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  1. Article ; Online: Bilateral Hypopyon in a Young Woman.

    Sechrist, Samantha J / Zhang, Yi Stephanie / Brodie, Frank L

    JAMA ophthalmology

    2023  Volume 141, Issue 6, Page(s) 598–599

    MeSH term(s) Female ; Humans ; Suppuration
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2023.0939
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    In stock of ZB MED Cologne/Königswinter

    Ul I Zs.26: Show issues Location:
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  2. Article ; Online: A young man with red eye.

    Chang, Chun-Hsiang / Huang, Yi-Hsun

    BMJ (Clinical research ed.)

    2022  Volume 376, Page(s) e064287

    MeSH term(s) Adult ; Conjunctivitis, Bacterial/diagnosis ; Conjunctivitis, Bacterial/microbiology ; Diagnosis, Differential ; Eye/microbiology ; Humans ; Male ; Medical Illustration ; Neisseria gonorrhoeae ; Neisseriaceae Infections/diagnosis
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2021-064287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Young Man with Epigastric Pain.

    Lin, Cheng-Han / Yang, Chih-Jen / Tsai, Yi-Da / Yang, Chih-Wei / Ke, Hung-Yen / Chou, Hua-Kang

    Annals of emergency medicine

    2022  Volume 80, Issue 3, Page(s) e25–e26

    MeSH term(s) Abdominal Pain/diagnostic imaging ; Abdominal Pain/etiology ; Humans ; Male
    Language English
    Publishing date 2022-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2022.04.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1344: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: “My young life, finished already?”

    Aysha Farwin / Amanda Low / Natasha Howard / Huso Yi

    Globalization and Health, Vol 19, Iss 1, Pp 1-

    a qualitative study of embedded social stressors and their effects on mental health of low-wage male migrant workers in Singapore

    2023  Volume 16

    Abstract: Abstract Background Increasing evidence shows low-wage migrant workers experience a high prevalence of mental health disorders and adverse health outcomes. Significant disparities in health services usage among migrant workers create added vulnerability ... ...

    Abstract Abstract Background Increasing evidence shows low-wage migrant workers experience a high prevalence of mental health disorders and adverse health outcomes. Significant disparities in health services usage among migrant workers create added vulnerability to health complications. However, much remains unclear about how vulnerabilities are constructed in migrant worker populations. Additionally, no studies in Singapore have attempted to critically examine the degree to which social environment and structures affect the health and wellbeing of migrant workers. Therefore, this study aimed to critically situate the socio-structural factors creating conditions of vulnerability among migrant workers using a social stress perspective. Methods We conducted semi-structured individual and group interviews with migrant workers focused on individual life experiences, community experiences (individual and collective social capital), health (mental and physical health concerns) and stress response behaviours. We used a grounded theory approach to identify sources of stress and stress responses and uncover pathways to social vulnerabilities. Results Findings from 21 individual and 2 group interviews revealed that migrant workers were embedded in a cycle of chronic stress driven by structural factors that were mutually reinforced by stressors arising from their social environment. Socio-structural stressors enacted as poor living, working and social conditions resulted in their negative quality-of-life appraisal. Stressors arising from being “foreign” resulted in anticipated stigma, concealment, and healthcare avoidance. These factors synergistically created a persistent mental health burden for migrant workers. Conclusions Findings highlight the need to address the mental health burden placed on migrant workers and create avenues for migrant workers to seek psychosocial support to manage their stressors.
    Keywords Migrant workers ; Social stress ; Vulnerability ; Mental health ; Stress responses ; Health inequity ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Erythematous flexural eruption in a young man.

    Kuo, Yi-Wen

    Clinical and experimental dermatology

    2022  Volume 47, Issue 11, Page(s) 2052–2054

    Abstract: A young man presented with a 2-week history of well-defined erythematous plaques symmetrically ...

    Abstract A young man presented with a 2-week history of well-defined erythematous plaques symmetrically distributed in multiple intertriginous areas. He had received topical corticosteroids, antifungals and oral prednisolone without improvement. Histopathological examination revealed confluent parakeratosis with retention of basophilic keratohyalin granules within the stratum corneum. Click here for the corresponding questions to this CME article.
    MeSH term(s) Humans ; Male ; Antifungal Agents/therapeutic use ; Parakeratosis/pathology ; Epidermis/pathology ; Exanthema/pathology ; Prednisolone/therapeutic use ; Adrenal Cortex Hormones
    Chemical Substances Antifungal Agents ; Prednisolone (9PHQ9Y1OLM) ; Adrenal Cortex Hormones
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/ced.15331
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1278: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Young Professionals in Neuroradiology: Opportunities, Challenges, and Future Directions.

    Trofimova, Anna V / Li, Yi / Mazaheri, Parisa / Krishnan, Arun / Payabvash, Seyedmehdi / Kappelhof, Manon / Gadde, Judith A

    AJNR. American journal of neuroradiology

    2024  Volume 45, Issue 3, Page(s) 256–261

    Abstract: The Young Professionals Committee of the American Society of Neuroradiology identifies and serves ... the interests of young professionals in neuroradiology, defined as those still in training or within 5 years ... of its completion. Being a young professional is an exciting, dynamic, and demanding stage of one's professional ...

    Abstract The Young Professionals Committee of the American Society of Neuroradiology identifies and serves the interests of young professionals in neuroradiology, defined as those still in training or within 5 years of its completion. Being a young professional is an exciting, dynamic, and demanding stage of one's professional career. As the landscape of neuroradiology practice changes, new opportunities and challenges occur for those in the early stage of their career. It is important to recognize and support the needs of young professionals because an investment in their professional development is an investment in the future of our specialty. In this article, we aimed to address the most notable developments relevant to current and future young professionals in neuroradiology as well as highlight the work done by the Young Professionals Committee of the American Society of Neuroradiology in serving the needs of these young professionals, focusing on early neuroradiology engagement, flexible work arrangements, private practice, social media, artificial intelligence, and international collaborations.
    MeSH term(s) Artificial Intelligence ; United States ; Neuroradiography ; Career Choice
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A8147
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    Zs.A 1580: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Development and validation of a nomogram model for predicting the risk of MAFLD in the young population.

    Yuan, Yi / Xu, Muying / Zhang, Xuefei / Tang, Xiaowei / Zhang, Yanlang / Yang, Xin / Xia, Guodong

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9376

    Abstract: ... indicators to predict the risk of metabolic-associated fatty liver disease (MAFLD) in young Chinese ... individuals. This study retrospectively analyzed a cohort of young population who underwent health examination ...

    Abstract This study aimed to develop and validate a nomogram model that includes clinical and laboratory indicators to predict the risk of metabolic-associated fatty liver disease (MAFLD) in young Chinese individuals. This study retrospectively analyzed a cohort of young population who underwent health examination from November 2018 to December 2021 at The Affiliated Hospital of Southwest Medical University in Luzhou City, Sichuan Province, China. We extracted the clinical and laboratory data of 43,040 subjects and randomized participants into the training and validation groups (7:3). Univariate logistic regression analysis, the least absolute shrinkage and selection operator regression, and multivariate logistic regression models identified significant variables independently associated with MAFLD. The predictive accuracy of the model was analyzed in the training and validation sets using area under the receiver operating characteristic (AUROC), calibration curves, and decision curve analysis. In this study, we identified nine predictors from 31 variables, including age, gender, body mass index, waist-to-hip ratio, alanine aminotransferase, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, uric acid, and smoking. The AUROC for the subjects in the training and validation groups was 0.874 and 0.875, respectively. The calibration curves show excellent accuracy of the nomogram. This nomogram which was based on demographic characteristics, lifestyle habits, anthropometrics, and laboratory data can visually and individually predict the risk of developing MAFLD. This nomogram is a quick and effective screening tool for assessing the risk of MAFLD in younger populations and identifying individuals at high risk of MAFLD, thereby contributing to the improvement of MAFLD management.
    MeSH term(s) Humans ; Nomograms ; Female ; Male ; Adult ; Retrospective Studies ; Risk Factors ; China/epidemiology ; Young Adult ; ROC Curve ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/blood ; Risk Assessment/methods
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60100-y
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  8. Article: Cholestatic Hepatitis with Concomitant Nephrotic Syndrome due to Secondary Syphilis in a Young Man.

    Yang, Chun-Chi / Chen, Jui-Yi / Chang, Hsuan-Yuan / Sheu, Ming-Jen / Feng, I-Che / Wang, Su-Hung / Kuo, Hsing-Tao

    Case reports in gastroenterology

    2024  Volume 18, Issue 1, Page(s) 136–143

    Abstract: ... nephrotic syndrome in secondary syphilis is rare.: Case presentation: A young man presented with fatigue, abnormal ... highlights the importance of considering syphilis in young patients with MSM and presenting with unexplained ...

    Abstract Introduction: Syphilis, an ancient sexually transmitted disease, is recognized as a systemic infection disease manifesting with diverse symptoms and variations. Secondary syphilis characterized by systemic symptoms resulted from hematogenous and lymphatic dissemination of the infection, may include manifestations such as hepatitis and nephrotic syndrome. However, the simultaneous occurrence of hepatitis and nephrotic syndrome in secondary syphilis is rare.
    Case presentation: A young man presented with fatigue, abnormal liver function tests, and hyperbilirubinemia and had history of men who have sex with men (MSM). Serological tests confirmed the diagnosis of secondary syphilis, and kidney biopsy indicated membranous nephritis. After antibiotic treatment, the patient experienced resolution of proteinuria, and liver enzyme levels returned to normal.
    Conclusion: Syphilis should be considered in the differential diagnosis of simultaneous liver and kidney dysfunction, particularly in patients engaging in high-risk sexual behavior. This case highlights the importance of considering syphilis in young patients with MSM and presenting with unexplained nephrotic syndrome and liver abnormalities.
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2440540-1
    ISSN 1662-0631
    ISSN 1662-0631
    DOI 10.1159/000537922
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  9. Article ; Online: Young osteocyte-derived extracellular vesicles facilitate osteogenesis by transferring tropomyosin-1.

    Wang, Zhen-Xing / Lin, Xiao / Cao, Jia / Liu, Yi-Wei / Luo, Zhong-Wei / Rao, Shan-Shan / Wang, Qiang / Wang, Yi-Yi / Chen, Chun-Yuan / Zhu, Guo-Qiang / Li, Fu-Xing-Zi / Tan, Yi-Juan / Hu, Yin / Yin, Hao / Li, You-You / He, Ze-Hui / Liu, Zheng-Zhao / Yuan, Ling-Qing / Zhou, Yong /
    Wang, Zheng-Guang / Xie, Hui

    Journal of nanobiotechnology

    2024  Volume 22, Issue 1, Page(s) 208

    Abstract: ... Results: Primary osteocytes were isolated from 2-month-old and 16-month-old mice to obtain young ... culture medium. Following intravenous injection into young and elderly mouse models, YO-EVs demonstrated ...

    Abstract Background: Bone marrow mesenchymal stem cells (BMSCs) can undergo inadequate osteogenesis or excessive adipogenesis as they age due to changes in the bone microenvironment, ultimately resulting in decreased bone density and elevated risk of fractures in senile osteoporosis. This study aims to investigate the effects of osteocyte senescence on the bone microenvironment and its influence on BMSCs during aging.
    Results: Primary osteocytes were isolated from 2-month-old and 16-month-old mice to obtain young osteocyte-derived extracellular vesicles (YO-EVs) and senescent osteocyte-derived EVs (SO-EVs), respectively. YO-EVs were found to significantly increase alkaline phosphatase activity, mineralization deposition, and the expression of osteogenesis-related genes in BMSCs, while SO-EVs promoted BMSC adipogenesis. Neither YO-EVs nor SO-EVs exerted an effect on the osteoclastogenesis of primary macrophages/monocytes. Our constructed transgenic mice, designed to trace osteocyte-derived EV distribution, revealed abundant osteocyte-derived EVs embedded in the bone matrix. Moreover, mature osteoclasts were found to release osteocyte-derived EVs from bone slices, playing a pivotal role in regulating the functions of the surrounding culture medium. Following intravenous injection into young and elderly mouse models, YO-EVs demonstrated a significant enhancement of bone mass and biomechanical strength compared to SO-EVs. Immunostaining of bone sections revealed that YO-EV treatment augmented the number of osteoblasts on the bone surface, while SO-EV treatment promoted adipocyte formation in the bone marrow. Proteomics analysis of YO-EVs and SO-EVs showed that tropomyosin-1 (TPM1) was enriched in YO-EVs, which increased the matrix stiffness of BMSCs, consequently promoting osteogenesis. Specifically, the siRNA-mediated depletion of Tpm1 eliminated pro-osteogenic activity of YO-EVs both in vitro and in vivo.
    Conclusions: Our findings suggested that YO-EVs played a crucial role in maintaining the balance between bone resorption and formation, and their pro-osteogenic activity declining with aging. Therefore, YO-EVs and the delivered TPM1 hold potential as therapeutic targets for senile osteoporosis.
    MeSH term(s) Animals ; Extracellular Vesicles/metabolism ; Osteogenesis ; Mice ; Osteocytes/metabolism ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/cytology ; Tropomyosin/metabolism ; Tropomyosin/genetics ; Mice, Inbred C57BL ; Mice, Transgenic ; Cells, Cultured ; Osteoporosis/metabolism ; Adipogenesis ; Osteoclasts/metabolism ; Male ; Cell Differentiation
    Chemical Substances Tropomyosin
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-024-02367-x
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  10. Article: Encephalopathy in a Young Female With COVID-19: A Case Report.

    Kim, Andrew / Valdez, Cristian / Truman, Weston / Trad, George / Solomon, Cordelia / McWhorter, Yi

    Cureus

    2023  Volume 15, Issue 4, Page(s) e37373

    Abstract: ... comorbidities. We present a case of encephalitis in a young female patient with a history of chronic marijuana ...

    Abstract Cases of severe central nervous system (CNS) complications have been reported in relation to coronavirus-19 (COVID-19). Cases of encephalitis have been reported primarily in older patients with multiple comorbidities. We present a case of encephalitis in a young female patient with a history of chronic marijuana use that presented with nausea, vomiting, and acute altered mental status. Extensive testing for infectious and autoimmune causes of encephalitis were negative, except for a positive COVID-19 test. She was treated with steroids and intravenous immune globulin (IVIG) and improved with residual mutism.
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.37373
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