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Book ; Online: Burden of disease attributable to selected environmental factors and injuries among Europe's children and adolescents / Francesca Valent . [et al.]

Valent, Francesca, / LIttle, D' Anna / Tamburlini, Giorgio / Varbone, Fabio / Prüss-Üstün, Annette / Campbell-Lendrum, Diarmid H / Corvalán, Carlos F / Woodward, Alistair / World Health Organization. Occupational and Environmental Health Team / WHO European Ministerial Conference on Environment and Health (4th : 2004: Budapest, Hungary)

2004

Abstract: 79 p. ...

Abstract	79 p.
Keywords	Environmental pollution ; Wounds and injuries ; Infant mortality ; Cost of illness ; Epidemiologic studies ; Risk assessment ; Infant ; Child ; Adolescent ; Europe ; Environment and Public Health ; adverse effects ; chemically induced ; methods
Language	English
Publisher	Geneva : World Health Organization
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Burden of disease attributable to selected environmental factors and injuries among Europe's children and adolescents / Francesca Valent . [et al.]

2004

Abstract: 79 p. ...

Abstract	79 p.
Keywords	Environmental Pollution ; Wounds and Injuries ; Infant Mortality ; Cost of Illness ; Epidemiologic Studies ; Risk Assessment ; Infant ; Child ; Adolescent ; Europe ; Environment and Public Health ; adverse effects ; chemically induced ; methods
Language	English
Publisher	World Health Organization
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Road traffic accidents in Italy during COVID-19.

Valent, Francesca

Traffic injury prevention

2022 Volume 23, Issue 4, Page(s) 193–197

Abstract: Objective: To assess changes in the number and severity of road traffic accidents in Italy in 2020, in particular after the beginning of COVID-19 and during the lockdown, as compared with 2019, with monthly details and geographical variations within the ...

Abstract	Objective: To assess changes in the number and severity of road traffic accidents in Italy in 2020, in particular after the beginning of COVID-19 and during the lockdown, as compared with 2019, with monthly details and geographical variations within the country. Methods: Official monthly data on road traffic accidents recorded by the Police in Italy in 2020 were compared with those in 2019. The comparison regarded number of accidents, percent change, non-fatal injuries, deaths, injury index (injuries/accidents ×100) and fatality index (deaths/accidents ×100). Monthly data were graphically presented separately for each of the 21 Italian Regions and autonomous Provinces. Results: A steep generalized decrease in the number of road traffic accidents was observed in March and April 2020 (Italian lockdown) as compared with the corresponding months of 2019 (more than 70% change), with a smaller change in the number of deaths, more variable among Regions. Smaller decreases were observed in the following part of 2020. Conclusions: In Italy, lockdown and limitation of mobility due to COVID-19 determined a strong decrease in the number of road traffic accidents and their health consequences. Inter-regional variability in the decrease of deaths might be associated with the severity of the SARS-CoV-2 local outbreak, although specific causes need to be investigated. These data are useful to inform traffic and public health policy makers.
MeSH term(s)	Accidents, Traffic ; COVID-19/epidemiology ; Communicable Disease Control ; Humans ; Italy/epidemiology ; SARS-CoV-2
Language	English
Publishing date	2022-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2089818-6
ISSN	1538-957X ; 1538-9588
ISSN (online)	1538-957X
ISSN	1538-9588
DOI	10.1080/15389588.2022.2047956
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Article ; Online: Polypharmacy in the general population of a Northern Italian area: analysis of administrative data.

Valent, Francesca

Annali dell'Istituto superiore di sanita

2019 Volume 55, Issue 3, Page(s) 233–239

Abstract: Introduction: The aim of this study was to estimate the prevalence and assess patient-related determinants of polypharmacy in the general population of the Italian area around Udine.: Materials and methods: A retrospective cohort study was conducted ... ...

Abstract	Introduction: The aim of this study was to estimate the prevalence and assess patient-related determinants of polypharmacy in the general population of the Italian area around Udine. Materials and methods: A retrospective cohort study was conducted using administrative databases: drug prescriptions, hospital discharges, ambulatory care prescriptions, exemptions from medical charges. Various definitions of polypharmacy were adopted (co-prescription of multiple medications, use of multiple medications for overlapping time periods). The role of patient's characteristics on polypharmacy was assessed through regression analyses. Results: In 2017, 63.7% of the general population received at least one drug prescription. 25 218 persons were co-prescribed ≥ 5 medications at least once. The prevalence of co-prescriptions among persons ≥ 65 years was 31.7%. 20 793 persons used ≥ 60 DDDs of ≥ 5 medications. The prevalence of all these phenomena was much higher in the elderly than in children and adults. The number of comorbidities significantly affected all types of polypharmacy. Conclusions: In this area, the prevalence of polypharmacy is high, particularly among the elderly. Age and comorbidities significantly affect the risk. Further research will aim at evaluating the health effects and appropriateness of polyphamacy.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Ambulatory Care/statistics & numerical data ; Child ; Child, Preschool ; Cohort Studies ; Databases, Factual ; Drug Prescriptions/statistics & numerical data ; Humans ; Infant ; Italy ; Middle Aged ; Patient Discharge/statistics & numerical data ; Patients ; Pharmaceutical Services/organization & administration ; Polypharmacy ; Prevalence ; Retrospective Studies ; Socioeconomic Factors ; Young Adult
Language	English
Publishing date	2019-09-25
Publishing country	Italy
Document type	Journal Article
ZDB-ID	950344-4
ISSN	2384-8553 ; 0021-2571
ISSN (online)	2384-8553
ISSN	0021-2571
DOI	10.4415/ANN_19_03_06
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Article ; Online: A population-based study of the incidence of laboratory-confirmed Clostridium difficile infections and their recurrence in the Italian province of Udine.

Valent, Francesca

Anaerobe

2019 Volume 61, Page(s) 102144

Abstract: Clostridium difficile infections (CDI) are a frequent cause of healthcare-associated infection and are also increasingly described in the outpatient setting. Epidemiological data in Italy have been collected through hospital-based study designs. We aimed ...

Abstract	Clostridium difficile infections (CDI) are a frequent cause of healthcare-associated infection and are also increasingly described in the outpatient setting. Epidemiological data in Italy have been collected through hospital-based study designs. We aimed at studying the epidemiology of laboratory-confirmed CDI through a population-based analysis in the Italian 500,000-inhabitant province of Udine. Various health administrative databases were linked at the individual patient level through an anonymous stochastic key: laboratory tests, hospital discharges, nursing homes, drug prescriptions. The incidence of CDI in 2018 was calculated as new cases per 100,000 inhabitants and, for cases diagnosed during a hospital or nursing home stay, per 1000 patient admissions and per 10,000 patient-days. The frequency of recurrent infections was also estimated. In the population of Udine, 240 positive tests were observed, corresponding to 225 infection episodes and 185 persons (35 new cases/100,000 population-year). 75.1% of CDI episodes were diagnosed during hospital stays, 8.9% during nursing home stays, and 16.0% in non-institutionalized persons. Among hospital inpatients, the incidence was 2.03/1000 admissions and 2.85/10,000 patient-days; in nursing homes, there were 3.22 cases/1000 admissions and 1.42/10,000 patient-days. 15% of patients had at least one recurrence. Our results are consistent with international incidence estimates and show higher incidence and frequency of recurrence than those reported in a previous hospital-based study conducted in the Hospital of Udine providing insights for diagnosis and prevention of CDIs.
MeSH term(s)	Aged ; Clostridium Infections/diagnosis ; Clostridium Infections/epidemiology ; Clostridium Infections/microbiology ; Clostridium difficile ; Female ; Hospitalization ; Humans ; Incidence ; Italy/epidemiology ; Male ; Middle Aged ; Odds Ratio ; Population Surveillance ; Recurrence
Language	English
Publishing date	2019-12-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1237621-8
ISSN	1095-8274 ; 1075-9964
ISSN (online)	1095-8274
ISSN	1075-9964
DOI	10.1016/j.anaerobe.2019.102144
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Article ; Online: Sexually transmitted infections and the HPV-related burden: evolution of Italian epidemiology and policy.

Gazzetta, Silvia / Valent, Francesca / Sala, Alessia / Driul, Lorenza / Brunelli, Laura

Frontiers in public health

2024 Volume 12, Page(s) 1336250

Abstract: Sexually transmitted infections (STIs) are a major public health problem worldwide, with a high prevalence between the ages of 15 and 25 in most Western countries. High notification rates of chlamydia, gonorrhea, and syphilis are reported in the WHO ... ...

Abstract	Sexually transmitted infections (STIs) are a major public health problem worldwide, with a high prevalence between the ages of 15 and 25 in most Western countries. High notification rates of chlamydia, gonorrhea, and syphilis are reported in the WHO European Region, with differences between countries. In Italy, the total number of STIs alerts increased by 18% from 2020 to 2021. HPV is the most common sexually transmitted infection; globally one in seven women is infected by this virus, and certain sexual behaviors are important risk factors for HPV-related cancers, particularly cervical cancer (CC), anogenital cancers and cancers of the head and neck. The burden of CC is relevant worldwide, in particular in Europe CC is the third leading cause of cancer-related deaths in women aged 15-44. This HPV-related tumor is preventable through a combined strategy of vaccination and screening for precursor lesions. In Italy, the coverage of organized screening varies from region to region and the average HPV vaccination rate is still far from the expected optimal threshold of 95% at the age of 12. To address the challenges of health promotion and HPV prevention, priority actions are needed such as: promoting education and information at every level, from schools to healthcare professionals. In Italy, education of adolescents on sexual and reproductive health, still remains critical, regionally inhomogeneous and much lower than in other European countries. Equitable measures need to be taken, and schools are an important place for health promotion activities.
MeSH term(s)	Adolescent ; Female ; Humans ; Young Adult ; Adult ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/prevention & control ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/prevention & control ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/diagnosis ; Italy/epidemiology ; Policy
Language	English
Publishing date	2024-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1336250
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Article: A population-based study of the incidence of laboratory-confirmed Clostridium difficile infections and their recurrence in the Italian province of Udine

Valent, Francesca

Anaerobe. 2020 Feb., v. 61

2020

Abstract	Clostridium difficile infections (CDI) are a frequent cause of healthcare-associated infection and are also increasingly described in the outpatient setting. Epidemiological data in Italy have been collected through hospital-based study designs. We aimed at studying the epidemiology of laboratory-confirmed CDI through a population-based analysis in the Italian 500,000-inhabitant province of Udine.Various health administrative databases were linked at the individual patient level through an anonymous stochastic key: laboratory tests, hospital discharges, nursing homes, drug prescriptions. The incidence of CDI in 2018 was calculated as new cases per 100,000 inhabitants and, for cases diagnosed during a hospital or nursing home stay, per 1000 patient admissions and per 10,000 patient-days. The frequency of recurrent infections was also estimated.In the population of Udine, 240 positive tests were observed, corresponding to 225 infection episodes and 185 persons (35 new cases/100,000 population-year). 75.1% of CDI episodes were diagnosed during hospital stays, 8.9% during nursing home stays, and 16.0% in non-institutionalized persons. Among hospital inpatients, the incidence was 2.03/1000 admissions and 2.85/10,000 patient-days; in nursing homes, there were 3.22 cases/1000 admissions and 1.42/10,000 patient-days. 15% of patients had at least one recurrence.Our results are consistent with international incidence estimates and show higher incidence and frequency of recurrence than those reported in a previous hospital-based study conducted in the Hospital of Udine providing insights for diagnosis and prevention of CDIs.
Keywords	Clostridium difficile ; databases ; drugs ; epidemiology ; hospitals ; laboratory experimentation ; nursing homes ; patients ; Italy
Language	English
Dates of publication	2020-02
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1237621-8
ISSN	1075-9964
ISSN	1075-9964
DOI	10.1016/j.anaerobe.2019.102144
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Vaccination against human papilloma virus in a Northeastern Italian area.

Valent, Francesca / Deroma, Laura / Degani, Giulia

Annali dell'Istituto superiore di sanita

2023 Volume 59, Issue 3, Page(s) 223–230

Abstract: Objectives: Vaccination against human papilloma virus (HPV) in adolescents and persons at increased risk of infection and related consequences is an effective strategy to prevent genital cancers. The objective of this study was to assess vaccination ... ...

Abstract	Objectives: Vaccination against human papilloma virus (HPV) in adolescents and persons at increased risk of infection and related consequences is an effective strategy to prevent genital cancers. The objective of this study was to assess vaccination activity and coverages in a Northeastern Italian area. Methods: Anonymous data from various health administrative databases of the Italian 530,000-inhabitant Health Authority "Azienda Sanitaria Universitaria Friuli Centrale" were deterministically linked at the individual level through an anonymous stochastic key. Doses of HPV vaccine administered by year and coverages in different birth cohorts were calculated. Vaccinations of women treated for a CIN2+ lesion were also identified. Results: The number of doses administered by year followed the evolution of national and regional laws. A steep drop was observed in 2020 and 2021 in both males and females (from 6,907 in 2019 to 5,027 in 2020 in males and from 6,989 in 2019 to 4,348 in 2020 in females). Coverages in adolescents were variable across Vaccination Services located in different sub-areas (complete cycle coverage in the 2008 cohort ranged from <40% in some Districts to >70% in others). Vaccination doses administered in adult women have increased almost steadily since 2018. One third of women treated for a CIN2+ were vaccinated. Conclusions: In this area, efforts must be done to catch-up with doses missed during the pandemic and to overcome differences among different sub-areas.
MeSH term(s)	Adult ; Male ; Adolescent ; Humans ; Female ; Human Papillomavirus Viruses ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/prevention & control ; Vaccination ; Vaccines ; Papillomavirus Vaccines/therapeutic use
Chemical Substances	Vaccines ; Papillomavirus Vaccines
Language	English
Publishing date	2023-08-11
Publishing country	Italy
Document type	Journal Article
ZDB-ID	950344-4
ISSN	2384-8553 ; 0021-2571
ISSN (online)	2384-8553
ISSN	0021-2571
DOI	10.4415/ANN_23_03_09
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Article ; Online: New oral anticoagulant prescription rate and risk of bleeding in an Italian region.

Valent, Francesca

Pharmacoepidemiology and drug safety

2017 Volume 26, Issue 10, Page(s) 1205–1212

Abstract: Purpose: The purpose of this study was to measure the prescription rate of new oral anticoagulants (NOACs) and to investigate whether there is an increased risk of bleeding associated with these medications in the 1 220 000-inhabitant Italian region ... ...

Abstract	Purpose: The purpose of this study was to measure the prescription rate of new oral anticoagulants (NOACs) and to investigate whether there is an increased risk of bleeding associated with these medications in the 1 220 000-inhabitant Italian region Friuli Venezia Giulia. Methods: The administrative data of the Regional Health Information System, linkable with each other at the individual patient level through an anonymous stochastic key, were used as the source of information. Prescription rates for rivaroxaban, dabigatran, and apixaban were calculated in the regional population in 2014 and 2015, also stratified by age class and gender. A case-crossover analysis with pair-matched interval approach and a case-time-control analysis were conducted to assess the risk of hospitalization with a diagnosis of bleeding and prescription of NOACs. Results: In the regional population ≥18 years of age, 1626 NOACs prescriptions per 100 000 population-years were filled in 2014 and 3370 in 2015. Prescription rate increased with age and was greater in males than in females. Overall, being a current NOACs user was not associated with the risk of hospitalization for bleeding compared to being a nonuser. A nonsignificant increase in risk was observed among patients with low prescription intensity. Conclusions: This study showed an increasing time trend in NOACs prescriptions NOACs in Friuli Venezia Giulia. In this Italian population, NOACs users had no significantly increased risk of bleeding events as compared with nonusers.
Language	English
Publishing date	2017-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1099748-9
ISSN	1099-1557 ; 1053-8569
ISSN (online)	1099-1557
ISSN	1053-8569
DOI	10.1002/pds.4279
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Article ; Online: Falls requiring visit to emergency room in a population-based cohort of diabetic patients in Italy.

Valent, Francesca

Journal of injury & violence research

2017 Volume 9, Issue 2, Page(s) 83–90

Abstract: Background: The aims were to assess the frequency of falls among the diabetic adult population of the Italian Northeastern region Friuli Venezia Giulia and to identify risk factors.: Methods: This was a population-based retrospective cohort study ... ...

Abstract	Background: The aims were to assess the frequency of falls among the diabetic adult population of the Italian Northeastern region Friuli Venezia Giulia and to identify risk factors. Methods: This was a population-based retrospective cohort study using administrative data of the regional health information system as the source of information. In a cohort of diabetics 18 years of age or more, living in the region on December 31, 2014, the occurrence of falls requiring a visit to the regional Emergency Rooms was assessed. Multivariate logistic regression was used to identify factors associated with increased risk of falling. Results: Of 80,162 cohort subjects, 2967 (3.7%) had at least one fall requiring a visit to ER. Factors associated with increased risk of falling were female sex, older age, prescription of a thiazolidinedione as the last antidiabetic medication in 2014, increasing number of active principles prescribed in 2014, longer diabetes duration, and prescription of certain classes of medications other than antidiabetics in 2014. Conclusions: In Friuli Venezia Giulia, injurious falls are a complication of diabetes relevant from the public health viewpoint. Efforts are needed to screen diabetic patients, review their prescriptions, provide appropriate care, and implement targeted interventions to minimize the individual risk of falls.
MeSH term(s)	Accidental Falls/statistics & numerical data ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Diabetes Complications ; Emergency Medical Services/statistics & numerical data ; Emergency Medical Services/utilization ; Female ; Humans ; Italy ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Young Adult
Language	English
Publishing date	2017-07
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2573562-7
ISSN	2008-4072 ; 2008-2053
ISSN (online)	2008-4072
ISSN	2008-2053
DOI	10.5249/jivr.v9i2.859
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