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  1. Article ; Online: Development Path and Urgency of further Strengthening Construction of Public Hospitals Based on Novel Coronavirus Pneumonia Treatment.

    Liao, Jia-Zhi / Wu, Jing

    Current medical science

    2020  Volume 40, Issue 2, Page(s) 290–294

    Abstract: During the outbreak of novel coronavirus pneumonia (NCP) in Wuhan, public hospitals have played an important role in intensive care, case guidance and scheme optimization. At the same time, it also faces unprecedented challenges and tests. Based on the ... ...

    Abstract During the outbreak of novel coronavirus pneumonia (NCP) in Wuhan, public hospitals have played an important role in intensive care, case guidance and scheme optimization. At the same time, it also faces unprecedented challenges and tests. Based on the treatment of severe patients in Wuhan, combined with the treatment practice in Tongji Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, this paper puts forward the urgency of further strengthening the construction of public hospitals, discusses the feasible path for promoting the development of public hospitals, so as to meet the growing medical needs of the people, improve the ability to respond to major public health emergencies, and effectively guarantee the safety of people's lives and the promotion of a healthy China construction.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Epidemics ; Equipment and Supplies ; Hospitals, Public/supply & distribution ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-26
    Publishing country China
    Document type Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-020-2175-3
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  2. Article ; Online: The Pathway of China's Integrated Delivery System: Based on the Analysis of the Medical Consortium Policies.

    Gao, Huan / Du, Xing-Li / Liao, Jia-Zhi / Xiang, Li

    Current medical science

    2022  

    Abstract: With the deepening of China's health-care reform, an integrated delivery system has gradually emerged with the function of improving the efficiency of the health-care delivery system. For China's integrated delivery system, a medical consortium plays an ... ...

    Abstract With the deepening of China's health-care reform, an integrated delivery system has gradually emerged with the function of improving the efficiency of the health-care delivery system. For China's integrated delivery system, a medical consortium plays an important role in integrating public hospitals and primary care facilities. The first medical consortium policy issued after the COVID-19 pandemic apparently placed hope on accelerating the implementation of a medical consortium and tiered health-care delivery system. This paper illustrates the possible future pathway of China's medical consortium through retrospection of the 10-year process, changes of the series of policies, and characteristics of the policy issued in 2020. We considered that a fully integrated medical consortium would be a major phenomenon in China's medical industry, which would lead to the formation of a dualistic care pattern in China.
    Language English
    Publishing date 2022-10-17
    Publishing country China
    Document type Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-022-2654-9
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  3. Article: Development Path and Urgency of further Strengthening Construction of Public Hospitals Based on Novel Coronavirus Pneumonia Treatment

    Liao, Jia-Zhi / Wu, Jing

    Curr Med Sci

    Abstract: During the outbreak of novel coronavirus pneumonia (NCP) in Wuhan, public hospitals have played an important role in intensive care, case guidance and scheme optimization. At the same time, it also faces unprecedented challenges and tests. Based on the ... ...

    Abstract During the outbreak of novel coronavirus pneumonia (NCP) in Wuhan, public hospitals have played an important role in intensive care, case guidance and scheme optimization. At the same time, it also faces unprecedented challenges and tests. Based on the treatment of severe patients in Wuhan, combined with the treatment practice in Tongji Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, this paper puts forward the urgency of further strengthening the construction of public hospitals, discusses the feasible path for promoting the development of public hospitals, so as to meet the growing medical needs of the people, improve the ability to respond to major public health emergencies, and effectively guarantee the safety of people's lives and the promotion of a healthy China construction.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #17742
    Database COVID19

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  4. Article ; Online: Analysis of Monitoring, Early Warning and Emergency Response System for New Major Infectious Diseases in China and Overseas.

    Du, Xing-Li / Zhao, Xin-Rui / Gao, Huan / Shen, Wan-Wan / Liao, Jia-Zhi

    Current medical science

    2021  Volume 41, Issue 1, Page(s) 62–68

    Abstract: In recent years, the impact of new major infectious diseases on people's normal life is becoming more and more frequent, which has brought great impact on people's life safety and social economy, especially the corona virus disease 2019, which has been ... ...

    Abstract In recent years, the impact of new major infectious diseases on people's normal life is becoming more and more frequent, which has brought great impact on people's life safety and social economy, especially the corona virus disease 2019, which has been sweeping the globe. Public health and disease prevention and control systems in different countries have different performances in response to the pandemic, but they all have exposed many shortcomings. Countries around the world urgently need to improve the monitoring, early warning and emergency response systems for new major infectious diseases. As the outpost and main part of medical rescue, the hospital urgently needs to establish a set of scientifically advanced emergency response mechanism that is suitable for the business process of the medical system and unified standards in order to improve the response efficiency and quality of emergency treatment.
    MeSH term(s) China ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Communicable Disease Control/standards ; Communicable Disease Control/statistics & numerical data ; Emergency Medical Dispatch/organization & administration ; Emergency Medical Dispatch/standards ; Emergency Medical Dispatch/statistics & numerical data ; Epidemiological Monitoring ; Global Health ; Humans ; Practice Guidelines as Topic ; World Health Organization
    Language English
    Publishing date 2021-02-13
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-021-2319-0
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  5. Article ; Online: Global research trends and hotspots of Helicobacter pylori eradication based on clinical trial registration platforms: A cross-sectional analysis.

    Guan, Jia-Lun / Feng, Li-Na / Han, Ying-Ying / Xia, Su-Hong / Zhao, Kai / Zhang, Ming-Yu / Zhang, Yu / Dong, Ruo-Nan / Huang, Yu-Jie / Li, Ji-Yan / Liao, Jia-Zhi / Li, Pei-Yuan

    Clinics and research in hepatology and gastroenterology

    2023  Volume 47, Issue 10, Page(s) 102233

    Abstract: Background: This study aimed to obtain an overview of clinical trials on Helicobacter pylori (H. pylori) eradication and analyze the global trends and hotspots in this field.: Methods: We collected the data from clinical trials focused on H. pylori ... ...

    Abstract Background: This study aimed to obtain an overview of clinical trials on Helicobacter pylori (H. pylori) eradication and analyze the global trends and hotspots in this field.
    Methods: We collected the data from clinical trials focused on H. pylori eradication in the primary clinical trial registries from 2000 to 2022 in the world. Then we analyzed the research trends and hotspots in H. pylori eradication regimens in different regions at different periods.
    Results: A total of 780 clinical trials were included, which were mainly conducted in Asia (682), followed by Europe (59), Africa (20), North America (16), South America (7), Oceania (2). The most active countries were China (343), Iran (140), South Korea (63), and Japan (73). "Bismuth-containing quadruple therapy (BQT)" was the most studied regimen (159, 20.38 %). Additionally, clinical trials focused on potassium-competitive acid blockers (P-CABs)-based therapy, probiotics, and high-dose dual therapy (HDDT) were constantly increasing. BQT received the most attention in China (26.53 %) and Iran (22.14 %), while it was tailored therapy in South Korea (23.29 %). P-CABs-based therapy was the main reseach hotspot in Japan (61.90 %).
    Conclusion: How to eradicate H. pylori infection has been a heated research topic. BQT, P-CABs-based therapy, probiotics, and HDDT attracted the most attention in recent years.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Helicobacter pylori ; Cross-Sectional Studies ; Proton Pump Inhibitors/therapeutic use ; Drug Therapy, Combination ; Helicobacter Infections/drug therapy ; Bismuth/therapeutic use ; Amoxicillin/therapeutic use ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Proton Pump Inhibitors ; Bismuth (U015TT5I8H) ; Amoxicillin (804826J2HU)
    Language English
    Publishing date 2023-10-24
    Publishing country France
    Document type Journal Article
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2023.102233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of body size on efficacy of high-dose dual therapy for Helicobacter pylori eradication.

    Guan, Jia-Lun / Han, Ying-Ying / Wang, Mu-Ru / Xia, Su-Hong / Li, Ji-Yan / Zhang, Ming-Yu / Zhao, Kai / Feng, Li-Na / Zhang, Yu / Dong, Ruo-Nan / Liao, Jia-Zhi / Li, Pei-Yuan

    Helicobacter

    2023  Volume 28, Issue 2, Page(s) e12953

    Abstract: Background: High-dose dual therapy (HDDT) is an emerging and promising therapeutic regime for Helicobacter pylori (H. pylori) eradication. However, the pharmacokinetics of the components of HDDT, amoxicillin and proton pump inhibitor, are likely to be ... ...

    Abstract Background: High-dose dual therapy (HDDT) is an emerging and promising therapeutic regime for Helicobacter pylori (H. pylori) eradication. However, the pharmacokinetics of the components of HDDT, amoxicillin and proton pump inhibitor, are likely to be affected by body size. In this study, we aimed to find out the impact of body size on the efficacy of HDDT.
    Methods: We collected the medical data of 385 treatment-naive patients infected with H. pylori who received HDDT (esomeprazole 20 mg and amoxicillin 750 mg four times daily) for 14 days from July 2020 to December 2021. The associations among the eradication efficacy, adverse events, and variables (sex, age, height, body weight, body mass index (BMI), body surface area (BSA), smoking, drinking, etc.) were analyzed respectively in our study. Among these factors, continuous variables were classified into categorical variables using the cut-off values which were calculated by receiver operating characteristic analysis.
    Results: The eradication rate of HDDT was 89.9%. There were 55 (14.3%) patients who occurred adverse events during the treatment. Patients with height <170.5 cm, body weight <60.5 kg, BMI <20.55 kg/m
    Conclusion: HDDT could achieve better eradication efficacy in patients with small BSA. Clinicians should be aware of the impact of BSA on the H. pylori eradication rate and pay more attention to patients with large BSA.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Helicobacter pylori ; Helicobacter Infections/drug therapy ; Drug Therapy, Combination ; Amoxicillin/therapeutic use ; Proton Pump Inhibitors/therapeutic use ; Body Size ; Body Weight ; Treatment Outcome ; Clarithromycin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Amoxicillin (804826J2HU) ; Proton Pump Inhibitors ; Clarithromycin (H1250JIK0A)
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330665-0
    ISSN 1523-5378 ; 1083-4389
    ISSN (online) 1523-5378
    ISSN 1083-4389
    DOI 10.1111/hel.12953
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4801: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Determination of an Appropriate Endoscopic Monitoring Interval for Patients with Gastric Precancerous Conditions in China.

    Zhao, Kai / Feng, Li-Na / Xia, Su-Hong / Zhou, Wang-Dong / Zhang, Ming-Yu / Zhang, Yu / Dong, Ruo-Nan / Tian, De-An / Liu, Mei / Liao, Jia-Zhi

    Current medical science

    2023  Volume 43, Issue 2, Page(s) 268–273

    Abstract: Objective: Gastric precancerous conditions such as atrophic gastritis (AG) and intestinal metaplasia (IM) are considered independent risk factors for gastric cancer (GC). The suitable endoscopic monitoring interval is unclear when we attempt to prevent ... ...

    Abstract Objective: Gastric precancerous conditions such as atrophic gastritis (AG) and intestinal metaplasia (IM) are considered independent risk factors for gastric cancer (GC). The suitable endoscopic monitoring interval is unclear when we attempt to prevent GC development. This study investigated the appropriate monitoring interval for AG/IM patients.
    Methods: Totally, 957 AG/IM patients who satisfied the criteria for evaluation between 2010 and 2020 were included in the study. Univariate and multivariate analyses were used to determine the risk factors for progression to high-grade intraepithelial neoplasia (HGIN)/GC in AG/IM patients, and to determine an appropriate endoscopic monitoring scheme.
    Results: During follow-up, 28 AG/IM patients developed gastric neoplasia lesions including gastric low-grade intraepithelial neoplasia (LGIN) (0.7%), HGIN (0.9%), and GC (1.3%). Multivariate analysis identified H. pylori infection (P=0.022) and extensive AG/IM lesions (P=0.002) as risk factors for HGIN/GC progression (P=0.025).
    Conclusion: In our study, HGIN/GC was present in 2.2% of AG/IM patients. In AG/IM patients with extensive lesions, a 1-2-year surveillance interval is recommended for early detection of HIGN/GC in AG/IM patients with extensive lesions.
    MeSH term(s) Humans ; Gastritis, Atrophic/diagnosis ; Gastritis, Atrophic/epidemiology ; Gastritis, Atrophic/etiology ; Precancerous Conditions/diagnosis ; Precancerous Conditions/complications ; Precancerous Conditions/epidemiology ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/epidemiology ; Risk Factors ; Endoscopy/adverse effects
    Language English
    Publishing date 2023-03-02
    Publishing country China
    Document type Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-023-2705-x
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  8. Article ; Online: Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease.

    Liu, Cong / Liao, Jia-Zhi / Li, Pei-Yuan

    World journal of gastroenterology

    2017  Volume 23, Issue 11, Page(s) 1964–1973

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases around the world due to the modern sedentary and food-abundant lifestyle, which is characterized by excessive fat accumulation in the liver related with ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases around the world due to the modern sedentary and food-abundant lifestyle, which is characterized by excessive fat accumulation in the liver related with causes other than alcohol abuse. It is widely acknowledged that insulin resistance, dysfunctional lipid metabolism, endoplasmic reticulum stress, oxidative stress, inflammation, and apoptosis/necrosis may all contribute to NAFLD. Autophagy is a protective self-digestion of intracellular organelles, including lipid droplets (lipophagy), in response to stress to maintain homeostasis. Lipophagy is another pathway for lipid degradation besides lipolysis. It is reported that impaired autophagy also contributes to NAFLD. Some studies have suggested that the histological characteristics of NAFLD (steatosis, lobular inflammation, and peri-sinusoid fibrosis) might be improved by treatment with traditional Chinese herbal extracts, while autophagy may be induced. This review will provide insights into the characteristics of autophagy in NAFLD and the related role/mechanisms of autophagy induced by traditional Chinese herbal extracts such as resveratrol, Lycium barbarum polysaccharides, dioscin, bergamot polyphenol fraction, capsaicin, and garlic-derived S-allylmercaptocysteine, which may inhibit the progression of NAFLD. Regulation of autophagy/lipophagy with traditional Chinese herbal extracts may be a novel approach for treating NAFLD, and the molecular mechanisms should be elucidated further in the near future.
    MeSH term(s) Apoptosis/drug effects ; Autophagy/drug effects ; Drugs, Chinese Herbal/therapeutic use ; Endoplasmic Reticulum Stress/drug effects ; Humans ; Inflammation/complications ; Inflammation/drug therapy ; Insulin Resistance ; Lipid Metabolism/drug effects ; Medicine, Chinese Traditional/methods ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Oxidative Stress/drug effects
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2017-03-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v23.i11.1964
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: [Clinical Effect of Surgical Reconstruction of Extracranial Vertebral Artery].

    Yang, Gen-Huan / Liao, Peng-Zhi / Wang, Yan / Jia, Yu-Long

    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

    2023  Volume 45, Issue 2, Page(s) 251–256

    Abstract: Objective To evaluate the effect of surgical reconstruction of extracranial vertebral artery and to summarize the experience. Methods The clinical data of 15 patients undergoing surgical reconstruction of extracranial vertebral artery from September 2018 ...

    Abstract Objective To evaluate the effect of surgical reconstruction of extracranial vertebral artery and to summarize the experience. Methods The clinical data of 15 patients undergoing surgical reconstruction of extracranial vertebral artery from September 2018 to June 2022 were collected.The operation methods,operation duration,intraoperative blood loss,operation complications,and relief of symptoms were retrospectively analyzed. Results Eleven patients underwent vertebral artery (V1 segment) to common carotid artery transposition,two patients underwent endarterectomy of V1 segment,two patients underwent V3 segment to external carotid artery bypass or transposition.The operation duration,intraoperative blood loss,and blocking time of common carotid artery varied within 120-340 min,50-300 ml,and 12-25 min,with the medians of 240 min,100 ml,and 16 min,respectively.There was no cardiac accident,cerebral hyperperfusion syndrome,cerebral hemorrhage or lymphatic leakage during the perioperative period.One patient suffered from cerebral infarction and three patients suffered from incomplete Horner's syndrome after the operation.During the follow-up (4-45 months,median of 26 months),there was no anastomotic stenosis,new cerebral infarction or cerebral ischemia. Conclusion Surgical reconstruction of extracranial vertebral artery is safe and effective,and individualized reconstruction strategy should be adopted according to different conditions.
    MeSH term(s) Humans ; Vertebral Artery/surgery ; Blood Loss, Surgical ; Retrospective Studies ; Brain Ischemia ; Cerebral Infarction
    Language Chinese
    Publishing date 2023-05-08
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604853-5
    ISSN 1000-503X
    ISSN 1000-503X
    DOI 10.3881/j.issn.1000-503X.15171
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2554: Show issues Location:
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  10. Article ; Online: Trend of unplanned reoperation rates after lumbar degenerative surgery from 2011 to 2019: a large patient population study.

    Luo, Zhi-Wen / Wu, Jia-Bao / Sun, Bo-Lin / Liao, Wei-Jie / Huang, Shan-Hu / Zhang, Zhi-Hong / Liu, Zhi-Li / Liu, Jia-Ming

    ANZ journal of surgery

    2023  Volume 93, Issue 6, Page(s) 1658–1664

    Abstract: Background: Unplanned reoperation is commonly performed due to postoperative complications. Previous studies have reported the incidence of unplanned reoperation following lumbar spinal surgery. But few study focused on the trend of reoperation rates, ... ...

    Abstract Background: Unplanned reoperation is commonly performed due to postoperative complications. Previous studies have reported the incidence of unplanned reoperation following lumbar spinal surgery. But few study focused on the trend of reoperation rates, and the reasons of unplanned reoperation were not clear. In this study, we conducted a retrospective study to determine the trend of unplanned reoperation rates after degenerative lumbar spinal surgery from 2011 to 2019, and the reasons and risk factors of unplanned reoperation were also determined.
    Methods: Data of patients who were diagnosed with degenerative lumbar spinal disease and underwent posterior lumbar spinal fusion surgery in our institution from January 2011 to December 2019 were reviewed. Those who received unplanned reoperation during the primary admission were identified. The demographics, diagnosis, surgical segments and postoperative complications of these patients were recorded. The rates of unplanned reoperation from 2011 to 2019 were calculated, and the reasons of unplanned reoperation were statistically analysed.
    Results: A total of 5289 patients were reviewed. Of them, 1.91% (n = 101) received unplanned reoperation during the primary admission. The unplanned reoperation rates of degenerative lumbar spinal surgery firstly increased from 2011 to 2014, with a peak rate in 2014 (2.53%). Then, the rates decreased from 2014 to 2019, with the lowest one in 2019 (1.46%). Patients with lumbar spinal stenosis have a higher rate of unplanned reoperation (2.67%) compared with those diagnosed as lumbar disc herniation (1.50%) and lumbar spondylolisthesis (2.04%) (P < 0.05). The main reasons for unplanned reoperation were wound infection (42.57%), followed by wound hematoma (23.76%). Patients who underwent 2-segment spinal surgery had a higher unplanned reoperation rate (3.79%) than those receiving other segments surgery (P < 0.001). And different spine surgeons had different reoperation rates.
    Conclusions: The rates of unplanned reoperation after lumbar degenerative surgery increased at first and then decreased during past 9 years. Wound infection was the major reason for unplanned reoperation. 2-segment surgery and surgeon's surgical skills were related to the reoperation rate.
    MeSH term(s) Humans ; Reoperation ; Retrospective Studies ; Lumbar Vertebrae/surgery ; Spinal Fusion/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery ; Postoperative Complications/etiology ; Wound Infection/complications
    Language English
    Publishing date 2023-03-26
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18430
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    Zs.A 180: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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