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Article ; Online: Remdesivir, Sinus Bradycardia and Therapeutic Drug Monitoring in Children With Severe COVID-19.

Rau, Cornelius / Apostolidou, Sofia / Singer, Dominique / Avataneo, Valeria / Kobbe, Robin

The Pediatric infectious disease journal

2021 Volume 40, Issue 12, Page(s) e528–e529

MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Bradycardia/chemically induced ; COVID-19/drug therapy ; Child ; Drug Monitoring ; Humans ; SARS-CoV-2
Chemical Substances	remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2021-12-03
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003309
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Article ; Online: Host Single Nucleotide Polymorphisms and Biomarkers of Neuronal Damage and Inflammation in People Living with HIV.

Cusato, Jessica / Manca, Alessandra / Palermiti, Alice / Mula, Jacopo / Avataneo, Valeria / Antonucci, Miriam / Marinaro, Letizia / Bonora, Stefano / Trunfio, Mattia / Perri, Giovanni Di / D'Avolio, Antonio / Calcagno, Andrea

International journal of antimicrobial agents

2024 , Page(s) 107137

Abstract: Background: Blood brain barrier impairment is frequent in people living with HIV (PLWH), affecting the penetration of target cells and antiretrovirals into the central nervous system, through transporters (e.g. ABCB1), leading to neuroinflammation.: ... ...

Abstract	Background: Blood brain barrier impairment is frequent in people living with HIV (PLWH), affecting the penetration of target cells and antiretrovirals into the central nervous system, through transporters (e.g. ABCB1), leading to neuroinflammation. Objectives: The aim of this study was to identify variants of genes encoding transporters able to predict neuroinflammation biomarker levels. Materials and methods: Cerebrospinal fluid (CSF) and plasma samples were obtained from PLWH. CSF biomarkers were quantified by commercial assays. Genetic variants were evaluated through real-time polymerase chain reaction (PCR). Results: 107 PLWH (163 samples) were included in the study: 79% were male, median age was 48.5 years, CD4% was 25%, HIV-associated neurolocognitive disorder (HAND) was observed in 17.8% of patients. ABCB1 2677G>T genetic variant showed a different allelic distribution according to the clinical group (p=0.026). In linear regression analyses, HIV-related central nervous system disorders, ABCG2 1194+928CC genotype, log viral load, CSAR, β-1,42 levels and CSF proteins were retained in the final model as factors independently associated with CSF neopterin levels; CSF proteins and integrase inhibitors use were associated with CSF tau level in the multivariate model. Phospho-tau regression analysis reported ABCB1 2677GT/TT genotype and CSF proteins as predictors in the final model; gender and protease inhibitors, neopterin, ABCB1 2677 GT/ TT genotype resulted predictors in the multivariate regression for β-1,42. Conclusions: For the first time, pharmacogenetic and clinical features were predictors of neuro-inflammation biomarkers.
Language	English
Publishing date	2024-03-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107137
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

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Article ; Online: Monthly Increase in Vitamin D Levels upon Supplementation with 2000 IU/Day in Healthy Volunteers: Result from "Integriamoci", a Pilot Pharmacokinetic Study.

Avataneo, Valeria / Palermiti, Alice / De Nicolò, Amedeo / Cusato, Jessica / Giussani, Gloria / Calcagno, Andrea / D'Avolio, Antonio

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 3

Abstract: Vitamin D (VD) is a calcium- and phosphate-controlling hormone used to treat bone disorders; yet, several other effects are progressively emerging. VD deficiency is highly prevalent worldwide, with suboptimal exposure to sunlight listed among the leading ...

Abstract	Vitamin D (VD) is a calcium- and phosphate-controlling hormone used to treat bone disorders; yet, several other effects are progressively emerging. VD deficiency is highly prevalent worldwide, with suboptimal exposure to sunlight listed among the leading causes: oral supplementation with either cholecalciferol or calcitriol is used. However, there is a scarcity of clinical studies investigating how quickly VD concentrations can increase after supplementation. In this pilot study, the commercial supplement ImmuD3 (by
MeSH term(s)	Adult ; Aged ; Bone Density Conservation Agents/administration & dosage ; Bone Density Conservation Agents/blood ; Bone Density Conservation Agents/therapeutic use ; Cholecalciferol/administration & dosage ; Cholecalciferol/blood ; Cholecalciferol/therapeutic use ; Dietary Supplements/analysis ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/therapy ; Vitamins/administration & dosage ; Vitamins/blood ; Vitamins/therapeutic use ; Young Adult
Chemical Substances	Bone Density Conservation Agents ; Vitamins ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2022-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27031042
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Article: Antiretroviral Levels in the Cerebrospinal Fluid: The Effect of Inflammation and Genetic Variants.

Cusato, Jessica / Avataneo, Valeria / Antonucci, Miriam / Trunfio, Mattia / Marinaro, Letizia / Palermiti, Alice / Manca, Alessandra / Di Perri, Giovanni / Mula, Jacopo / Bonora, Stefano / D'Avolio, Antonio / Calcagno, Andrea

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 2

Abstract: Neurocognitive impairments are common in people living with HIV. Some conditions, such as chronic inflammation, astrocyte infection and an impaired blood-brain barrier (BBBi), along with host genetic variants in transporter genes, may affect ... ...

Abstract	Neurocognitive impairments are common in people living with HIV. Some conditions, such as chronic inflammation, astrocyte infection and an impaired blood-brain barrier (BBBi), along with host genetic variants in transporter genes, may affect antiretroviral (ARV) exposure in the cerebrospinal fluid (CSF). The aim of this study was to evaluate ARV CSF penetration according to compartmental inflammation, BBB permeability and single-nucleotide polymorphisms (SNPs) in drug transporter encoding genes. CSF neopterin (ELISA), plasma and CSF ARV concentrations (HPLC) and host genetic variants in
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13020295
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Article: A Non-Invasive Method for Detection of Antihypertensive Drugs in Biological Fluids: The Salivary Therapeutic Drug Monitoring.

Avataneo, Valeria / Fanelli, Elvira / De Nicolò, Amedeo / Rabbia, Franco / Palermiti, Alice / Pappaccogli, Marco / Cusato, Jessica / De Rosa, Francesco Giuseppe / D'Avolio, Antonio / Veglio, Franco

Frontiers in pharmacology

2022 Volume 12, Page(s) 755184

Abstract: Objectives: ...

Abstract	Objectives:
Language	English
Publishing date	2022-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.755184
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Article ; Online: Monthly Increase in Vitamin D Levels upon Supplementation with 2000 IU/Day in Healthy Volunteers

Valeria Avataneo / Alice Palermiti / Amedeo De Nicolò / Jessica Cusato / Gloria Giussani / Andrea Calcagno / Antonio D’Avolio

Molecules, Vol 27, Iss 1042, p

Result from “Integriamoci”, a Pilot Pharmacokinetic Study

2022 Volume 1042

Abstract	Vitamin D (VD) is a calcium- and phosphate-controlling hormone used to treat bone disorders; yet, several other effects are progressively emerging. VD deficiency is highly prevalent worldwide, with suboptimal exposure to sunlight listed among the leading causes: oral supplementation with either cholecalciferol or calcitriol is used. However, there is a scarcity of clinical studies investigating how quickly VD concentrations can increase after supplementation. In this pilot study, the commercial supplement ImmuD3 (by Erboristeria Magentina ® ) was chosen as the source of VD and 2000 IU/day was administered for one month to 21 healthy volunteers that had not taken any other VD supplements in the previous 30 days. Plasma VD levels were measured through liquid chromatography coupled to tandem mass spectrometry after 7, 14, and 28 days of supplementation. We found that 95% of the participants had insufficient VD levels at baseline (<30 ng/mL; median 23.72 ng/mL; IQR 18.10–26.15), but after 28 days of supplementation, this percentage dropped to 62% (median 28.35 ng/mL; IQR 25.78–35.20). The median increase in VD level was 3.09 ng/mL (IQR 1.60–5.68) after 7 days and 8.85 ng/mL (IQR 2.85–13.97F) after 28 days. This study suggests the need for continuing VD supplementation and for measuring target level attainment.
Keywords	vitamin D ; LC-MS/MS ; oral integration ; supplements ; micronutrients ; Organic chemistry ; QD241-441
Subject code	333
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Antiretroviral Levels in the Cerebrospinal Fluid

Jessica Cusato / Valeria Avataneo / Miriam Antonucci / Mattia Trunfio / Letizia Marinaro / Alice Palermiti / Alessandra Manca / Giovanni Di Perri / Jacopo Mula / Stefano Bonora / Antonio D’Avolio / Andrea Calcagno

Diagnostics, Vol 13, Iss 295, p

The Effect of Inflammation and Genetic Variants

2023 Volume 295

Abstract: Neurocognitive impairments are common in people living with HIV. Some conditions, such as chronic inflammation, astrocyte infection and an impaired blood–brain barrier (BBBi), along with host genetic variants in transporter genes, may affect ... ...

Abstract	Neurocognitive impairments are common in people living with HIV. Some conditions, such as chronic inflammation, astrocyte infection and an impaired blood–brain barrier (BBBi), along with host genetic variants in transporter genes, may affect antiretroviral (ARV) exposure in the cerebrospinal fluid (CSF). The aim of this study was to evaluate ARV CSF penetration according to compartmental inflammation, BBB permeability and single-nucleotide polymorphisms (SNPs) in drug transporter encoding genes. CSF neopterin (ELISA), plasma and CSF ARV concentrations (HPLC) and host genetic variants in ABCC2 , HNF4α , SLCO1A2 and SLC22A6 (real-time PCR) were measured. Bi- and multivariate analyses were performed for single ARV and classes. We included 259 participants providing 405 paired plasma and CSF samples. CSF/plasma ratios (CPR) showed an increase for NRTIs and nevirapine with low penetrations for the majority of ARVs. At bi-variate analysis, several associations, including the effect of BBBi (emtricitabine, raltegravir), age (zidovudine and darunavir), and high CSF neopterin (NRTIs and border-line for PIs) were suggested. An association was found between genetic variants and integrase strand transfer ( ABCC2 and HNF4α), non-nucleoside reverse transcriptase inhibitors ( SLCO1A2 ), and protease inhibitors (SLC22A6). At multivariate analysis age, gender, BMI, and altered BBB were independent predictors of nucleoside reverse transcriptase CSF concentrations; age (for protease inhibitors) and body mass index and altered BBB (integrase strand transfer inhibitors) were also associated with ARV CSF exposure. We describe factors associated with CSF concentrations, showing that demographic, BBB integrity and, partially, genetic factors may be predictors of drug passage in the central nervous system.
Keywords	pharmacogenetics ; ART ; CSF ; pharmacokinetics ; neopterin ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2.

D'Avolio, Antonio / Avataneo, Valeria / Manca, Alessandra / Cusato, Jessica / De Nicolò, Amedeo / Lucchini, Renzo / Keller, Franco / Cantù, Marco

Nutrients

2020 Volume 12, Issue 5

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), with a clinical outcome ranging from mild to severe, including death. To date, it is unclear why some patients develop severe symptoms. Many authors ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), with a clinical outcome ranging from mild to severe, including death. To date, it is unclear why some patients develop severe symptoms. Many authors have suggested the involvement of vitamin D in reducing the risk of infections; thus, we retrospectively investigated the 25-hydroxyvitamin D (25(OH)D) concentrations in plasma obtained from a cohort of patients from Switzerland. In this cohort, significantly lower 25(OH)D levels (
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Dietary Supplements ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Polymerase Chain Reaction ; Retrospective Studies ; SARS-CoV-2 ; Switzerland ; Vitamin D/administration & dosage ; Vitamin D/analogs & derivatives ; Vitamin D/blood
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Keywords	covid19
Language	English
Publishing date	2020-05-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12051359
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Article ; Online: Effect of Gender and Age on Voriconazole Trough Concentrations in Italian Adult Patients.

Allegra, Sarah / De Francia, Silvia / De Nicolò, Amedeo / Cusato, Jessica / Avataneo, Valeria / Manca, Alessandra / Antonucci, Miriam / D'Avolio, Antonio

European journal of drug metabolism and pharmacokinetics

2020 Volume 45, Issue 3, Page(s) 405–412

Abstract: Background and objectives: The broad-spectrum triazole antifungal agent, voriconazole, is widely used in the treatment of invasive fungal infections. Its treatment efficacy and the occurrence of adverse events are associated with plasma drug ... ...

Abstract	Background and objectives: The broad-spectrum triazole antifungal agent, voriconazole, is widely used in the treatment of invasive fungal infections. Its treatment efficacy and the occurrence of adverse events are associated with plasma drug concentration, rendering inconsistent or inadequate dosing in many patients. The aim of this study was to evaluate the effect of gender, age, body mass index, ethnicity, serum creatinine and drug dose on voriconazole trough concentration. Methods: A fully validated chromatographic method was used to quantify voriconazole concentration in plasma collected from adult patients at the end of dosing interval. Associations between variables were tested using the Pearson test. The Mann-Whitney U test was used to probe the influence of categorical variables on continuous ones. Results: In a cohort of 330 Italian patients treated with voriconazole, males reported a significantly higher drug concentration than females, with values higher than 1000 ng/mL. Moreover, in the univariate analysis, a significant correlation was found between trough concentration and increasing age. Conclusion: Increasing age and gender could influence voriconazole trough concentrations.
MeSH term(s)	Adult ; Age Factors ; Aged ; Antifungal Agents/administration & dosage ; Antifungal Agents/pharmacokinetics ; Body Mass Index ; Chromatography, High Pressure Liquid ; Cohort Studies ; Creatinine/blood ; Dose-Response Relationship, Drug ; Female ; Humans ; Invasive Fungal Infections/drug therapy ; Italy ; Male ; Middle Aged ; Retrospective Studies ; Sex Factors ; Voriconazole/administration & dosage ; Voriconazole/pharmacokinetics
Chemical Substances	Antifungal Agents ; Creatinine (AYI8EX34EU) ; Voriconazole (JFU09I87TR)
Language	English
Publishing date	2020-01-21
Publishing country	France
Document type	Journal Article
ZDB-ID	196729-0
ISSN	2107-0180 ; 0398-7639 ; 0378-7966
ISSN (online)	2107-0180
ISSN	0398-7639 ; 0378-7966
DOI	10.1007/s13318-019-00603-6
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Article ; Online: LC-MS application for therapeutic drug monitoring in alternative matrices.

Avataneo, Valeria / D'Avolio, Antonio / Cusato, Jessica / Cantù, Marco / De Nicolò, Amedeo

Journal of pharmaceutical and biomedical analysis

2018 Volume 166, Page(s) 40–51

Abstract: Nowadays the practice of therapeutic drug monitoring, consisting in the measurement of drugs concentrations in biological matrices in order to guide possible posological adjustments, is becoming more and more important for the management and optimization ...

Abstract	Nowadays the practice of therapeutic drug monitoring, consisting in the measurement of drugs concentrations in biological matrices in order to guide possible posological adjustments, is becoming more and more important for the management and optimization of several treatments, especially when drugs with narrow therapeutic indexes are administered. Although TDM on plasma samples is currently considered the gold standard, this practice shows some limitations: it requires venous blood sampling, centrifugation and, if necessary, shipment with refrigeration; moreover, drug concentrations in plasma or blood do not necessarily reflect the ones in the target tissues or cells. Therefore, in the recent years great attention has been given to alternative matrices for TDM purpose, in order to reduce invasiveness, costs or to obtain better information about drug concentrations at the active sites. This evolution is strongly sustained by the spreading use of liquid chromatography coupled with mass spectrometry (LC-MS) techniques for the analysis of small molecules, which is constantly increasing sensitivity and specificity of TDM assays. In this review, we present and summarize recently published LC-MS applications providing alternatives to plasma testing, in order to avoid blood withdrawal, plasma separation, refrigerated shipment or, if possible, to obtain better information about drug exposure in target cells. By analyzing the last 5 years of literature, reported in PubMed website, LC-MS/MS applications have been reported, with particular focus on the ones with higher probability to enter in the near future in clinical practice. Microsampling strategies and alternative biological matrices, from urine to tissue samples, have been included.
MeSH term(s)	Chromatography, Liquid/methods ; Drug Monitoring/methods ; Humans ; Tandem Mass Spectrometry/methods
Language	English
Publishing date	2018-12-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2018.12.040
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