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  1. Article ; Online: Updated antimicrobial dosing recommendations for obese patients.

    Castro-Balado, Ana / Varela-Rey, Iria / Mejuto, Beatriz / Mondelo-García, Cristina / Zarra-Ferro, Irene / Rodríguez-Jato, Teresa / Fernández-Ferreiro, Anxo

    Antimicrobial agents and chemotherapy

    2024  , Page(s) e0171923

    Abstract: The prevalence of obesity has increased considerably in the last few decades. Pathophysiological changes in obese patients lead to pharmacokinetic (PK) and pharmacodynamic (PD) alterations that can condition the correct exposure to antimicrobials if ... ...

    Abstract The prevalence of obesity has increased considerably in the last few decades. Pathophysiological changes in obese patients lead to pharmacokinetic (PK) and pharmacodynamic (PD) alterations that can condition the correct exposure to antimicrobials if standard dosages are used. Inadequate dosing in obese patients can lead to toxicity or therapeutic failure. In recent years, additional antimicrobial PK/PD data, extended infusion strategies, and studies in critically ill patients have made it possible to obtain data to provide a better dosage in obese patients. Despite this, it is usually difficult to find information on drug dosing in this population, which is sometimes contradictory. This is a comprehensive review of the dosing of different types of antimicrobials (antibiotics, antifungals, antivirals, and antituberculosis drugs) in obese patients, where the literature on PK and possible dosing strategies in obese adults was critically assessed.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01719-23
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  2. Article ; Online: Regulating innovation in compounded ophthalmic preparations.

    Castro-Balado, Ana / González-Barcia, Miguel

    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

    2020  Volume 44, Issue 4, Page(s) 123–124

    Title translation Regulación de la innovación en formulación magistral oftálmica.
    MeSH term(s) Drug Compounding ; Drug Delivery Systems ; Humans ; Ophthalmic Solutions
    Chemical Substances Ophthalmic Solutions
    Language English
    Publishing date 2020-07-01
    Publishing country Spain
    Document type Editorial ; Comment
    ZDB-ID 1122680-8
    ISSN 2171-8695 ; 1130-6343
    ISSN (online) 2171-8695
    ISSN 1130-6343
    DOI 10.7399/fh.11452
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  3. Article: Towards Precision Medicine in Clinical Practice: Alinity C vs. UHPLC-MS/MS in Plasma Aripiprazole Determination.

    Toja-Camba, Francisco José / Bandín-Vilar, Enrique / Hermelo-Vidal, Gonzalo / Feitosa-Medeiros, Carolina / Cañizo-Outeiriño, Antonio / Castro-Balado, Ana / Varela-Rey, Iria / Zarra-Ferro, Irene / Fernández-Ferreiro, Anxo / Mondelo-García, Cristina

    Pharmaceutics

    2024  Volume 16, Issue 1

    Abstract: Therapeutic drug monitoring improves the benefit-risk balance of antipsychotic therapy. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) is considered the gold-standard method for measuring plasma drug concentrations; ... ...

    Abstract Therapeutic drug monitoring improves the benefit-risk balance of antipsychotic therapy. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) is considered the gold-standard method for measuring plasma drug concentrations; however, the Alinity C system has emerged as a promising alternative. This is the first study aimed at comparing UHPLC-MS/MS versus Alinity C in measuring plasma concentrations of aripiprazole and dehydroaripiprazole. A total of 86 plasma samples were analyzed. The active moiety of aripiprazole was measured in 60 samples using both systems and 26 samples were analyzed twice using Alinity C with an intermediate period of 6 months to assess its reproducibility. Spearman's correlation revealed a good association between the two assays (rs = 0.96) and no significance differences were found by McNemar's test when classifying samples between infra-, supra- and therapeutic ranges. Passing-Bablock regression showed a good correlation among methods (rs = 0.93) and a slope of 1.12 indicating a slight tendency of Alinity C to measure higher values than UHPLC-MS/MS. In addition, a good intra-method correlation across the two sequential analyses with Alinity C was obtained (rs = 0.99). Nonetheless, clinical decisions could be different in 15% of the cases depending on the chosen method. No differences were found in active moiety determination by Alinity C depending on the concentration of aripiprazole and dehydroaripiprazole of the samples.
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16010104
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  4. Article ; Online: Erratum found in «Farmacia Hospitalaria. 2020;44(4):149-57».

    Castro-Balado, Ana / Mondelo-García, Cristina / Zarra-Ferro, Irene / Fernández-Ferreiro, Anxo

    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

    2021  Volume 45, Issue 2, Page(s) 11682

    Title translation Fe de errores de «Farmacia Hospitalaria. 2020;44(4):149-57».
    MeSH term(s) Bibliometrics ; Humans ; Pharmacy
    Language English
    Publishing date 2021-03-11
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1122680-8
    ISSN 2171-8695 ; 1130-6343
    ISSN (online) 2171-8695
    ISSN 1130-6343
    DOI 10.7399/fh.11682
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  5. Article ; Online: Regulating innovation in compounded ophthalmic preparations

    Ana Castro-Balado / Miguel González-Barcia

    Farmacia Hospitalaria, Vol 44, Iss 4, Pp 123-

    2020  Volume 124

    Keywords Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Grupo Aula Médica
    Document type Article ; Online
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  6. Article ; Online: Correction: A Review of Population Pharmacokinetic Analyses of Linezolid.

    Bandín-Vilar, Enrique / García-Quintanilla, Laura / Castro-Balado, Ana / Zarra-Ferro, Irene / González-Barcia, Miguel / Campos-Toimil, Manuel / Mangas-Sanjuan, Víctor / Mondelo-García, Cristina / Fernández-Ferreiro, Anxo

    Clinical pharmacokinetics

    2023  Volume 62, Issue 9, Page(s) 1331

    Language English
    Publishing date 2023-08-02
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 197627-8
    ISSN 1179-1926 ; 0312-5963
    ISSN (online) 1179-1926
    ISSN 0312-5963
    DOI 10.1007/s40262-023-01295-7
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    Zs.A 1246: Show issues Location:
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  7. Article ; Online: Towards precision medicine of long-acting aripiprazole through population pharmacokinetic modelling.

    Bandín-Vilar, Enrique / Toja-Camba, Francisco José / Vidal-Millares, María / Durán-Maseda, María José / Pou-Álvarez, Marta / Castro-Balado, Ana / Maroñas, Olalla / Gil-Rodríguez, Almudena / Carracedo, Ángel / Zarra-Ferro, Irene / Soy, Dolors / Fernández-Ferreiro, Anxo / Mangas-Sanjuan, Víctor / Mondelo-García, Cristina

    Psychiatry research

    2024  Volume 333, Page(s) 115721

    Abstract: Population pharmacokinetic (popPK) models constitute a valuable tool for characterizing the pharmacokinetic properties of once-monthly long-acting injectable aripiprazole (LAI aripiprazole) and quantifying the sources of variability in drug exposure. Our ...

    Abstract Population pharmacokinetic (popPK) models constitute a valuable tool for characterizing the pharmacokinetic properties of once-monthly long-acting injectable aripiprazole (LAI aripiprazole) and quantifying the sources of variability in drug exposure. Our aim is to develop a popPK model of both aripiprazole and its metabolite dehydro-aripiprazole in patients treated with LAI aripiprazole, and to personalize the dosing regimen of aripiprazole across different sub-groups of patients. This is a prospective study investigating the pharmacokinetics of LAI aripiprazole. A total of 93 patients were included, 21 for model development and 71 for external model evaluation. A one-compartment model with linear absorption and elimination adequately described both aripiprazole and dehydro-aripiprazole concentrations. The weight of the patients has been shown to be the factor that most influences the absorption. However, the metabolizing phenotype for CYP2D6 and the concomitant treatment with strong inhibitors of this cytochrome have been shown to be the covariates that most influence total drug exposure. This is the first popPK model developed for LAI aripiprazole that includes aripiprazole and its main active metabolite, dehydroaripiprazole. It provides a personalized dosage recommendation that maximizes the probability of achieving optimal therapeutic concentrations and minimizes the difficulties associated with trial-and-error therapeutic strategies carried out in clinical practice.
    MeSH term(s) Humans ; Aripiprazole/pharmacology ; Aripiprazole/therapeutic use ; Antipsychotic Agents/therapeutic use ; Precision Medicine ; Prospective Studies ; Cytochrome P-450 CYP2D6/genetics
    Chemical Substances Aripiprazole (82VFR53I78) ; Antipsychotic Agents ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1)
    Language English
    Publishing date 2024-01-05
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2024.115721
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    Zs.A 1541: Show issues Location:
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  8. Article ; Online: New ophthalmic drug delivery systems.

    Castro-Balado, Ana / Mondelo-García, Cristina / Zarra-Ferro, Irene / Fernández-Ferreiro, Anxo

    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

    2020  Volume 44, Issue 4, Page(s) 149–157

    Abstract: For decades, topical ophthalmic drug administration through the use of eye  drops has been the most widely used technique for the treatment of eye diseases. The development of galenic formulation has led to the use and commercialization of new ... ...

    Title translation Nuevos sistemas de liberación de fármacos a nivel ocular.
    Abstract For decades, topical ophthalmic drug administration through the use of eye  drops has been the most widely used technique for the treatment of eye diseases. The development of galenic formulation has led to the use and commercialization of new formulations, such as suspensions, emulsions, and  ophthalmic ointments that increase residence time in the site of  action. Recently, new administration systems have been developed, such as  devices and inserts that provide the sustained release of active substance. Some of these systems are already available on the market, whereas others are still undergoing clinical trials, such as promising systems based on nanostructures (nanocapsules, cyclodextrins, nanoemulsions, etc.). Similarly,  various formulations and devices have been developed in the field of intravitreal administration, with different implants available on the European  market for the treatment of age-related macular degeneration (AMD), diabetic  macular edema, or infections that affect the posterior segment. This review  includes current developments in ophthalmic topical and intravitreal drug  administration routes as well as those under investigation.
    MeSH term(s) Administration, Topical ; Cyclodextrins/therapeutic use ; Drug Delivery Systems ; Eye Diseases/drug therapy ; Humans ; Ophthalmic Solutions/therapeutic use
    Chemical Substances Cyclodextrins ; Ophthalmic Solutions
    Language English
    Publishing date 2020-07-01
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 1122680-8
    ISSN 2171-8695 ; 1130-6343
    ISSN (online) 2171-8695
    ISSN 1130-6343
    DOI 10.7399/fh.11388
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  9. Article ; Online: Erratum found in «Farmacia Hospitalaria. 2020;44(4):149-57»

    Ana Castro-Balado / Cristina Mondelo-García / Irene Zarra-Ferro / Anxo Fernández-Ferreiro

    Farmacia Hospitalaria, Vol 45, Iss 2, Pp 108-

    2021  Volume 108

    Keywords Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Grupo Aula Médica
    Document type Article ; Online
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  10. Article: Cysteamine Eye Drops in Hyaluronic Acid Packaged in Innovative Single-Dose Systems, Part II: Long-Term Stability and Clinical Ocular Biopermanence.

    Castro-Balado, Ana / Cuartero-Martínez, Andrea / Pena-Verdeal, Hugo / Hermelo-Vidal, Gonzalo / Schmidt, Anja / Montero, Belén / Hernández-Blanco, Manuela / Zarra-Ferro, Irene / González-Barcia, Miguel / Mondelo-García, Cristina / Giráldez, María Jesús / Yebra-Pimentel, Eva / Otero-Espinar, Francisco J / Fernández-Ferreiro, Anxo

    Pharmaceutics

    2023  Volume 15, Issue 11

    Abstract: Background: Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in several tissues and organs causing, among others, severe eye symptoms. The high instability of cysteamine eye drops makes it difficult to develop ... ...

    Abstract Background: Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in several tissues and organs causing, among others, severe eye symptoms. The high instability of cysteamine eye drops makes it difficult to develop formulations with an acceptable shelf life to be prepared in hospital pharmacy departments. Previously, a new compounded formulation of cysteamine eye drops in hyaluronic acid (HA) packaged in innovative single-dose systems was developed.
    Methods: Long-term stability at -20 °C of this formulation was studied considering the content of cysteamine, pH, osmolality, viscosity, and microbiological analysis. The oxygen permeability of single-dose containers was also studied and an ocular biopermanence study was conducted in healthy volunteers measuring lacrimal stability and volume parameters.
    Results: Data confirm that cysteamine concentration remained above 90% for 120 days, all parameters remaining within the accepted range for ophthalmic formulations. The permeability of the containers was reduced over time, while ocular biopermanence was maintained despite the freezing process and storage time.
    Conclusions: 0.55% cysteamine hydrochloride formulation in HA and packaged in single-dose containers preserved at -20 °C is stable for 120 days protected from light, presenting high potential for its translation into clinical practice when commercial presentations are not available.
    Language English
    Publishing date 2023-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15112589
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