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Article ; Online: RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation.

Fontaine, Valérie / Boumedine, Thinhinane / Monteiro, Elodie / Fournié, Mylène / Gersende, Gendre / Sahel, José-Alain / Picaud, Serge / Veillet, Stanislas / Lafont, René / Latil, Mathilde / Dilda, Pierre J / Camelo, Serge

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: ... ...

Abstract	N
MeSH term(s)	Anti-Inflammatory Agents ; Carotenoids ; Drug Inverse Agonism ; Inflammation ; Macular Degeneration/metabolism ; para-Aminobenzoates ; Peroxisome Proliferator-Activated Receptors/metabolism ; Quinolines ; Retinoic Acid Receptor alpha/metabolism ; Retinoid X Receptors/metabolism ; Retinoids/metabolism ; Transcriptional Activation ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid ; Anti-Inflammatory Agents ; Carotenoids (36-88-4) ; norbixin (E8M59E17AI) ; para-Aminobenzoates ; Peroxisome Proliferator-Activated Receptors ; Quinolines ; Retinoic Acid Receptor alpha ; Retinoid X Receptors ; Retinoids ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25053037
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Article ; Online: BIO101 stimulates myoblast differentiation and improves muscle function in adult and old mice.

Serova, Maria / Didry-Barca, Blaise / Deloux, Robin / Foucault, Anne-Sophie / Veillet, Stanislas / Lafont, René / Dilda, Pierre J / Latil, Mathilde

Journal of cachexia, sarcopenia and muscle

2023 Volume 15, Issue 1, Page(s) 55–66

Abstract: Background: Muscle aging is associated with a consistent decrease in the ability of muscle tissue to regenerate following intrinsic muscle degradation, injury or overuse. Age-related imbalance of protein synthesis and degradation, mainly regulated by ... ...

Abstract	Background: Muscle aging is associated with a consistent decrease in the ability of muscle tissue to regenerate following intrinsic muscle degradation, injury or overuse. Age-related imbalance of protein synthesis and degradation, mainly regulated by AKT/mTOR pathway, leads to progressive loss of muscle mass. Maintenance of anabolic and regenerative capacities of skeletal muscles may be regarded as a therapeutic option for sarcopenia and other muscle wasting diseases. Our previous studies have demonstrated that BIO101, a pharmaceutical grade 20-hydroxyecdysone, increases protein synthesis through the activation of MAS receptor involved in the protective arm of renin-angiotensin-aldosterone system. The purpose of the present study was to assess the anabolic and pro-differentiating properties of BIO101 on C2C12 muscle cells in vitro and to investigate its effects on adult and old mice models in vivo. Methods: The effects of BIO101 on C2C12 differentiation were assessed using myogenic transcription factors and protein expression of major kinases of AKT/mTOR pathway by Western blot. The in vivo effects of BIO101 have been investigated in BIO101 orally-treated (50 mg/kg/day) adult mice (3 months) for 28 days. To demonstrate potential beneficial effect of BIO101 treatment in a sarcopenic mouse model, we use orally treated 22-month-old C57Bl6/J mice, for 14 weeks with vehicle or BIO101. Mice body and muscle weight were recorded. Physical performances were assessed using running capacity and muscle contractility tests. Results: Anabolic properties of BIO101 were confirmed by the rapid activation of AKT/mTOR, leading to an increase of C2C12 myotubes diameters (+26%, P < 0.001). Pro-differentiating effects of BIO101 on C2C12 myoblasts were revealed by increased expression of muscle-specific differentiation transcription factors (MyoD, myogenin), resulting in increased fusion index and number of nuclei per myotube (+39% and +53%, respectively, at day 6). These effects of BIO101 were like those of angiotensin (1-7) and were abolished with the use of A779, a MAS receptor specific antagonist. Chronic BIO101 oral treatment induced AKT/mTOR activation and anabolic effects accompanied with improved physical performances in adult and old animals (maximal running distance and maximal running velocity). Conclusions: Our data suggest beneficial anabolic and pro-differentiating effects of BIO101 rendering BIO101 a potent drug candidate for treating sarcopenia and possibly other muscle wasting disorders.
MeSH term(s)	Mice ; Animals ; Sarcopenia/pathology ; Proto-Oncogene Proteins c-akt/metabolism ; Muscle, Skeletal/pathology ; Muscular Diseases/metabolism ; Muscular Atrophy/pathology ; TOR Serine-Threonine Kinases/metabolism ; Myoblasts/metabolism ; Transcription Factors/metabolism ; Transcription Factors/pharmacology
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Transcription Factors
Language	English
Publishing date	2023-12-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2586864-0
ISSN	2190-6009 ; 2190-5991
ISSN (online)	2190-6009
ISSN	2190-5991
DOI	10.1002/jcsm.13326
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Article ; Online: Developing new drugs that activate the protective arm of the renin-angiotensin system as a potential treatment for respiratory failure in COVID-19 patients.

Latil, Mathilde / Camelo, Serge / Veillet, Stanislas / Lafont, René / Dilda, Pierre J

Drug discovery today

2021 Volume 26, Issue 5, Page(s) 1311–1318

Abstract: COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has reached pandemic proportions with negative impacts on global health, the world economy and human society. The clinical picture of COVID-19, and the fact that ... ...

Abstract	COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has reached pandemic proportions with negative impacts on global health, the world economy and human society. The clinical picture of COVID-19, and the fact that Angiotensin converting enzyme 2 (ACE2) is a receptor of SARS-CoV-2, suggests that SARS-CoV-2 infection induces an imbalance in the renin-angiotensin system (RAS). We review clinical strategies that are attempting to rebalance the RAS in COVID-19 patients by using ACE inhibitors, angiotensin receptor blockers, or agonists of angiotensin-II receptor type 2 or Mas receptor (MasR). We also propose that the new MasR activator BIO101, a pharmaceutical grade formulation of 20-hydroxyecdysone that has anti-inflammatory, anti-fibrotic and cardioprotective properties, could restore RAS balance and improve the health of COVID-19 patients who have severe pneumonia.
MeSH term(s)	Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; COVID-19/drug therapy ; COVID-19/metabolism ; COVID-19/virology ; Commelinaceae ; Drug Development ; Ecdysone/analogs & derivatives ; Ecdysone/therapeutic use ; Host-Pathogen Interactions ; Humans ; Plant Extracts/therapeutic use ; Proto-Oncogene Proteins/agonists ; Proto-Oncogene Proteins/metabolism ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/metabolism ; Renin-Angiotensin System/drug effects ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity
Chemical Substances	20-hydroxylecdysone ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Plant Extracts ; Proto-Oncogene Proteins ; Receptors, G-Protein-Coupled ; proto-oncogene proteins c-mas-1 ; Ecdysone (3604-87-3)
Language	English
Publishing date	2021-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2021.02.010
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Article ; Online: Publisher Correction: p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity.

Nature medicine

2024

Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-024-02842-w
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Article ; Online: Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degeneration (AMD).

Fontaine, Valérie / Balducci, Christine / Dinan, Laurence / Monteiro, Elodie / Boumedine, Thinhinane / Fournié, Mylène / Nguyen, Vincent / Guibout, Louis / Clatot, Justine / Latil, Mathilde / Veillet, Stanislas / Sahel, José-Alain / Lafont, René / Dilda, Pierre J / Camelo, Serge

International journal of molecular sciences

2023 Volume 24, Issue 6

Abstract: 9'- ...

Abstract	9'-
MeSH term(s)	Animals ; Mice ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/metabolism ; ATP-Binding Cassette Transporters/metabolism ; Carotenoids/metabolism ; Macular Degeneration/drug therapy ; Macular Degeneration/metabolism ; Retinal Degeneration/drug therapy ; Retinal Degeneration/metabolism ; Retinal Pigment Epithelium/metabolism ; Retinoids/pharmacology ; Rats
Chemical Substances	Abca4 protein, mouse ; Anti-Inflammatory Agents ; ATP-Binding Cassette Transporters ; Carotenoids (36-88-4) ; norbixin (E8M59E17AI) ; Retinoids
Language	English
Publishing date	2023-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24065296
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Article ; Online: An agent-based model to simulate SARS-CoV-2 contamination of surfaces and meat cuts in processing plants.

Luong, Ngoc-Du Martin / Guillier, Laurent / Federighi, Michel / Guillois, Yvonnick / Kooh, Pauline / Maillard, Anne-Laure / Pivette, Mathilde / Boué, Géraldine / Martin-Latil, Sandra / Chaix, Estelle / Duret, Steven

International journal of food microbiology

2023 Volume 404, Page(s) 110321

Abstract: At the beginning of the COVID-19 pandemic, several contamination clusters were reported in food-processing plants in France and several countries worldwide. Therefore, a need arose to better understand viral transmission in such occupational environments ...

Abstract	At the beginning of the COVID-19 pandemic, several contamination clusters were reported in food-processing plants in France and several countries worldwide. Therefore, a need arose to better understand viral transmission in such occupational environments from multiple perspectives: the protection of workers in hotspots of viral circulation; the prevention of supply disruption due to the closure of plants; and the prevention of cluster expansion due to exports of food products contaminated by the virus to other locations. This paper outlines a simulation-based approach (using agent-based models) to study the effects of measures taken to prevent the contamination of workers, surfaces, and food products. The model includes user-defined parameters to integrate characteristics relating to SARS-CoV-2 (variant of concern to be considered, symptom onset…), food-processing plants (dimensions, ventilation…), and other sociodemographic transmission factors based on laboratory experiments as well as industrial and epidemiological investigations. Simulations were performed for a typical meat-processing plant in different scenarios for illustration purposes. The results suggested that increasing the mask-wearing ratio led to great reductions in the probability of observing clusters of more than 25 infections. In the case of clusters, masks being worn by all workers limited the presence of contamination (defined as levels of at least 5 log
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; Pandemics/prevention & control ; Meat ; RNA, Viral
Chemical Substances	RNA, Viral
Language	English
Publishing date	2023-07-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2023.110321
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Article ; Online: Beyond AREDS Formulations, What Is Next for Intermediate Age-Related Macular Degeneration (iAMD) Treatment? Potential Benefits of Antioxidant and Anti-inflammatory Apocarotenoids as Neuroprotectors.

Camelo, Serge / Latil, Mathilde / Veillet, Stanislas / Dilda, Pierre J / Lafont, René

Oxidative medicine and cellular longevity

2020 Volume 2020, Page(s) 4984927

Abstract: Age-related macular degeneration (AMD) is the commonest cause of severe visual loss and blindness in developed countries among individuals aged 60 and older. AMD slowly progresses from early AMD to intermediate AMD (iAMD) and ultimately late-stage AMD. ... ...

Abstract	Age-related macular degeneration (AMD) is the commonest cause of severe visual loss and blindness in developed countries among individuals aged 60 and older. AMD slowly progresses from early AMD to intermediate AMD (iAMD) and ultimately late-stage AMD. Late AMD encompasses either neovascular AMD (nAMD) or geographic atrophy (GA). nAMD is defined by choroidal neovascularization (CNV) and hemorrhage in the subretinal space at the level of the macula. This induces a rapid visual impairment caused by the death of photoreceptor cells. Intravitreal injection of anti-vascular endothelial growth factor (VEGF) antibodies is the standard treatment of nAMD but adds to the burden of patient care. GA is characterized by slowly expanding photoreceptor, and retinal pigment epithelium (RPE) degeneration patches progressively leading to blindness. There is currently no therapy to cure GA. Late AMD continues to be an unmet medical need representing a major health problem with millions of patients worldwide. Oxidative stress and inflammation are recognized as some of the main risk factors to developing late AMD. The antioxidant formulation AREDS (Age-Related Eye Disease Studies), contains
MeSH term(s)	Aged ; Aged, 80 and over ; Anti-Inflammatory Agents/therapeutic use ; Antioxidants/chemistry ; Antioxidants/therapeutic use ; Carotenoids/chemistry ; Carotenoids/therapeutic use ; Disease Progression ; Humans ; Macular Degeneration/therapy ; Middle Aged ; Retinal Pigment Epithelium/drug effects ; Severity of Illness Index
Chemical Substances	Anti-Inflammatory Agents ; Antioxidants ; Carotenoids (36-88-4) ; crocin (877GWI46C2) ; norbixin (E8M59E17AI)
Language	English
Publishing date	2020-12-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2020/4984927
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Article ; Online: An agent-based model to simulate SARS-CoV-2 contamination of surfaces and meat cuts in processing plants

Luong, Ngoc-Du Martin / Guillier, Laurent / Federighi, Michel / Guillois, Yvonnick / Kooh, Pauline / Maillard, Anne-Laure / Pivette, Mathilde / Boue, Géraldine / Martin-Latil, Sandra / Chaix, Estelle / Duret, Steven

International Journal of Food Microbiology. 2023 July 13, p.110321-

2023 , Page(s) 110321–

Abstract	At the beginning of the COVID-19 pandemic, several contamination clusters were reported in food-processing plants in France and several countries worldwide. Therefore, a need arose to better understand viral transmission in such occupational environments from multiple perspectives: the protection of workers in hotspots of viral circulation; the prevention of supply disruption due to the closure of plants; and the prevention of cluster expansion due to exports of food products contaminated by the virus to other locations. This paper outlines a simulation-based approach (using agent-based models) to study the effects of measures taken to prevent the contamination of workers, surfaces, and food products. The model includes user-defined parameters to integrate characteristics relating to SARS-CoV-2 (variant of concern to be considered, symptom onset…), food-processing plants (dimensions, ventilation…), and other sociodemographic transmission factors based on laboratory experiments as well as industrial and epidemiological investigations. Simulations were performed for a typical meat-processing plant in different scenarios for illustration purposes. The results suggested that increasing the mask-wearing ratio led to great reductions in the probability of observing clusters of >25 infections. In the case of clusters, masks being worn by all workers limited the presence of contamination (defined as levels of at least 5 log₁₀ viral RNA copies) on meat cuts at <0.05 % and maintained the production capacity of the plant at optimal levels. Increasing the average distance between two workers from <1 m to >2 m decreased the cluster-occurrence probability by up to 15 % as well as contamination of food products during cluster situations. The developed approach can open up several perspectives in terms of potential communication-support tools for the agri-food sector and further reuses or adaptations for other hazards and occupational environments.
Keywords	COVID-19 infection ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; food contamination ; food industry ; food microbiology ; food processing ; meat ; meat processing plants ; probability ; simulation models ; virus transmission ; viruses ; France ; Coronavirus ; Viral transmission ; Occupational environment ; Preventive measure ; ABM
Language	English
Dates of publication	2023-0713
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2023.110321
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: RHOJ controls EMT-associated resistance to chemotherapy.

Debaugnies, Maud / Rodríguez-Acebes, Sara / Blondeau, Jeremy / Parent, Marie-Astrid / Zocco, Manuel / Song, Yura / de Maertelaer, Viviane / Moers, Virginie / Latil, Mathilde / Dubois, Christine / Coulonval, Katia / Impens, Francis / Van Haver, Delphi / Dufour, Sara / Uemura, Akiyoshi / Sotiropoulou, Panagiota A / Méndez, Juan / Blanpain, Cédric

Nature

2023 Volume 616, Issue 7955, Page(s) 168–175

Abstract: The resistance of cancer cells to therapy is responsible for the death of most patients with ... ...

Abstract	The resistance of cancer cells to therapy is responsible for the death of most patients with cancer
MeSH term(s)	Actins/drug effects ; Actins/metabolism ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Epithelial-Mesenchymal Transition/drug effects ; Proteomics ; rho GTP-Binding Proteins/genetics ; rho GTP-Binding Proteins/metabolism ; Animals ; Mice ; Skin Neoplasms/drug therapy ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Gene Expression Profiling ; Genome
Chemical Substances	Actins ; rho GTP-Binding Proteins (EC 3.6.5.2) ; Rhoj protein, mouse
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-05838-7
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Article ; Online: A comparison between virus- versus patients-centred therapeutic attempts to reduce COVID-19 mortality.

Camelo, Serge / Latil, Mathilde / Agus, Sam / Dioh, Waly / Veillet, Stanislas / Lafont, René / Dilda, Pierre J

Emerging microbes & infections

2021 Volume 10, Issue 1, Page(s) 2256–2263

Abstract: Since December 2019, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has changed our lives. Elderly and those with comorbidities represent the vast majority of patients ... ...

Abstract	Since December 2019, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has changed our lives. Elderly and those with comorbidities represent the vast majority of patients hospitalized with severe COVID-19 symptoms, including acute respiratory disease syndrome and cardiac dysfunction. Despite a huge effort of the scientific community, improved treatment modalities limiting the severity and mortality of hospitalized COVID-19 patients are still required. Here, we compare the effectiveness of virus- and patients-centred strategies to reduce COVID-19 mortality. We also discuss the therapeutic options that might further reduce death rates associated with the disease in the future. Unexpectedly, extensive review of the literature suggests that SARS-CoV-2 viral load seems to be associated neither with the severity of symptoms nor with mortality of hospitalized patients with COVID-19. This may explain why, so far, virus-centred strategies using antivirals aiming to inhibit the viral replicative machinery have failed to reduce COVID-19 mortality in patients with respiratory failure. By contrast, anti-inflammatory treatments without antiviral capacities but centred on patients, such as dexamethasone or Tocilizumab
MeSH term(s)	Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/immunology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/immunology ; COVID-19/mortality ; COVID-19/virology ; Humans ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; COVID-19 Drug Treatment
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Anti-Inflammatory Agents ; Antiviral Agents ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-11-16
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2021.2006579
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