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Article ; Online: Association of Protein Z with Prediabetes and Type 2 Diabetes (Endocrinol Metab 2021;36:637-46, Yun-Ui Bae et al.).

You, Ji Hong / Bae, Yun-Ui / Cho, Ho Chan

Endocrinology and metabolism (Seoul, Korea)

2021 Volume 36, Issue 5, Page(s) 1149–1150

MeSH term(s)	Blood Glucose ; Blood Proteins ; Diabetes Mellitus, Type 2 ; Humans ; Prediabetic State
Chemical Substances	Blood Glucose ; Blood Proteins ; plasma protein Z
Language	English
Publishing date	2021-09-16
Publishing country	Korea (South)
Document type	Letter ; Comment
ZDB-ID	2802452-7
ISSN	2093-5978 ; 2093-5978
ISSN (online)	2093-5978
ISSN	2093-5978
DOI	10.3803/EnM.2021.502
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Jian Yun Qing Hua Decoction inhibits malignant behaviors of gastric carcinoma cells via COL12A1 mediated ferroptosis signal pathway.

Liu, Baoxinzi / Li, Yu / Xu, Yuanyuan / Xue, Weiwei / Jin, Zhichao

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 118

Abstract: Background: Jian Yun Qing Hua Decoction (JYQHD), a traditional Chinese medicine decoction ...

Abstract	Background: Jian Yun Qing Hua Decoction (JYQHD), a traditional Chinese medicine decoction, which has been applied in the treatment of gastric cancer (GC). We attempt to confirm the anti-gastric cancer effect of JYQHD and explore the mechanism of JYQHD. Methods: Acute toxicity test was used to understand the toxicity of JYQHD. We studied the expression and prognostic outcome of COL12A1 within GC tissues through the network databases. Using several web-based databases, we analyzed the major components and targets of JYQHD, as well as known therapeutic targets in gastric cancer. The Venn diagram was utilized to obtain the overlapped genes. Lentiviral vector, shRNAs and plasmids, were used to transfect GC cells. Cell counting kit-8 (CCK8), sphere formation, malondialdehyde (MDA), glutathione (GSH), reactive oxygen species (ROS), Fe Results: The results showed that JYQHD was non-toxic and safe. JYQHD inhibited growth and sphere formation ability through inducing the ferroptosis of GC cells, and suppressed the GC cells induced subcutaneous xenograft tumor growth. COL12A1 was highly expressed in gastric cancer tissues, indicating poor prognosis. COL12A1 specifically enhanced GC cell progression and stemness via suppressing ferroptosis. JYQHD down-regulated COL12A1 in order to suppress the stemness of GC cells via inducing ferroptosis. Conclusion: COL12A1 inhibited ferroptosis and enhanced stemness in GC cells. JYQHD inhibited the development of GC cells by inhibiting cancer cell stemness via the ferroptosis pathway mediated by COL12A1.
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00799-5
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Article ; Online: Seasonal Variation in Chemical Compositions of Essential Oils Extracted from Lavandin Flowers in the Yun-Gui Plateau of China.

Liao, Zhenni / Huang, Qing / Cheng, Qiming / Khan, Sardar / Yu, Xiaoying

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 18

Abstract: Lavandin, as an important cash crop, is cultivated in Kunming, Yun-Gui Plateau of China ... to the researcher, the farmer, and investor for sustainable industrialization of the plant grown in the Yun-Gui ...

Abstract	Lavandin, as an important cash crop, is cultivated in Kunming, Yun-Gui Plateau of China. For the special growing environment, Lavandin was grown here and used to investigate the changes in the yield and chemical compositions of essential oils extracted from the flowers in different seasons. The essential oils were extracted by hydro-distillation and analysis by gas chromatography-mass spectrometry (GC-MS). Results indicated great changes in chemical composition depending on the season of harvesting. The yields of essential oils ranged from 2.0% to 3.8% among the seasons, and the highest yield was in the summer. Chemical composition data showed that the extracted oils were rich in oxygenated monoterpenes (55.4-81.4%), eucalyptol (38.7-49.8%), camphor (8.41-14.26%), α-bisabolol (6.6-25.5%), and linalool (4.6-12.5%). The contents of eucalyptol and α-bisabolol changed in a contrary trend with seasonal variations. The results provided new insight for Chinese Lavandin germplasm to be used in application and development, and reference to the researcher, the farmer, and investor for sustainable industrialization of the plant grown in the Yun-Gui Plateau of China, but also the similar plateau area of the sustainable developments.
MeSH term(s)	China ; Flowers ; Oils, Volatile ; Seasons
Chemical Substances	Oils, Volatile
Language	English
Publishing date	2021-09-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26185639
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Article: Efficacy of Yun-Type Optimized Pelvic Floor Training Therapy for Middle-Aged Women With Severe Overactive Bladder: A Randomized Clinical Trial.

Shi, Chaoliang / Zhou, Dan / Yu, Wandong / Jiao, Wei / Shi, Guowei / Wang, Yangyun

Frontiers in surgery

2021 Volume 8, Page(s) 670123

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2021.670123
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Article: [The prevent miscarriage effects of Yun Kang oral liquid on threatened abortion rat induced by kidney deficiency and luteum inhibition].

Dai, Ming Zhu / Lyu, Gui Yuan / Xu, Yu Yue / Zheng, Xiang / Chen, Su Hong

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

2019 Volume 35, Issue 1, Page(s) 9–12

Abstract: Objective: Yun Kang oral liquid is a listed proprietary Chinese Medicine. To further evaluate ... model to observe the effects of Yun Kang oral liquid.: Methods: Sixty pregnant rats were randomly ... divided into normal control group (NC), model group (MG), dydrogesterone group (DT, 3.02 mg/kg), and Yun ...

Abstract	Objective: Yun Kang oral liquid is a listed proprietary Chinese Medicine. To further evaluate its efficacy, this experiment established a kidney deficiency and luteum inhibition threatened abortion rat model to observe the effects of Yun Kang oral liquid. Methods: Sixty pregnant rats were randomly divided into normal control group (NC), model group (MG), dydrogesterone group (DT, 3.02 mg/kg), and Yun Kang oral liquid low-dose group (YK-L, 4 ml/kg), medium dose group (YK-M, 6 ml/kg), high dose group (YK-H, 9 ml/kg), 10 in each group. On the first day of pregnancy, each administration group was treated with the test drug at the prescribed dose every morning, and the NC group and the MG group were given an equal volume of purified water for 10 days; the rats were intragastrically administrated every afternoon, except for the NC group. In addition, the other groups were intragastrically administered with hydroxyurea at a dose of 450 mg/kg for 9 days, and mifepristone was administered at a dose of 4.0 mg/kg on the 10th day. On the 9th day of pregnancy, behavioral signs such as back temperature, grasping force, pain threshold, and autonomic activity were measured in each group. On the 11th day of pregnancy, blood was collected from the abdominal aorta in each group to determine serum levels of estradiol (E Results: Compared with the NC group, the back temperature, grip, pain threshold, number of spontaneous activities, number of embryos, embryo diameter, uterus index and serum E Conclusion: Yun Kang oral liquid has a clear kidney-filling effect on rats with threatened abortion caused by kidney deficiency-luteal suppression. The mechanism may be related to raising serum E
MeSH term(s)	Abortion, Spontaneous/prevention & control ; Abortion, Threatened/prevention & control ; Animals ; Drugs, Chinese Herbal/pharmacology ; Estradiol ; Female ; Humans ; Kidney/physiopathology ; Luteal Phase ; Pregnancy ; Progesterone ; Rats ; Uterus
Chemical Substances	Drugs, Chinese Herbal ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E)
Language	Chinese
Publishing date	2019-06-27
Publishing country	China
Document type	Journal Article
ISSN	1000-6834
ISSN	1000-6834
DOI	10.12047/j.cjap.5749.2019.003
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Article ; Online: Seasonal Variation in Chemical Compositions of Essential Oils Extracted from Lavandin Flowers in the Yun-Gui Plateau of China

Zhenni Liao / Qing Huang / Qiming Cheng / Sardar Khan / Xiaoying Yu

Molecules, Vol 26, Iss 5639, p

2021 Volume 5639

Abstract	Lavandin, as an important cash crop, is cultivated in Kunming, Yun-Gui Plateau of China. For the special growing environment, Lavandin was grown here and used to investigate the changes in the yield and chemical compositions of essential oils extracted from the flowers in different seasons. The essential oils were extracted by hydro-distillation and analysis by gas chromatography-mass spectrometry (GC-MS). Results indicated great changes in chemical composition depending on the season of harvesting. The yields of essential oils ranged from 2.0% to 3.8% among the seasons, and the highest yield was in the summer. Chemical composition data showed that the extracted oils were rich in oxygenated monoterpenes (55.4–81.4%), eucalyptol (38.7–49.8%), camphor (8.41–14.26%), α-bisabolol (6.6–25.5%), and linalool (4.6–12.5%). The contents of eucalyptol and α-bisabolol changed in a contrary trend with seasonal variations. The results provided new insight for Chinese Lavandin germplasm to be used in application and development, and reference to the researcher, the farmer, and investor for sustainable industrialization of the plant grown in the Yun-Gui Plateau of China, but also the similar plateau area of the sustainable developments.
Keywords	Lavandin ; essential oil ; Yun-Gui Plateau ; monoterpenes ; eucalyptol ; camphor ; Organic chemistry ; QD241-441
Subject code	550
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [The Incidence of Hypertension in Beijing Region Based on Yun-qi Theory: an Exploratory Research].

Hao, Yu / Tang, Qiao-ling / Zhang, Xuan / Fei, Zhan-yang / He, Juan

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

2015 Volume 35, Issue 5, Page(s) 568–571

Abstract: ... host climatic qi, guest climatic qi) was deducted based on Yun-qi theory. Their ratios of different ... difference in each period, which is consistent with Yun-qi theory. ...

Abstract	Objective: To explore the scientificity of Yunqi theory based on incidence of disease related recognitions such as year evolutive phase, host climatic qi, six climatic factors, celestial manager qi, qi in the earth by analyzing data of hypertension incidence. Methods: A total of 1,265 inpatients with confirmed first diagnosis as hypertension were recruited at Dongzhimen Hospital, Beijing University of Chinese Medicine from February 4, 1999 to February 4, 2011. Each period (including year evolutive phase, host climatic qi, guest climatic qi) was deducted based on Yun-qi theory. Their ratios of different phases and qi in the total number of hypertension inpatients number were calculated and statistically tested. Results: There was statistical difference in ratios at year evolutive phase, celestial manager qi, and qi in the earth (P < 0.05). Conclusion: The incidence of hypertension has certain difference in each period, which is consistent with Yun-qi theory.
MeSH term(s)	Beijing/epidemiology ; Humans ; Hypertension/epidemiology ; Incidence ; Medicine, Chinese Traditional ; Qi ; Research
Language	Chinese
Publishing date	2015-05
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1195456-5
ISSN	1003-5370
ISSN	1003-5370
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Article ; Online: Dissecting the Underlying Pharmaceutical Mechanism of Chinese Traditional Medicine Yun-Pi-Yi-Shen-Tong-Du-Tang Acting on Ankylosing Spondylitis through Systems Biology Approaches.

Xie, Duoli / Huang, Lin / Zhao, Guanghui / Yu, Yiran / Gao, Jiawei / Li, Haichang / Wen, Chengping

Scientific reports

2017 Volume 7, Issue 1, Page(s) 13436

Abstract: ... Spondylitis (AS) treatment for a long time. Yun-Pi-Yi-Shen-Tong-Du-Tang (Y-Y-T) is a novel empirical formula ...

Abstract	Traditional Chinese Medicine (TCM) has been served as complementary medicine for Ankylosing Spondylitis (AS) treatment for a long time. Yun-Pi-Yi-Shen-Tong-Du-Tang (Y-Y-T) is a novel empirical formula designed by Prof. Chengping Wen. In this study, a retrospective investigation supported efficacy of Y-Y-T and then we deciphered the underlying molecular mechanism of the efficacy. Herbal ingredients and targeting proteins were collected from TCMID. PPI networks were constructed to further infer the relationship among Y-Y-T, drugs used for treating AS, differentially expressed genes of AS patients and AS disease proteins. Finally, it was suggested that TLR signaling pathway and T cell receptor signaling pathway may involve in the biological processes of AS progression and contribute to the curative effect and proteins such as JAK2, STAT3, HSP90AA1, TNF and PTEN were the key targets. Our systemic investigation to infer therapeutic mechanism of Y-Y-T for AS treatment provides a new insight in understanding TCM pharmacology.
MeSH term(s)	Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Janus Kinase 2/metabolism ; PTEN Phosphohydrolase/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Spondylitis, Ankylosing/drug therapy ; Systems Biology ; Toll-Like Receptors/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Drugs, Chinese Herbal ; HSP90 Heat-Shock Proteins ; HSP90AA1 protein, human ; STAT3 Transcription Factor ; STAT3 protein, human ; Toll-Like Receptors ; Tumor Necrosis Factor-alpha ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
Language	English
Publishing date	2017-10-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-13723-3
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Article: Efficacy of optimized pelvic floor training of YUN combined with pelvic floor magnetic stimulation on female moderate stress urinary incontinence and sexual function: a retrospective cohort study.

Wang, Yangyun / Shi, Chaoliang / Zhou, Dan / Yu, Wandong / Jiao, Wei / Shi, Guowei

Translational andrology and urology

2018 Volume 11, Issue 4, Page(s) 554–560

Abstract: ... of YUN combined with pelvic floor magnetic stimulation on female moderate stress urinary incontinence ... stimulation combined with optimized pelvic floor training of YUN. Evaluations were scheduled ... 44/49 : Conclusions: Optimized pelvic floor training of YUN combined with pelvic floor magnetic ...

Abstract	Background: Owing to its tediousness and monotony, traditional pelvic floor muscle training (PFMT) is difficult to ensure the correctness of exercise, and it is difficult for patients to adhere to treatment. We designed this study to evaluate and analyze the efficacy of optimized pelvic floor training of YUN combined with pelvic floor magnetic stimulation on female moderate stress urinary incontinence (SUI) and sexual function. Methods: This is a retrospective cohort study. This study was carried out in 95 female patients with moderate SUI. The inclusion criteria were as follows: premenopausal women aged 25-45; moderate SUI; over 3 months of disease duration; informed consent and cooperation with treatment and follow-up. The participants in group 1 (control group, n=46) were treated with pelvic floor magnetic stimulation, while those in group 2 (trial group, n=49) were treated with pelvic floor magnetic stimulation combined with optimized pelvic floor training of YUN. Evaluations were scheduled before the treatment (0 week), after 6 weeks of treatment (6 weeks), and after 12 weeks of treatment (12 weeks). And compare the differences between the two groups. Results: There was no significant difference in age, body mass index (BMI), duration of disease, and abdominal leak point pressure (ALPP) between the two groups (P>0.05). The total effective rate of the trial group was higher than that of the control group (89.80%, 44/49 Conclusions: Optimized pelvic floor training of YUN combined with pelvic floor magnetic are more effective for the treatment of female moderate SUI and sexual function. It has become a safe, effective, and well tolerated new type of pelvic floor functional reconstruction training method with good patient compliance.
Language	English
Publishing date	2018-12-03
Publishing country	China
Document type	Journal Article
ZDB-ID	2851630-8
ISSN	2223-4691 ; 2223-4691 ; 2223-4683
ISSN (online)	2223-4691
ISSN	2223-4691 ; 2223-4683
DOI	10.21037/tau-22-222
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Article: Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial.

Lee, Chien-Ying / Yu, Min-Chien / Lin, Chun-Che / Lee, Ming-Yung / Wei, James Cheng-Chung / Shih, Hung-Che

Chinese journal of integrative medicine

2013 Volume 21, Issue 8, Page(s) 587–593

Abstract: Objective: Animal studies have demonstrated a lipid-modulating effect of yun-cai tea ... lowering effects and safety of yun-cai tea in patients with elevated lipid levels in a human clinical trial ... to the yun-cai tea group (30 patients) and the placebo group (30 patients), for 8 weeks of treatment and 4 ...

Abstract	Objective: Animal studies have demonstrated a lipid-modulating effect of yun-cai tea. However, little is known about the lipid-lowering effect in humans.The aim of this study was to evaluate the lipid lowering effects and safety of yun-cai tea in patients with elevated lipid levels in a human clinical trial. Methods: This was a 12-week, randomly assigned, parallel-group, double-blind, and placebo-controlled pilot clinical study. Sixty primary hyperlipidemia patients were included and randomly assigned to the yun-cai tea group (30 patients) and the placebo group (30 patients), for 8 weeks of treatment and 4 weeks of follow-up. The primary endpoint was changes in plasma low-density lipoprotein-cholesterol (LDL-C) at 8 weeks. The secondary endpoints included total cholesterol (TC) and triglycerides (TG). Results: Our results revealed no statistically signifificant differences in LDL-C and TC between the two groups. Despite the lack of a statistically signifificant difference in the level of TG between the two groups, a declining trend was noted. A signifificant reduction of TG was observed in the yun-cai tea group at week 8, compared to baseline (P=0.048). The incidence of stomach discomfort, gastroesophageal reflfl ux, diarrhea, and constipation was slightly higher in the yun-cai tea group. No other signifificant adverse events were found. Conclusion: It is unlikely that yun-cai tea used had a blood lipid reduction effect. Further larger scale clinical trials with a longer duration and larger dose are necessary.
MeSH term(s)	Adult ; Double-Blind Method ; Drugs, Chinese Herbal/therapeutic use ; Female ; Herbal Medicine ; Humans ; Hyperlipidemias/drug therapy ; Hypolipidemic Agents/therapeutic use ; Male ; Middle Aged ; Placebos
Chemical Substances	Drugs, Chinese Herbal ; Hypolipidemic Agents ; Placebos ; yun-cai
Language	English
Publishing date	2013-02-28
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-012-1219-3
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