano, Misaki / Saito, Yohei / Fukuyoshi, Shuichi / Miyake, Katsunori / Newman, David J / O'Keefe, Barry R / Lee, Kuo-Hsiung / Nakagawa-Goto, Kyoko

Journal of natural products

2019 Volume 82, Issue 9, Page(s) 2368–2378

Abstract: ... A ... ...

Abstract	A CH
MeSH term(s)	Antineoplastic Agents, Phytogenic/chemistry ; Cell Line, Tumor ; Cryptocarya/chemistry ; Humans ; Lactones/chemistry ; Molecular Structure ; Monoterpenes/chemistry ; Plant Leaves/chemistry ; Spectrum Analysis/methods ; Spiro Compounds/chemistry
Chemical Substances	Antineoplastic Agents, Phytogenic ; Lactones ; Monoterpenes ; Spiro Compounds
Language	English
Publishing date	2019-08-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.8b00732
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1144: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Insulin-like growth factor I receptor regulates the radiation-induced G2/M checkpoint in HeLa cells.

Manila, Nisha Gowri / Kaida, Atsushi / Nakahama, Ken-Ichi / Miura, Masahiko

Biochemical and biophysical research communications

2018 Volume 503, Issue 4, Page(s) 2977–2983

Abstract: ... with release from G2 arrest. We conclude that IGF-IR directly regulates the G2/M checkpoint via the PI3K/AKT ...

Abstract	Insulin-like growth factor I receptor (IGF-IR) plays pivotal roles in various biological events, including cell growth, transformation, survival, and DNA repair. In this study, we explored its possible involvement in cell cycle checkpoints, using HeLa cells expressing the fluorescent ubiquitination-based cell cycle indicator (Fucci). We found that IGF-IR inhibitor delayed release from radiation-induced G2 arrest, as demonstrated by FACS and pedigree analysis of Fucci fluorescence. Elongated G2 arrest was also induced by inhibitors of phosphatidylinositol-3 kinase (PI3K) and AKT, but not by inhibitor of MEK, which are two major IGF-IR downstream signaling pathways. Double-strand break (DSB) repair kinetics were not affected by IGF-IR inhibitor. CHK1 inhibitor abrogated radiation-induced G2 arrest, whereas radiation-induced phosphorylation of CHK1 at Ser 345 or Ser 296 was decreased by the IGF-IR inhibitor. However, radiation-induced nuclear localization of CHK1 was prolonged in IGF-IR inhibitor-treated cells in comparison with cells that received radiation alone; in the latter, CHK1 returned to the original diffuse distribution in conjunction with release from G2 arrest. We conclude that IGF-IR directly regulates the G2/M checkpoint via the PI3K/AKT pathway without influencing DSB repair, in part by controlling CHK1 localization between the nucleus and cytoplasm.
MeSH term(s)	Cell Cycle Checkpoints/radiation effects ; Checkpoint Kinase 1/metabolism ; Fluorescence ; G2 Phase Cell Cycle Checkpoints/radiation effects ; HeLa Cells ; Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, IGF Type 1/physiology
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Receptor, IGF Type 1 (EC 2.7.10.1) ; Checkpoint Kinase 1 (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2018-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2018.08.080
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The discovery of (1R, 3R)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile, a potent and selective agonist of human transient receptor potential cation channel subfamily m member 5 (TRPM5) and evaluation of as a potential gastrointestinal prokinetic agent.

Sabat, M / Raveglia, L F / Aldegheri, L / Barilli, A / Bianchi, F / Brault, L / Brodbeck, D / Feriani, A / Lingard, I / Miura, J / Myers, R / Piccoli, L / Tassini, S / Tyhonas, J / Ton-Nu, T / Wang, H / Virginio, C

Bioorganic & medicinal chemistry

2022 Volume 76, Page(s) 117084

Abstract: ... channel subfamily M member 5 (TRPM5) agonists culminating with the identification of the lead compound (1R ...

Abstract	This publication details the discovery of a series of selective transient receptor potential cation channel subfamily M member 5 (TRPM5) agonists culminating with the identification of the lead compound (1R, 3R)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile (39). We describe herein our biological rationale for agonism of the target, the examination of the then current literature tool molecules, and finally the process of our discovery starting with a high throughput screening hit through lead development. We also detail the selectivity of the lead compound 39 versus related family members TRPA1, TRPV1, TRPV4, TRPM4 and TRPM8, the drug metabolism and pharmacokinetics (DMPK) profile and in vivo efficacy in a mouse model of gastrointestinal motility.
MeSH term(s)	Animals ; Mice ; Humans ; Transient Receptor Potential Channels ; TRPM Cation Channels ; TRPV Cation Channels
Chemical Substances	1,2,3,4-tetrahydroisoquinoline (56W89FBX3E) ; Transient Receptor Potential Channels ; TRPM4 protein, mouse ; TRPM Cation Channels ; Trpv4 protein, mouse ; TRPV Cation Channels ; Trpm5 protein, mouse
Language	English
Publishing date	2022-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2022.117084
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3815: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: On-chip light-sheet fluorescence imaging flow cytometry at a high flow speed of 1 m/s.

Miura, Taichi / Mikami, Hideharu / Isozaki, Akihiro / Ito, Takuro / Ozeki, Yasuyuki / Goda, Keisuke

Biomedical optics express

2018 Volume 9, Issue 7, Page(s) 3424–3433

Abstract: ... flowing at a high speed of 1 m/s, which is comparable to the flow speed of conventional non-imaging flow ...

Abstract	We present on-chip fluorescence imaging flow cytometry by light-sheet excitation on a mirror-embedded microfluidic chip. The method allows us to obtain microscopy-grade fluorescence images of cells flowing at a high speed of 1 m/s, which is comparable to the flow speed of conventional non-imaging flow cytometers. To implement the light-sheet excitation of flowing cells in a microchannel, we designed and fabricated a mirror-embedded PDMS-based microfluidic chip. To show its broad utility, we used the method to classify large populations of microalgal cells (
Language	English
Publishing date	2018-06-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2572216-5
ISSN	2156-7085
ISSN	2156-7085
DOI	10.1364/BOE.9.003424
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Book ; Online: Perpendicular magnetic anisotropy at Fe/Au(111) interface studied by M\"{o}ssbauer, x-ray absorption, and photoemission spectroscopies

Okabayashi, Jun / Li, Songtian / Sakai, Seiji / Kobayashi, Yasuhiro / Mitsui, Takaya / Tanaka, Kiyohisa / Miura, Yoshio / Mitani, Seiji

2021

Abstract: ... layer on the Au(111) surface was examined using synchrotron-radiation-based M\"{o}ssbauer spectroscopy ...

Abstract	The origin of the interfacial perpendicular magnetic anisotropy (PMA) induced in the ultrathin Fe layer on the Au(111) surface was examined using synchrotron-radiation-based M\"{o}ssbauer spectroscopy (MS), X-ray magnetic circular dichroism (XMCD), and angle-resolved photoemission spectroscopy (ARPES). To probe the detailed interfacial electronic structure of orbital hybridization between the Fe 3$d$ and Au 6$p$ bands, we detected the interfacial proximity effect, which modulates the valence-band electronic structure of Fe, resulting in PMA. MS and XMCD measurements were used to detect the interfacial magnetic structure and anisotropy in orbital magnetic moments, respectively. $In$-$situ$ ARPES also confirms the initial growth of Fe on large spin-orbit coupled surface Shockley states under Au(111) modulated electronic states in the vicinity of the Fermi level. This suggests that PMA in the Fe/Au(111) interface originates from the cooperation effects among the spin, orbital magnetic moments in Fe, and large spin-orbit coupling in Au. These findings pave the way to develop interfacial PMA using $p$-$d$ hybridization with a large spin-orbit interaction.
Keywords	Condensed Matter - Materials Science
Subject code	530
Publishing date	2021-03-11
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function.

Xue, Lian / Furusawa, Yoshiya / Okayasu, Ryuichi / Miura, Masahiko / Cui, Xing / Liu, Cuihua / Hirayama, Ryoichi / Matsumoto, Yoshitaka / Yajima, Hirohiko / Yu, Dong

DNA repair

2015 Volume 25, Page(s) 72–83

Abstract: ... we investigated how the complexity of DSB influences the function of ATR pathway on the G2/M checkpoint regulation ... played a pivotal role and functioned in a dose- and LET-dependent way to regulate the early G2/M arrest ... Furthermore, ATR pathway also functioned more efficiently in ATM-proficient cells to block G2 to M transition ...

Abstract	DNA double strand break (DSB) repair pathway choice following ionizing radiation (IR) is currently an appealing research topic, which is still largely unclear. Our recent paper indicated that the complexity of DSBs is a critical factor that enhances DNA end resection. It has been well accepted that the RPA-coated single strand DNA produced by resection is a signaling structure for ATR activation. Therefore, taking advantage of high linear energy transfer (LET) radiation to effectively produce complex DSBs, we investigated how the complexity of DSB influences the function of ATR pathway on the G2/M checkpoint regulation. Human skin fibroblast cells with or without ATM were irradiated with X rays or heavy ion particles, and dual-parameter flow cytometry was used to quantitatively assess the mitotic entry at early period post radiation by detecting the cells positive for phosphor histone H3. In ATM-deficient cells, ATR pathway played a pivotal role and functioned in a dose- and LET-dependent way to regulate the early G2/M arrest even as low as 0.2Gy for heavy ion radiation, which indicated that ATR pathway could be rapidly activated and functioned in an ATM-independent, but DSB complexity-dependent manner following exposure to IR. Furthermore, ATR pathway also functioned more efficiently in ATM-proficient cells to block G2 to M transition at early period of particle radiation exposure. Accordingly, in contrast to ATM inhibitor, ATR inhibitor had a more effective radiosensitizing effect on survival fraction following heavy ion beams as compared with X ray radiation. Taken together, our results reveal that the complexity of DSBs is a crucial factor for the activation of ATR pathway for G2/M checkpoint regulation, and ATM-dependent end resection is not essential for the activation.
MeSH term(s)	Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cells, Cultured ; DNA/metabolism ; DNA/radiation effects ; DNA Breaks, Double-Stranded ; DNA End-Joining Repair ; G2 Phase/radiation effects ; G2 Phase Cell Cycle Checkpoints/genetics ; Humans ; Linear Energy Transfer ; Phosphorylation ; Radiation, Ionizing ; Recombinational DNA Repair ; Signal Transduction
Chemical Substances	DNA (9007-49-2) ; ATM protein, human (EC 2.7.11.1) ; ATR protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
Language	English
Publishing date	2015-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2071608-4
ISSN	1568-7856 ; 1568-7864
ISSN (online)	1568-7856
ISSN	1568-7864
DOI	10.1016/j.dnarep.2014.11.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5555: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Complete nucleotide sequence of the IncN plasmid encoding IMP-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in Japan.

Kayama, Shizuo / Shigemoto, Norifumi / Kuwahara, Ryuichi / Oshima, Kenshiro / Hirakawa, Hideki / Hisatsune, Junzo / Jové, Thomas / Nishio, Hisaaki / Yamasaki, Katsutoshi / Wada, Yasunao / Ueshimo, Takeshi / Miura, Tetsuya / Sueda, Taijiro / Onodera, Makoto / Yokozaki, Michiya / Hattori, Masahira / Ohge, Hiroki / Sugai, Motoyuki

Antimicrobial agents and chemotherapy

2015 Volume 59, Issue 2, Page(s) 1356–1359

Abstract: ... which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth ... with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members ...

Abstract	We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not detectable with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members of the family Enterobacteriaceae.
MeSH term(s)	Enterobacteriaceae/drug effects ; Enterobacteriaceae/enzymology ; Imipenem/pharmacology ; Japan ; Microbial Sensitivity Tests ; Molecular Sequence Data ; Plasmids/genetics ; beta-Lactamases/metabolism
Chemical Substances	Imipenem (71OTZ9ZE0A) ; beta-lactamase CTX-2 (EC 3.5.2.-) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2015-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.04759-14
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito