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Book ; Thesis: Einfluss reduzierter Expression der Immunglobulin-m-schweren [Immunglobulin-my-schweren] Kette auf die Entwicklung und Selektion von B-Lymphozyten

Brenner, Sven

2010

Author's details	vorgelegt von Sven Brenner
Language	German
Size	126 S., Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Erlangen, Nürnberg, Univ., Diss., 2010
HBZ-ID	HT016467187
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: HIV-1 group O integrase displays lower enzymatic efficiency and higher susceptibility to raltegravir than HIV-1 group M subtype B integrase.

Depatureaux, Agnès / Quashie, Peter K / Mesplède, Thibault / Han, Yingshan / Koubi, Hannah / Plantier, Jean-Christophe / Oliveira, Maureen / Moisi, Daniela / Brenner, Bluma / Wainberg, Mark A

Antimicrobial agents and chemotherapy

2014 Volume 58, Issue 12, Page(s) 7141–7150

Abstract: ... an HIV-O divergent strain, and HIV-1 group M (HIV-M, subtype B), used as a reference. To assess enzymatic ... to integrase inhibitors. Accordingly, we cloned and purified integrase proteins from each of HIV-1 group O clades A and B ... viruses, respectively, and compared with those of HIV-M. The results showed that HIV-O integrase displayed ...

Abstract	HIV-1 group O (HIV-O) is a rare HIV-1 variant characterized by a high number of polymorphisms, especially in the integrase coding region. As HIV-O integrase enzymes have not previously been studied, our aim was to assess the impact of HIV-O integrase polymorphisms on enzyme function and susceptibility to integrase inhibitors. Accordingly, we cloned and purified integrase proteins from each of HIV-1 group O clades A and B, an HIV-O divergent strain, and HIV-1 group M (HIV-M, subtype B), used as a reference. To assess enzymatic function of HIV-O integrase, we carried out strand transfer and 3' processing assays with various concentrations of substrate (DNA target and long terminal repeats [LTR], respectively) and characterized these enzymes for susceptibility to integrase strand transfer inhibitors (INSTIs) in cell-free assays and in tissue culture, in the absence or presence of various concentrations of several INSTIs. The inhibition constant (Ki) and 50% effective concentration (EC50) values were calculated for HIV-O integrases and HIV-O viruses, respectively, and compared with those of HIV-M. The results showed that HIV-O integrase displayed lower activity in strand transfer assays than did HIV-M enzyme, whereas 3' processing activities were similar to those of HIV-M. HIV-O integrases were more susceptible to raltegravir (RAL) in competitive inhibition assays and in tissue culture than were HIV-M enzymes and viruses, respectively. Molecular modeling suggests that two key polymorphic residues that are close to the integrase catalytic site, 74I and 153A, may play a role in these differences.
MeSH term(s)	3' Flanking Region ; Binding Sites ; Binding, Competitive ; Cloning, Molecular ; Drug Resistance, Viral ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; HIV Integrase/chemistry ; HIV Integrase/classification ; HIV Integrase/genetics ; HIV Integrase Inhibitors/chemistry ; HIV-1/chemistry ; HIV-1/enzymology ; Humans ; Kinetics ; Molecular Docking Simulation ; Protein Binding ; Pyrrolidinones/chemistry ; Raltegravir Potassium ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics
Chemical Substances	HIV Integrase Inhibitors ; Pyrrolidinones ; Recombinant Proteins ; Raltegravir Potassium (43Y000U234) ; HIV Integrase (EC 2.7.7.-) ; p31 integrase protein, Human immunodeficiency virus 1 (YY6481J2FF)
Language	English
Publishing date	2014-09-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.03819-14
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Book ; Online ; Thesis: Einfluss reduzierter Expression der Immunglobulin-m-schweren [Immunglobulin-my-schweren] Kette auf die Entwicklung und Selektion von B-Lymphozyten

Brenner, Sven

2010

Author's details	vorgelegt von Sven Brenner
Language	German
Size	Online-Ressource
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Nürnberg, Univ., Diss.--Erlangen, 2010
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi: 10.1002/ijc.29559.

Jay, Raman / Brennan, P / Brenner / Overvad, K / Olsen, A / Tjønneland, A / Boutron-Ruault, M C / Clavel-Chapelon, F / Fagherazzi / Katzke, V / Kühn, T / Boeing, H / Bergmann, M M / Steffen, A / Naska, A / Trichopoulou, A / Trichopoulos, D / Saieva, C / Grioni, S /

Urologic oncology

2017 Volume 35, Issue 3, Page(s) 117

Abstract: Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women ...

Abstract	Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment vs. the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), and 0.91 (0.63-1.30), respectively, (ptrend = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.
MeSH term(s)	Alcohol Drinking ; Female ; Humans ; Kidney Neoplasms ; Male ; Nutritional Status ; Proportional Hazards Models ; Prospective Studies ; Risk Factors
Language	English
Publishing date	2017-02-01
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2016.12.022
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Book ; Thesis: Charakteristika einsamer älterer Patienten in der hausärztlichen Versorgung unter Erfassung geschlechtsspezifischer Unterschiede

Zeutzheim, Maike / Wild, Beate

2019

Institution	Universität Heidelberg
Author's details	vorgelegt von Maike Zeutzheim ; Doktormutter: Frau apl. Prof. Dr. sc. hum. Dipl. Math. Dipl. Psych. Beate Wild
Language	German
Size	53 Blätter, Diagramme, 30 cm
Publishing place	Heidelberg
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Ruprecht-Karls-Universität Heidelberg, 2020
HBZ-ID	HT020548669
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Online updating of obstacle positions when intercepting a virtual target.

Crowe, Emily M / Smeets, Jeroen B J / Brenner, Eli

Experimental brain research

2023 Volume 241, Issue 7, Page(s) 1811–1820

Abstract: People rely upon sensory information in the environment to guide their actions. Ongoing goal-directed arm movements are constantly adjusted to the latest estimate of both the target and hand's positions. Does the continuous guidance of ongoing arm ... ...

Abstract	People rely upon sensory information in the environment to guide their actions. Ongoing goal-directed arm movements are constantly adjusted to the latest estimate of both the target and hand's positions. Does the continuous guidance of ongoing arm movements also consider the latest visual information of the position of obstacles in the surrounding? To find out, we asked participants to slide their finger across a screen to intercept a laterally moving virtual target while moving through a gap that was created by two virtual circular obstacles. At a fixed time during each trial, the target suddenly jumped slightly laterally while still continuing to move. In half the trials, the size of the gap changed at the same moment as the target jumped. As expected, participants adjusted their movements in response to the target jump. Importantly, the magnitude of this response depended on the new size of the gap. If participants were told that the circles were irrelevant, changing the gap between them had no effect on the responses. This shows that obstacles' instantaneous positions can be considered when visually guiding goal-directed movements.
MeSH term(s)	Humans ; Fingers ; Hand/physiology ; Movement/physiology ; Psychomotor Performance/physiology
Language	English
Publishing date	2023-05-27
Publishing country	Germany
Document type	Clinical Trial ; Journal Article
ZDB-ID	1201-4
ISSN	1432-1106 ; 0014-4819
ISSN (online)	1432-1106
ISSN	0014-4819
DOI	10.1007/s00221-023-06634-5
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Article ; Online: Spatial contextual cues that help predict how a target will accelerate can be used to guide interception.

Crowe, Emily M / Smeets, Jeroen B J / Brenner, Eli

Journal of vision

2023 Volume 23, Issue 12, Page(s) 7

Abstract: Objects in one's environment do not always move at a constant velocity but often accelerate or decelerate. People are very poor at visually judging acceleration and normally make systematic errors when trying to intercept accelerating objects. If the ... ...

Abstract	Objects in one's environment do not always move at a constant velocity but often accelerate or decelerate. People are very poor at visually judging acceleration and normally make systematic errors when trying to intercept accelerating objects. If the acceleration is perpendicular to the direction of motion, it gives rise to a curved path. Can spatial contextual cues help one predict such accelerations and thereby help interception? To answer this question, we asked participants to hit a target that moved as if it were attached to a rolling disk, like a valve (target) on a bicycle wheel (disk) moves when cycling: constantly accelerating toward the wheel's center. On half the trials, the disk was visible such that participants could use the spatial relations between the target and the rolling disk to guide their interception. On the other half, the disk was not visible, so participants had no help in predicting the target's complicated pattern of accelerations and decelerations. Importantly, the target's path was the same in both cases. Participants hit more targets when the disk was visible than when it was invisible, even when using a strategy that can compensate for neglecting acceleration. We conclude that spatial contextual cues that help predict the target's accelerations can help intercept it.
MeSH term(s)	Humans ; Psychomotor Performance ; Motion Perception ; Cues ; Motion ; Acceleration
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2106064-2
ISSN	1534-7362 ; 1534-7362
ISSN (online)	1534-7362
ISSN	1534-7362
DOI	10.1167/jov.23.12.7
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Article ; Online: Post-operative C-reactive protein as a strong independent predictor of long-term colorectal cancer outcomes: consistent findings from two large patient cohorts.

Gwenzi, T / Schrotz-King, P / Anker, S C / Schöttker, B / Hoffmeister, M / Brenner, H

ESMO open

2024 Volume 9, Issue 4, Page(s) 102982

Abstract: Background: Post-surgery blood-based biomarkers may be useful for guiding treatment and surveillance decisions among colorectal cancer (CRC) patients. However, most candidate biomarkers provide little if any predictive value beyond stage at diagnosis. ... ...

Abstract	Background: Post-surgery blood-based biomarkers may be useful for guiding treatment and surveillance decisions among colorectal cancer (CRC) patients. However, most candidate biomarkers provide little if any predictive value beyond stage at diagnosis. We aimed to investigate the independent prognostic value of post-operative serum C-reactive protein (CRP), a highly sensitive biomarker of inflammation, for long-term CRC outcomes in two large patient cohorts. Materials and methods: CRP levels were measured from serum samples of CRC patients collected ≥1 month post-surgery in the German DACHS (n = 1416) and the UK Biobank (n = 1149) cohorts. Associations of post-operative CRP with overall survival (OS) and CRC-specific survival (CSS) were assessed using Cox regression and presented as hazard ratios (HRs) with 95% confidence intervals (CIs), adjusted for key sociodemographic and clinical covariates. Results: In both cohorts, consistent strong dose-response relationships between post-operative CRP and both OS and CSS were observed. Adjusted HRs (95% CI) for CRP >10 versus <3 mg/l were 1.93 (1.58-2.35) and 2.70 (2.03-3.59) in the DACHS cohort, and 2.70 (1.96-3.71) and 2.61 (1.83-3.72) in the UK Biobank cohort, respectively. Associations between post-operative CRP and OS were particularly strong among younger patients (<65 years at diagnosis; P value for interaction by age <0.01). Conclusions: Serum CRP determined a month or more after surgery may be useful as a strong independent prognostic biomarker for guiding therapeutic decisions and for surveillance of the course of disease of CRC patients, particularly those <65 years of age at diagnosis.
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ISSN	2059-7029
ISSN (online)	2059-7029
DOI	10.1016/j.esmoop.2024.102982
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: New-Onset Tinnitus After Dorsal Root Ganglion Stimulator Implantation: A Case Report.

Pressler, Mark P / Brenner, Brian / Kohan, Lynn R / Mendelson, Andrew M

A&A practice

2024 Volume 18, Issue 3, Page(s) e01747

Abstract: Dorsal column (dcSCS) and dorsal root ganglion stimulation (DRG-S) complications are similar, typically related to placement and device failure. We present the first case of tinnitus after DRG-S implantation. The patient presented with complex regional ... ...

Abstract	Dorsal column (dcSCS) and dorsal root ganglion stimulation (DRG-S) complications are similar, typically related to placement and device failure. We present the first case of tinnitus after DRG-S implantation. The patient presented with complex regional pain syndrome (CRPS) type 2. After previous failed treatments, she had a lumbosacral DRG-S trial, which provided relief; however, she briefly noted ringing in her ears. After permanent implantation, she reported persistent, intolerable left-sided tinnitus. Tinnitus can be modulated by secondary somatosensory inputs to the cochlear nucleus from the dcSCS. Therefore, lumbosacral DRG-S stimulating distal sensory neurons leading to tinnitus is a feasible complication.
MeSH term(s)	Female ; Humans ; Tinnitus/etiology ; Tinnitus/therapy ; Ganglia, Spinal ; Spinal Nerve Roots
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2575-3126
ISSN (online)	2575-3126
DOI	10.1213/XAA.0000000000001747
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Article ; Online: Enhanced selection of people for lung cancer screening using AHRR (cg05575921) or F2RL3 (cg03636183) methylation as biological markers of smoking exposure.

Bhardwaj, Megha / Schöttker, Ben / Holleczek, Bernd / Brenner, Hermann

Cancer communications (London, England)

2023 Volume 43, Issue 8, Page(s) 956–959

MeSH term(s)	Humans ; Early Detection of Cancer ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Biomarkers ; DNA Methylation ; Smoking/adverse effects ; Repressor Proteins/genetics ; Basic Helix-Loop-Helix Transcription Factors/genetics
Chemical Substances	Biomarkers ; AHRR protein, human ; Repressor Proteins ; Basic Helix-Loop-Helix Transcription Factors
Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Intramural
ISSN	2523-3548
ISSN (online)	2523-3548
DOI	10.1002/cac2.12450
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