LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 553

Search options

  1. Article ; Online: The best place for doravirine.

    Mussini, Cristina / Guaraldi, Giovanni

    The lancet. HIV

    2023  Volume 11, Issue 2, Page(s) e64–e65

    MeSH term(s) Humans ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Reverse Transcriptase Inhibitors/therapeutic use ; Pyridones/therapeutic use ; Triazoles
    Chemical Substances doravirine (913P6LK81M) ; Anti-HIV Agents ; Reverse Transcriptase Inhibitors ; Pyridones ; Triazoles
    Language English
    Publishing date 2023-12-20
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(23)00326-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Another piece in the COVID-19 treatment puzzle.

    Mussini, Cristina / Cozzi-Lepri, Alessandro

    Lancet (London, England)

    2022  Volume 399, Issue 10325, Page(s) 609–610

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00154-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Monkeypox vaccination-an opportunity for HIV prevention.

    Mussini, Cristina / Guaraldi, Giovanni / Orkin, Chloe

    The lancet. HIV

    2022  Volume 9, Issue 11, Page(s) e741–e742

    MeSH term(s) Humans ; Smallpox Vaccine ; HIV Infections/prevention & control ; Mpox (monkeypox)/prevention & control ; Vaccination ; Acquired Immunodeficiency Syndrome
    Chemical Substances Smallpox Vaccine
    Language English
    Publishing date 2022-10-07
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(22)00292-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: The role of antimicrobial stewardship in preventing KPC-producing Klebsiella pneumoniae.

    Carrara, Elena / Conti, Michela / Meschiari, Marianna / Mussini, Cristina

    The Journal of antimicrobial chemotherapy

    2021  Volume 76, Issue Suppl 1, Page(s) i12–i18

    Abstract: Antimicrobial stewardship programmes are widely considered to be a core component of the response to the antimicrobial resistance threat. However, a positive impact of these interventions in terms of microbiological outcomes remains difficult to ... ...

    Abstract Antimicrobial stewardship programmes are widely considered to be a core component of the response to the antimicrobial resistance threat. However, a positive impact of these interventions in terms of microbiological outcomes remains difficult to demonstrate, especially when focusing on specific resistant phenotypes. The first part of this review aims to explore the complex relationship between antibiotic exposure and resistance development in KPC-producing Klebsiella pneumoniae. In the second part we aim to summarize published examples of antimicrobial stewardship interventions intended to impact on the epidemiology of KPC-producing K. pneumoniae. For this purpose, a literature search was performed and seven studies were included in the review. Both restrictive and non-restrictive interventions were associated with an overall reduction in antibiotic consumption, and a decrease in carbapenem resistance rates was observed in five studies. The overall quality of the evidence was low, mainly due to the poor reporting of microbiological outcomes, lack of a control group and suboptimal study design. Although the link between antibiotic use and resistance development is supported by strong evidence, demonstrating the impact of antimicrobial stewardship interventions on microbiological outcomes remains difficult. Studies with adequate design and appropriate outcome measures are needed to further promote antimicrobial stewardship and elucidate which interventions are more successful for controlling the spread of KPC-producing K. pneumoniae.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Bacterial Proteins ; Humans ; Klebsiella Infections/drug therapy ; Klebsiella Infections/prevention & control ; Klebsiella pneumoniae ; Microbial Sensitivity Tests ; beta-Lactamases
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2021-02-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkaa493
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Signals were broadly positive for months, but never definitive: the tocilizumab story.

    Cozzi-Lepri, Alessandro / Smith, Colette / Mussini, Cristina

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 28, Issue 3, Page(s) 371–374

    Abstract: Background: Most treatment guidelines for coronavirus disease 2019 (COVID-19) currently recommend tocilizumab in combination with dexamethasone in critically ill patients who are exhibiting rapid respiratory decompensation.: Aims: To produce a ... ...

    Abstract Background: Most treatment guidelines for coronavirus disease 2019 (COVID-19) currently recommend tocilizumab in combination with dexamethasone in critically ill patients who are exhibiting rapid respiratory decompensation.
    Aims: To produce a critical review and summary of the pathway which led to the repurposing of tocilizumab for COVID-19 treatment, from in vitro observations to guidelines recommendations.
    Sources: All studies evaluating the effectiveness of tocilizumab to treat COVID-19 disease published between July 2020 and July 2021.
    Content: Two large and methodologically well conducted observational studies, the TESEO and the STOP COVID cohorts, showed a reduction in the risk of invasive mechanical ventilation or death in patients treated with tocilizumab as compared to standard of care in 2020. Concomitantly, and up to February 2021, a number of randomized trials (RCTs) with small sample sizes were showing discrepant results. These RCTs had a number of issues: small sample size, various designs and inclusion criteria, and different dosages of tocilizumab used. The confidence interval of the meta-analytic estimate for the RCT results was consistent with the hypothesis of no efficacy of tocilizumab. In our opinion, this was mainly because the meta-analysis included small and heterogeneous studies. These results led to a delay in the inclusion of tocilizumab in guidelines which occurred only in the summer of 2021.
    Implications: Although observational studies are unable to control for unmeasured confounding, they can be put together quickly during a pandemic and promptly provide important information. The large sample size allows us to investigate effect measure modifiers and to better target interventions. It is key that the effect size is somewhat large (RR > 2), all sources of bias are properly accounted for, and the direct evidence is weighted against these factors. It appears to us that for tocilizumab, not having dismissed the results of carefully designed and analysed observational studies in 2020 could have prevented many deaths over those months.
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/drug therapy ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2021-11-09
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.10.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Indications for starting ART.

    Mussini, Cristina / Cossarizza, Andrea

    The lancet. HIV

    2018  Volume 5, Issue 4, Page(s) e157–e158

    MeSH term(s) Anti-HIV Agents ; CD4 Lymphocyte Count ; HIV Infections ; Humans
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2018
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(18)30004-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Measles-induced immune amnesia likely recorded in the 18th century.

    Galassi, Francesco M / Varotto, Elena / Mussini, Cristina / Cossarizza, Andrea

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2021  Volume 141, Page(s) 104899

    MeSH term(s) Amnesia ; Humans ; Measles/epidemiology
    Language English
    Publishing date 2021-07-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2021.104899
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3790: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: COVID-19: Importance of the Awareness of the Clinical Syndrome by Urologists.

    Sighinolfi, Maria Chiara / Rocco, Bernardo / Mussini, Cristina

    European urology

    2020  Volume 78, Issue 1, Page(s) e40–e41

    MeSH term(s) Awareness ; Betacoronavirus ; COVID-19 ; Clinical Competence ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Disease Management ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Urologic Diseases/complications ; Urologic Diseases/therapy ; Urologists/standards
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.03.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Re: 'Methodological evaluation of bias in observational COVID-19 studies on drug effectiveness' by Wolkewitz et al.

    Cozzi-Lepri, Alessandro / Guaraldi, Giovanni / Meschiari, Marianna / Mussini, Cristina

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 27, Issue 7, Page(s) 1043–1044

    MeSH term(s) Bias ; COVID-19 ; Humans ; Pharmaceutical Preparations ; SARS-CoV-2
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2021-05-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.04.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Comment on: Long-term outcome of dolutegravir-containing regimens according to sex: data from the ICONA study.

    Ciccullo, Arturo / Baldin, Gianmaria / Sterrantino, Gaetana / Madeddu, Giordano / D'ettorre, Gabriella / Mussini, Cristina / Di Giambenedetto, Simona

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 7, Page(s) 1808–1809

    MeSH term(s) Humans ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Oxazines/therapeutic use ; Heterocyclic Compounds, 3-Ring/adverse effects ; Pyridones/therapeutic use
    Chemical Substances dolutegravir (DKO1W9H7M1) ; Anti-HIV Agents ; Oxazines ; Heterocyclic Compounds, 3-Ring ; Pyridones
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Letter ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad151
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top