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Book: Flüsse der Alpen

Muhar, Susanne / Muhar, Andreas / Siegrist, Dominik / Egger, Gregory

Vielfalt in Natur und Kultur

2019

Keywords	EGRR010 ; EGRA020 ; EGRA060 ; Erde/Klima/Wasser ; Europa ; Wasser ; Geographie ; Flüsse ; Alpen
Language	German
Size	512 p.
Edition	1
Publisher	Haupt Verlag
Document type	Book
Note	Ernährungs-, Umwelt- und Agrarwissenschaften 250418
Format	222 x 271 x 38
ISBN	9783258081144 ; 325808114X
Database	PDA

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Article ; Online: Response to 'Chest compressions at altitude are of decreased quality, require more effort and cannot reliably be self-evaluated'.

Niederer, Maximilian / Roth, Dominik / Egger, Alexander

Scandinavian journal of trauma, resuscitation and emergency medicine

2023 Volume 31, Issue 1, Page(s) 99

MeSH term(s)	Humans ; Altitude ; Cardiopulmonary Resuscitation ; Heart Arrest ; Heart
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2455990-8
ISSN	1757-7241 ; 1757-7241
ISSN (online)	1757-7241
ISSN	1757-7241
DOI	10.1186/s13049-023-01158-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Electrochemistry and Stability of 1,1'-Ferrocene-Bisphosphonates.

Egger, Melissa / Koehne, Ingo / Wickenhauser, Dominik / Schlemmer, Werner / Spirk, Stefan / Pietschnig, Rudolf

ACS omega

2023 Volume 8, Issue 12, Page(s) 10899–10905

Abstract: Here, we investigate the electrochemical properties and stability of 1,1'-ferrocene-bisphosphonates in aqueous solutions. ...

Abstract	Here, we investigate the electrochemical properties and stability of 1,1'-ferrocene-bisphosphonates in aqueous solutions.
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c07234
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: Advanced cell culture technologies to boost cell-based therapies, volume II.

Egger, Dominik / Hansmann, Jan / Kasper, Cornelia / Kouroupis, Dimitrios

Frontiers in bioengineering and biotechnology

2022 Volume 10, Page(s) 999765

Language	English
Publishing date	2022-08-30
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2022.999765
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dynamic cultivation of human mesenchymal stem/stromal cells for the production of extracellular vesicles in a 3D bioreactor system.

Almeria, Ciarra / Weiss, René / Keck, Maike / Weber, Viktoria / Kasper, Cornelia / Egger, Dominik

Biotechnology letters

2024 Volume 46, Issue 2, Page(s) 279–293

Abstract: Purpose: 3D cell culture and hypoxia have been demonstrated to increase the therapeutic effects of mesenchymal stem/stromal cells (MSCs)-derived extracellular vesicles (EVs). In this study, a process for the production of MSC-EVs in a novel 3D ... ...

Abstract	Purpose: 3D cell culture and hypoxia have been demonstrated to increase the therapeutic effects of mesenchymal stem/stromal cells (MSCs)-derived extracellular vesicles (EVs). In this study, a process for the production of MSC-EVs in a novel 3D bioreactor system under normoxic and hypoxic conditions was established and the resulting EVs were characterized. Methods: Human adipose-derived MSCs were seeded and cultured on a 3D membrane in the VITVO® bioreactor system for 7 days. Afterwards, MSC-EVs were isolated and characterized via fluorescence nanoparticle tracking analysis, flow cytometry with staining against annexin V (Anx5) as a marker for EVs exposing phosphatidylserine, as well as CD73 and CD90 as MSC surface markers. Results: Cultivation of MSC in the VITVO® bioreactor system demonstrated a higher concentration of MSC-EVs from the 3D bioreactor (9.1 × 10 Conclusion: The production of MSC-EVs in a 3D bioreactor system under hypoxic conditions resulted in increased EV concentration and purity. This system could be especially useful in screening culture conditions for the production of 3D-derived MSC-EVs.
MeSH term(s)	Humans ; Extracellular Vesicles/metabolism ; Mesenchymal Stem Cells ; Bioreactors
Language	English
Publishing date	2024-02-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	423853-9
ISSN	1573-6776 ; 0141-5492
ISSN (online)	1573-6776
ISSN	0141-5492
DOI	10.1007/s10529-024-03465-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The fluorochrome-to-protein ratio is crucial for the flow cytometric detection of tissue factor on extracellular vesicles.

Weiss, René / Mostageer, Marwa / Eichhorn, Tanja / Huber, Silke / Egger, Dominik / Spittler, Andreas / Tripisciano, Carla / Kasper, Cornelia / Weber, Viktoria

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6419

Abstract: Extracellular vesicles (EVs) have crucial roles in hemostasis and coagulation. They sustain coagulation by exposing phosphatidylserine and initiate clotting by surface expression of tissue factor (TF) under inflammatory conditions. As their relevance as ... ...

Abstract	Extracellular vesicles (EVs) have crucial roles in hemostasis and coagulation. They sustain coagulation by exposing phosphatidylserine and initiate clotting by surface expression of tissue factor (TF) under inflammatory conditions. As their relevance as biomarkers of coagulopathy is increasingly recognized, there is a need for the sensitive and reliable detection of TF
MeSH term(s)	Thromboplastin/metabolism ; Fluorescent Dyes/metabolism ; Blood Coagulation ; Extracellular Vesicles/metabolism
Chemical Substances	Thromboplastin (9035-58-9) ; Fluorescent Dyes
Language	English
Publishing date	2024-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56841-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Concepts for the implementation of physiologic conditions for the cultivation of human mesenchymal stem cells

Egger, Dominik [Verfasser]

2017

Author's details	Dominik Egger
Keywords	Geowissenschaften ; Earth Sciences
Subject code	sg550
Language	English
Publisher	Technische Informationsbibliothek (TIB)
Publishing place	Hannover
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions.

Almeria, Ciarra / Kreß, Sebastian / Weber, Viktoria / Egger, Dominik / Kasper, Cornelia

Cell & bioscience

2022 Volume 12, Issue 1, Page(s) 51

Abstract: Extracellular vesicles (EVs) are cell-derived membrane structures exerting major effects in physiological as well as pathological processes by functioning as vehicles for the delivery of biomolecules to their target cells. An increasing number of effects ...

Abstract	Extracellular vesicles (EVs) are cell-derived membrane structures exerting major effects in physiological as well as pathological processes by functioning as vehicles for the delivery of biomolecules to their target cells. An increasing number of effects previously attributed to cell-based therapies have been recognized to be actually mediated by EVs derived from the respective cells, suggesting the administration of purified EVs instead of living cells for cell-based therapies. In this review, we focus on the heterogeneity of EVs derived from mesenchymal stem/stromal cells (MSC) and summarize upstream process parameters that crucially affect the resulting therapeutic properties and biological functions. Hereby, we discuss the effects of the cell source, medium composition, 3D culture, bioreactor culture and hypoxia. Furthermore, aspects of the isolation and storage strategies influences EVs are described. Conclusively, optimization of upstream process parameters should focus on controlling MSC-derived EV heterogeneity for specific therapeutic applications.
Language	English
Publishing date	2022-05-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2593367-X
ISSN	2045-3701
ISSN	2045-3701
DOI	10.1186/s13578-022-00786-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Physiologic isolation and expansion of human mesenchymal stem/stromal cells for manufacturing of cell-based therapy products.

Egger, Dominik / Lavrentieva, Antonina / Kugelmeier, Patrick / Kasper, Cornelia

Engineering in life sciences

2021 Volume 22, Issue 3-4, Page(s) 361–372

Abstract: The utilization of mesenchymal stem/stromal cells raises new hopes in treatment of diseases and pathological conditions, while at the same time bringing immense challenges for researchers, manufacturers and physicians. It is essential to consider all ... ...

Abstract	The utilization of mesenchymal stem/stromal cells raises new hopes in treatment of diseases and pathological conditions, while at the same time bringing immense challenges for researchers, manufacturers and physicians. It is essential to consider all steps along the in vitro fabrication of cell-based products in order to reach efficient and reproducible treatment outcomes. Here, the optimal protocols for isolation, cultivation and differentiation of mesenchymal stem cells are required. In this review we discuss these aspects and their influence on the final cell-based product quality. We demonstrate that physiological in vitro cell cultivation conditions play a crucial role in therapeutic functionalities of cultivated cells. We show that three-dimensional cell culture, dynamic culture conditions and physiologically relevant in vitro oxygen concentrations during isolation and expansion make a decisive contribution towards the improvement of cell-based products in regenerative medicine.
Language	English
Publishing date	2021-10-27
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2071199-2
ISSN	1618-2863 ; 1618-0240
ISSN (online)	1618-2863
ISSN	1618-0240
DOI	10.1002/elsc.202100097
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions

Ciarra Almeria / Sebastian Kreß / Viktoria Weber / Dominik Egger / Cornelia Kasper

Cell & Bioscience, Vol 12, Iss 1, Pp 1-

2022 Volume 15

Abstract: Abstract Extracellular vesicles (EVs) are cell-derived membrane structures exerting major effects in physiological as well as pathological processes by functioning as vehicles for the delivery of biomolecules to their target cells. An increasing number ... ...

Abstract	Abstract Extracellular vesicles (EVs) are cell-derived membrane structures exerting major effects in physiological as well as pathological processes by functioning as vehicles for the delivery of biomolecules to their target cells. An increasing number of effects previously attributed to cell-based therapies have been recognized to be actually mediated by EVs derived from the respective cells, suggesting the administration of purified EVs instead of living cells for cell-based therapies. In this review, we focus on the heterogeneity of EVs derived from mesenchymal stem/stromal cells (MSC) and summarize upstream process parameters that crucially affect the resulting therapeutic properties and biological functions. Hereby, we discuss the effects of the cell source, medium composition, 3D culture, bioreactor culture and hypoxia. Furthermore, aspects of the isolation and storage strategies influences EVs are described. Conclusively, optimization of upstream process parameters should focus on controlling MSC-derived EV heterogeneity for specific therapeutic applications. Graphical Abstract
Keywords	Extracellular vesicles ; Mesenchymal Stem Cells ; Cell Culture Conditions ; Scalability ; Regenerative Medicine ; Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
Subject code	571
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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