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Article: Diagnosis of recurrent and metastatic disease using f-18 fluorodeoxyglucose-positron emission tomography in breast cancer.

Eubank, William B

2007 Volume 45, Issue 4, Page(s) 659–67, vi

Abstract: One of the major strengths of F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) in breast cancer imaging is in the evaluation of patients who have suspected loco-regional recurrence or distant metastasis. In general, FDG-PET is more ... ...

Abstract	One of the major strengths of F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) in breast cancer imaging is in the evaluation of patients who have suspected loco-regional recurrence or distant metastasis. In general, FDG-PET is more sensitive than conventional imaging for the detection of recurrent disease. Because of its ability to more accurately stage patients who have advanced breast cancer, FDG-PET has a significant impact on choice of treatment and management in this patient group.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Male ; Neoplasm Metastasis/diagnostic imaging ; Neoplasm Recurrence, Local/diagnostic imaging ; Predictive Value of Tests ; Radionuclide Imaging ; Radiopharmaceuticals ; Sensitivity and Specificity
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2007-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	215712-3
ISSN	1557-8275 ; 0033-8389
ISSN (online)	1557-8275
ISSN	0033-8389
DOI	10.1016/j.rcl.2007.05.005
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Article: Diagnosis of Recurrent and Metastatic Disease Using F-18 Fluorodeoxyglucose-Positron Emission Tomography.

Eubank, William B

PET clinics

2006 Volume 1, Issue 1, Page(s) 15–24

Abstract	One of the major strengths of F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) in breast cancer imaging is in the evaluation of patients who have suspected loco-regional recurrence or distant metastasis. In general, FDG-PET is more sensitive than conventional imaging for the detection of recurrent disease. Because of its ability to more accurately stage patients who have advanced breast cancer, FDG-PET has a significant impact on choice of treatment and management in this patient group.
Language	English
Publishing date	2006-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2764575-7
ISSN	1879-9809 ; 1556-8598
ISSN (online)	1879-9809
ISSN	1556-8598
DOI	10.1016/j.cpet.2005.09.002
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Article: Current and future use of positron emission tomography (PET) in breast cancer.

Mankoff, David A / Eubank, William B

Journal of mammary gland biology and neoplasia

2006 Volume 11, Issue 2, Page(s) 125–136

Abstract: Positron emission tomography (PET) is a radiotracer imaging method that is increasingly used in both the clinical care of breast cancer patients and in translational breast cancer research. This review emphasizes current and future clinical applications ... ...

Abstract	Positron emission tomography (PET) is a radiotracer imaging method that is increasingly used in both the clinical care of breast cancer patients and in translational breast cancer research. This review emphasizes current and future clinical applications of PET to breast cancer, and highlights some translational research using PET to elucidate the clinical biology of breast cancer. PET principles are reviewed, followed by a review of current applications of (18)F-fluorodeoxyglucose (FDG) to clinical breast cancer care. Finally we review work done with other radiopharmaceuticals beyond FDG designed to image a number of aspects of breast cancer biology, emphasizing those most likely to enter clinical trials in the near future.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/secondary ; Female ; Fluorodeoxyglucose F18 ; Forecasting ; Humans ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Staging/methods ; Positron-Emission Tomography/methods ; Positron-Emission Tomography/trends ; Preoperative Care ; Prognosis ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy/methods
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2006-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1327345-0
ISSN	1083-3021
ISSN	1083-3021
DOI	10.1007/s10911-006-9019-z
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Article ; Online: [¹⁸F]fluorodeoxyglucose positron emission tomography-computed tomography in breast cancer: when... and when not?

Mankoff, David A / Specht, Jennifer M / Eubank, William B / Kessler, Larry

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2012 Volume 30, Issue 12, Page(s) 1252–1254

MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lymph Nodes/diagnostic imaging ; Lymphatic Metastasis/diagnostic imaging ; Positron-Emission Tomography/methods ; Sentinel Lymph Node Biopsy/methods
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2012-04-20
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2011.40.6975
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Article: Disease Restaging and Diagnosis of Recurrent and Metastatic Disease Following Primary Therapy with FDG-PET Imaging.

Eubank, William B / Lee, Jean H / Mankoff, David A

PET clinics

2009 Volume 4, Issue 3, Page(s) 299–312

Language	English
Publishing date	2009-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2764575-7
ISSN	1879-9809 ; 1556-8598
ISSN (online)	1879-9809
ISSN	1556-8598
DOI	10.1016/j.cpet.2009.09.001
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Article: Evolving role of positron emission tomography in breast cancer imaging.

Eubank, William B / Mankoff, David A

Seminars in nuclear medicine

2005 Volume 35, Issue 2, Page(s) 84–99

Abstract: 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been used for detection, staging, and response monitoring in breast cancer patients. Although studies have proven its accuracy in detection of the primary tumor and axillary staging, its ... ...

Abstract	18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been used for detection, staging, and response monitoring in breast cancer patients. Although studies have proven its accuracy in detection of the primary tumor and axillary staging, its most important current clinical application is in detection and defining the extent of recurrent or metastatic breast cancer and for monitoring response to therapy. PET is complementary to conventional methods of staging in that it provides better sensitivity in detecting nodal and lytic bone metastases; however, it should not be considered a substitute for conventional staging studies, including computed tomography and bone scintigraphy. FDG uptake in the primary tumor carries prognostic information, but the underlying biochemical mechanisms responsible for enhanced glucose metabolism have not been completely elucidated. Future work using other PET tracers besides FDG will undoubtedly help our understanding of tumor biology and help tailor therapy to individual patient by improving our ability to quantify the therapeutic target, identify drug resistance factors, and measure and predict early response.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/therapy ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lymphatic Metastasis ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/prevention & control ; Positron-Emission Tomography/methods ; Positron-Emission Tomography/trends ; Prognosis ; Radiopharmaceuticals ; Risk Assessment/methods ; Risk Factors ; Treatment Outcome
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2005-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	120248-0
ISSN	0001-2998
ISSN	0001-2998
DOI	10.1053/j.semnuclmed.2004.11.001
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Article: Breast Cancer Imaging with Novel PET Tracers.

Mankoff, David A / Lee, Jean H / Eubank, William B

PET clinics

2009 Volume 4, Issue 4, Page(s) 371–380

Abstract: Whereas (18)F-fluorodeoxyglucose (FDG)-PET/computed tomography has proven to be valuable for breast cancer diagnosis and response evaluation, it is likely that PET radiopharmaceuticals beyond FDG will contribute further to the understanding of breast ... ...

Abstract	Whereas (18)F-fluorodeoxyglucose (FDG)-PET/computed tomography has proven to be valuable for breast cancer diagnosis and response evaluation, it is likely that PET radiopharmaceuticals beyond FDG will contribute further to the understanding of breast cancer and thereby further direct breast cancer care. Increasingly specific and quantitative approaches will help direct treatment selection from an ever-expanding and increasing array of targeted breast cancer therapies. This article highlights 4 areas of ongoing research where preliminary patient results look promising: (1) tumor perfusion and angiogenesis, (2) drug delivery and transport, (3) tumor receptor imaging, and (4) early response evaluation. For each area, the biologic background is reviewed and early results are highlighted.
Language	English
Publishing date	2009-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2764575-7
ISSN	1879-9809 ; 1556-8598
ISSN (online)	1879-9809
ISSN	1556-8598
DOI	10.1016/j.cpet.2009.10.003
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Article: Current and future uses of positron emission tomography in breast cancer imaging.

Eubank, William B / Mankoff, David A

Seminars in nuclear medicine

2004 Volume 34, Issue 3, Page(s) 224–240

Abstract: Positron emission tomography using (18)F-fluorodeoxyglucose (FDG-PET) has been used for the detection, staging, and response monitoring in breast cancer patients. Although studies have proven its accuracy in detection of the primary tumor and axillary ... ...

Abstract	Positron emission tomography using (18)F-fluorodeoxyglucose (FDG-PET) has been used for the detection, staging, and response monitoring in breast cancer patients. Although studies have proven its accuracy in detection of the primary tumor and axillary staging, its most important current clinical application is in detection and defining the extent of recurrent or metastatic breast cancer and for monitoring response to therapy. PET is complementary to conventional methods of staging in that it provides better sensitivity in detecting nodal and lytic bone metastases; however, it should not be considered a substitute for conventional staging studies, including computed tomography and bone scintigraphy. FDG uptake in the primary tumor carries prognostic information, but the underlying biochemical mechanisms that are responsible for enhanced glucose metabolism have not been completely elucidated. Future work using other PET tracers besides FDG will undoubtedly help our understanding of tumor biology, improve our ability to measure and predict response and help tailor therapy to individual patients.
MeSH term(s)	Axilla ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Fluorodeoxyglucose F18/pharmacokinetics ; Humans ; Image Interpretation, Computer-Assisted/methods ; Image Processing, Computer-Assisted/methods ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Neoplasm Staging/methods ; Neoplasm Staging/trends ; Prognosis ; Radiopharmaceuticals/pharmacokinetics ; Receptors, Estrogen/metabolism ; Tomography, Emission-Computed/methods ; Tomography, Emission-Computed/trends ; Treatment Outcome
Chemical Substances	Biomarkers, Tumor ; Radiopharmaceuticals ; Receptors, Estrogen ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2004-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	120248-0
ISSN	0001-2998
ISSN	0001-2998
DOI	10.1053/j.semnuclmed.2004.03.007
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Zs.A 763: Show issues

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Article ; Online: FDG PET, PET/CT, and breast cancer imaging.

Rosen, Eric L / Eubank, William B / Mankoff, David A

Radiographics : a review publication of the Radiological Society of North America, Inc

2007 Volume 27 Suppl 1, Page(s) S215–29

Abstract: Currently, the clinical role of positron emission tomography (PET) and PET/computed tomography (CT) in patients with breast cancer is to provide additional information in select scenarios in which results of conventional imaging are indeterminate or of ... ...

Abstract	Currently, the clinical role of positron emission tomography (PET) and PET/computed tomography (CT) in patients with breast cancer is to provide additional information in select scenarios in which results of conventional imaging are indeterminate or of limited utility. There is currently no clinical role for fluorodeoxyglucose (FDG) PET in detection of breast cancer or evaluation of axillary lymph nodes, but these are areas of active research. FDG PET is complementary to conventional staging procedures and should not be a replacement for either bone scintigraphy or diagnostic CT. FDG PET and PET/CT have been shown to be particularly useful in the restaging of breast cancer, in evaluation of response to therapy, and as a problem-solving method when results of conventional imaging are equivocal. In these situations, FDG PET often demonstrates locoregional or unsuspected distant disease that affects management. PET has demonstrated a particular capability for evaluation of chemotherapy response in both patients with locally advanced breast carcinoma and those with metastatic disease.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Fluorodeoxyglucose F18 ; Humans ; Neoplasm Staging ; Positron-Emission Tomography ; Radiopharmaceuticals ; Tomography, X-Ray Computed
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2007-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.27si075517
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Article: Utilizing SENSE to achieve lower station sub-millimeter isotropic resolution and minimal venous enhancement in peripheral MR angiography.

Maki, Jeffrey H / Wilson, Gregory J / Eubank, William B / Hoogeveen, Romhild M

Journal of magnetic resonance imaging : JMRI

2002 Volume 15, Issue 4, Page(s) 484–491

Abstract: Purpose: To use the parallel imaging technique, sensitivity encoding (SENSE), to increase spatial resolution and decrease venous contamination in peripheral magnetic resonance angiography (MRA).: Materials and methods: Moving table, single-bolus ... ...

Abstract	Purpose: To use the parallel imaging technique, sensitivity encoding (SENSE), to increase spatial resolution and decrease venous contamination in peripheral magnetic resonance angiography (MRA). Materials and methods: Moving table, single-bolus peripheral contrast-enhanced (CE) -MRA was performed on nine patients. Manual table movement combined with SENSE in the upper station allowed for more rapid overall scan coverage such that acquisition of the lower station began 34 seconds after aortic contrast arrival. True sub- millimeter isotropic resolution was achieved in the lower station. Results: Diagnostic MR angiograms of all three stations were obtained in all nine patients. Venous enhancement did not confound interpretation in any case. Sub-millimeter lower station resolution provided excellent vascular detail. Conclusion: Decreased delay time between upper and lower station acquisition in single bolus peripheral MR angiograms, now possible using parallel imaging techniques, combined with lower station sub-millimeter resolution may decrease venous contamination and increase overall interpretability, thus increasing clinical acceptance of peripheral MRA.
MeSH term(s)	Humans ; Magnetic Resonance Angiography/methods ; Peripheral Vascular Diseases/diagnosis
Language	English
Publishing date	2002-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.10079
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