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Article ; Online: Neurogenic heterotopic ossification of the hip: Magnetic resonance imaging versus computed tomography for pre-surgical assessment.

Amar, Raphaël / Salga, Marjorie / Tordjman, Mickaël / Venturelli, Nadia / Nkam, Lionelle / Jacota, Madalina / Grimaldi-Bensouda, Lamiae / Cale, Fabien / Carlier, Robert-Yves

European journal of radiology

2024 Volume 175, Page(s) 111466

Abstract: Purpose: Neurogenic heterotopic ossification (NHO) of the hip is a frequent complication of spinal cord injuries, often requiring surgical management. Pre-surgical imaging assessment is essential, usually with computed tomography (CT)-scan. We aimed to ... ...

Abstract	Purpose: Neurogenic heterotopic ossification (NHO) of the hip is a frequent complication of spinal cord injuries, often requiring surgical management. Pre-surgical imaging assessment is essential, usually with computed tomography (CT)-scan. We aimed to compare magnetic resonance imaging (MRI) and CT for pre-surgical imaging assessment of the NHO, particularly for their relationships with vessels and nerves. Method: This prospective study included consecutive patients who underwent surgery for NHO from July 2019 to April 2022. All patients had CT angiography and MRI including Zero Echo Time and TRICKS sequences. Radiologists used standardized reports for CT and MRI to evaluate NHO and their features, bone mineralization, and relation to the arteries, veins and nerves. Agreement between pre-surgical CT and MRI was evaluated. Results: Twenty-four patients (mean age: 53.5 ± 12.2 years) were included, among which 7 had bilateral NHO (31 hips). NHO were anterior in 15/31 hips (48 %), multifragmented in 25/31 hips (81 %). Mild and significant demineralization was most frequent. Gutter and tunnel were reported in 11.1 % of the arteries. Nerves were more often identified in MRI than in CT-scan. Agreement coefficients between CT and MRI were excellent for NHO location (0.95) and implantation (0.92), good for fragmentation (0.70), contact with joint capsule (0.66), bone mineralization (0.74), and relation to arteries (0.85), veins (0.76), sciatic nerve (0.7) and moderate for femoral nerve (0.47). Conclusion: MRI exhibited a good agreement with CT for pre-surgical assessment of NHO of the hip, especially to evaluate their relationships with the arteries, veins and sciatic nerve. Femoral nerves were more often identified in MRI than in CT-scan.
Language	English
Publishing date	2024-04-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2024.111466
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Article ; Online: Erratum for: How AI May Transform Musculoskeletal Imaging.

Guermazi, Ali / Omoumi, Patrick / Tordjman, Mickael / Fritz, Jan / Kijowski, Richard / Regnard, Nor-Eddine / Carrino, John / Kahn, Charles E / Knoll, Florian / Rueckert, Daniel / Roemer, Frank W / Hayash, Daichi

Radiology

2024 Volume 310, Issue 1, Page(s) e249002

Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Published Erratum
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.249002
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Article ; Online: Sternal mass caused by Mycobacterium tuberculosis in an immunocompetent young adult.

Tordjman, Mickael / Pouchelon, Clara / Canouï, Etienne / Omri, Manel / Dion, Elisabeth

Journal of travel medicine

2021 Volume 28, Issue 6

MeSH term(s)	Humans ; Mycobacterium tuberculosis ; Sternum/diagnostic imaging ; Tomography, X-Ray Computed ; Young Adult
Language	English
Publishing date	2021-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taab021
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Article ; Online: Nephrometry Scoring Systems for Nephron Sparing Surgery in Children.

Mrad, Chaima / Chamouni, Alexandre / Guerra, Xavier / Tordjman, Mickaël / Tabone, Marie-Dominique / Audry, Georges / Irtan, Sabine

Journal of pediatric hematology/oncology

2023 Volume 46, Issue 1, Page(s) 1–7

Abstract: The surgical decision to attempt nephron-sparing surgery (NSS) in children with renal tumors can be difficult. In adults, nephrometric tools are used for decision-making. More than 90% of low-complexity tumors are eligible for NSS, and high-complexity ... ...

Abstract	The surgical decision to attempt nephron-sparing surgery (NSS) in children with renal tumors can be difficult. In adults, nephrometric tools are used for decision-making. More than 90% of low-complexity tumors are eligible for NSS, and high-complexity tumors often require total nephrectomy. We retrospectively applied those nephrometric tools [Radius, Exophytic, Nearness to the sinus or collecting system, Anterior/posterior, Location relative to polar lines (RENAL), Preoperative Aspects and Dimensions Used for an Anatomical classification (PADUA), and Renal Tumor Invasion Index (RTII) scoring systems] to the preoperative imaging of children operated for renal tumors in our institution from 2015 to 2019 and correlated them with the type of surgery. The scores were assessed by 2 independent surgeons and 1 radiologist. Forty-four tumors were removed, including 16 NSS, 38 after neo-adjuvant chemotherapy, and 6 upfront surgeries, in 30 children. More than 50% of patients in the low and medium-risk population for RENAL, PADUA, and RTII scores, and ~15% in the high-complexity categories underwent NSS. Tumors removed through NSS were significantly less complex according to each score. Interobserver reliability was good for 3 scores. The application of the RENAL, PADUA, and RTII was able to accurately classify most of the pediatric tumors, according to their complexity. These scores could help increase the indications of NSS in renal tumor surgery.
MeSH term(s)	Adult ; Child ; Humans ; Retrospective Studies ; Reproducibility of Results ; Nephrectomy/methods ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Nephrons/surgery ; Nephrons/pathology ; Carcinoma, Renal Cell/pathology
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002781
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Article ; Online: Esophageal brucellosis? Straight to the goat.

de Nettancourt, Annabel / Dahmane, Lotfi / Noussair, Latifa / Tordjman, Mickael / Davido, Benjamin

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2022 Volume 122, Page(s) 276–278

Abstract: We report the case of a 58-year-old immunocompetent man from Algeria, who presented to the hospital with fever and hepatic cytolysis. Abdominal computed tomography scan showed a homogeneous splenomegaly and a hypodense 12-mm mass on the posterior wall of ...

Abstract	We report the case of a 58-year-old immunocompetent man from Algeria, who presented to the hospital with fever and hepatic cytolysis. Abdominal computed tomography scan showed a homogeneous splenomegaly and a hypodense 12-mm mass on the posterior wall of the esophagus. After ruling out tuberculosis, the patient was diagnosed with brucellosis. Patient was cured after receiving 6 weeks of oral doxycycline and intravenous gentamicin during the 7 first days of therapy. Such treatment was considered as an acceptable alternative of the recommended first-line therapy. This case illustrates the diagnostic issues in the context of an authentic brucellosis presenting as upper gastrointestinal symptoms, with impaired general condition.
MeSH term(s)	Animals ; Anti-Bacterial Agents/therapeutic use ; Brucella melitensis ; Brucellosis/diagnosis ; Brucellosis/drug therapy ; Esophagus/diagnostic imaging ; Goats ; Humans
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-05-28
Publishing country	Canada
Document type	Case Reports
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2022.05.054
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Article ; Online: How AI May Transform Musculoskeletal Imaging.

Radiology

2024 Volume 310, Issue 1, Page(s) e230764

Abstract: While musculoskeletal imaging volumes are increasing, there is a relative shortage of subspecialized musculoskeletal radiologists to interpret the studies. Will artificial intelligence (AI) be the solution? For AI to be the solution, the wide ... ...

Abstract	While musculoskeletal imaging volumes are increasing, there is a relative shortage of subspecialized musculoskeletal radiologists to interpret the studies. Will artificial intelligence (AI) be the solution? For AI to be the solution, the wide implementation of AI-supported data acquisition methods in clinical practice requires establishing trusted and reliable results. This implementation will demand close collaboration between core AI researchers and clinical radiologists. Upon successful clinical implementation, a wide variety of AI-based tools can improve the musculoskeletal radiologist's workflow by triaging imaging examinations, helping with image interpretation, and decreasing the reporting time. Additional AI applications may also be helpful for business, education, and research purposes if successfully integrated into the daily practice of musculoskeletal radiology. The question is not whether AI will replace radiologists, but rather how musculoskeletal radiologists can take advantage of AI to enhance their expert capabilities.
MeSH term(s)	Humans ; Artificial Intelligence ; Radionuclide Imaging ; Commerce ; Physical Examination ; Radiologists
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.230764
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Article: Integrating Artificial Intelligence and PET Imaging for Drug Discovery: A Paradigm Shift in Immunotherapy.

McGale, Jeremy P / Howell, Harrison J / Beddok, Arnaud / Tordjman, Mickael / Sun, Roger / Chen, Delphine / Wu, Anna M / Assi, Tarek / Ammari, Samy / Dercle, Laurent

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 2

Abstract: The integration of artificial intelligence (AI) and positron emission tomography (PET) imaging has the potential to become a powerful tool in drug discovery. This review aims to provide an overview of the current state of research and highlight the ... ...

Abstract	The integration of artificial intelligence (AI) and positron emission tomography (PET) imaging has the potential to become a powerful tool in drug discovery. This review aims to provide an overview of the current state of research and highlight the potential for this alliance to advance pharmaceutical innovation by accelerating the development and deployment of novel therapeutics. We previously performed a scoping review of three databases (Embase, MEDLINE, and CENTRAL), identifying 87 studies published between 2018 and 2022 relevant to medical imaging (e.g., CT, PET, MRI), immunotherapy, artificial intelligence, and radiomics. Herein, we reexamine the previously identified studies, performing a subgroup analysis on articles specifically utilizing AI and PET imaging for drug discovery purposes in immunotherapy-treated oncology patients. Of the 87 original studies identified, 15 met our updated search criteria. In these studies, radiomics features were primarily extracted from PET/CT images in combination (
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17020210
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Article ; Online: Heterotopic ossification and COVID 19: Imaging analysis of ten consecutive cases.

Mezghani, Sarah / Salga, Marjorie / Tordjman, Mickael / Amar, Raphaël / Carlier, Robert-Yves / Chiche, Lea

European journal of radiology

2022 Volume 152, Page(s) 110336

Abstract: Purpose: Heterotopic ossification (HO) is defined by the formation of mature lamellar bone in periarticular soft tissue due to prolonged immobility. This study aimed to explore the imaging features of HOs in immobilized COVID-19 patients compared to ... ...

Abstract	Purpose: Heterotopic ossification (HO) is defined by the formation of mature lamellar bone in periarticular soft tissue due to prolonged immobility. This study aimed to explore the imaging features of HOs in immobilized COVID-19 patients compared to other causes previously described in the literature. Method: This retrospective single centre study included patients with severe COVID-19 hospitalized in intensive care unit (ICU) with mechanical ventilation and affected by HOs between March 2020 and December 2021. Two radiologists reviewed imaging features of biphasic CT-scans using a standardized template including morphological findings and anatomical relationship of the HO with the joint, vessels and nerves. Results: 10 COVID-19 patients with 19 analyzed HOs following ICU hospitalization were including. Biphasic CT imaging characteristics were analyzed. The hips were the most commonly affected joint (n = 14/19; 74%). The distribution was mainly posterior (n = 7/19; 38%). HOs were located away from main arteries. No case of severe demineralization was observed. Capsular disruption was observed for three HOs (n = 3/19; 16%). One patient presented concomitant venous thrombosis ipsilateral to the HO. CT-scan demonstrated neural involvement of the sciatic nerve in 3 patients with HO (n = 3/19; 16%). Conclusion: Severe COVID-19 patients with a biphasic CT imaging presented HO mainly located around the hips, with rare vessel and nerve invasion and no severe demineralization. Some features such as a lower level of local invasion differ from HOs related to other disorders as described in the literature whereas morphological aspects are similar.
MeSH term(s)	COVID-19/diagnostic imaging ; Hospitalization ; Humans ; Ossification, Heterotopic/diagnostic imaging ; Retrospective Studies ; Tomography, X-Ray Computed/adverse effects
Language	English
Publishing date	2022-04-30
Publishing country	Ireland
Document type	Letter
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2022.110336
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Article ; Online: In-vivo characterization of the lumbar annulus fibrosus in adults with ultrasonography and shear wave elastography.

Galinié, Priscilla / Eyssartier, Camille / Sauret, Christophe / Tordjman, Mickael / Pissonier, Marie-Line / Carlier, Robert / Skalli, Wafa / Vergari, Claudio

Medical engineering & physics

2023 Volume 120, Page(s) 104044

Abstract: In vivo characterization of intervertebral disc (IVD) mechanical properties and microstructure could give an insight into the onset and progression of disc pathologies. Ultrasound shearwave elastography provided promising results in children, but ... ...

Abstract	In vivo characterization of intervertebral disc (IVD) mechanical properties and microstructure could give an insight into the onset and progression of disc pathologies. Ultrasound shearwave elastography provided promising results in children, but feasibility in adult lumbar discs, which are deep in the abdomen, was never proved. The aim of this work was to determine the feasibility and reliability of ultrasound assessment of lumbar IVD in adults. Thirty asymptomatic adults were included (22 to 67 years old). Subjects were lying supine, and the annulus fibrosus of the L3-L4 IVD was imaged by conventional ultrasonography and shearwave elastography. Shear wave speed (SWS) and lamellar thickness were measured. Reliability was determined through repeated measurements acquired by three operators. Average SWS in AF at the L3L4 level was 4.0 ± 0.9 m/s, with an inter-operator uncertainty of 8.7%, while lamellar thickness was 255 ± 27 µm with an uncertainty of 9.6%. Measurement was not feasible in one out of four subjects with BMI > 24 kg/m² (overweight). Ultrasound assessment of annulus fibrosus revealed feasible, within certain limitations, and reproducible. This method gives an insight into disc microstructure and mechanical properties, and it could be applied for the early detection or follow-up of disc pathologies.
MeSH term(s)	Child ; Humans ; Adult ; Young Adult ; Middle Aged ; Aged ; Annulus Fibrosus/diagnostic imaging ; Elasticity Imaging Techniques ; Reproducibility of Results ; Intervertebral Disc/diagnostic imaging ; Ultrasonography ; Intervertebral Disc Degeneration/diagnostic imaging
Language	English
Publishing date	2023-08-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1181080-4
ISSN	1873-4030 ; 1350-4533
ISSN (online)	1873-4030
ISSN	1350-4533
DOI	10.1016/j.medengphy.2023.104044
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Article ; Online: Endovascular treatment of haemorrhagic pancreatic serous cystadenoma.

Le Tat, Thomas / Carlier, Robert / El Hajjam, Mostafa / Sarrot, Guillaume-Marie / Obadia, Ilan / Tordjman, Mickael / Zhou, Jeffery

CVIR endovascular

2022 Volume 5, Issue 1, Page(s) 65

Abstract: Background: Pancreatic microcystic serous cystadenoma are rare benign pancreatic tumors. No treatment is needed in most cases as this lesion is often discovered incidentally. Surgery is not required except in symptomatic cases.: Case presentation: We ...

Abstract	Background: Pancreatic microcystic serous cystadenoma are rare benign pancreatic tumors. No treatment is needed in most cases as this lesion is often discovered incidentally. Surgery is not required except in symptomatic cases. Case presentation: We report herein a rare case of pancreatic serous cystadenoma complicated with a hemorrhage in a 95 years old patient treated with arterial embolization since surgery was not possible. The patient recovered without any adverse events or bleed recurrence in the 6 months following the procedure. Conclusion: Hemorrhage secondary to a pancreatic serous cystadenoma was successfully treated with arterial embolization, which may represent an alternative therapeutic option to surgery.
Language	English
Publishing date	2022-12-14
Publishing country	Switzerland
Document type	Journal Article
ISSN	2520-8934
ISSN (online)	2520-8934
DOI	10.1186/s42155-022-00343-w
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