Article ; Online: Neuroinflammation and COVID-19.
Current opinion in neurobiology
2022 Volume 76, Page(s) 102608
Abstract: Coronavirus disease 2019 (COVID-19) has caused a historic pandemic of respiratory disease. COVID-19 also causes acute and post-acute neurological symptoms, which range from mild, such as headaches, to severe, including hemorrhages. Current evidence ... ...
Abstract | Coronavirus disease 2019 (COVID-19) has caused a historic pandemic of respiratory disease. COVID-19 also causes acute and post-acute neurological symptoms, which range from mild, such as headaches, to severe, including hemorrhages. Current evidence suggests that there is no widespread infection of the central nervous system (CNS) by SARS-CoV-2, thus what is causing COVID-19 neurological disease? Here, we review potential immunological mechanisms driving neurological disease in COVID-19 patients. We begin by discussing the implications of imbalanced peripheral immunity on CNS function. Next, we examine the evidence for dysregulation of the blood-brain barrier during SARS-CoV-2 infection. Last, we discuss the role myeloid cells may play in promoting COVID-19 neurological disease. Combined, we highlight the role of innate immunity in COVID-19 neuroinflammation and suggest areas for future research. |
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MeSH term(s) | COVID-19/complications ; Humans ; Nervous System Diseases ; Neuroinflammatory Diseases ; Pandemics ; SARS-CoV-2 |
Language | English |
Publishing date | 2022-06-29 |
Publishing country | England |
Document type | Journal Article ; Review ; Research Support, N.I.H., Extramural |
ZDB-ID | 1078046-4 |
ISSN | 1873-6882 ; 0959-4388 |
ISSN (online) | 1873-6882 |
ISSN | 0959-4388 |
DOI | 10.1016/j.conb.2022.102608 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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