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  1. Article ; Online: Base excess and lactate for guidance of peri-operative fluid management: A survey of anaesthetists, residents and intensive care physicians attending 2022 ESAIC in Milan.

    Heldeweg, Micah L A / Stohlmann, Julius A H / Loer, Stephan A

    European journal of anaesthesiology

    2023  Volume 40, Issue 8, Page(s) 610–612

    MeSH term(s) Humans ; Lactic Acid ; Critical Care ; Surveys and Questionnaires ; Physicians ; Anesthetists ; Perioperative Care
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Letter
    ZDB-ID 605770-6
    ISSN 1365-2346 ; 0265-0215
    ISSN (online) 1365-2346
    ISSN 0265-0215
    DOI 10.1097/EJA.0000000000001850
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1955: Show issues Location:
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  2. Article ; Online: Validation of New Quantitative Lung Ultrasound Protocol and Comparison With Lung Ultrasound Score in Patients With COVID-19.

    Heldeweg, Micah L A / Lieveld, Arthur W E / Mousa, Amne / Pisani, Luigi / Tuinman, Pieter R

    Chest

    2023  Volume 164, Issue 6, Page(s) 1512–1515

    MeSH term(s) Humans ; COVID-19 ; Ultrasonography ; Lung/diagnostic imaging
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.07.022
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  3. Article ; Online: Altitude Pre-Acclimatization with an Erythropoiesis-Stimulating Agent.

    Heldeweg, Micah L A / Medina Feliz, Jonathan X / Berend, Kenrick

    European journal of case reports in internal medicine

    2023  Volume 10, Issue 4, Page(s) 3792

    Abstract: Introduction: High altitude illness is a complication of rapid ascent above 2,500 m elevation. Ventilatory, circulatory and haematological adjustments, known as acclimatization, occur to maintain adequate delivery of oxygen. Although (non-) ... ...

    Abstract Introduction: High altitude illness is a complication of rapid ascent above 2,500 m elevation. Ventilatory, circulatory and haematological adjustments, known as acclimatization, occur to maintain adequate delivery of oxygen. Although (non-)pharmaceutical strategies that modulate ventilation and circulation have long been accepted, the haematological approach has not.
    Case description: This report describes the application of a comprehensive strategy, including prior pre-acclimatization using an erythropoiesis-stimulating agent (ESA), in two healthy subjects ascending from sea level to 6,268 m. Following ESA administration 30 days prior to ascent, the subjects had a cumulative haemoglobin rise of 7.1% and 11.9%, respectively. Both subjects experienced minimal symptoms during four incremental ascents to the final altitude and no adverse events occurred.
    Discussion: This report has limited external validity, lacking both a sample size and controls, but can serve as practical exploration of the concept. Administration of an ESA may be a safe and useful pre-acclimatization strategy but cannot be recommended based on current evidence. More comprehensive research is needed.
    Learning points: High altitude illness (HAI) is a debilitating syndrome with potentially lethal consequences caused by ascent to a hypobaric atmosphere without acclimatization.Pharmacological strategies aimed at increasing oxygen delivery may be used to prevent and treat HAI.Administration of an erythropoiesis-stimulating agent may be a safe and useful pre-acclimatization strategy but cannot be recommended based on current evidence alone.
    Language English
    Publishing date 2023-03-21
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2023_003792
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  4. Article ; Online: Interrater Agreement for Lung Ultrasound Scoring: Practice and Methods, Make Perfect.

    Heldeweg, Micah L A / Heldeweg, Tomas T R / Schober, Patrick / Tuinman, Pieter Roel / de Grooth, Harm-Jan

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2022  Volume 42, Issue 4, Page(s) 951–952

    MeSH term(s) Humans ; Ultrasonography ; Reproducibility of Results ; Observer Variation
    Language English
    Publishing date 2022-09-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.16094
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    Zs.A 1793: Show issues Location:
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    Zs.MO 495: Show issues

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  5. Article ; Online: Authors' response: "Lung ultrasound to predict gas-exchange response to prone positioning in COVID-19 patients: A prospective study in pilot and confirmation cohorts".

    Heldeweg, Micah L A / Mousa, Amne / Lieveld, Arthur W E / Smit, J M / Haaksma, M E / Tuinman, Pieter Roel

    Journal of critical care

    2023  Volume 77, Page(s) 154321

    MeSH term(s) Humans ; Prospective Studies ; Prone Position/physiology ; COVID-19 ; Lung/diagnostic imaging ; Respiration, Artificial ; Pulmonary Gas Exchange/physiology
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2023.154321
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    Zs.A 2152: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Lung ultrasound to discriminate non-cardiogenic interstitial syndrome from cardiogenic pulmonary edema: Is "gestalt" as good as it gets?

    Heldeweg, Micah L A / Haaksma, Mark E / Smit, Jasper M / Smit, Marry R / Tuinman, Pieter R

    Journal of critical care

    2022  Volume 73, Page(s) 154180

    MeSH term(s) Humans ; Pulmonary Edema/diagnostic imaging ; Pulmonary Edema/etiology ; Lung/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Letter
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2022.154180
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    Zs.A 2152: Show issues Location:
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  7. Article ; Online: Bacterial Contamination of Ultrasound and Stethoscope Surfaces in Low- and High-Resource Settings.

    Heldeweg, Micah L A / Berend, Kenrick / Cadenau, Laura / Rosingh, Andert / Duits, Ashley J / van Mansfeld, Rosa / Tuinman, Pieter R

    The American journal of tropical medicine and hygiene

    2022  Volume 107, Issue 2, Page(s) 463–466

    Abstract: Point-of-care ultrasound is an accurate diagnostic and monitoring tool. Its increasing affordability, portability, and versatility make it an excellent component of standard clinical evaluation alongside the stethoscope. However, like the stethoscope, ... ...

    Abstract Point-of-care ultrasound is an accurate diagnostic and monitoring tool. Its increasing affordability, portability, and versatility make it an excellent component of standard clinical evaluation alongside the stethoscope. However, like the stethoscope, ultrasound carries risks of surface contamination and potential cross-infection. In this international observational study, we compared the surface contamination of ultrasound equipment to stethoscopes in two medical centers: a tropical low-resource hospital and academic high-resource hospital. Ultrasound equipment and coupling gel had similar prevalence of microbial surface contamination compared with observed stethoscopes. Most microbes were commensal Gram-positive, but some were opportunistic and pathogenic microbes (such as Escherichia coli and Staphylococcus aureus). In conclusion, it is crucial to appreciate and reduce the risk of ultrasound device contaminations. When ultrasound is used bedside, similar to stethoscopes, conscientious hygiene measures are equally fundamental.
    MeSH term(s) Humans ; Stethoscopes/microbiology ; Bacteria ; Staphylococcus aureus ; Cross Infection/microbiology ; Staphylococcal Infections ; Escherichia coli
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.22-0074
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    Ud II Zs.61: Show issues Location:
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  8. Article ; Online: Determining the optimal number of lung ultrasound zones to monitor COVID-19 patients: can we keep it ultra-short and ultra-simple?

    Heldeweg, Micah L A / Lieveld, Arthur W E / de Grooth, Harm J / Heunks, Leo M A / Tuinman, Pieter R

    Intensive care medicine

    2021  Volume 47, Issue 9, Page(s) 1041–1043

    MeSH term(s) COVID-19 ; Humans ; Lung/diagnostic imaging ; Point-of-Care Systems ; SARS-CoV-2 ; Ultrasonography
    Language English
    Publishing date 2021-06-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-021-06463-6
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    Zs.A 1089: Show issues Location:
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  9. Article ; Online: Monitoring of pulmonary involvement in critically ill COVID-19 patients - should lung ultrasound be preferred over CT?

    Lieveld, Arthur W E / Heldeweg, Micah L A / Schouwenburg, Jasper / Veldhuis, Lars / Haaksma, Mark E / van Haaften, Rutger M / Teunissen, Berend P / Smit, Jasper M / Twisk, Jos / Heunks, Leo / Nanayakkara, Prabath W B / Tuinman, Pieter Roel

    The ultrasound journal

    2023  Volume 15, Issue 1, Page(s) 11

    Abstract: Background: It is unclear if relevant changes in pulmonary involvement in critically ill COVID-19 patients can be reliably detected by the CT severity score (CTSS) and lung ultrasound score (LUSS), or if these changes have prognostic implications. In ... ...

    Abstract Background: It is unclear if relevant changes in pulmonary involvement in critically ill COVID-19 patients can be reliably detected by the CT severity score (CTSS) and lung ultrasound score (LUSS), or if these changes have prognostic implications. In addition, it has been argued that adding pleural abnormalities to the LUSS could improve its prognostic value. The objective of this study was to compare LUSS and CTSS for the monitoring of COVID-19 pulmonary involvement through: first, establishing the correlation of LUSS (± pleural abnormalities) and CTSS throughout admission; second, assessing agreement and measurement error between raters for LUSS, pleural abnormalities, and CTSS; third, evaluating the association of the LUSS (± pleural abnormalities) and CTSS with mortality at different timepoints.
    Methods: This is a prospective, observational study, conducted during the second COVID-19 wave at the AmsterdamUMC, location VUmc. Adult COVID-19 ICU patients were prospectively included when a CT or a 12-zone LUS was performed at admission or at weekly intervals according to local protocol. Patients were followed 90 days or until death. We calculated the: (1) Correlation of the LUSS (± pleural abnormalities) and CTSS throughout admission with mixed models; (2) Intra-class correlation coefficients (ICCs) and smallest detectable changes (SDCs) between raters; (3) Association between the LUSS (± pleural abnormalities) and CTSS with mixed models.
    Results: 82 consecutive patients were included. Correlation between LUSS and CTSS was 0.45 (95% CI 0.31-0.59). ICCs for LUSS, pleural abnormalities, and CTSS were 0.88 (95% CI 0.73-0.95), 0.94 (95% CI 0.90-0.96), and 0.84 (95% CI 0.65-0.93), with SDCs of 4.8, 1.4, and 3.9. The LUSS was associated with mortality in week 2, with a score difference between patients who survived or died greater than its SDC. Addition of pleural abnormalities was not beneficial. The CTSS was associated with mortality only in week 1, but with a score difference less than its SDC.
    Conclusions: LUSS correlated with CTSS throughout ICU admission but performed similar or better at agreement between raters and mortality prognostication. Given the benefits of LUS over CT, it should be preferred as initial monitoring tool.
    Language English
    Publishing date 2023-02-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2965029-X
    ISSN 2524-8987 ; 2036-3176
    ISSN (online) 2524-8987
    ISSN 2036-3176
    DOI 10.1186/s13089-022-00299-x
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  10. Article: Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational Study.

    Mousa, Amne / Blok, Siebe G / Karssen, Dian / Aman, Jurjan / Annema, Jouke T / Bogaard, Harm Jan / Bonta, Peter I / Haaksma, Mark E / Heldeweg, Micah L A / Lieveld, Arthur W E / Nanayakkara, Prabath / Nossent, Esther J / Smit, Jasper M / Smit, Marry R / Vlaar, Alexander P J / Schultz, Marcus J / Bos, Lieuwe D J / Paulus, Frederique / Tuinman, Pieter R /
    Amsterdam Umc Covid-Biobank Investigators

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Serum biomarkers and lung ultrasound are important measures for prognostication and treatment allocation in patients with COVID-19. Currently, there is a paucity of studies investigating relationships between serum biomarkers and ultrasonographic ... ...

    Abstract Serum biomarkers and lung ultrasound are important measures for prognostication and treatment allocation in patients with COVID-19. Currently, there is a paucity of studies investigating relationships between serum biomarkers and ultrasonographic biomarkers derived from lung ultrasound. This study aims to assess correlations between serum biomarkers and lung ultrasound findings. This study is a secondary analysis of four prospective observational studies in adult patients with COVID-19. Serum biomarkers included markers of epithelial injury, endothelial dysfunction and immune activation. The primary outcome was the correlation between biomarker concentrations and lung ultrasound score assessed with Pearson's (r) or Spearman's (r
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14040421
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