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  1. Article ; Online: Durable Viral Suppression Among Young Adults Living with HIV Receiving Ryan White Services in New York City.

    Feldman, Matthew B / Montero, Noelisa / Thomas, Jacinthe A / Hoffman, Susie / Nguyen, Nadia / Lentz, Cody L / Sukumaran, Stephen / Mellins, Claude A

    AIDS and behavior

    2023  Volume 27, Issue 10, Page(s) 3197–3205

    Abstract: ... received ≥ 1 Ryan White Part A service in New York City from 1/2017 to 12/2019. Individuals were classified ...

    Abstract Identifying factors associated with durable viral suppression (DVS) can inform interventions to support young adults living with HIV (YALWH) in sustaining optimal health. We examined associations between client characteristics and DVS among YALWH aged 18-29 who completed an intake assessment and received ≥ 1 Ryan White Part A service in New York City from 1/2017 to 12/2019. Individuals were classified as achieving DVS at least once if they had ≥ 2 suppressed viral load test results ≥ 90 days apart with: (a) no intervening unsuppressed viral load test results in a 12-month period; and (b) no unsuppressed viral load test results after achieving DVS in that 12-month period. Of 2208 YALWH, 92.1% (n = 2034) had sufficient data in the New York City HIV Surveillance Registry to ascertain DVS status. Of these, 68% achieved DVS at least once. Controlling for ART prescription status at intake, YALWH with higher incomes were significantly more likely to achieve DVS at least once. YALWH with lifetime and recent histories of incarceration and/or drug use were significantly less likely to achieve DVS. Our findings underscore the potential role of tailored harm reduction and post-incarceration programs in reducing health inequities among YALWH.
    MeSH term(s) Humans ; Young Adult ; Harm Reduction ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Income ; New York City/epidemiology
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-023-04040-0
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  2. Article ; Online: Diagnosis and Management of HIV-Associated Pulmonary Diseases in a Ryan White-Funded Primary Care Setting.

    Harrington, Kristin R V / Staitieh, Bashar S / Nguyen, Minh Ly T / Colasanti, Jonathan A / Sumitani, Jieri / Marconi, Vincent C / Auld, Sara C

    AIDS patient care and STDs

    2021  Volume 35, Issue 7, Page(s) 239–248

    Abstract: Despite widespread use of antiretroviral therapy (ART), people with HIV (PWH) continue to suffer substantial morbidity and mortality from pulmonary diseases. We sought to evaluate the prevalence of pulmonary symptoms, evaluations, and diagnoses (both ... ...

    Abstract Despite widespread use of antiretroviral therapy (ART), people with HIV (PWH) continue to suffer substantial morbidity and mortality from pulmonary diseases. We sought to evaluate the prevalence of pulmonary symptoms, evaluations, and diagnoses (both infectious and noninfectious) among PWH receiving care at one of the largest HIV clinics in the United States. All PWH seen at the Infectious Disease Program in Atlanta, Georgia, from July 2013 to June 2018 were included. Multivariable logistic regression was used to assess the odds of all-cause mortality. Among 8387 patients, median age was 48 years, 35% had documented smoking, 74% were male, and the 47% with ≥1 pulmonary symptom or diagnosis were older and had higher rates of smoking compared to those without any symptoms or diagnoses (
    MeSH term(s) Cohort Studies ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Lung Diseases/diagnosis ; Lung Diseases/epidemiology ; Male ; Middle Aged ; Primary Health Care ; Smoking ; United States/epidemiology
    Language English
    Publishing date 2021-07-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1326868-5
    ISSN 1557-7449 ; 0893-5068 ; 1087-2914
    ISSN (online) 1557-7449
    ISSN 0893-5068 ; 1087-2914
    DOI 10.1089/apc.2021.0020
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  3. Article ; Online: Short communication: spectrum of non-Hodgkin lymphoma in an urban Ryan White-funded clinic in the established antiretroviral era.

    Silverton, Alexandra / Gunthel, Clifford / Adamski, Marylyn / Mosunjac, Marina / Nguyen, Minh Ly

    AIDS research and human retroviruses

    2014  Volume 30, Issue 7, Page(s) 665–669

    Abstract: People living with HIV/AIDS (PLWHA) are at a higher risk of developing non-Hodgkin lymphoma (NHL). The influence of combined antiretrovirals (cART) on the presentation, treatment, and outcomes of HIV-associated NHL (HIV-NHL) warrants further ... ...

    Abstract People living with HIV/AIDS (PLWHA) are at a higher risk of developing non-Hodgkin lymphoma (NHL). The influence of combined antiretrovirals (cART) on the presentation, treatment, and outcomes of HIV-associated NHL (HIV-NHL) warrants further investigation. We performed a retrospective analysis of PLWHA diagnosed with NHL who received care at the Infectious Diseases Ponce de Leon Center in Atlanta, Georgia, from January 1, 2004 to December 31, 2010. Thirty-five patients with HIV-NHL were identified. Among these patients, 7 had Burkitt lymphoma (BL), 20 had diffuse large B cell lymphoma (DLBCL), 7 had plasmablastic lymphoma (PL), and 1 had primary effusion lymphoma (PEL). The majority of patients (82.9%) presented with advanced disease, and 63% were not on ART at diagnosis. Despite having good performance status at presentation, the majority of patients presented with high International Prognostic Index (IPI) scores. There were differences between the histologic subtypes of NHL in regard to treatment, complications, and outcomes. The median CD4 lymphocyte count at diagnosis was 110 cells/mm(3) for patients with DLBCL [interquartile range (IQR): 66, 203], 165 cells/mm(3) for Burkitt lymphoma (IQR: 36, 199), and 98 cells/mm(3) for plasmablastic lymphoma (IQR: 34, 214). Overall, patients completed 67% of planned chemotherapy cycles. Common causes for chemotherapy termination were persistent myelosuppression (18.2%), social factors (22.7%), and disease progression (36.4%). Social factors included lack of transportation, substance abuse, unstable housing, and poor adherence. Two-year overall survival was 40% for all HIV-NHL. Half of the patients with DLBCL (n=10), 42% of patients with PL (n=3), and only 14.3% of patients with BL (n=1) were alive at 2 years. Among the overall survivors at 2 years, 85.7% had CD4 >200 cells/mm(3) and 78.6% had undetectable HIV viral loads (VL) at that time.
    MeSH term(s) Acquired Immunodeficiency Syndrome/drug therapy ; Acquired Immunodeficiency Syndrome/epidemiology ; Adult ; Anti-Retroviral Agents/therapeutic use ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Burkitt Lymphoma/drug therapy ; Burkitt Lymphoma/epidemiology ; CD4 Lymphocyte Count ; Cyclophosphamide/therapeutic use ; Disease Progression ; Doxorubicin/therapeutic use ; Female ; Hepatitis B/complications ; Hepatitis B/virology ; Humans ; Lymphoma, AIDS-Related/drug therapy ; Lymphoma, AIDS-Related/epidemiology ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/epidemiology ; Lymphoma, Primary Effusion/drug therapy ; Lymphoma, Primary Effusion/epidemiology ; Male ; Middle Aged ; Prednisone/therapeutic use ; Retrospective Studies ; Rituximab ; Vincristine/therapeutic use ; Viral Load
    Chemical Substances Anti-Retroviral Agents ; Antibodies, Monoclonal, Murine-Derived ; Antineoplastic Agents ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2014-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2013.0188
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    Zs.A 1928: Show issues Location:
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  4. Article ; Online: promSEMBLE: Hard Pattern Mining and Ensemble Learning for Detecting DNA Promoter Sequences.

    Nagda, Bindi M / Nguyen, Van Minh / White, Ryan T

    IEEE/ACM transactions on computational biology and bioinformatics

    2024  Volume 21, Issue 1, Page(s) 208–214

    Abstract: Accurate identification of DNA promoter sequences is of crucial importance in unraveling the underlying mechanisms that regulate gene transcription. Initiation of transcription is controlled through regulatory transcription factors binding to promoter ... ...

    Abstract Accurate identification of DNA promoter sequences is of crucial importance in unraveling the underlying mechanisms that regulate gene transcription. Initiation of transcription is controlled through regulatory transcription factors binding to promoter core regions in the DNA sequence. Detection of promoter regions is necessary if we are to build genetic regulatory networks for biomedical and clinical applications, and for identification of rarely expressed genes. We propose a novel ensemble learning technique using deep recurrent neural networks with convolutional feature extraction and hard negative pattern mining to detect several types of promoter sequences, including promoter sequences with the TATA-box and without the TATA-box, within DNA sequences of four different species. Using extensive independent tests and previously published results, we demonstrate that our method sets a new state-of-the-art of over 98% Matthews correlation coefficient in all eight organism categories for recognizing the stretch of base pairs that code for the promoter region within DNA sequences.
    MeSH term(s) Base Sequence ; Promoter Regions, Genetic/genetics ; TATA Box ; DNA/genetics ; Machine Learning ; Transcription, Genetic
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 1557-9964
    ISSN (online) 1557-9964
    DOI 10.1109/TCBB.2023.3339597
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  5. Article ; Online: Identifying Sources of Inter-hospital Variation in Episode Spending for Sepsis Care.

    Sankaran, Roshun / Gulseren, Baris / Prescott, Hallie C / Langa, Kenneth M / Nguyen, Thuy / Ryan, Andrew M

    Medical care

    2024  

    Abstract: Objective: To evaluate inter-hospital variation in 90-day total episode spending for sepsis, estimate the relative contributions of each component of spending, and identify drivers of spending across the distribution of episode spending on sepsis care.!# ...

    Abstract Objective: To evaluate inter-hospital variation in 90-day total episode spending for sepsis, estimate the relative contributions of each component of spending, and identify drivers of spending across the distribution of episode spending on sepsis care.
    Data sources/study setting: Medicare fee-for-service claims for beneficiaries (n=324,694) discharged from acute care hospitals for sepsis, defined by MS-DRG, between October 2014 and September 2018.
    Research design: Multiple linear regression with hospital-level fixed effects was used to identify average hospital differences in 90-day episode spending. Separate multiple linear regression and quantile regression models were used to evaluate drivers of spending across the episode spending distribution.
    Results: The mean total episode spending among hospitals in the most expensive quartile was $30,500 compared with $23,150 for the least expensive hospitals (P<0.001). Postacute care spending among the most expensive hospitals was almost double that of least expensive hospitals ($7,045 vs. $3,742), accounting for 51% of the total difference in episode spending between the most expensive and least expensive hospitals. Female patients, patients with more comorbidities, urban hospitals, and BPCI-A-participating hospitals were associated with significantly increased episode spending, with the effect increasing at the right tail of the spending distribution.
    Conclusion: Inter-hospital variation in 90-day episode spending on sepsis care is driven primarily by differences in post-acute care spending.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 411646-x
    ISSN 1537-1948 ; 0025-7079
    ISSN (online) 1537-1948
    ISSN 0025-7079
    DOI 10.1097/MLR.0000000000002000
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  6. Article ; Online: The Everlasting Effects of the Covid-19 Pandemic on Oral and Maxillofacial Surgery Residency Match.

    Maloney, Katelyn O / Nguyen, Ryan M / Ford, Brian P

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

    2023  Volume 81, Issue 6, Page(s) 661–662

    MeSH term(s) Humans ; COVID-19/epidemiology ; Internship and Residency ; Pandemics/prevention & control ; SARS-CoV-2 ; Surgery, Oral
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392404-x
    ISSN 1531-5053 ; 0278-2391
    ISSN (online) 1531-5053
    ISSN 0278-2391
    DOI 10.1016/j.joms.2023.02.002
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  7. Article ; Online: Rehabilitation considerations for palato-pharyngo-laryngeal myoclonus associated dysphagia.

    Chiang, Cheng-Chuan / Masterson, Ryan / T Nguyen, Eric / Azola, Alba

    PM & R : the journal of injury, function, and rehabilitation

    2023  

    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Letter
    ZDB-ID 2608988-9
    ISSN 1934-1563 ; 1934-1482
    ISSN (online) 1934-1563
    ISSN 1934-1482
    DOI 10.1002/pmrj.13080
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  8. Article ; Online: Who enjoys solitude? autonomous functioning (but not introversion) predicts self-determined motivation (but not preference) for solitude.

    Nguyen, Thuy-Vy T / Weinstein, Netta / Ryan, Richard M

    PloS one

    2022  Volume 17, Issue 5, Page(s) e0267185

    Abstract: Within the solitude literature, two discrete constructs reflect different perspectives on how time spent alone is motivated. Self-determined motivation for solitude reflects wanting time alone to find enjoyment and gain meaningful benefits from it, ... ...

    Abstract Within the solitude literature, two discrete constructs reflect different perspectives on how time spent alone is motivated. Self-determined motivation for solitude reflects wanting time alone to find enjoyment and gain meaningful benefits from it, whereas preference for solitude concerns wanting time for oneself over others' company regardless of reasons for why time alone is wanted. We investigated two personality characteristics: introversion from Big-Five personality theory and dispositional autonomy from self-determination theory. In two diary studies university students completed personality measures and reported about their experiences with time spent alone over a period of seven days. Across both studies, contrary to popular belief that introverts spend time alone because they enjoy it, results showed no evidence that introversion is predictive of either preference or motivation for solitude. Dispositional autonomy-the tendency to regulate from a place of self-congruence, interest, and lack of pressure-consistently predicted self-determined motivation for solitude but was unrelated to preference for solitude. These findings provided evidence supporting the link between valuing time spent alone with individual differences in the capacity to self-regulate in choiceful and authentic way.
    MeSH term(s) Humans ; Introversion, Psychological ; Motivation ; Personal Autonomy ; Personality ; Pleasure
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0267185
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  9. Article ; Online: Precision Doppler shift measurements with a frequency comb calibrated laser heterodyne radiometer.

    Cole, Ryan K / Fredrick, Connor / Nguyen, Newton H / Diddams, Scott A

    Optics letters

    2023  Volume 48, Issue 20, Page(s) 5185–5188

    Abstract: We report precision atmospheric spectroscopy of ... ...

    Abstract We report precision atmospheric spectroscopy of CO
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.500652
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  10. Article ; Online: Stereocontrolled Access to Quaternary Centers by Birch Reduction/Alkylation of Chiral Esters of Salicylic Acids.

    Kozlowski, Ryan A / Nguyen, Hanh T / Lehman, Michael E / Vanderwal, Christopher D

    The Journal of organic chemistry

    2023  Volume 88, Issue 9, Page(s) 6232–6236

    Abstract: 8-Phenylmenthol esters of salicylic acid derivatives undergo efficient Birch reduction ... ...

    Abstract 8-Phenylmenthol esters of salicylic acid derivatives undergo efficient Birch reduction and
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c00306
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