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  1. Book ; Online: Alzheimers Disease and the Fornix

    Oishi, Kenichi / Lyketsos, Constantine G.

    2016  

    Abstract: This e-book focuses primarily on the role of the fornix as a functional, prognostic, and diagnostic marker of Alzheimer's disease (AD), and the application of such a marker in clinical practice. Researchers have long been focused on the cortical ... ...

    Abstract This e-book focuses primarily on the role of the fornix as a functional, prognostic, and diagnostic marker of Alzheimer's disease (AD), and the application of such a marker in clinical practice. Researchers have long been focused on the cortical pathology of AD, since the most important pathologic features are the senile plaques found in the cortex, and the neurofibrillary tangles and neuronal loss that start from the entorhinal cortex and the hippocampus. In addition to gray matter structures, histopathological studies indicate that the white matter is also altered in AD. The fornix is a white matter bundle that constitutes a core element of the limbic circuits, and is one of the most important anatomical structures related to memory. The fornices originate from the bilateral hippocampi, merge at the midline of the brain, again divide into the left and right side, and then into the precommissural and the postcommissural fibers, and terminate at the septal nuclei, nucleus accumbens (precommissural fornix), and hypothalamus (postcommissural fornix). These functional and anatomical features of the fornix have naturally captured researchers' attention as possible diagnostic and prognostic markers of AD. Growing evidence indicates that the alterations seen in the fornix are potentially a good marker with which to predict future conversion from mild cognitive impairment to AD, and even from a cognitively normal state to AD. The degree of alteration is correlated with the degree of memory impairment, indicating the potential for the use of the fornix as a functional marker. Moreover, there have been attempts to stimulate the fornix to recover the cognitive function lost with AD. Our goal is to provide information about the status of current research and to facilitate further scientific and clinical advancement in this topic
    Keywords Science (General) ; Neurosciences. Biological psychiatry. Neuropsychiatry
    Size 1 electronic resource (110 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090678
    ISBN 9782889199594 ; 2889199592
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The glymphatic system's role in traumatic brain injury-related neurodegeneration.

    Peters, Matthew E / Lyketsos, Constantine G

    Molecular psychiatry

    2023  Volume 28, Issue 7, Page(s) 2707–2715

    Abstract: ... research focused on the need for biomarkers of glymphatic system function (e.g., neuroimaging modalities ... accumulation and deposition (e.g., amyloid β, tau). The same studies suggest that glymphatic dysfunction leads ...

    Abstract In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of future neurodegenerative illness. This review focuses on the association between the brain-based paravascular drainage pathway known as the "glymphatic system" and TBI-related neurodegeneration. The glymphatic system is composed of cerebrospinal fluid (CSF) flowing into the brain parenchyma along paravascular spaces surrounding penetrating arterioles where it mixes with interstitial fluid (ISF) before being cleared along paravenous drainage pathways. Aquaporin-4 (AQP4) water channels on astrocytic end-feet appear essential for the functioning of this system. The current literature linking glymphatic system disruption and TBI-related neurodegeneration is largely based on murine models with existing human research focused on the need for biomarkers of glymphatic system function (e.g., neuroimaging modalities). Key findings from the existing literature include evidence of glymphatic system flow disruption following TBI, mechanisms of this decreased flow (i.e., AQP4 depolarization), and evidence of protein accumulation and deposition (e.g., amyloid β, tau). The same studies suggest that glymphatic dysfunction leads to subsequent neurodegeneration, cognitive decline, and/or behavioral change although replication in humans is needed. Identified emerging topics from the literature are as follows: link between TBI, sleep, and glymphatic system dysfunction; influence of glymphatic system disruption on TBI biomarkers; and development of novel treatments for glymphatic system disruption following TBI. Although a burgeoning field, more research is needed to elucidate the role of glymphatic system disruption in TBI-related neurodegeneration.
    MeSH term(s) Humans ; Mice ; Animals ; Glymphatic System/metabolism ; Amyloid beta-Peptides/metabolism ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/metabolism ; Brain/metabolism ; Aquaporin 4/metabolism ; Biomarkers/metabolism
    Chemical Substances Amyloid beta-Peptides ; Aquaporin 4 ; Biomarkers
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02070-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Psychiatric aspects of neurologic diseases

    Lyketsos, Constantine G.

    practical approaches to patient care

    2008  

    Author's details ed. by Constantine G. Lyketsos
    Keywords Nervous System Diseases / complications ; Mental Disorders / etiology ; Mental Disorders / therapy ; Nervous system/Diseases/Complications ; Nervous system/Diseases/Patients/Care ; Psychological manifestations of general diseases ; Mental illness/Etiology ; Mental illness/Treatment
    Subject code 616.80475
    Language English
    Size XIX, 435 S. : Ill.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT015462850
    ISBN 0-19-530943-X ; 978-0-19-530943-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 2212 order for loan Magazin

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  4. Article ; Online: Complimentary Subspecialties: Consultation-Liaison Psychiatry and Neuropsychiatry.

    Peters, Matthew E / Roy, Durga / Lyketsos, Constantine G

    Journal of the Academy of Consultation-Liaison Psychiatry

    2021  Volume 63, Issue 2, Page(s) 107–109

    MeSH term(s) Neuropsychiatry ; Psychiatry ; Referral and Consultation
    Language English
    Publishing date 2021-12-11
    Publishing country Netherlands
    Document type Editorial
    ISSN 2667-2960
    ISSN (online) 2667-2960
    DOI 10.1016/j.jaclp.2021.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Neuropsychiatric symptoms and incident Lewy body dementia in male versus female older adults with mild cognitive impairment.

    Liampas, Ioannis / Siokas, Vasileios / Zoupa, Elli / Lyketsos, Constantine G / Dardiotis, Efthimios

    Psychiatry and clinical neurosciences

    2023  Volume 78, Issue 2, Page(s) 144–146

    MeSH term(s) Male ; Humans ; Female ; Aged ; Lewy Body Disease/psychology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/psychology ; Alzheimer Disease
    Language English
    Publishing date 2023-12-15
    Publishing country Australia
    Document type Letter
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.13621
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  6. Article ; Online: Now is the time for true reform of mental health services.

    Lyketsos, Constantine G

    JAMA internal medicine

    2015  Volume 175, Issue 1, Page(s) 65–66

    MeSH term(s) Depressive Disorder/therapy ; Female ; Home Care Services ; Humans ; Male ; Patient Care Team
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2014.6086
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  7. Article ; Online: Neuropsychiatric Symptoms of Alzheimer's Disease: An Anatomic-Genetic Framework for Treatment Development.

    Nowrangi, Milap A / Outen, John D / Kim, John / Avramopoulos, Dimitrios / Lyketsos, Constantine G / Rosenberg, Paul B

    Journal of Alzheimer's disease : JAD

    2023  Volume 95, Issue 1, Page(s) 53–68

    Abstract: Background: Despite the burden on patients and caregivers, there are no approved therapies for the neuropsychiatric symptoms of Alzheimer's disease (NPS-AD). This is likely due to an incomplete understanding of the underlying mechanisms.: Objective: ... ...

    Abstract Background: Despite the burden on patients and caregivers, there are no approved therapies for the neuropsychiatric symptoms of Alzheimer's disease (NPS-AD). This is likely due to an incomplete understanding of the underlying mechanisms.
    Objective: To review the neurobiological mechanisms of NPS-AD, including depression, psychosis, and agitation.
    Methods: Understanding that genetic encoding gives rise to the function of neural circuits specific to behavior, we review the genetics and neuroimaging literature to better understand the biological underpinnings of depression, psychosis, and agitation.
    Results: We found that mechanisms involving monoaminergic biosynthesis and function are likely key elements of NPS-AD and while current treatment approaches are in line with this, the lack of effectiveness may be due to contributions from additional mechanisms including neurodegenerative, vascular, inflammatory, and immunologic pathways.
    Conclusion: Within an anatomic-genetic framework, development of novel effective biological targets may engage targets within these pathways but will require a better understanding of the heterogeneity in NPS-AD.
    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Alzheimer Disease/therapy ; Alzheimer Disease/diagnosis ; Psychotic Disorders ; Caregivers ; Anxiety ; Neuroimaging
    Language English
    Publishing date 2023-07-31
    Publishing country Netherlands
    Document type Systematic Review
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-221247
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  8. Article ; Online: Utility of amyloid PET Imaging in a Memory Clinic.

    Pletnikova, Alexandra / Okhravi, Hamid R / Jamil, Nimra / Kirby, Mackenzie / Lyketsos, Constantine G / Oh, Esther S

    Alzheimer disease and associated disorders

    2023  Volume 37, Issue 4, Page(s) 270–273

    Abstract: There is greater interest in amyloid biomarker for the diagnosis of Alzheimer disease (AD) with the recent Food and Drug Administration approval of amyloid-targeted therapy. The goal of this study was to assess the clinical utility of amyloid positron ... ...

    Abstract There is greater interest in amyloid biomarker for the diagnosis of Alzheimer disease (AD) with the recent Food and Drug Administration approval of amyloid-targeted therapy. The goal of this study was to assess the clinical utility of amyloid positron emission tomography (PET) in clinically ambiguous cases of cognitive impairment by examining outcomes of patients enrolled in the Imaging Dementia-Evidence of Amyloid Scanning study at 2 academic institutions. Of the 112 patients in the study, 66.1% (n=74) of patients had a positive amyloid PET scan, and 33.96% (n=38) had a negative amyloid PET scan. Lower cognitive test scores were predictive of positive amyloid PET scan ( P =0.001). Eighty-two percent (92/112) of the patients were seen for follow-up. Of the 30 patients with negative amyloid PET scan results, 90% had a diagnosis of non-AD etiology after receiving the negative results, suggesting a negative amyloid scan can be used to rule out AD diagnosis.
    MeSH term(s) Humans ; Alzheimer Disease/diagnostic imaging ; Cognitive Dysfunction/diagnostic imaging ; Amyloid ; Amyloidogenic Proteins ; Positron-Emission Tomography/methods ; Amyloid beta-Peptides
    Chemical Substances Amyloid ; Amyloidogenic Proteins ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/WAD.0000000000000575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Generation and Characterization of a Human-Derived and Induced Pluripotent Stem Cell (iPSC) Line from an Alzheimer's Disease Patient with Neuropsychiatric Symptoms.

    Sagar, Ram / Zivko, Cristina / Xydia, Ariadni / Weisman, David C / Lyketsos, Constantine G / Mahairaki, Vasiliki

    Biomedicines

    2023  Volume 11, Issue 12

    Abstract: Agitation is one of the most eminent characteristics of neuropsychiatric symptoms (NPS) affecting people living with Alzheimer's and Dementia and has serious consequences for patients and caregivers. The current consensus is that agitation results, in ... ...

    Abstract Agitation is one of the most eminent characteristics of neuropsychiatric symptoms (NPS) affecting people living with Alzheimer's and Dementia and has serious consequences for patients and caregivers. The current consensus is that agitation results, in part, from the disruption of ascending monoamine regulators of cortical circuits, especially the loss of serotonergic activity. It is believed that the first line of treatment for these conditions is selective serotonin reuptake inhibitors (SSRIs), but these are effective in only about 40% of patients. Person-specific biomarkers, for example, ones based on in vitro iPSC-derived models of serotonin activity, which predict who with Agitation responds to an SSRI, are a major clinical priority. Here, we report the generation of human-induced pluripotent stem cells (iPSCs) from a 74-year-old AD patient, the homozygous APOE ε4/ε4 carrier, who developed Agitation. His iPSCs were reprogrammed from peripheral blood mononuclear cells (PBMCs) using the transient expression of pluripotency genes. These display typical iPSC characteristics that are karyotypically normal and attain the capacity to differentiate into three germ layers. The newly patient-derived iPSC line offers a unique resource to investigate the underlying mechanisms associated with neuropsychiatric symptom progression in AD.
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11123313
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  10. Article ; Online: Associations between neuropsychiatric symptoms and incident Alzheimer's dementia in men versus women.

    Liampas, Ioannis / Siokas, Vasileios / Lyketsos, Constantine G / Dardiotis, Efthimios

    Journal of neurology

    2022  Volume 270, Issue 4, Page(s) 2069–2083

    Abstract: Objective: To examine whether associations between individual neuropsychiatric symptoms (NPS) and incident Alzheimer's dementia (AD) differ in men versus women.: Methods: Data were acquired from the National Alzheimer's Coordinating Center (NACC) ... ...

    Abstract Objective: To examine whether associations between individual neuropsychiatric symptoms (NPS) and incident Alzheimer's dementia (AD) differ in men versus women.
    Methods: Data were acquired from the National Alzheimer's Coordinating Center (NACC) Uniform Data Set. Two sets of older (≥ 60 years) participants were formed: one of cognitively unimpaired (CU) individuals, and one of participants with mild cognitive impairment (MCI). NPS were assessed using the Neuropsychiatric Inventory Questionnaire. Cox proportional hazards models examined associations between individual NPS and AD incidence separately for each participant set. These models featured individual NPS, sex, NPS by sex interactions as well as a number of covariates.
    Results: The analysis involved 9,854 CU individuals followed for 5.5 ± 3.8 years and 6,369 participants with MCI followed for 3.8 ± 3.0 years. NPS were comparably associated with future AD in men and women with MCI. Regarding CU participants, the following significant sex by NPS interactions were noted: female sex moderated the risk conferred by moderate/severe apathy (HR = 7.36, 3.25-16.64) by 74%, mitigated the risk conferred by moderate/severe depression (HR = 3.61, 2.08-6.28) by 52%, and augmented the risks conferred by mild depression (HR = 1.00, 0.60-1.68) and agitation (HR = 0.81, 0.40-1.64) by 83% and 243%, respectively.
    Conclusions: Apathy, depression and agitation were differentially associated with incident AD in CU men and women. No individual NPS was associated with different risks of future AD in men versus women with MCI.
    MeSH term(s) Female ; Humans ; Male ; Alzheimer Disease/diagnosis ; Apathy ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/diagnosis ; Neuropsychological Tests
    Language English
    Publishing date 2022-12-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-022-11541-w
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