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  1. Article ; Online: The new generation of messenger RNA (mRNA) vaccines against influenza.

    Reina, Jordi

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2022  Volume 41, Issue 5, Page(s) 301–304

    Abstract: Today there are multiple types of flu vaccines. The emergence of nucleic acid technology used in vaccines against SARS-CoV-2 suggests its future application against this infection. Against influenza, two types of vaccines have been developed based on ... ...

    Abstract Today there are multiple types of flu vaccines. The emergence of nucleic acid technology used in vaccines against SARS-CoV-2 suggests its future application against this infection. Against influenza, two types of vaccines have been developed based on messenger RNA (mRNA): conventional or non-replicative and self-amplifying or replicative (auRNA), both included in lipid nanoparticles. Animal studies carried out with the former have shown their strong capacity to induce Th-1 antibodies and cellular immunity against influenza haemagglutinin (HA) with few side effects. Human trials have shown 87% seroconversion and 100% seroprotection. The auRNA vaccines have obtained similar results in animals but at a concentration 64 times lower than the conventional one. Vaccines based on mRNA platforms meet the WHO requirements for next generation influenza vaccines.
    MeSH term(s) Animals ; Humans ; Influenza, Human/prevention & control ; Influenza Vaccines ; mRNA Vaccines ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2 ; RNA, Messenger/genetics
    Chemical Substances Influenza Vaccines ; mRNA Vaccines ; COVID-19 Vaccines ; RNA, Messenger
    Language English
    Publishing date 2022-07-26
    Publishing country Spain
    Document type Journal Article ; Review
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2022.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Influenza vaccination in the time of SARS-CoV-2.

    Reina, Jordi

    Medicina clinica (English ed.)

    2020  Volume 156, Issue 1, Page(s) 17–19

    Language English
    Publishing date 2020-12-11
    Publishing country Spain
    Document type Journal Article
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2020.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: La nueva generación de vacunas de ARN mensajero (ARNm) frente a la gripe.

    Reina, Jordi

    Enfermedades infecciosas y microbiologia clinica

    2021  Volume 41, Issue 5, Page(s) 301–304

    Abstract: Today there are multiple types of flu vaccines. The emergence of nucleic acid technology used in vaccines against SARS-CoV-2 suggests its future application against this infection. Against influenza, two types of vaccines have been developed based on ... ...

    Title translation The new generation of messenger RNA (mRNA) vaccines against influenza.
    Abstract Today there are multiple types of flu vaccines. The emergence of nucleic acid technology used in vaccines against SARS-CoV-2 suggests its future application against this infection. Against influenza, two types of vaccines have been developed based on messenger RNA (mRNA): conventional or non-replicative and self-amplifying or replicative (auRNA), both included in lipid nanoparticles. Animal studies carried out with the former have shown their strong capacity to induce Th-1 antibodies and cellular immunity against influenza haemagglutinin (HA) with few side effects. Human trials have shown 87% seroconversion and 100% seroprotection. The auRNA vaccines have obtained similar results in animals but at a concentration 64 times lower than the conventional one. Vaccines based on mRNA platforms meet the WHO requirements for next generation influenza vaccines.
    Language Spanish
    Publishing date 2021-08-27
    Publishing country Spain
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1070941-1
    ISSN 1578-1852 ; 0213-005X
    ISSN (online) 1578-1852
    ISSN 0213-005X
    DOI 10.1016/j.eimc.2021.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: La vacunación de la gripe en el tiempo del SARS-CoV-2.

    Reina, Jordi

    Medicina clinica

    2020  Volume 156, Issue 1, Page(s) 17–19

    Title translation Influenza vaccination in the time of SARS-CoV-2.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/prevention & control ; Coinfection/epidemiology ; Coinfection/immunology ; Coinfection/prevention & control ; Global Health ; Health Services Accessibility ; Humans ; Influenza Vaccines ; Influenza, Human/epidemiology ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Pandemics/prevention & control ; Seasons
    Chemical Substances Influenza Vaccines
    Language Spanish
    Publishing date 2020-11-13
    Publishing country Spain
    Document type Editorial
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2020.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.279: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Vaccines against monkeypox.

    Reina, Jordi / Iglesias, Carla

    Medicina clinica (English ed.)

    2023  Volume 160, Issue 7, Page(s) 305–309

    Abstract: The monkeypox virus is a virus that has 90% genomic homology with the human (smallpox), but it is naturally transmitted between different wild animal reservoirs and is considered a zoonosis. Throughout the 20th century, different vaccines based on the ... ...

    Abstract The monkeypox virus is a virus that has 90% genomic homology with the human (smallpox), but it is naturally transmitted between different wild animal reservoirs and is considered a zoonosis. Throughout the 20th century, different vaccines based on the vaccinia poxvirus were developed and used for vaccination against smallpox. After the eradication of smallpox, these vaccines were no longer used. Current vaccines against monkeypox virus are classified by the WHO as replicative (ACAM2000), minimally replicative (LC16m8) and non-replicative (MVA-BN), the latter being the one currently used. The 2022 extra-African monkeypox virus epidemic has highlighted the lack of vaccines with proven efficacy and low reactogenicity. It is considered that the use of this vaccine in the current outbreak may play a role in the prevention or attenuation of the disease as pre-exposure prophylaxis in close contacts of confirmed cases.
    Language English
    Publishing date 2023-03-24
    Publishing country Spain
    Document type Journal Article ; Review
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2023.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Vacunas frente a la viruela del mono (monkeypox).

    Reina, Jordi / Iglesias, Carla

    Medicina clinica

    2023  Volume 160, Issue 7, Page(s) 305–309

    Abstract: The monkeypox virus is a virus that has 90% genomic homology with the human (smallpox), but it is naturally transmitted between different wild animal reservoirs and is considered a zoonosis. Throughout the 20th century, different vaccines based on the ... ...

    Title translation Vaccines against monkeypox.
    Abstract The monkeypox virus is a virus that has 90% genomic homology with the human (smallpox), but it is naturally transmitted between different wild animal reservoirs and is considered a zoonosis. Throughout the 20th century, different vaccines based on the vaccinia poxvirus were developed and used for vaccination against smallpox. After the eradication of smallpox, these vaccines were no longer used. Current vaccines against monkeypox virus are classified by the WHO as replicative (ACAM2000), minimally replicative (LC16m8) and non-replicative (MVA-BN), the latter being the one currently used. The 2022 extra-African monkeypox virus epidemic has highlighted the lack of vaccines with proven efficacy and low reactogenicity. It is considered that the use of this vaccine in the current outbreak may play a role in the prevention or attenuation of the disease as pre-exposure prophylaxis in close contacts of confirmed cases.
    MeSH term(s) Animals ; Humans ; Mpox (monkeypox)/epidemiology ; Mpox (monkeypox)/prevention & control ; Mpox (monkeypox)/drug therapy ; Smallpox/epidemiology ; Smallpox/prevention & control ; Vaccinia virus ; Monkeypox virus ; Vaccination
    Language Spanish
    Publishing date 2023-02-10
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2023.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.279: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Author Correction: Synthesis and characterization of dendritic compounds containing nitrogen: monomer precursors in the construction of biomimetic membranes.

    Guardià, Jordi / Zare, Alireza / Eleeza, John / Giamberini, Marta / Reina, José Antonio / Montané, Xavier

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6701

    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57172-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Acute retinal necrosis caused by herpes simplex type 2.

    Reina, Jordi / Costa, Catia / Fernández-Billón, María

    Medicina clinica

    2022  Volume 159, Issue 9, Page(s) e63–e64

    Title translation Necrosis retiniana aguda causada por herpes simple tipo 2.
    MeSH term(s) Humans ; Retinal Necrosis Syndrome, Acute/diagnosis ; Retinal Necrosis Syndrome, Acute/drug therapy ; Retinal Necrosis Syndrome, Acute/etiology ; Herpes Simplex/complications ; Herpes Simplex/diagnosis ; Herpes Simplex/drug therapy ; Acyclovir/therapeutic use ; Antiviral Agents/therapeutic use ; DNA, Viral
    Chemical Substances Acyclovir (X4HES1O11F) ; Antiviral Agents ; DNA, Viral
    Language Spanish
    Publishing date 2022-09-08
    Publishing country Spain
    Document type Letter
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2022.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.279: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Situación actual del tratamiento farmacológico frente a la enfermedad causada por el virus Ébola.

    Reina, Jordi

    Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

    2016  Volume 29, Issue 1, Page(s) 1–7

    Abstract: The recent epidemic of disease caused by the Ebola virus has highlighted the need to develop specific drugs and have to deal with this entity. According to virological analysis they have been designed to give you some new drugs and are proven to others ... ...

    Title translation Current status of drug treatment against the disease caused by the Ebola virus.
    Abstract The recent epidemic of disease caused by the Ebola virus has highlighted the need to develop specific drugs and have to deal with this entity. According to virological analysis they have been designed to give you some new drugs and are proven to others might be effective against this virus. The main lines of therapy are based on immunotherapy (convalescent serum of patients and specific monoclonal antibodies), antiviral drugs (favipiravir, BCX4430, brincidofovir), interfering RNAs (TKM-Ebola) and antisense oligonucleotides (morpholino phosphorodiamidate) and other drugs no antiviral (clomiphene NSC62914, FGI-103, amiloride and ouabain). Existing studies are scarce and mainly in animal models and clinical trials have been inconclusive most by the drastic reduction in the number of new cases. However, progress has been made in the biological knowledge of Ebola virus and have been located new therapeutic targets for the future development of specific antiviral.
    MeSH term(s) Animals ; Antiviral Agents/therapeutic use ; Disease Outbreaks ; Ebolavirus/drug effects ; Hemorrhagic Fever, Ebola/drug therapy ; Humans ; Immunotherapy ; Oligonucleotides, Antisense/therapeutic use
    Chemical Substances Antiviral Agents ; Oligonucleotides, Antisense
    Language Spanish
    Publishing date 2016-02
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 1018135-0
    ISSN 1988-9518 ; 0214-3429
    ISSN (online) 1988-9518
    ISSN 0214-3429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2833: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Changes in the incidence and clinical manifestations of paediatric respiratory infections of viral aetiology during the SARS-CoV-2 pandemic.

    Díaz Pérez, David / Reina, Jordi / Arcay, Ricardo M / Osona, Borja

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2022  Volume 40, Issue 8, Page(s) 463–464

    MeSH term(s) COVID-19/epidemiology ; Child ; Humans ; Incidence ; Pandemics ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/etiology ; SARS-CoV-2
    Language English
    Publishing date 2022-05-13
    Publishing country Spain
    Document type Case Reports
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2022.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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