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Article ; Online: Two new species of the genus Macromotettixoides Zheng, Wei & Jiang (Orthoptera: Tetrigidae: Metrodorinae) from China

Wei, Shi-Zhen / Deng, Wei-an

Oriental Insects. 2023 Apr. 03, v. 57, no. 2 p.626-642

2023

Abstract: New species, Macromotettixoides daweishana sp. nov. from Yunnan and Macromotettixoides orthomargina sp. nov. from Sichuan, are described and illustrated. M. daweishana is similar to M. undulatifemura but differs in the shape of pronotum and narrow vertex. ...

Abstract	New species, Macromotettixoides daweishana sp. nov. from Yunnan and Macromotettixoides orthomargina sp. nov. from Sichuan, are described and illustrated. M. daweishana is similar to M. undulatifemura but differs in the shape of pronotum and narrow vertex. M. orthomargina is similar to M. shengtangshanensis but differs in the shape of infrascapular area and the wide vertex. The distribution and a key to the species of Macromotettixoides are given. http://www.zoobank.org/urn:lsid:zoobank.org:pub:38128DB6-2DFB-4C8B-9AD4-6B773B9EA8F3
Keywords	Tetrigidae ; new species ; taxonomic keys ; China ; Tetrigoidea ; pygmy grasshoppers ; taxonomy ; Yunnan ; Sichuan
Language	English
Dates of publication	2023-0403
Size	p. 626-642.
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	2157-8745
DOI	10.1080/00305316.2022.2098198
Database	NAL-Catalogue (AGRICOLA)

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Article: A research on the mechanism of NSAID-related gastric ulcer treated by jia wei wu qi san based on the p38mapk signal pathway.

Zheng, Liang / Wang, Pei / Wang, Yuan-Yuan / Li, Zhen / Tian, Ye

Pakistan journal of pharmaceutical sciences

2021 Volume 34, Issue 2, Page(s) 585–589

Abstract: This study aims to explore the mechanism of NSAID-related gastric ulcer treated by JIA WEI WU QI ... was given rabeprazole (2mg/kg), and group D was administered with JIA WEI WU QI SAN (2g/kg ... D (P<0.05). (4) The expression of p-P38MAPK decreased in group D (P<0.05). JIA WEI WU QI SAN has ...

Abstract	This study aims to explore the mechanism of NSAID-related gastric ulcer treated by JIA WEI WU QI SAN. Clean-grade SD rats were randomly divided into four groups. Group A was assigned as the control group. Groups B, C and D were intragastrically administered with 2.5mg/kg of indomethacin solution QD after 48 hours. After 15 days of treatment, group B was administered with 0.9% sodium chloride, group C was given rabeprazole (2mg/kg), and group D was administered with JIA WEI WU QI SAN (2g/kg). Abdominal aorta sampling was performed, and gastric tissues were isolated on the 29th day. The protein expression of p-P38MAPK and COX-2 were detected by western blot, while the concentration of PGE2 and IL-1 were determined by ELISA. (1) The expression of IL-1ingroup B dramatically declined in group D (P<0.01). (2)The expression of PGE-2dramatically increased in group D(P<0.01). (3) The expression of COX-2 increased in group D (P<0.05). (4) The expression of p-P38MAPK decreased in group D (P<0.05). JIA WEI WU QI SAN has multiple functions, including the activation of the p-P38MAPK signaling pathway, which promote the activation of COX-2, induce the arachidonic acid to increase the level of PG, and decrease the concentration of IL-1, thereby inducing an inflammatory reaction, and promote gastric mucosa repair.
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Arachidonic Acid/metabolism ; Cyclooxygenase 2/drug effects ; Cyclooxygenase 2/metabolism ; Dinoprostone/metabolism ; Drugs, Chinese Herbal/pharmacology ; Indomethacin/adverse effects ; Interleukin-1/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Stomach/drug effects ; Stomach/metabolism ; Stomach Ulcer/chemically induced ; Stomach Ulcer/metabolism ; p38 Mitogen-Activated Protein Kinases/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Drugs, Chinese Herbal ; Interleukin-1 ; Arachidonic Acid (27YG812J1I) ; Cyclooxygenase 2 (EC 1.14.99.1) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Dinoprostone (K7Q1JQR04M) ; Indomethacin (XXE1CET956)
Language	English
Publishing date	2021-07-19
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article ; Online: Screening the Q-markers of TCMs from RA rat plasma using UHPLC-QTOF/MS technique for the comprehensive evaluation of Wu-Wei-Wen-Tong Capsule.

Jiang, Hui / Liu, Jian / Wang, Yanling / Chen, Leijing / Liu, Hui / Wang, Zhen / Wang, Bin

Journal of mass spectrometry : JMS

2021 Volume 56, Issue 5, Page(s) e4711

Abstract: ... quality evaluation of traditional Chinese medicines (TCMs) has much more significance. Wu-Wei-Wen-Tong Capsule (WWWTC ...

Abstract	The appropriate selection of quality marker (Q-marker) for performing the comprehensive quality evaluation of traditional Chinese medicines (TCMs) has much more significance. Wu-Wei-Wen-Tong Capsule (WWWTC), a TCMs prescription, is mainly utilized to treat rheumatoid arthritis (RA) in China. However, the comprehensive quality control for WWWTC has not been achieved because of lacking system analysis for the Q-marker. In this study, a dual wavelength, 203 and 270 nm, was selected based on the feature of 15 Q-markers, and a reliable UHPLC-UV fingerprinting approach was established, achieving the comprehensive quality evaluation of WWWTC. First, we identified 91 prototypes in rat plasma after administering a set amount of WWWTC by using UHPLC-QTOF/MS technique and selected them as the candidate Q-markers. Next, based on the "five principles" of Q-marker selection, 15 absorbed components among them including coumarin, cinnamic acid, cinnamaldehyde, cinnamic alcohol, and 2-methoxycinnamaldehyde derived from Monarch medicine of Cmnamomi Mmulus; epimedin C, icariin, baohuoside I, and anhydroicaritin derived from Monarch medicine Epimedii Folium; germacrone, the sesquiterpene compound in Minister medicine Rhizoma Wenyujin Concisum; pachymic acid, the tetracyclic triterpenoid acids in Assistant medicine Poria; baicalin, baicalein, wogonin, and wogonoside in Guide medicine Scutellariae Radix, respectively, were seriously chosen as the Q-markers, indicating preferable pharmacological effect on RA, characterization of transitivity and traceability as well as measurable components in WWWTC. The effective and meaningful strategy displayed a unique perspective for the exploration of Q-markers in the quality evaluation and further ensured efficacy and safety of the TCMs.
MeSH term(s)	Acrolein/analogs & derivatives ; Acrolein/blood ; Acrolein/metabolism ; Animals ; Arthritis, Experimental ; Arthritis, Rheumatoid/drug therapy ; Biomarkers, Pharmacological/blood ; Chromatography, High Pressure Liquid ; Cinnamates/blood ; Cinnamates/metabolism ; Coumarins/blood ; Coumarins/metabolism ; Drug Development ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/pharmacology ; Flavanones/blood ; Flavanones/metabolism ; Humans ; Medicine, Chinese Traditional ; Propanols/blood ; Propanols/metabolism ; Quality Control ; Rats ; Tandem Mass Spectrometry/methods ; Triterpenes/blood ; Triterpenes/metabolism
Chemical Substances	Biomarkers, Pharmacological ; Cinnamates ; Coumarins ; Drugs, Chinese Herbal ; Flavanones ; Propanols ; Triterpenes ; cinnamic acid (140-10-3) ; 2-methoxycinnamaldehyde (4940G3R6HE) ; baicalein (49QAH60606) ; Acrolein (7864XYD3JJ) ; coumarin (A4VZ22K1WT) ; cinnamaldehyde (SR60A3XG0F) ; cinnamyl alcohol (SS8YOP444F) ; pachymic acid (X2FCK16QAH)
Language	English
Publishing date	2021-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1221763-3
ISSN	1096-9888 ; 1076-5174
ISSN (online)	1096-9888
ISSN	1076-5174
DOI	10.1002/jms.4711
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Article ; Online: Efficacy of Jia Wei Yang He formula as an adjunctive therapy for asthma: study protocol for a randomized, double blinded, controlled trial.

Jiang, Wenhan / Ma, Zifeng / Zhang, Huiyong / Lynn, Henry S / Xu, Beiqi / Zhang, Xiao / Bi, Rongrong / Fu, Jiyou / Chen, Yue / Xiao, Zhen / Zhang, Zhijie / Lu, Zhenhui

Trials

2018 Volume 19, Issue 1, Page(s) 355

Abstract: ... asthma patients. The aim of this study is to evaluate the efficacy of the Jia Wei Yang He (JWYH) formula ...

Abstract	Background: Over the past two or three decades, the prevalence of asthma has significantly increased worldwide; therefore, effective treatment without side effects is of utmost importance. Traditional Chinese medicine (TCM) plays a vital role in reducing symptoms and improving the quality of life in persistent-asthma patients. The aim of this study is to evaluate the efficacy of the Jia Wei Yang He (JWYH) formula in the treatment of asthma and to explore the relationship between the airway microbiome and TCM treatment in asthma patients. Methods/design: This multicenter, parallel-arm, randomized, double-blinded, placebo-controlled trial will assess the efficacy of JWYH in asthma patients with usual care. Persistent-asthma patients without life-threatening disease will be enrolled on a random basis and are equally assigned to a high- or a low-dose JWYH plus usual care group, or a placebo plus usual care group. Patients are followed up for 4 months. Accordingly, 240 patients will yield sufficient statistical power to determine a difference between groups. Based on modified intent-to-treat (mITT) analyses, the three groups will be compared at 4 weeks after the beginning of treatment. The primary efficacy measurement is the mean change in the Asthma Control Test (ACT) score from baseline to 4 weeks post treatment. Secondary outcomes include forced expiratory volume in 1 s (FEV Discussion: In this study, a randomized clinical trial design is described. The results are based on several outcomes that estimate the efficacy of the JWYH formula and prospective links between the airway microbiome and asthma treatment. Trial registration: ClinicalTrials.gov, ID: NCT03299322 . Registered on 3 October 2017.
MeSH term(s)	Asthma/drug therapy ; Asthma/physiopathology ; Double-Blind Method ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Lung/microbiology ; Lung/physiopathology ; Medicine, Chinese Traditional/adverse effects ; Microbiota ; Multicenter Studies as Topic ; Quality Control ; Randomized Controlled Trials as Topic ; Sample Size
Chemical Substances	Drugs, Chinese Herbal ; yanghe
Language	English
Publishing date	2018-07-04
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-018-2739-8
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Article ; Online: Efficacy of Jia Wei Yang He formula as an adjunctive therapy for asthma

Wenhan Jiang / Zifeng Ma / Huiyong Zhang / Henry S. Lynn / Beiqi Xu / Xiao Zhang / Rongrong Bi / Jiyou Fu / Yue Chen / Zhen Xiao / Zhijie Zhang / Zhenhui Lu

Trials, Vol 19, Iss 1, Pp 1-

study protocol for a randomized, double blinded, controlled trial

2018 Volume 9

Abstract: ... asthma patients. The aim of this study is to evaluate the efficacy of the Jia Wei Yang He (JWYH) formula ...

Abstract	Abstract Background Over the past two or three decades, the prevalence of asthma has significantly increased worldwide; therefore, effective treatment without side effects is of utmost importance. Traditional Chinese medicine (TCM) plays a vital role in reducing symptoms and improving the quality of life in persistent-asthma patients. The aim of this study is to evaluate the efficacy of the Jia Wei Yang He (JWYH) formula in the treatment of asthma and to explore the relationship between the airway microbiome and TCM treatment in asthma patients. Methods/design This multicenter, parallel-arm, randomized, double-blinded, placebo-controlled trial will assess the efficacy of JWYH in asthma patients with usual care. Persistent-asthma patients without life-threatening disease will be enrolled on a random basis and are equally assigned to a high- or a low-dose JWYH plus usual care group, or a placebo plus usual care group. Patients are followed up for 4 months. Accordingly, 240 patients will yield sufficient statistical power to determine a difference between groups. Based on modified intent-to-treat (mITT) analyses, the three groups will be compared at 4 weeks after the beginning of treatment. The primary efficacy measurement is the mean change in the Asthma Control Test (ACT) score from baseline to 4 weeks post treatment. Secondary outcomes include forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF), and asthma exacerbations. This trial also includes analyses of the associations between airway microbiome and asthma treatment. Discussion In this study, a randomized clinical trial design is described. The results are based on several outcomes that estimate the efficacy of the JWYH formula and prospective links between the airway microbiome and asthma treatment. Trial registration ClinicalTrials.gov, ID: NCT03299322. Registered on 3 October 2017.
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Screening the Q‐markers of TCMs from RA rat plasma using UHPLC‐QTOF/MS technique for the comprehensive evaluation of Wu‐Wei‐Wen‐Tong Capsule

Jiang, Hui / Liu, Jian / Wang, Yanling / Chen, Leijing / Liu, Hui / Wang, Zhen / Wang, Bin

Journal of mass spectrometry. 2021 May, v. 56, no. 5

2021

Abstract: ... quality evaluation of traditional Chinese medicines (TCMs) has much more significance. Wu‐Wei‐Wen‐Tong Capsule (WWWTC ...

Abstract	The appropriate selection of quality marker (Q‐marker) for performing the comprehensive quality evaluation of traditional Chinese medicines (TCMs) has much more significance. Wu‐Wei‐Wen‐Tong Capsule (WWWTC), a TCMs prescription, is mainly utilized to treat rheumatoid arthritis (RA) in China. However, the comprehensive quality control for WWWTC has not been achieved because of lacking system analysis for the Q‐marker. In this study, a dual wavelength, 203 and 270 nm, was selected based on the feature of 15 Q‐markers, and a reliable UHPLC‐UV fingerprinting approach was established, achieving the comprehensive quality evaluation of WWWTC. First, we identified 91 prototypes in rat plasma after administering a set amount of WWWTC by using UHPLC‐QTOF/MS technique and selected them as the candidate Q‐markers. Next, based on the “five principles” of Q‐marker selection, 15 absorbed components among them including coumarin, cinnamic acid, cinnamaldehyde, cinnamic alcohol, and 2‐methoxycinnamaldehyde derived from Monarch medicine of Cmnamomi Mmulus; epimedin C, icariin, baohuoside I, and anhydroicaritin derived from Monarch medicine Epimedii Folium; germacrone, the sesquiterpene compound in Minister medicine Rhizoma Wenyujin Concisum; pachymic acid, the tetracyclic triterpenoid acids in Assistant medicine Poria; baicalin, baicalein, wogonin, and wogonoside in Guide medicine Scutellariae Radix, respectively, were seriously chosen as the Q‐markers, indicating preferable pharmacological effect on RA, characterization of transitivity and traceability as well as measurable components in WWWTC. The effective and meaningful strategy displayed a unique perspective for the exploration of Q‐markers in the quality evaluation and further ensured efficacy and safety of the TCMs.
Keywords	Poria ; alcohols ; baicalin ; cinnamic acid ; coumarin ; icariin ; mass spectrometry ; rats ; rheumatoid arthritis ; rhizomes ; sesquiterpenoids ; traceability ; triterpenoids ; wavelengths ; China
Language	English
Dates of publication	2021-05
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	1221763-3
ISSN	1096-9888 ; 1076-5174
ISSN (online)	1096-9888
ISSN	1076-5174
DOI	10.1002/jms.4711
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Article ; Online: Antinociceptive activity and chemical composition of Wei-Chang-An-Wan extracts.

Liu, Zhen / Zhang, Jingze / Gao, Wenyuan / Liu, Changxiao

Pharmaceutical biology

2013 Volume 51, Issue 6, Page(s) 790–797

Abstract: ... development in China. Wei-Chang-An-Wan (WCAW) as one of them has been used for treating various ...

Abstract	Context: Currently, famous traditional Chinese medicine formulas have undergone re-evaluation and development in China. Wei-Chang-An-Wan (WCAW) as one of them has been used for treating various gastrointestinal diseases for several decades. The secondary development of WCAW is in progress so as to interpret the effective material basis or find new pharmacological activity. Objective: To evaluate the antinociceptive effect of methanol extract of WCAW (ME) as well as four fractions (P.E., EtOAc, n-BuOH, H2O) and obtain information on the correlation between the contents of the fractions and antinociceptive effect. Materials and methods: ME was divided into four parts extracted by petroleum ether, ethyl acetate and n-butanol. Antinociceptive activity was evaluated by three models of acetic acid-induced writhing, formalin and hot-plate test in mice after repetitive administration of ME at 200, 400 or 800 mg/kg, P.E. 132 mg/kg, EtOAc 106 mg/kg, n-BuOH 176 mg/kg and H2O 176 mg/kg for six days. The chemical compounds were analyzed by HPLC-ESI-MS. Results: ME at 800 mg/kg inhibited acid-induced writhing by 84.69%, and reduced the licking time of second phase in formalin test by 53.23%. The inhibition rates in acid-induced writhing of P.E., EtOAc, n-BuOH and H2O were 27.79, 33.85, 38.97 and 37.69%, respectively, and in formalin test about 50%. They had no effect on the hot-plate test. HPLC-ESI-MS analysis showed that 68 chemical compounds were detected and 41 compounds were identified from ME. Discussion and conclusion: The results obtained herein indicate that WCAW possesses the antinociceptive activity that provides a new aspect in clinical application.
MeSH term(s)	Analgesics/administration & dosage ; Analgesics/chemistry ; Analgesics/pharmacology ; Animals ; Chromatography, High Pressure Liquid/methods ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Female ; Male ; Medicine, Chinese Traditional ; Mice ; Pain/drug therapy ; Pain/pathology ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Solvents/chemistry ; Spectrometry, Mass, Electrospray Ionization/methods
Chemical Substances	Analgesics ; Drugs, Chinese Herbal ; Plant Extracts ; Solvents ; Wei-Chang-An-Wan
Language	English
Publishing date	2013-06
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.3109/13880209.2013.766893
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Article: [Effect of Chinese drugs for strengthening Pi, harmonizing Wei, and dispersing blood stasis on the expression of gastric mucosal heat shock protein 70 in chronic atrophic gastritis patients].

Thou, Jia-he / Fu, Zhi-quan / Deng, Jian-ping / Li, Chun-xia / Qiao, Zhen / Zhu, Wei-qin / Zhao, Hong-wen / Li, Zhen

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

2015 Volume 35, Issue 4, Page(s) 406–410

Abstract: Objective: To observe the effect of Chinese drugs for strengthening Pi, harmonizing Wei, and ...

Abstract	Objective: To observe the effect of Chinese drugs for strengthening Pi, harmonizing Wei, and dispersing blood stasis (CDSPHWDBS) on the expression of gastric mucosal heat shock protein 70 (HSP70) in chronic atrophic gastritis (CAG) patients. Methods: A total of 100 CAG patients were assigned to the control group and the treatment group by random digit table, 50 in each group. Patients in the control group took Folic Acid Tablet 10 mg each time, 3 times per day. Those in the treatment group took CDSPHWDBS, 100 mL each time, once per day. The treatment course was 6 months for all. Clinical symptoms and signs, endoscopic and histopathological changes were observed before and after treatment in the two groups. The expression of gastric mucosal HSP70 in CAG patients was determined using SP immunohistochemistry. Data were collected by HPIAS-1 000 pathological graphic analysis system, and its expression semi-quantitatively analyzed. Results: The total effective rate of clinical Chinese medical symptoms and signs was 88. 0% (44/50 cases) in the treatment group and 56. 0% (28/50 cases) in the control group, with significant difference between the two groups (P <0. 01). The improvement rate of endoscopic manifestations such as congestion and edema, erosion, bile regurgitation, pale gastric mucosa, exposed blood vessels, particles proliferation in the treatment group were superior to those in the control group (P <0. 05). The total effective rate of atrophy was 80. 0% (40/50 cases) in the treatment group and 54. 0% (27/50 cases) in the control group, with significant difference between the two groups (P<0. 01). The effective rate of intestinal metaplasia was 75. 0% (12/16 cases) in the treatment group and 33.3% (5/15 cases) in the control group, with significant difference between the two groups (P < 0. 05). The optical density value of gastric mucosal HSP70 was significantly elevated in the two groups after treatment (both P <0. 05). It was higher in the treatment group than in the control group after treatment with significant difference (P <0. 01). Conclusion: CDSPHWDBS had obvious effect in treatment of CAG and could improve pathological changes of precancerous lesions possibly by promoting the expression of gastric mucosal HSP70 in CAG patients.
MeSH term(s)	Drugs, Chinese Herbal/therapeutic use ; Gastric Mucosa/metabolism ; Gastritis, Atrophic/drug therapy ; Gastritis, Atrophic/metabolism ; HSP70 Heat-Shock Proteins/metabolism ; Humans ; Immunohistochemistry ; Medicine, East Asian Traditional
Chemical Substances	Drugs, Chinese Herbal ; HSP70 Heat-Shock Proteins
Language	Chinese
Publishing date	2015-04
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1195456-5
ISSN	1003-5370
ISSN	1003-5370
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Article: [Tongjiang granule intervened non-erosive reflux disease patients of Gan-Wei incoordination syndrome: a curative effect observation].

Li, Bao-Shuang / Zhang, Li-Ying / Peng, Zhen-Ting / Lin, Yang-Ying / Tang, Xu-Dong

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

2013 Volume 33, Issue 7, Page(s) 915–919

Abstract: ... disease (NERD) of Gan-Wei incoordination syndrome (GWIS).: Methods: Totally 128 NERD patients of GWIS ...

Abstract	Objective: To assess the effectiveness of Tongjiang Granule (TJG) in treating non-erosive reflux disease (NERD) of Gan-Wei incoordination syndrome (GWIS). Methods: Totally 128 NERD patients of GWIS were recruited from outpatients or inpatients at Department of Digestive Disease, Xiyuan Hospital, China Academy of Chinese Medical Sciences from February 2009 to November 2010. They were randomly assigned to two groups using the block group in the ratio of 1:1, 64 cases in each group. Patients in the experiment group were treated with TJG, 10 g each time, three times a day, while those in the control group were treated with Omeprazole Tablet, 20 mg each time, two times a day. The treatment course of both groups was 4 weeks. The symptoms questionnaires and SF-36 quality of life scale were observed. Results: Finally 114 patients completed the trial. There was statistical difference in epigastric upset, pharyngeal foreign body sensation, abdominal swelling or abdominal pain, and integral of excrement between the two groups before treatment (P < 0.05). However, there was no statistical difference in the rest indices between the two groups (P > 0.05). Compared with before treatment in the same group, the scores of each symptom or the total symptoms were somewhat improved in the two groups (P < 0.01, P < 0.05). There was statistical difference in the rest scores (P > 0.05) except the score of mental health in the experiment group (P < 0.01, P < 0.05). There was statistical difference in the rest scores (P > 0.05) except the score of physical function in the control group (P < 0.01, P < 0.05). There was statistical difference in post-treatment acid reflux, irritability, depression, body pain, roles of emotions (P < 0.01, P < 0.05). The total effective rate was higher in the experimental group, showing no statistical difference when compared with that of the control group (P > 0.05). Conclusions: TJG had confirmative efficacy in treating NERD patients of GWIS. Meanwhile, it could improve their quality of life, with no obvious adverse reaction.
MeSH term(s)	Adult ; Drugs, Chinese Herbal/therapeutic use ; Female ; Gastroesophageal Reflux/drug therapy ; Humans ; Male ; Middle Aged ; Phytotherapy ; Quality of Life ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal ; tongjiang
Language	Chinese
Publishing date	2013-07
Publishing country	China
Document type	English Abstract ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1195456-5
ISSN	1003-5370
ISSN	1003-5370
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Article: [Effects of Jia Wei Huang Lian A Jiao Tang on expression of TGF-beta1 in nephrotoxicity-rats induced by cisplatin].

Yang, Gui-Ran / Li, Shu-Zhen / Liu, Na / Yang, Yan-Mei / Wang, Xiao-Yu

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

2010 Volume 26, Issue 4, Page(s) 426–7, 473

MeSH term(s)	Animals ; Cisplatin/adverse effects ; Drugs, Chinese Herbal/pharmacology ; Kidney/drug effects ; Kidney/metabolism ; Male ; Proteinuria/etiology ; Rats ; Rats, Sprague-Dawley ; Transforming Growth Factor beta1/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Tgfb1 protein, rat ; Transforming Growth Factor beta1 ; Cisplatin (Q20Q21Q62J)
Language	Chinese
Publishing date	2010-11
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1000-6834
ISSN	1000-6834
Database	MEDical Literature Analysis and Retrieval System OnLINE

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