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  1. Article ; Online: Immunoglobulin G Immune Complexes May Contribute to Neutrophil Activation in the Course of Severe Coronavirus Disease 2019.

    Mazzitelli, Ignacio / Bleichmar, Lucia / Ludueña, María Guillermina / Pisarevsky, Andrea / Labato, Mariana / Chiaradia, Verónica / Finocchieto, Paola / Paulin, Francisco / Hormanstorfer, Macarena / Baretto, María Constanza / Adanza, Santiago Piombi / Parodi, María Noel / Ragusa, Martín / Melucci, Claudia / Díaz, Fernando Erra / Paletta, Ana / Di Diego, Facundo / Ceballos, Ana / Geffner, Jorge

    The Journal of infectious diseases

    2021  Volume 224, Issue 4, Page(s) 575–585

    Abstract: Severe coronavirus disease 2019 (COVID-19) is associated with an overactive inflammatory response mediated by macrophages. Here, we analyzed the phenotype and function of neutrophils in patients with COVID-19. We found that neutrophils from patients with ...

    Abstract Severe coronavirus disease 2019 (COVID-19) is associated with an overactive inflammatory response mediated by macrophages. Here, we analyzed the phenotype and function of neutrophils in patients with COVID-19. We found that neutrophils from patients with severe COVID-19 express high levels of CD11b and CD66b, spontaneously produce CXCL8 and CCL2, and show a strong association with platelets. Production of CXCL8 correlated with plasma concentrations of lactate dehydrogenase and D-dimer. Whole blood assays revealed that neutrophils from patients with severe COVID-19 show a clear association with immunoglobulin G (IgG) immune complexes. Moreover, we found that sera from patients with severe disease contain high levels of immune complexes and activate neutrophils through a mechanism partially dependent on FcγRII (CD32). Interestingly, when integrated in immune complexes, anti-severe acute respiratory syndrome coronavirus 2 IgG antibodies from patients with severe COVID-19 displayed a higher proinflammatory profile compared with antibodies from patients with mild disease. Our study suggests that IgG immune complexes might promote the acquisition of an inflammatory signature by neutrophils, worsening the course of COVID-19.
    MeSH term(s) Adult ; Aged ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antigen-Antibody Complex/blood ; Antigen-Antibody Complex/immunology ; Antigens, CD/immunology ; CD11b Antigen/immunology ; COVID-19/immunology ; Cell Adhesion Molecules/immunology ; Female ; GPI-Linked Proteins/immunology ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Interleukin-8/immunology ; Male ; Middle Aged ; Neutrophil Activation/immunology ; Neutrophils/immunology ; Receptors, IgG/immunology ; SARS-CoV-2/immunology ; Young Adult
    Chemical Substances Antibodies, Viral ; Antigen-Antibody Complex ; Antigens, CD ; CD11b Antigen ; CEACAM8 protein, human ; CXCL8 protein, human ; Cell Adhesion Molecules ; GPI-Linked Proteins ; Immunoglobulin G ; Interleukin-8 ; Receptors, IgG
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Development of Simple and Sensitive Score to Assess the Risk of Pneumonia in COVID-19 Patients.

    Hormanstorfer, Macarena / Ragusa, Martin A / Poggio, Lucia / Moreira-Facundo, Jorge / Orellana-Villa, Zulma / Bobrowski, Florencia A / Martinez-Serventi, Joaquin / Piombi Adanza, Santiago N / Enrique Barletta, Jose A / Sisto, Alicia / Delle-Piane, Hugo / Carrillo, Juan M / Presas, Jose L / Paulin, Francisco

    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

    2020  Volume 73, Issue 1, Page(s) 52–58

    Abstract: Background: Severe pneumonia is the most common cause of intensive care unit (ICU) admission and death due to novel coronavirus (SARS-CoV-2) respiratory disease (COVID-19). Due to its rapid outbreak, units for the evaluation of febrile patients in the ... ...

    Abstract Background: Severe pneumonia is the most common cause of intensive care unit (ICU) admission and death due to novel coronavirus (SARS-CoV-2) respiratory disease (COVID-19). Due to its rapid outbreak, units for the evaluation of febrile patients in the pre-hospital setting were created.
    Objective: The objective of the study was to develop a sensitive and simple tool to assess the risk of pneumonia in COVID-19 patients and thus select which patients would require a chest imaging study.
    Materials and methods: We conducted a cross-sectional study in a cohort of individuals with suspected COVID-19 evaluated in a public academic healthcare center in Buenos Aires city. All adult patients with positive RT-PCR assay for SARS-COV2 between April 24 and May 19 of 2020 were included in the study. Pneumonia was defined as the presence of compatible signs and symptoms with imaging confirmation. Univariate and multivariate logistic regression was performed. A risk indicator score was developed.
    Results: One hundred and forty-eight patients were included, 71 (48%) received the diagnosis of pneumonia. The final clinical model included four variables: age >- 40 years, cough, absence of sore throat, and respiratory rate >- 22. To create the score, we assigned values to the variables according to their ORs: 2 points for respiratory rate >- 22 and 1 point to the other variables. The AUC of the ROC curve was 0.80 (CI 95% 0.73-0.86). A cutoff value of 2 showed a sensitivity of 95.7% and a specificity of 43.24%.
    Conclusion: This sensible score may improve the risk stratification of COVID-19 patients in the pre-hospital setting.
    MeSH term(s) Adolescent ; Adult ; Argentina ; COVID-19/complications ; COVID-19/diagnosis ; Cohort Studies ; Cross-Sectional Studies ; Female ; Fever/diagnosis ; Fever/virology ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/etiology ; Prospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; Risk ; Sensitivity and Specificity ; Severity of Illness Index ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-10-19
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 138348-6
    ISSN 0034-8376
    ISSN 0034-8376
    DOI 10.24875/RIC.20000295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Development of Simple and Sensitive Score to Assess the Risk of Pneumonia in COVID-19 Patients

    Hormanstorfer, Macarena / Ragusa, Martin A / Poggio, Lucia / Moreira-Facundo, Jorge / Orellana-Villa, Zulma / Bobrowski, Florencia A / Martinez-Serventi, Joaquin / Piombi Adanza, Santiago N / Enrique Barletta, Jose A / Sisto, Alicia / Delle-Piane, Hugo / Carrillo, Juan M / Presas, Jose L / Paulin, Francisco

    Rev. invest. clin

    Abstract: BACKGROUND: Severe pneumonia is the most common cause of intensive care unit (ICU) admission and death due to novel coronavirus (SARS-CoV-2) respiratory disease (COVID-19). Due to its rapid outbreak, units for the evaluation of febrile patients in the ... ...

    Abstract BACKGROUND: Severe pneumonia is the most common cause of intensive care unit (ICU) admission and death due to novel coronavirus (SARS-CoV-2) respiratory disease (COVID-19). Due to its rapid outbreak, units for the evaluation of febrile patients in the pre-hospital setting were created. OBJECTIVE: The objective of the study was to develop a sensitive and simple tool to assess the risk of pneumonia in COVID-19 patients and thus select which patients would require a chest imaging study. MATERIALS AND METHODS: We conducted a cross-sectional study in a cohort of individuals with suspected COVID-19 evaluated in a public academic healthcare center in Buenos Aires city. All adult patients with positive RT-PCR assay for SARS-COV2 between April 24 and May 19 of 2020 were included in the study. Pneumonia was defined as the presence of compatible signs and symptoms with imaging confirmation. Univariate and multivariate logistic regression was performed. A risk indicator score was developed. RESULTS: One hundred and forty-eight patients were included, 71 (48%) received the diagnosis of pneumonia. The final clinical model included four variables: age >- 40 years, cough, absence of sore throat, and respiratory rate >- 22. To create the score, we assigned values to the variables according to their ORs: 2 points for respiratory rate >- 22 and 1 point to the other variables. The AUC of the ROC curve was 0.80 (CI 95% 0.73-0.86). A cutoff value of 2 showed a sensitivity of 95.7% and a specificity of 43.24%. CONCLUSION: This sensible score may improve the risk stratification of COVID-19 patients in the pre-hospital setting.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #875093
    Database COVID19

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  4. Article ; Online: Biomarkers of Progression after HIV Acute/Early Infection: Nothing Compares to CD4⁺ T-cell Count?

    Turk, Gabriela / Ghiglione, Yanina / Hormanstorfer, Macarena / Laufer, Natalia / Coloccini, Romina / Salido, Jimena / Trifone, César / Ruiz, María Julia / Falivene, Juliana / Holgado, María Pía / Caruso, María Paula / Figueroa, María Inés / Salomón, Horacio / Giavedoni, Luis D / Pando, María de Los Ángeles / Gherardi, María Magdalena / Rabinovich, Roberto Daniel / Pury, Pedro A / Sued, Omar

    Viruses

    2018  Volume 10, Issue 1

    Abstract: Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees. A ... ...

    Abstract Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees. A total of seventy-five treatment-naïve subjects were enrolled during acute/early HIV infection. CD4⁺ T-cell counts (CD4TC) and viral load (VL) levels were determined at enrollment and for one year. Immune activation, HIV-specific immune response, Human Leukocyte Antigen (HLA) and C-C chemokine receptor type 5 (CCR5) genotypes, and plasma levels of 39 cytokines were determined. Data were analyzed by machine learning and non-parametric methods. Variable hierarchization was performed by Weka correlation-based feature selection and J48 decision tree. Plasma interleukin (IL)-10, interferon gamma-induced protein (IP)-10, soluble IL-2 receptor alpha (sIL-2Rα) and tumor necrosis factor alpha (TNF-α) levels correlated directly with baseline VL, whereas IL-2, TNF-α, fibroblast growth factor (FGF)-2 and macrophage inflammatory protein (MIP)-1β correlated directly with CD4⁺ T-cell activation (
    MeSH term(s) Acute Disease ; Adult ; Biomarkers/blood ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology ; Chemokine CXCL10/blood ; Cytokines/immunology ; Disease Progression ; Female ; HIV Infections/blood ; HIV Infections/diagnosis ; HIV-1 ; Humans ; Male ; Receptors, CCR5/blood ; Viral Load
    Chemical Substances Biomarkers ; CCR5 protein, human ; CXCL10 protein, human ; Chemokine CXCL10 ; Cytokines ; Receptors, CCR5
    Language English
    Publishing date 2018-01-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v10010034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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