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  1. Article ; Online: Structural and Magnetization Dynamics of Borohydride-Bridged Rare-Earth Metallocenium Cations.

    Price, Christopher G T / Mondal, Arpan / Durrant, James P / Tang, Jinkui / Layfield, Richard A

    Inorganic chemistry

    2023  Volume 62, Issue 25, Page(s) 9924–9933

    Abstract: The structure and magnetic properties of the bimetallic borohydride-bridged dysprosocenium compound [{( ... ...

    Abstract The structure and magnetic properties of the bimetallic borohydride-bridged dysprosocenium compound [{(η
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c01038
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  2. Article ; Online: Clear cell variant of atypical fibroxanthoma and pleomorphic dermal sarcoma: Molecular characterization and review of the literature.

    Coelho-Lima, Jose / Bruty, Jonathan / Watkins, James / Liu, Hongxiang / Price, Richard / Stefanos, Niki

    Journal of cutaneous pathology

    2022  Volume 49, Issue 12, Page(s) 1031–1034

    Abstract: Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are unusual cutaneous tumors that typically arise in sun-damaged skin of elderly individuals. Several histopathologic variants have been described, but the clear cell variant is ... ...

    Abstract Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are unusual cutaneous tumors that typically arise in sun-damaged skin of elderly individuals. Several histopathologic variants have been described, but the clear cell variant is particularly rare with only 18 cases of AFX and one case of PDS reported. Here, we present two cases of clear cell AFX and PDS highlighting key histopathologic findings and molecular alterations assessed by next-generation sequencing.
    MeSH term(s) Humans ; Aged ; Female ; Biomarkers, Tumor/genetics ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Histiocytoma, Malignant Fibrous/genetics ; High-Throughput Nucleotide Sequencing ; Bone Neoplasms ; Breast Neoplasms
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Review ; Case Reports
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.14307
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    Zs.A 1043: Show issues Location:
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  3. Article ; Online: Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure.

    Caseras, Xavier / Simmonds, Emily / Pardiñas, Antonio F / Anney, Richard / Legge, Sophie E / Walters, James T R / Harrison, Neil A / O'Donovan, Michael C / Escott-Price, Valentina

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 194

    Abstract: Recent research has highlighted the role of complement genes in shaping the microstructure of the brain during early development, and in contributing to common allele risk for Schizophrenia. We hypothesised that common risk variants for schizophrenia ... ...

    Abstract Recent research has highlighted the role of complement genes in shaping the microstructure of the brain during early development, and in contributing to common allele risk for Schizophrenia. We hypothesised that common risk variants for schizophrenia within complement genes will associate with structural changes in white matter microstructure within tracts innervating the frontal lobe. Results showed that risk alleles within the complement gene set, but also intergenic alleles, significantly predict axonal density in white matter tracts connecting frontal cortex with parietal, temporal and occipital cortices. Specifically, risk alleles within the Major Histocompatibility Complex region in chromosome 6 appeared to drive these associations. No significant associations were found for the orientation dispersion index. These results suggest that changes in axonal packing - but not in axonal coherence - determined by common risk alleles within the MHC genomic region - including variants related to the Complement system - appear as a potential neurobiological mechanism for schizophrenia.
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-024-02910-2
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  4. Article ; Online: Single-level cervical disc replacement (CDR) versus anterior cervical discectomy and fusion (ACDF): A Nationwide matched analysis of complications, 30- and 90-day readmission rates, and cost.

    Nunna, Ravi S / Ryoo, James S / Ostrov, Philip B / Patel, Saavan / Godolias, Periklis / Daher, Zeyad / Price, Richard / Chapman, Jens R / Oskouian, Rod J

    World neurosurgery: X

    2023  Volume 21, Page(s) 100242

    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ISSN 2590-1397
    ISSN (online) 2590-1397
    DOI 10.1016/j.wnsx.2023.100242
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  5. Article ; Online: Diagnostic Ability of Simple Noninvasive Blood Tests to Predict Increased Liver Stiffness in People Living With HIV and Steatotic Liver Disease.

    Sterling, Richard K / Vilar-Gomez, Eduardo / Wilson, Laura A / Loomba, Rohit / Gawrieh, Samer / Price, Jennifer / Naggie, Susanna / Lake, Jordan E / Heath, Sonya / Tonascia, James / Sulkowski, Mark / Chalasani, Naga

    The American journal of gastroenterology

    2024  

    Abstract: Introduction: Steatotic liver disease is common in people with HIV (PWH). Identifying those with advanced fibrosis (AF, bridging fibrosis or cirrhosis), F3-4, is important. We aimed to examine the performance of FIB-4 and nonalcoholic fatty liver ... ...

    Abstract Introduction: Steatotic liver disease is common in people with HIV (PWH). Identifying those with advanced fibrosis (AF, bridging fibrosis or cirrhosis), F3-4, is important. We aimed to examine the performance of FIB-4 and nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) in PWH to identify those with AF assessed by liver stiffness measurement (LSM).
    Methods: We prospectively collected data on adults participating in 2 National Institute of Health-sponsored HIV NAFLD networks. All had HIV on antiretroviral therapy (ART) ≥6 months with HIV RNA <200 copies/mL. Those with viral hepatitis, other liver disease, excessive alcohol use, or hepatic decompensation were excluded. Vibration-controlled transient elastrography for LSM was performed, and AF defined as ≥11 kPa was compared with FIB-4 and NFS at predefined thresholds (<1.3 and >2.67 for FIB-4 and <-1.455 and >0.675 for NFS).
    Results: A total of 1,065 participants were analyzed: mean age 51.6 years, 74% male, 28% White, 46% Black, 22% Hispanic, with 34% overweight (body mass index 25-29 kg/m 2 ) and 43% obese (body mass index ≥30 kg/m 2 ). Features of the metabolic syndrome were common: hyperlipidemia 35%, type 2 diabetes 17%, and hypertension 48%. The median CD4 + T-cell count was 666 cells/mm 3 , 74% had undetectable HIV RNA, and duration of HIV-1 was 17 years with most taking a nucleoside reverse transcriptase inhibitor (92%) and an integrase inhibitor (83%). The mean LSM was 6.3 kPa, and 6.3% had AF. The area under the receiver characteristic curve for FIB-4 and NFS to identify AF were 0.70 and 0.75, respectively. While both had high negative predictive values (97%-98%), the sensitivity at low thresholds and specificity at high thresholds were 64% and 97% for FIB-4 and 80% and 96% for NFS, respectively. Neither FIB-4 nor NFS at either threshold had good positive predictive value to detect AF.
    Discussion: FIB-4 and NFS have excellent specificity and negative predictive value for detecting AF, and thus can be used as screening tools in PWH to exclude those with AF who do not need further testing (LSM) or referral to hepatologist.
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002700
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  6. Article ; Online: Quantitative evaluation of the feasibility of sampling the ice plumes at Enceladus for biomarkers of extraterrestrial life.

    New, James S / Kazemi, Bahar / Spathis, Vassilia / Price, Mark C / Mathies, Richard A / Butterworth, Anna L

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 37

    Abstract: Enceladus, an icy moon of Saturn, is a compelling destination for a probe seeking biosignatures of extraterrestrial life because its subsurface ocean exhibits significant organic chemistry that is directly accessible by sampling cryovolcanic plumes. ... ...

    Abstract Enceladus, an icy moon of Saturn, is a compelling destination for a probe seeking biosignatures of extraterrestrial life because its subsurface ocean exhibits significant organic chemistry that is directly accessible by sampling cryovolcanic plumes. State-of-the-art organic chemical analysis instruments can perform valuable science measurements at Enceladus provided they receive sufficient plume material in a fly-by or orbiter plume transit. To explore the feasibility of plume sampling, we performed light gas gun experiments impacting micrometer-sized ice particles containing a fluorescent dye biosignature simulant into a variety of soft metal capture surfaces at velocities from 800 m ⋅ s
    MeSH term(s) Atmosphere ; Biomarkers/analysis ; Exobiology/methods ; Extraterrestrial Environment/chemistry ; Feasibility Studies ; Ice/analysis ; Moon ; Origin of Life ; Saturn
    Chemical Substances Biomarkers ; Ice
    Language English
    Publishing date 2021-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2106197118
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    Zs.A 1148: Show issues Location:
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  7. Article ; Online: Can emergency physicians accurately interpret computed tomography scans performed for suspected nontraumatic subarachnoid haemorrhage: a cross-sectional study.

    Austin, Richard / Price, James / Boyle, Adrian

    European journal of emergency medicine : official journal of the European Society for Emergency Medicine

    2018  Volume 25, Issue 6, Page(s) 447–448

    MeSH term(s) Clinical Competence/standards ; Cross-Sectional Studies ; Emergency Medicine/standards ; Emergency Service, Hospital/standards ; Humans ; Medical Staff, Hospital/standards ; Subarachnoid Hemorrhage/diagnostic imaging ; Tomography, X-Ray Computed/standards
    Language English
    Publishing date 2018-10-31
    Publishing country England
    Document type Letter
    ZDB-ID 1233544-7
    ISSN 1473-5695 ; 0969-9546
    ISSN (online) 1473-5695
    ISSN 0969-9546
    DOI 10.1097/MEJ.0000000000000560
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    Zs.A 4264: Show issues Location:
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  8. Article ; Online: Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank.

    Chambers, Tom / Escott-Price, Valentina / Legge, Sophie / Baker, Emily / Singh, Krish D / Walters, James T R / Caseras, Xavier / Anney, Richard J L

    Molecular psychiatry

    2022  Volume 27, Issue 4, Page(s) 2282–2290

    Abstract: Interest in the cerebellum is expanding given evidence of its contributions to cognition and emotion, and dysfunction in various psychopathologies. However, research into its genetic architecture and shared influences with liability for mental disorders ... ...

    Abstract Interest in the cerebellum is expanding given evidence of its contributions to cognition and emotion, and dysfunction in various psychopathologies. However, research into its genetic architecture and shared influences with liability for mental disorders is lacking. We conducted a genome-wide association study (GWAS) of total cerebellar volume and underlying cerebellar lobe volumes in 33,265 UK-Biobank participants. Total cerebellar volume was heritable (h
    MeSH term(s) Autism Spectrum Disorder ; Biological Specimen Banks ; Cerebellum ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Humans ; Mental Disorders/genetics ; Polymorphism, Single Nucleotide/genetics ; United Kingdom
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01443-8
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    Zs.A 4812: Show issues Location:
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  9. Article ; Online: Response to comment on 'The clinical pharmacology of tafenoquine in the radical cure of

    Watson, James A / Commons, Robert J / Tarning, Joel / Simpson, Julie A / Llanos Cuentas, Alejandro / Lacerda, Marcus V G / Green, Justin A / Koh, Gavin C K W / Chu, Cindy S / Nosten, François H / Price, Richard N / Day, Nicholas P J / White, Nicholas J

    eLife

    2024  Volume 13

    Abstract: In our recent paper on the clinical pharmacology of tafenoquine (Watson et al., 2022), we used all available individual patient pharmacometric data from the tafenoquine pre-registration clinical efficacy trials to characterise the determinants of anti- ... ...

    Abstract In our recent paper on the clinical pharmacology of tafenoquine (Watson et al., 2022), we used all available individual patient pharmacometric data from the tafenoquine pre-registration clinical efficacy trials to characterise the determinants of anti-relapse efficacy in tropical vivax malaria. We concluded that the currently recommended dose of tafenoquine (300 mg in adults, average dose of 5 mg/kg) is insufficient for cure in all adults, and a 50% increase to 450 mg (7.5 mg/kg) would halve the risk of vivax recurrence by four months. We recommended that clinical trials of higher doses should be carried out to assess their safety and tolerability. Sharma and colleagues at the pharmaceutical company GSK defend the currently recommended adult dose of 300 mg as the optimum balance between radical curative efficacy and haemolytic toxicity (Sharma et al., 2024). We contend that the relative haemolytic risks of the 300 mg and 450 mg doses have not been sufficiently well characterised to justify this opinion. In contrast, we provided evidence that the currently recommended 300 mg dose results in sub-maximal efficacy, and that prospective clinical trials of higher doses are warranted to assess their risks and benefits.
    MeSH term(s) Adult ; Humans ; Aminoquinolines ; Antimalarials/therapeutic use ; Hemolysis ; Malaria, Vivax/drug therapy ; Primaquine/therapeutic use ; Prospective Studies ; Meta-Analysis as Topic
    Chemical Substances Aminoquinolines ; Antimalarials ; Primaquine (MVR3634GX1) ; tafenoquine (262P8GS9L9)
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.91283
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  10. Article ; Online: A natively flexible 32-bit Arm microprocessor.

    Biggs, John / Myers, James / Kufel, Jedrzej / Ozer, Emre / Craske, Simon / Sou, Antony / Ramsdale, Catherine / Williamson, Ken / Price, Richard / White, Scott

    Nature

    2021  Volume 595, Issue 7868, Page(s) 532–536

    Abstract: Nearly 50 years ago, Intel created the world's first commercially produced microprocessor-the 4004 (ref. ...

    Abstract Nearly 50 years ago, Intel created the world's first commercially produced microprocessor-the 4004 (ref.
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-021-03625-w
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