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  1. Article ; Online: Challenges in the development of novel therapies, vaccines and siRNAs for the treatment of hypertension.

    Nakagami, Hironori

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 7, Page(s) 1812–1815

    MeSH term(s) RNA, Small Interfering/genetics ; RNA, Small Interfering/therapeutic use ; Antihypertensive Agents ; Vaccines ; Receptors, Adrenergic ; Immunotherapy, Active
    Chemical Substances RNA, Small Interfering ; Antihypertensive Agents ; Vaccines ; Receptors, Adrenergic
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01302-1
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    Zs.A 3898: Show issues Location:
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  2. Article ; Online: Mechanisms underlying the bidirectional association between nonalcoholic fatty liver disease and hypertension.

    Nakagami, Hironori

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 46, Issue 2, Page(s) 539–541

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/complications ; Prospective Studies ; Insulin Resistance ; Hypertension/complications
    Language English
    Publishing date 2022-12-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-01117-6
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  3. Article ; Online: New wave of digital hypertension management for clinical applications.

    Nakagami, Hironori

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 45, Issue 10, Page(s) 1549–1551

    MeSH term(s) Blood Pressure/physiology ; Blood Pressure Monitoring, Ambulatory/instrumentation ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology ; Stress, Psychological ; Wearable Electronic Devices
    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-00977-2
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  4. Article ; Online: Development of COVID-19 vaccines utilizing gene therapy technology.

    Nakagami, Hironori

    International immunology

    2021  Volume 33, Issue 10, Page(s) 521–527

    Abstract: There is currently an outbreak of respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) is caused by infection with SARS-CoV-2. Individuals with COVID-19 have symptoms that are ... ...

    Abstract There is currently an outbreak of respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) is caused by infection with SARS-CoV-2. Individuals with COVID-19 have symptoms that are usually asymptomatic or mild in most initial cases. However, in some cases, moderate and severe symptoms have been observed with pneumonia. Many companies are developing COVID-19 vaccine candidates using different technologies that are classified into four groups (intact target viruses, proteins, viral vectors and nucleic acids). For rapid development, RNA vaccines and adenovirus vector vaccines have been urgently approved, and their injection has already started across the world. These types of vaccine technologies have been developed over more than 20 years using translational research for use against cancer or diseases caused by genetic disorders but the COVID-19 vaccines are the first licensed drugs to prevent infectious diseases using RNA vaccine technology. Although these vaccines are highly effective in preventing COVID-19 for a short period, safety and efficiency evaluations should be continuously monitored over a long time period. As the time of writing, more than 10 projects are now in phase 3 to evaluate the prevention of infection in double-blind studies. Hopefully, several projects may be approved to ensure high-efficiency and safe vaccines.
    MeSH term(s) Animals ; COVID-19/immunology ; COVID-19 Vaccines/immunology ; Double-Blind Method ; Genetic Therapy/methods ; Humans ; SARS-CoV-2/immunology ; Technology/methods ; Vaccines, Synthetic/immunology ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines, Synthetic
    Language English
    Publishing date 2021-03-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxab013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Development of therapeutic vaccine for life style-related diseases].

    Nakagami, Hironori

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2019  Volume 154, Issue 5, Page(s) 270–274

    Abstract: ... In the ... ...

    Abstract In the 18
    MeSH term(s) Humans ; Hypertension/therapy ; Life Style ; Vaccines/therapeutic use
    Chemical Substances Vaccines
    Language Japanese
    Publishing date 2019-11-08
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.154.270
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  6. Article ; Online: Cellular senescence and senescence-associated T cells as a potential therapeutic target.

    Nakagami, Hironori

    Geriatrics & gerontology international

    2019  Volume 20, Issue 2, Page(s) 97–100

    Abstract: More than 50 years ago, Hayflick et al. found that no long-lived, proliferative cells remained in long-term cell culture experiments; this phenomenon is called "cellular senescence." This finding has allowed us to understand basic individual tissue aging ...

    Abstract More than 50 years ago, Hayflick et al. found that no long-lived, proliferative cells remained in long-term cell culture experiments; this phenomenon is called "cellular senescence." This finding has allowed us to understand basic individual tissue aging and cancer inhibition from the view of cellular aging. Senescent cells survive and accumulate in the body, and secrete various inflammatory cytokines or chemokines, which is different from the cell fate in apoptosis. These phenomena describe the so-called senescence-associated secretory phenotype, and chronic inflammation and carcinogenesis are induced in the surrounding tissue through senescence-associated secretory phenotype factors. For example, senescence-associated T cells are an age-dependent CD4(
    MeSH term(s) Aging/physiology ; Apoptosis ; Cellular Senescence/physiology ; Humans ; Inflammation ; Neoplasms/therapy ; Phenotype ; T-Lymphocytes/immunology
    Language English
    Publishing date 2019-12-14
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.13851
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    Zs.A 5801: Show issues Location:
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  7. Article ; Online: Monitoring with wearable devices will clarify the association between indoor temperature and blood pressure.

    Nakagami, Hironori / Otsuka, Hiroki / Akiyama, Hitoshi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 6, Page(s) 1450–1455

    Abstract: The association of blood pressure and temperature is well known in seasonal observation, and low temperature in the winter season is often considered a cause of high blood pressure. The current evidence for short-term studies of temperature and blood ... ...

    Abstract The association of blood pressure and temperature is well known in seasonal observation, and low temperature in the winter season is often considered a cause of high blood pressure. The current evidence for short-term studies of temperature and blood pressure is based on the daily observation, however continuous monitoring with wearable devices will allow us to evaluate the rapid effect of cold temperature exposure on blood pressure. In a Japanese, prospective intervention study from 2014 to 2019 (the Smart Wellness Housing survey), approximately 90% of Japanese lived in cold houses (indoor temperature less than 18 °C). Importantly, the indoor temperature was associated with the increase of morning systolic blood pressure. We recently addressed the sympathetic nervous activation of individuals in both their houses and a highly insulated and airtight model house in the winter season using portable electrocardiography equipment. A few subjects showed a morning surge in sympathetic activity, which was more intense at their cold houses, which suggests the importance of the indoor environment in the management of early morning hypertension. In near future, real-time monitoring with wearable devices will provide important information for a better life-environment, leading to risk reduction of morning surge and cardiovascular events.
    MeSH term(s) Humans ; Blood Pressure/physiology ; Temperature ; Prospective Studies ; Hypertension ; Blood Pressure Monitoring, Ambulatory ; Wearable Electronic Devices
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01261-7
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    Zs.A 3898: Show issues Location:
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  8. Article ; Online: Design of therapeutic vaccines as a novel antibody therapy for cardiovascular diseases.

    Nakagami, Hironori

    Journal of cardiology

    2017  Volume 70, Issue 3, Page(s) 201–205

    Abstract: Vaccines are primarily used worldwide as a preventive medicine for infectious diseases and have recently been applied to cancer. We and others have developed therapeutic vaccines designed for cardiovascular diseases that are notably different from ... ...

    Abstract Vaccines are primarily used worldwide as a preventive medicine for infectious diseases and have recently been applied to cancer. We and others have developed therapeutic vaccines designed for cardiovascular diseases that are notably different from previous vaccines. In the case of cancer vaccines, a specific protein in cancer cells is a target antigen, and the activation of cytotoxic T cells (CTL) is required to kill and remove the antigen-presenting cancer cells. Our therapeutic vaccines work against hypertension by targeting angiotensin II (Ang II) as the antigen, which is an endogenous hormone. Therapeutic vaccines must avoid CTL activation and induce the blocking antibodies for Ang II. The goal of our therapeutic vaccine for cardiovascular diseases is to induce the specific antibody response toward the target protein without inducing T-cell or antibody-mediated inflammation through the careful selection of the target antigen, carrier protein and adjuvants. The goal of our therapeutic vaccine is similar to that of antibody therapy. Recently, multiple antibody-based drugs have been developed for cancer, immune-related diseases, and dyslipidemia, which are efficient but expensive. If the effect of a therapeutic vaccine is nearly equivalent to antibody therapy as an alternative approach, the lower medical cost and improvement in drug adherence can be advantages of therapeutic vaccines. In this review, we will describe our concept of therapeutic vaccines for cardiovascular diseases and the future directions of therapeutic vaccines as novel antibody therapies.
    Language English
    Publishing date 2017-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 639364-0
    ISSN 1876-4738 ; 0386-2887 ; 0914-5087
    ISSN (online) 1876-4738
    ISSN 0386-2887 ; 0914-5087
    DOI 10.1016/j.jjcc.2017.01.010
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  9. Article ; Online: Blood pressure fluctuations and the indoor environment in a highly insulated and airtight model house during the cold winter season.

    Nakagami, Hironori / Akiyama, Hiroshi / Otsuka, Hiroki / Iwamae, Atsushi / Yamada, Hidekazu

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 45, Issue 7, Page(s) 1217–1219

    MeSH term(s) Blood Pressure ; Seasons
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Letter
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-00928-x
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  10. Article ; Online: Evaluation of the genetic risk of hypertension-related diseases.

    Nakagami, Hironori

    Circulation journal : official journal of the Japanese Circulation Society

    2015  Volume 79, Issue 4, Page(s) 756–757

    MeSH term(s) Blood Pressure/genetics ; Coronary Artery Disease/genetics ; Cyclins/genetics ; Female ; Genetic Loci ; Humans ; Male ; Plasma Membrane Calcium-Transporting ATPases/genetics ; Polymorphism, Single Nucleotide
    Chemical Substances ATP2B1 protein, human ; CNNM2 protein, human ; Cyclins ; Plasma Membrane Calcium-Transporting ATPases (EC 3.6.3.8)
    Language English
    Publishing date 2015-02-25
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-15-0178
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