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Article: Cutaneous Delivery and Biodistribution of Cannabidiol in Human Skin after Topical Application of Colloidal Formulations.

Lapteva, Maria / Faro Barros, Jonathan / Kalia, Yogeshvar N

2024 Volume 16, Issue 2

Abstract: The objective of this study was to investigate the cutaneous delivery of cannabidiol (CBD) from aqueous formulations developed for the targeted local treatment of dermatological conditions. CBD was formulated using a proprietary colloidal drug delivery ... ...

Abstract	The objective of this study was to investigate the cutaneous delivery of cannabidiol (CBD) from aqueous formulations developed for the targeted local treatment of dermatological conditions. CBD was formulated using a proprietary colloidal drug delivery system (VESIsorb
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics16020202
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Article: Monochorionic Diamniotic Vasa Previa Pregnancy: A Medical Student Perspective.

Samuel, Joshua M / Ali, Fatima / Faro, Jonathan / Baum, Jonathan D

Case reports in obstetrics and gynecology

2021 Volume 2021, Page(s) 5513139

Abstract: Monochorionic diamniotic twins and vasa previa are uncommon. We present a case that was followed from ultrasound diagnosis to delivery. ...

Abstract	Monochorionic diamniotic twins and vasa previa are uncommon. We present a case that was followed from ultrasound diagnosis to delivery.
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627654-9
ISSN	2090-6692 ; 2090-6684
ISSN (online)	2090-6692
ISSN	2090-6684
DOI	10.1155/2021/5513139
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Article: Sepsis: use of clinical criteria as well as novel diagnostic tests aim to improve patient outcomes.

Faro, Jonathan

MLO: medical laboratory observer

2014 Volume 46, Issue 4, Page(s) 10, 13

MeSH term(s)	Antibodies, Bacterial/isolation & purification ; Diagnostic Tests, Routine ; Humans ; Quality Assurance, Health Care ; Sepsis/diagnosis ; Sepsis/drug therapy ; Treatment Outcome
Chemical Substances	Antibodies, Bacterial
Language	English
Publishing date	2014-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	603205-9
ISSN	0580-7247
ISSN	0580-7247
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Zs.B 2587: Show issues

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Article: More rapid testing group B streptococcus detection.

Faro, Jonathan

MLO: medical laboratory observer

2013 Volume 45, Issue 6, Page(s) 15

MeSH term(s)	Female ; Humans ; Infant, Newborn ; Pregnancy ; Reagent Kits, Diagnostic ; Streptococcal Infections/diagnosis ; Streptococcal Infections/microbiology ; Streptococcal Infections/prevention & control ; Streptococcus agalactiae/growth & development ; Streptococcus agalactiae/isolation & purification
Chemical Substances	Reagent Kits, Diagnostic
Language	English
Publishing date	2013-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	603205-9
ISSN	0580-7247
ISSN	0580-7247
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Zs.B 2587: Show issues

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Article ; Online: Impact of loss to follow-up on survival estimation for cystic fibrosis.

Ostrenga, Joshua S / Whitney Brown, A / Todd, Jonathan V / Elbert, Alexander / Fink, Aliza K / Faro, Albert / Marshall, Bruce C / Cromwell, Elizabeth A

Annals of epidemiology

2023 Volume 86, Page(s) 98–103.e5

Abstract: Purpose: Deaths among those lost to follow-up (LTFU) in the Cystic Fibrosis Foundation Patient Registry (CFFPR) are critically important to the epidemiology of cystic fibrosis (CF). Unreported deaths could impact estimates of survival if LTFU is ... ...

Abstract	Purpose: Deaths among those lost to follow-up (LTFU) in the Cystic Fibrosis Foundation Patient Registry (CFFPR) are critically important to the epidemiology of cystic fibrosis (CF). Unreported deaths could impact estimates of survival if LTFU is associated with disease trajectory. Methods: We characterized the LTFU population (1986-2017) from the CFFPR and identified deaths via linkage with the National Death Index (NDI). Median predicted survival age and conditional survival were estimated with and without additional deaths and person-time from the NDI. Results: Of the 10,582 individuals LTFU in the CFFPR, 2,460 (23.2%) matched to an NDI death record. Individuals who died after LTFU with a CF diagnosis were 43% female, 91% White/non-Hispanic, 59% had advanced CF lung disease based on last CFFPR recorded forced expiratory volume in one second (FEV Conclusions: Inclusion of deaths and additional person-time among those LTFU changed the point estimate of median predicted survival for most time periods and increased the point estimate from 2009 onwards.
MeSH term(s)	Humans ; Female ; Adult ; Male ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/epidemiology ; Follow-Up Studies ; Registries ; Forced Expiratory Volume ; Respiratory Function Tests
Language	English
Publishing date	2023-08-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1074355-8
ISSN	1873-2585 ; 1047-2797
ISSN (online)	1873-2585
ISSN	1047-2797
DOI	10.1016/j.annepidem.2023.07.008
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Zs.A 3225: Show issues

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Article ; Online: Cystic fibrosis prevalence in the United States and participation in the Cystic Fibrosis Foundation Patient Registry in 2020.

Cromwell, Elizabeth A / Ostrenga, Joshua S / Todd, Jonathan V / Elbert, Alexander / Brown, A Whitney / Faro, Albert / Goss, Christopher H / Marshall, Bruce C

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

2023 Volume 22, Issue 3, Page(s) 436–442

Abstract: Background: The Cystic Fibrosis Foundation Patient Registry (CFFPR) collects data on individuals with cystic fibrosis (CF) in the United States (US). In 2012, the US CF population was estimated at 33,292 to 34,327 individuals, with 81-84% CFFPR ... ...

Abstract	Background: The Cystic Fibrosis Foundation Patient Registry (CFFPR) collects data on individuals with cystic fibrosis (CF) in the United States (US). In 2012, the US CF population was estimated at 33,292 to 34,327 individuals, with 81-84% CFFPR participation. Methods: In this study, we update these estimates via simulation to account for uncertainty in CF incidence by race or Hispanic ethnicity, initiation of CF newborn screening (NBS) programs by state, and updated cumulative survival for CF births 1968-2020. We defined registry participation as the proportion of individuals alive as of 2020 with any prior CFFPR participation as well as the proportion with contributing data in 2019 or 2020; we summarize CFFPR participation for those born prior to 1968. Results: We estimated the 2020 prevalent CF population between 1968-2020 to be 38,804 (95% Uncertainty Interval (UI): 38,532 to 39,065) individuals, with 77% of the prevalent CF population contributing recent data. CFFPR participation differs by age (54% of those born in 1968) and exceeds >90% of the population born in 2009 or later. Conclusions: We demonstrate that the CFFPR remains a valid data source generalizable to the CF population. High participation among younger individuals may reflect the success of newborn screening programs and early referral to CF care. If engagement can be sustained, the percentage of individuals participating in the CFFPR will grow over time and there is an opportunity to identify factors associated with loss to follow up among older individuals to optimize the quality of the CFFPR data.
MeSH term(s)	Infant, Newborn ; Humans ; United States/epidemiology ; Middle Aged ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/epidemiology ; Prevalence ; Neonatal Screening ; Registries ; Incidence
Language	English
Publishing date	2023-03-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2084724-5
ISSN	1873-5010 ; 1569-1993
ISSN (online)	1873-5010
ISSN	1569-1993
DOI	10.1016/j.jcf.2023.02.009
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Zs.A 6028: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 459: Show issues

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Article ; Online: Does incarceration influence patients' goals for opioid use disorder treatment? A qualitative study of buprenorphine treatment in jail.

Vail, William / Faro, Elissa / Watnick, Dana / Giftos, Jonathan / Fox, Aaron D

Drug and alcohol dependence

2021 Volume 222, Page(s) 108529

Abstract: Background: Correctional facilities increasingly offer medications for opioid use disorder (OUD), including buprenorphine. Nevertheless, retention in treatment post-incarceration is suboptimal and overdose mortality remains high. Our objectives were to ... ...

Abstract	Background: Correctional facilities increasingly offer medications for opioid use disorder (OUD), including buprenorphine. Nevertheless, retention in treatment post-incarceration is suboptimal and overdose mortality remains high. Our objectives were to understand how incarcerated patients viewed buprenorphine treatment and identify modifiable factors that influenced treatment continuation post-release. Methods: We conducted semi-structured interviews with 22 men receiving buprenorphine treatment in an urban jail. Interviews were audio recorded, professionally transcribed, and analyzed using a grounded-theory approach. Team members constructed preliminary case memos from transcripts, and then interactively discussed themes within respective memos. We established participant 'typologies' by consensus. Results: Distinct typologies emerged based on participants' post-release treatment goals: (1) those who viewed buprenorphine treatment as a cure for OUD; (2) those who thought buprenorphine would help manage opioid-related problems; and (3) those who did not desire OUD treatment. Participants also described common social structural barriers to treatment continuation and community re-integration. Participants reported that post-release housing instability, unemployment, and negative interactions with parole contributed to opioid use relapse and re-incarceration. Conclusion: Participants had different goals for post-release buprenorphine treatment continuation, but their prior experiences suggested that social structural issues would complicate these plans. Incarceration can intensify marginalization, which when combined with heightened legal supervision, reinforced cycles of release, relapse, and re-incarceration. Participants valued buprenorphine treatment, but other structural and policy changes will be necessary to reduce incarceration-related inequities in opioid overdose mortality.
MeSH term(s)	Buprenorphine/therapeutic use ; Goals ; Humans ; Jails ; Male ; Opiate Substitution Treatment ; Opioid-Related Disorders/drug therapy ; Prisoners
Chemical Substances	Buprenorphine (40D3SCR4GZ)
Language	English
Publishing date	2021-03-18
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	519918-9
ISSN	1879-0046 ; 0376-8716
ISSN (online)	1879-0046
ISSN	0376-8716
DOI	10.1016/j.drugalcdep.2021.108529
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Zs.A 1310: Show issues

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Article ; Online: Recovery among post-arrest patients with mild-to-moderate cerebral edema.

Fuller, Zachary L / Faro, John W / Callaway, Clifton W / Coppler, Patrick J / Elmer, Jonathan

Resuscitation

2021 Volume 162, Page(s) 149–153

Abstract: Background: Cerebral edema after cardiac arrest may be a modifiable cause of secondary brain injury. We aimed to identify processes of care associated with recovery in a cohort of patients with mild to moderate edema.: Methods: We conducted a ... ...

Abstract	Background: Cerebral edema after cardiac arrest may be a modifiable cause of secondary brain injury. We aimed to identify processes of care associated with recovery in a cohort of patients with mild to moderate edema. Methods: We conducted a retrospective cohort study of adults resuscitated from out-of-hospital arrest (OHCA) at a single center from 2010 to 2018. We included those with cerebral edema ranging from mild to moderate (gray to white matter attenuation ratio (GWR) 1.2 to 1.3 on initial brain computerized tomography (CT). We used Pittsburgh Cardiac Arrest Category (PCAC) to adjust for illness severity and considered the following values in the first 24 h of admission as additional predictors: GWR, lab values affecting serum osmolality (sodium, glucose, blood urea nitrogen (BUN)), total osmolality, change in osmolality from 0 to 24 h, cardiac etiology of arrest, targeted temperature to 33 °C (vs 36 °C), time-weighted mean arterial pressure (MAP), partial pressures of arterial oxygen and carbon dioxide and select medications. Our primary outcome was discharge with cerebral performance category 1-3. We used unadjusted and adjusted logistic regression for analysis. Results: We included 214 patients for whom CT was performed median 3.8 [IQR 2.4-5.2] hours after collapse. Median age was 57 [IQR 48-67] years, 82 (38%) were female, and 68 (32%) arrested from ventricular tachycardia or fibrillation. In adjusted models, modifiable processes of care were not associated with outcome. Conclusions: Illness severity, but not modifiable processes of care, were associated with recovery among post-arrest patients with mild-to-moderate cerebral edema.
MeSH term(s)	Adult ; Brain ; Brain Edema/etiology ; Cardiopulmonary Resuscitation ; Female ; Heart Arrest ; Humans ; Middle Aged ; Out-of-Hospital Cardiac Arrest ; Retrospective Studies ; White Matter
Language	English
Publishing date	2021-03-01
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2021.02.033
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Zs.A 1048: Show issues

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Article ; Online: Repair of a recurrent rectovaginal fistula with a biological graft.

Berger, Kate / Faro, Jonathan / Faro, Sebastian

International urogynecology journal

2015 Volume 26, Issue 7, Page(s) 1071–1073

Abstract: This case involves a patient with the congenital absence of the lower third of the vagina. While undergoing surgical restoration of the vagina, she sustained a laceration, which ultimately led to the development of a rectovaginal fistula. After two ... ...

Abstract	This case involves a patient with the congenital absence of the lower third of the vagina. While undergoing surgical restoration of the vagina, she sustained a laceration, which ultimately led to the development of a rectovaginal fistula. After two unsuccessful attempts at repair, the recommendation was for a diverting colostomy with another attempted repair, and she presented to our clinic to discuss other possible surgical options. The patient underwent repair of the fistula using a porcine-derived small intestinal submucosal extracellular matrix graft, which resulted in the repair of the rectovaginal fistula without recurrence at 18 months' follow-up.
MeSH term(s)	Adult ; Female ; Humans ; Rectovaginal Fistula/surgery ; Transplants ; Vagina/abnormalities
Language	English
Publishing date	2015-07
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1050631-7
ISSN	1433-3023 ; 0937-3462
ISSN (online)	1433-3023
ISSN	0937-3462
DOI	10.1007/s00192-015-2701-1
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Zs.A 3070: Show issues

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Article ; Online: Necrotizing soft-tissue infections in obstetric and gynecologic patients.

Faro, Sebastian / Faro, Jonathan P

Clinical obstetrics and gynecology

2012 Volume 55, Issue 4, Page(s) 875–887

Abstract: For the clinician, necrotizing soft-tissue infections have remained a daunting opponent since the first writings on the subject over 2000 years ago. Early disease may be incorrectly diagnosed as cellulitis, and this delay in correctly diagnosing and ... ...

Abstract	For the clinician, necrotizing soft-tissue infections have remained a daunting opponent since the first writings on the subject over 2000 years ago. Early disease may be incorrectly diagnosed as cellulitis, and this delay in correctly diagnosing and expeditiously proceeding to radical surgical debridement may lead to a high degree of mortality. Although several inciting events and risk factors have been described that allow for the development and progression of this disease, the diagnosis is still made clinically. Only aggressive surgical management in combination with broad-spectrum antibiotics will offer a chance at improving patient outcomes.
MeSH term(s)	Fasciitis, Necrotizing/diagnosis ; Fasciitis, Necrotizing/epidemiology ; Fasciitis, Necrotizing/history ; Fasciitis, Necrotizing/microbiology ; Fasciitis, Necrotizing/therapy ; Female ; History, 19th Century ; History, 20th Century ; History, Ancient ; Humans ; Incidence ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/microbiology ; Postoperative Complications/therapy ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/microbiology ; Pregnancy Complications, Infectious/therapy ; Puerperal Infection/diagnosis ; Puerperal Infection/epidemiology ; Puerperal Infection/microbiology ; Puerperal Infection/therapy ; Risk Factors ; Soft Tissue Infections/diagnosis ; Soft Tissue Infections/epidemiology ; Soft Tissue Infections/microbiology ; Soft Tissue Infections/therapy
Language	English
Publishing date	2012-12
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	391207-3
ISSN	1532-5520 ; 0009-9201
ISSN (online)	1532-5520
ISSN	0009-9201
DOI	10.1097/GRF.0b013e31827146cd
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