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Article ; Online: Influence of diet fortification on body composition and apparent digestion in mature horses consuming a low-quality forage.

Much, Mattea L / Leatherwood, Jessica L / Zoller, Jennifer L / Bradbery, Amanda N / Martinez, Rafael E / Keegan, Abby D / Lamprecht, Emily D / Wickersham, Tryon A

Translational animal science

2019 Volume 4, Issue 1, Page(s) 1–9

Abstract: Stock-type mares (498 ± 9 kg BW; 12 ± 7 yr) were used in a completely randomized design for 56 d to test the hypothesis that concentrate fortification improves apparent digestion and enhances lean mass over the topline. Horses were stratified by age, BW, ...

Abstract	Stock-type mares (498 ± 9 kg BW; 12 ± 7 yr) were used in a completely randomized design for 56 d to test the hypothesis that concentrate fortification improves apparent digestion and enhances lean mass over the topline. Horses were stratified by age, BW, and BCS and randomly assigned to either a custom pelleted concentrate (CON;
Language	English
Publishing date	2019-08-27
Publishing country	England
Document type	Journal Article
ISSN	2573-2102
ISSN (online)	2573-2102
DOI	10.1093/tas/txz137
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Article ; Online: Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium.

Moal, Bertrand / Orieux, Arthur / Ferté, Thomas / Neuraz, Antoine / Brat, Gabriel A / Avillach, Paul / Bonzel, Clara-Lea / Cai, Tianxi / Cho, Kelly / Cossin, Sébastien / Griffier, Romain / Hanauer, David A / Haverkamp, Christian / Ho, Yuk-Lam / Hong, Chuan / Hutch, Meghan R / Klann, Jeffrey G / Le, Trang T / Loh, Ne Hooi Will /

PloS one

2023 Volume 18, Issue 1, Page(s) e0266985

Abstract: Purpose: In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ... ...

Abstract	Purpose: In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods: A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results: Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%). Conclusion: Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.
MeSH term(s)	Humans ; Young Adult ; Aged ; Adolescent ; Adult ; Middle Aged ; COVID-19/complications ; COVID-19/epidemiology ; SARS-CoV-2 ; Cohort Studies ; Retrospective Studies ; Electronic Health Records ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/complications ; Obesity/complications
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0266985
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Article ; Online: Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections

Emily Zoller / Connie Valente / Kyle Baker

Drug Design, Development and Therapy, Vol 2010, Iss default, Pp 299-

2010 Volume 311

Abstract: Emily Zoller, Connie Valente, Kyle Baker, Michael E KlepserFerris State University College ...

Abstract	Emily Zoller, Connie Valente, Kyle Baker, Michael E KlepserFerris State University College of Pharmacy, Kalamazoo, Michigan, USAAbstract: Posaconazole is an extended-spectrum azole antifungal that exhibits activity against a broad range of fungal pathogens, including yeasts and moulds. Clinical data have demonstrated the clinical utility of posaconazole against many therapy-refractory pathogens, including Aspergillus spp, Fusarium spp, and Zygomycetes. These data have provided clinicians with hope in these difficult situations. Some of the limitations that have emerged with the use of posaconazole are the lack of an intravenous formulation and erratic drug absorption. This fact is further complicated by the existence of saturable posaconazole absorption. Despite these drawbacks, posaconazole appears poised to become a prominent therapeutic modality for the prophylaxis and management of various fungal infections among high-risk patients.Keywords: posaconazole, pharmacokinetics, fungal infections
Keywords	Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Therapeutics. Pharmacology ; RM1-950 ; DOAJ:Therapeutics
Subject code	610
Language	English
Publishing date	2010-11-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
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Article ; Online: Nonmechanical Revision Indications Portend Repeat Limb-Salvage Failure Following Total Femoral Replacement.

Henderson, Eric R / Keeney, Benjamin J / Husson, Emily G / Bernthal, Nicholas M / Ji, Tao / Pala, Elisa / Funovics, Philipp T / Groundland, John S / Lozano-Calderon, Santiago / Puchner, Stephan / Zoller, Stephen D / Ruggieri, Pietro / Windhager, Reinhard / Guo, Wei / Hornicek, Francis J / Letson, G Douglas / Temple, H Thomas

The Journal of bone and joint surgery. American volume

2020 Volume 102, Issue 17, Page(s) 1511–1520

Abstract: Background: There is scant evidence to guide decision-making for patients considering total femoral replacement (TFR). We aimed to identify the indication, patient, disease, and surgical technique-related factors associated with failure. We hypothesized ...

Abstract	Background: There is scant evidence to guide decision-making for patients considering total femoral replacement (TFR). We aimed to identify the indication, patient, disease, and surgical technique-related factors associated with failure. We hypothesized that failure occurs more frequently in the setting of revision surgical procedures, with infection as the predominant failure mode. Methods: We performed a retrospective cohort study of patients receiving total femoral endoprostheses for oncological and revision arthroplasty indications; 166 patients met these criteria. Our primary independent variable of interest was TFR for a revision indication (arthroplasty or limb salvage); the primary outcome was failure. Analyses were performed for patient variables (age, sex, diagnosis group, indication), implant variables (model, decade, length, materials), and treatment variables. We analyzed TFR failures with respect to patient factors, operative technique, and time to failure. We conducted bivariate logistic regressions predicting failure and used a multivariate model containing variables showing bivariate associations with failure. Results: Forty-four patients (27%) had treatment failure. Failure occurred in 24 (23%) of 105 primary TFRs and in 20 (33%) of 61 revision TFRs; the difference was not significant (p = 0.134) in bivariate analysis but was significant (p = 0.044) in multivariate analysis. The mean age at the time of TFR was 37 years in the primary group and 51 years in the revision group (p = 0.0006). Of the patients who had mechanical failure, none had reoccurrence of their original failure mode, whereas all 8 patients from the nonmechanical cohort had reoccurrence of the original failure mode; this difference was significant (p = 0.0001). Conclusions: TFR has a high failure rate and a propensity for deep infection, especially in the setting of revision indications and prior infection. All failed TFRs performed for revision indications for infection or local recurrence failed by reoccurrence of the original failure mode and resulted in amputation. Level of evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip ; Child ; Cohort Studies ; Female ; Femoral Neoplasms/surgery ; Femur/surgery ; Humans ; Limb Salvage/methods ; Male ; Middle Aged ; Prosthesis Implantation ; Reoperation ; Retrospective Studies ; Treatment Failure ; Young Adult
Language	English
Publishing date	2020-05-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	220625-0
ISSN	1535-1386 ; 0021-9355
ISSN (online)	1535-1386
ISSN	0021-9355
DOI	10.2106/JBJS.19.01022
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Article ; Online: Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population

Bertrand Moal / Arthur Orieux / Thomas Ferté / Antoine Neuraz / Gabriel A Brat / Paul Avillach / Clara-Lea Bonzel / Tianxi Cai / Kelly Cho / Sébastien Cossin / Romain Griffier / David A Hanauer / Christian Haverkamp / Yuk-Lam Ho / Chuan Hong / Meghan R Hutch / Jeffrey G Klann / Trang T Le / Ne Hooi Will Loh /

PLoS ONE, Vol 18, Iss 1, p e

International observational federated study based on electronic health records through the 4CE consortium.

2023 Volume 0266985

Abstract: Purpose In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ... ...

Abstract	Purpose In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%). Conclusion Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections.

Zoller, Emily / Valente, Connie / Baker, Kyle / Klepser, Michael E

Drug design, development and therapy

2010 Volume 4, Page(s) 299–311

Abstract: Posaconazole is an extended-spectrum azole antifungal that exhibits activity against a broad range of fungal pathogens, including yeasts and moulds. Clinical data have demonstrated the clinical utility of posaconazole against many therapy-refractory ... ...

Abstract	Posaconazole is an extended-spectrum azole antifungal that exhibits activity against a broad range of fungal pathogens, including yeasts and moulds. Clinical data have demonstrated the clinical utility of posaconazole against many therapy-refractory pathogens, including Aspergillus spp, Fusarium spp, and Zygomycetes. These data have provided clinicians with hope in these difficult situations. Some of the limitations that have emerged with the use of posaconazole are the lack of an intravenous formulation and erratic drug absorption. This fact is further complicated by the existence of saturable posaconazole absorption. Despite these drawbacks, posaconazole appears poised to become a prominent therapeutic modality for the prophylaxis and management of various fungal infections among high-risk patients.
MeSH term(s)	Animals ; Antifungal Agents/administration & dosage ; Antifungal Agents/pharmacokinetics ; Antifungal Agents/therapeutic use ; Drug Resistance, Fungal ; Fungi/drug effects ; Humans ; Mycoses/drug therapy ; Mycoses/microbiology ; Mycoses/prevention & control ; Risk Factors ; Triazoles/administration & dosage ; Triazoles/pharmacokinetics ; Triazoles/therapeutic use
Chemical Substances	Antifungal Agents ; Triazoles ; posaconazole (6TK1G07BHZ)
Language	English
Publishing date	2010-11-04
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S7773
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Article ; Online: Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study.

Tan, Byorn W L / Tan, Bryce W Q / Tan, Amelia L M / Schriver, Emily R / Gutiérrez-Sacristán, Alba / Das, Priyam / Yuan, William / Hutch, Meghan R / García Barrio, Noelia / Pedrera Jimenez, Miguel / Abu-El-Rub, Noor / Morris, Michele / Moal, Bertrand / Verdy, Guillaume / Cho, Kelly / Ho, Yuk-Lam / Patel, Lav P / Dagliati, Arianna / Neuraz, Antoine /

Klann, Jeffrey G / South, Andrew M / Visweswaran, Shyam / Hanauer, David A / Maidlow, Sarah E / Liu, Mei / Mowery, Danielle L / Batugo, Ashley / Makoudjou, Adeline / Tippmann, Patric / Zöller, Daniela / Brat, Gabriel A / Luo, Yuan / Avillach, Paul / Bellazzi, Riccardo / Chiovato, Luca / Malovini, Alberto / Tibollo, Valentina / Samayamuthu, Malarkodi Jebathilagam / Serrano Balazote, Pablo / Xia, Zongqi / Loh, Ne Hooi Will / Chiudinelli, Lorenzo / Bonzel, Clara-Lea / Hong, Chuan / Zhang, Harrison G / Weber, Griffin M / Kohane, Isaac S / Cai, Tianxi / Omenn, Gilbert S / Holmes, John H / Ngiam, Kee Yuan

EClinicalMedicine

2022 Volume 55, Page(s) 101724

Abstract: Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking.: Methods: A retrospective multi-centre ... ...

Abstract	Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1-365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. Findings: Advanced age (HR 2.77, 95%CI 2.53-3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03-4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55-5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14-1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37-0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17-1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20-1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45-1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80-13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10-1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32-1.67) and 365 days (RR 1.54, 95%CI 1.21-1.96) compared to COVID-19 patients with no AKI. Interpretation: COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. Funding: Authors are supported by various funders, with full details stated in the acknowledgement section.
Language	English
Publishing date	2022-11-07
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2022.101724
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Article ; Online: SurvMaximin: Robust federated approach to transporting survival risk prediction models.

Wang, Xuan / Zhang, Harrison G / Xiong, Xin / Hong, Chuan / Weber, Griffin M / Brat, Gabriel A / Bonzel, Clara-Lea / Luo, Yuan / Duan, Rui / Palmer, Nathan P / Hutch, Meghan R / Gutiérrez-Sacristán, Alba / Bellazzi, Riccardo / Chiovato, Luca / Cho, Kelly / Dagliati, Arianna / Estiri, Hossein / García-Barrio, Noelia / Griffier, Romain /

Hanauer, David A / Ho, Yuk-Lam / Holmes, John H / Keller, Mark S / Klann MEng, Jeffrey G / L'Yi, Sehi / Lozano-Zahonero, Sara / Maidlow, Sarah E / Makoudjou, Adeline / Malovini, Alberto / Moal, Bertrand / Moore, Jason H / Morris, Michele / Mowery, Danielle L / Murphy, Shawn N / Neuraz, Antoine / Yuan Ngiam, Kee / Omenn, Gilbert S / Patel, Lav P / Pedrera-Jiménez, Miguel / Prunotto, Andrea / Jebathilagam Samayamuthu, Malarkodi / Sanz Vidorreta, Fernando J / Schriver, Emily R / Schubert, Petra / Serrano-Balazote, Pablo / South, Andrew M / Tan, Amelia L M / Tan, Byorn W L / Tibollo, Valentina / Tippmann, Patric / Visweswaran, Shyam / Xia, Zongqi / Yuan, William / Zöller, Daniela / Kohane, Isaac S / Avillach, Paul / Guo, Zijian / Cai, Tianxi

Journal of biomedical informatics

2022 Volume 134, Page(s) 104176

Abstract: Objective: For multi-center heterogeneous Real-World Data (RWD) with time-to-event outcomes and high-dimensional features, we propose the SurvMaximin algorithm to estimate Cox model feature coefficients for a target population by borrowing summary ... ...

Abstract	Objective: For multi-center heterogeneous Real-World Data (RWD) with time-to-event outcomes and high-dimensional features, we propose the SurvMaximin algorithm to estimate Cox model feature coefficients for a target population by borrowing summary information from a set of health care centers without sharing patient-level information. Materials and methods: For each of the centers from which we want to borrow information to improve the prediction performance for the target population, a penalized Cox model is fitted to estimate feature coefficients for the center. Using estimated feature coefficients and the covariance matrix of the target population, we then obtain a SurvMaximin estimated set of feature coefficients for the target population. The target population can be an entire cohort comprised of all centers, corresponding to federated learning, or a single center, corresponding to transfer learning. Results: Simulation studies and a real-world international electronic health records application study, with 15 participating health care centers across three countries (France, Germany, and the U.S.), show that the proposed SurvMaximin algorithm achieves comparable or higher accuracy compared with the estimator using only the information of the target site and other existing methods. The SurvMaximin estimator is robust to variations in sample sizes and estimated feature coefficients between centers, which amounts to significantly improved estimates for target sites with fewer observations. Conclusions: The SurvMaximin method is well suited for both federated and transfer learning in the high-dimensional survival analysis setting. SurvMaximin only requires a one-time summary information exchange from participating centers. Estimated regression vectors can be very heterogeneous. SurvMaximin provides robust Cox feature coefficient estimates without outcome information in the target population and is privacy-preserving.
MeSH term(s)	Algorithms ; Electronic Health Records ; Humans ; Privacy ; Proportional Hazards Models ; Survival Analysis
Language	English
Publishing date	2022-08-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2057141-0
ISSN	1532-0480 ; 1532-0464
ISSN (online)	1532-0480
ISSN	1532-0464
DOI	10.1016/j.jbi.2022.104176
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Article ; Online: Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury

Byorn W.L. Tan / Bryce W.Q. Tan / Amelia L.M. Tan / Emily R. Schriver / Alba Gutiérrez-Sacristán / Priyam Das / William Yuan / Meghan R. Hutch / Noelia García Barrio / Miguel Pedrera Jimenez / Noor Abu-el-rub / Michele Morris / Bertrand Moal / Guillaume Verdy / Kelly Cho / Yuk-Lam Ho / Lav P. Patel / Arianna Dagliati / Antoine Neuraz /

Jeffrey G. Klann / Andrew M. South / Shyam Visweswaran / David A. Hanauer / Sarah E. Maidlow / Mei Liu / Danielle L. Mowery / Ashley Batugo / Adeline Makoudjou / Patric Tippmann / Daniela Zöller / Gabriel A. Brat / Yuan Luo / Paul Avillach / Riccardo Bellazzi / Luca Chiovato / Alberto Malovini / Valentina Tibollo / Malarkodi Jebathilagam Samayamuthu / Pablo Serrano Balazote / Zongqi Xia / Ne Hooi Will Loh / Lorenzo Chiudinelli / Clara-Lea Bonzel / Chuan Hong / Harrison G. Zhang / Griffin M. Weber / Isaac S. Kohane / Tianxi Cai / Gilbert S. Omenn / John H. Holmes

EClinicalMedicine, Vol 55, Iss , Pp 101724- (2023)

An international multi-centre observational cohort studyResearch in context

1480

Abstract: Summary: Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centre ... ...

Abstract	Summary: Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1–365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. Findings: Advanced age (HR 2.77, 95%CI 2.53–3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03–4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55–5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14–1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37–0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17–1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20–1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45–1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80–13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10–1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32–1.67) and 365 days (RR 1.54, 95%CI 1.21–1.96) compared to COVID-19 patients with no AKI. Interpretation: COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. Funding: Authors are supported by various funders, with full details stated in the ...
Keywords	COVID-19 ; Acute kidney injury ; SARS-CoV-2 ; Chronic kidney disease ; Electronic health records ; Medicine (General) ; R5-920
Subject code	616 ; 610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Changes in laboratory value improvement and mortality rates over the course of the pandemic: an international retrospective cohort study of hospitalised patients infected with SARS-CoV-2.

Hong, Chuan / Zhang, Harrison G / L'Yi, Sehi / Weber, Griffin / Avillach, Paul / Tan, Bryce W Q / Gutiérrez-Sacristán, Alba / Bonzel, Clara-Lea / Palmer, Nathan P / Malovini, Alberto / Tibollo, Valentina / Luo, Yuan / Hutch, Meghan R / Liu, Molei / Bourgeois, Florence / Bellazzi, Riccardo / Chiovato, Luca / Sanz Vidorreta, Fernando J / Le, Trang T /

Wang, Xuan / Yuan, William / Neuraz, Antoine / Benoit, Vincent / Moal, Bertrand / Morris, Michele / Hanauer, David A / Maidlow, Sarah / Wagholikar, Kavishwar / Murphy, Shawn / Estiri, Hossein / Makoudjou, Adeline / Tippmann, Patric / Klann, Jeffery / Follett, Robert W / Gehlenborg, Nils / Omenn, Gilbert S / Xia, Zongqi / Dagliati, Arianna / Visweswaran, Shyam / Patel, Lav P / Mowery, Danielle L / Schriver, Emily R / Samayamuthu, Malarkodi Jebathilagam / Kavuluru, Ramakanth / Lozano-Zahonero, Sara / Zöller, Daniela / Tan, Amelia L M / Tan, Byorn W L / Ngiam, Kee Yuan / Holmes, John H / Schubert, Petra / Cho, Kelly / Ho, Yuk-Lam / Beaulieu-Jones, Brett K / Pedrera-Jiménez, Miguel / García-Barrio, Noelia / Serrano-Balazote, Pablo / Kohane, Isaac / South, Andrew / Brat, Gabriel A / Cai, T

BMJ open

2022 Volume 12, Issue 6, Page(s) e057725

Abstract: Objective: To assess changes in international mortality rates and laboratory recovery rates during hospitalisation for patients hospitalised with SARS-CoV-2 between the first wave (1 March to 30 June 2020) and the second wave (1 July 2020 to 31 January ... ...

Abstract	Objective: To assess changes in international mortality rates and laboratory recovery rates during hospitalisation for patients hospitalised with SARS-CoV-2 between the first wave (1 March to 30 June 2020) and the second wave (1 July 2020 to 31 January 2021) of the COVID-19 pandemic. Design, setting and participants: This is a retrospective cohort study of 83 178 hospitalised patients admitted between 7 days before or 14 days after PCR-confirmed SARS-CoV-2 infection within the Consortium for Clinical Characterization of COVID-19 by Electronic Health Record, an international multihealthcare system collaborative of 288 hospitals in the USA and Europe. The laboratory recovery rates and mortality rates over time were compared between the two waves of the pandemic. Primary and secondary outcome measures: The primary outcome was all-cause mortality rate within 28 days after hospitalisation stratified by predicted low, medium and high mortality risk at baseline. The secondary outcome was the average rate of change in laboratory values during the first week of hospitalisation. Results: Baseline Charlson Comorbidity Index and laboratory values at admission were not significantly different between the first and second waves. The improvement in laboratory values over time was faster in the second wave compared with the first. The average C reactive protein rate of change was -4.72 mg/dL vs -4.14 mg/dL per day (p=0.05). The mortality rates within each risk category significantly decreased over time, with the most substantial decrease in the high-risk group (42.3% in March-April 2020 vs 30.8% in November 2020 to January 2021, p<0.001) and a moderate decrease in the intermediate-risk group (21.5% in March-April 2020 vs 14.3% in November 2020 to January 2021, p<0.001). Conclusions: Admission profiles of patients hospitalised with SARS-CoV-2 infection did not differ greatly between the first and second waves of the pandemic, but there were notable differences in laboratory improvement rates during hospitalisation. Mortality risks among patients with similar risk profiles decreased over the course of the pandemic. The improvement in laboratory values and mortality risk was consistent across multiple countries.
MeSH term(s)	COVID-19 ; Hospitalization ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2022-06-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-057725
Database	MEDical Literature Analysis and Retrieval System OnLINE

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