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Article ; Online: Nursing Science Advances in Poststroke Fatigue, Return to Work, Sleep Disorders, and Mindfulness Following Stroke.

Hinkle, Janice L / Miller, Elaine T

2023 Volume 54, Issue 4, Page(s) 1120–1122

MeSH term(s)	Humans ; Mindfulness ; Return to Work ; Stroke/complications ; Stroke/therapy ; Fatigue/etiology ; Fatigue/therapy ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/therapy
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.123.042307
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Zs.A 448: Show issues

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Article ; Online: Nursing's Contributions to Stroke Care During COVID-19.

Miller, Elaine T / Hinkle, Janice L

Stroke

2022 Volume 53, Issue 4, Page(s) 1396–1398

MeSH term(s)	COVID-19 ; Humans ; Stroke/therapy
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.122.037447
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Article ; Online: Nursing Scientific Statements Advancing Stroke Care.

Hinkle, Janice L / Miller, Elaine T

Stroke

2021 Volume 52, Issue 4, Page(s) 1483–1485

MeSH term(s)	Humans ; Stroke/nursing
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.121.033559
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Article ; Online: Diagnostic accuracy of a novel lateral flow assay for histoplasmosis.

Burrows, Megan / Miller, Janice / Liesman, Rachael M / Bahr, Nathan C

Medical mycology

2024

Abstract: Antigen testing is an important diagnostic tool for histoplasmosis but has limited availability globally. We evaluated the OIDx urine lateral flow antigen assay among 204 persons suspected to have histoplasmosis. Among patients with proven histoplasmosis, ...

Abstract	Antigen testing is an important diagnostic tool for histoplasmosis but has limited availability globally. We evaluated the OIDx urine lateral flow antigen assay among 204 persons suspected to have histoplasmosis. Among patients with proven histoplasmosis, sensitivity was 33.3% (3/9, 95% CI 7.5-70.1%) and specificity 80.5% (157/195, 95% CI 74.3-85.8%). The MiraVista urine antigen test had better specificity (96.9%) and equal sensitivity. The OIDx test demonstrated 33.3% (3/9) positive agreement and 84.0% (163/194) negative agreement with the MiraVista test. These results should be considered in the context of our low HIV prevalence population with a mixture of pulmonary and disseminated disease.
Language	English
Publishing date	2024-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1421796-x
ISSN	1460-2709 ; 1369-3786
ISSN (online)	1460-2709
ISSN	1369-3786
DOI	10.1093/mmy/myae051
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Zs.A 520: Show issues

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Article ; Online: Aligning the Post Master's DNP with the 2021 AACN Essentials.

Gray, Kathy / Miller, Janice M / Manning, Mary Lou

Journal of professional nursing : official journal of the American Association of Colleges of Nursing

2023 Volume 46, Page(s) 65–69

Abstract: Background: The Essentials: Core Competencies for Professional Nursing Education was published in 2021 to establish competency-based education on two levels; entry and advanced. Advanced level competencies are intended for doctorally prepared ... ...

Abstract	Background: The Essentials: Core Competencies for Professional Nursing Education was published in 2021 to establish competency-based education on two levels; entry and advanced. Advanced level competencies are intended for doctorally prepared professionals. Purpose: The purpose of this initiative was to align a Post Master's Doctor of Nursing Practice (DNP) Program with the new 2021 American Association of Colleges of Nursing (AACN) Competency-Based Essentials. Methods: Three DNP faculty met weekly, outlined a timeframe and approached the revision as a quality improvement plan to revise the curriculum based on our comprehensive review of the domains and concepts of the revised (2021) AACN Essentials. DNP Course Leads were interviewed to evaluate the course objectives, student learning objectives, assignments, and course content. Results: Six new program outcomes (POs) were written. For each (PO), measurable student learning outcomes (SLOs) were articulated for each course. Several courses were combined or retired, and several new courses were added including an elective. The DNP project was reframed based on a 'systems' approach to implement quality improvement (QI) within the health care system in consideration of the concepts of diversity, equity, and inclusion (DEI) and the impact on patient outcomes. Conclusions: In keeping with the Mission, Vision and Values of the College and with the collaboration and support from the Dean, the graduate Chair, and faculty of the College, the post-master's DNP program was approved with an anticipated start date in Summer, 2023.
MeSH term(s)	Humans ; Education, Nursing, Graduate ; Education, Nursing ; Curriculum ; Competency-Based Education ; Faculty, Nursing
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	632951-2
ISSN	1532-8481 ; 8755-7223
ISSN (online)	1532-8481
ISSN	8755-7223
DOI	10.1016/j.profnurs.2022.11.007
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Zs.B 2985: Show issues

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Article ; Online: Adolescents' Perceptions of School Nurses' Role in Functional Seizures at School.

Tanner, Andrea / von Gaudecker, Jane / Buelow, Janice M / Miller, Wendy R

The Journal of school nursing : the official publication of the National Association of School Nurses

2023 , Page(s) 10598405231218287

Abstract: Adolescents with functional (psychogenic nonepileptic) seizures experience school-related struggles. School nurses are positioned to address such struggles. However, school nurses report having little education or confidence in their role of managing or ... ...

Abstract	Adolescents with functional (psychogenic nonepileptic) seizures experience school-related struggles. School nurses are positioned to address such struggles. However, school nurses report having little education or confidence in their role of managing or responding to this mental health condition. Little is known about adolescents' perceptions of school nurses' role in functional seizure care. This qualitative study used semi-structured interviews with 10 adolescents from across the United States with functional seizures to explore adolescents' perceptions of school nurses' roles in functional seizure care at school. Results revealed school nurses, when present, play a spectrum of roles according to adolescents' perceptions, ranging from negative (harmful and uninvolved) to positive (being present, expressing care, and actively doing tasks for the student). These perceived roles shed light upon school nurses' lack of functional seizure awareness and opportunities to incorporate mental health interventions for adolescents with functional seizures in the school setting.
Language	English
Publishing date	2023-12-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1217746-5
ISSN	1546-8364 ; 1059-8405 ; 0048-945X
ISSN (online)	1546-8364
ISSN	1059-8405 ; 0048-945X
DOI	10.1177/10598405231218287
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Zs.A 4182: Show issues

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Article: Use of perioperative telotristat in a patient with carcinoid heart disease.

Flynn, Maria / Noss, Christopher / Miller, Robert / Adams, Corey / Ruether, Dean / Chan, Denise / Pasieka, Janice / Lithgow, Kirstie

Endocrinology, diabetes & metabolism case reports

2024 Volume 2024, Issue 1

Abstract: Summary: Carcinoid heart disease is a rare complication of carcinoid syndrome, resulting in right-sided valvular heart disease and subsequent heart failure due to long-term exposure to vasoactive substances. The management of this condition is complex, ... ...

Abstract	Summary: Carcinoid heart disease is a rare complication of carcinoid syndrome, resulting in right-sided valvular heart disease and subsequent heart failure due to long-term exposure to vasoactive substances. The management of this condition is complex, often requiring surgical intervention. Current perioperative regimens entail the use of prophylactic somatostatin analogs to prevent carcinoid crisis; however, regimens vary widely among practitioners and evidence supporting their efficacy in this clinical setting is mixed. This case report describes the perioperative management of a 65-year-old man with carcinoid heart disease requiring tricuspid and pulmonary valve replacement surgery. As an adjunct to somatostatin analog therapy, the novel tyrosine hydroxylase inhibitor, telotristat, was initiated preoperatively. This combination resulted in normalization of preoperative urinary 5-HIAA levels. The patient successfully underwent tricuspid and pulmonic valve replacement without evidence of carcinoid crisis. This clinical case is the first published documenting the use of telotristat in the perioperative period in a patient with carcinoid syndrome and carcinoid heart disease and was associated with a good long-term outcome despite the high-risk nature of the case. Learning points: Carcinoid crisis is a life-threatening complication of carcinoid syndrome, resulting in hemodynamic instability, bronchospasm, and arrhythmia. Cardiac surgical patients with carcinoid syndrome present a unique challenge as they are subject to physiologic conditions and medications which can potentiate intraoperative carcinoid crisis. Perioperative management of patients with carcinoid syndrome currently entails the use of prophylactic somatostatin analogs; however, these agents do not prevent carcinoid crisis in all cases. Telotristat, a tryptophan hydroxylase inhibitor, shows promise as an adjunctive therapy to somatostatin analogs to reduce the risk of intraoperative carcinoid crisis.
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2785530-2
ISSN	2052-0573
ISSN	2052-0573
DOI	10.1530/EDM-23-0070
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Article ; Online: What AHRQ Learned While Working to Transform Primary Care.

Meyers, David / Miller, Therese / De La Mare, Jan / Gerteis, Jessie S / Makulowich, Gail / Weber, Gabrielle H / Zhan, Chunliu / Genevro, Janice

Annals of family medicine

2024 Volume 22, Issue 2, Page(s) 161–166

Abstract: Building on previous efforts to transform primary care, the Agency for Healthcare Research and Quality (AHRQ) launched EvidenceNOW: Advancing Heart Health in 2015. This 3-year initiative provided external quality improvement support to small and medium- ... ...

Abstract	Building on previous efforts to transform primary care, the Agency for Healthcare Research and Quality (AHRQ) launched EvidenceNOW: Advancing Heart Health in 2015. This 3-year initiative provided external quality improvement support to small and medium-size primary care practices to implement evidence-based cardiovascular care. Despite challenges, results from an independent national evaluation demonstrated that the EvidenceNOW model successfully boosted the capacity of primary care practices to improve quality of care, while helping to advance heart health. Reflecting on AHRQ's own learnings as the funder of this work, 3 key lessons emerged: (1) there will always be surprises that will require flexibility and real-time adaptation; (2) primary care transformation is about more than technology; and (3) it takes time and experience to improve care delivery and health outcomes. EvidenceNOW taught us that lasting practice transformation efforts need to be responsive to anticipated and unanticipated changes, relationship-oriented, and not tied to a specific disease or initiative. We believe these lessons argue for a national primary care extension service that provides ongoing support for practice transformation.
MeSH term(s)	United States ; Humans ; Primary Health Care/methods ; United States Agency for Healthcare Research and Quality ; Quality Improvement
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171425-3
ISSN	1544-1717 ; 1544-1709
ISSN (online)	1544-1717
ISSN	1544-1709
DOI	10.1370/afm.3090
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Zs.A 6065: Show issues

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Article ; Online: Gut metabolic changes during pregnancy reveal the importance of gastrointestinal region in sample collection.

Moore, Makala L / Ford, Jermaine L / Schladweiler, Mette C / Dye, Janice A / Jackson, Thomas W / Miller, Colette N

Metabolomics : Official journal of the Metabolomic Society

2024 Volume 20, Issue 2, Page(s) 40

Abstract: Introduction: Studies of gastrointestinal physiology and the gut microbiome often consider the influence of intestinal region on experimental endpoints. However, this same consideration is not often applied to the gut metabolome. Understanding the ... ...

Abstract	Introduction: Studies of gastrointestinal physiology and the gut microbiome often consider the influence of intestinal region on experimental endpoints. However, this same consideration is not often applied to the gut metabolome. Understanding the contribution of gut regionality may be critically important to the rapidly changing metabolic environments, such as during pregnancy. Objectives: We sought to characterize the difference in the gut metabolome in pregnant mice stratified by region-comparing the small intestine, cecum, and feces. Pre-pregnancy feces were collected to understand the influence of pregnancy on the fecal metabolome. Methods: Feces were collected from CD-1 female mice before breeding. On gestation day (GD) 18, gut contents were collected from the small intestine, cecum, and descending colon. Metabolites were analyzed with LC-MS/MS using the Biocrates MetaboINDICATOR™ MxP® Quant 500 kit. Results: Of the 104 small molecule metabolites meeting analysis criteria, we found that 84 (81%) were differentially abundant based on gut region. The most significant regional comparison observed was between the cecum and small intestines, with 52 (50%) differentially abundant metabolites. Pregnancy itself altered 41 (39.4%) fecal small molecule metabolites. Conclusions: The regional variation observed in the gut metabolome are likely due to the microbial and physiological differences between the different parts of the intestines. Additionally, pregnancy impacts the fecal metabolome, which may be due to evolving needs of both the dam and fetus.
MeSH term(s)	Pregnancy ; Female ; Mice ; Animals ; Metabolomics ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Metabolome ; Gastrointestinal Microbiome
Language	English
Publishing date	2024-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2250617-2
ISSN	1573-3890 ; 1573-3882
ISSN (online)	1573-3890
ISSN	1573-3882
DOI	10.1007/s11306-024-02099-x
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Article ; Online: Evaluation of hospital management of paediatric out-of-hospital cardiac arrest.

Gupte, Dhruv / Assaf, Maysaa / Miller, Michael R / McKenzie, Kate / Loosley, Jay / Tijssen, Janice A

Resuscitation plus

2023 Volume 15, Page(s) 100433

Abstract: Introduction: Pediatric out of hospital cardiac arrest (POHCA) is rare, with high mortality and neurological morbidity. Adherence to Pediatric Advanced Life Support guidelines standardizes in-hospital care and improves outcomes. We hypothesized that in- ... ...

Abstract	Introduction: Pediatric out of hospital cardiac arrest (POHCA) is rare, with high mortality and neurological morbidity. Adherence to Pediatric Advanced Life Support guidelines standardizes in-hospital care and improves outcomes. We hypothesized that in-hospital care of POHCA patients was variable and deviations from guidelines were associated with higher mortality. Methods: POHCA patients in the London-Middlesex region between January 2012 and June 2020 were included. The care of children with ongoing arrest (intra-arrest) and post-arrest outcomes were reviewed using the Children's Hospital, London Health Sciences Centre (LHSC) patient database and the Adverse Event Management System. Results: 50 POHCA patients arrived to hospital, with 15 (30%) patients admitted and 2 (4.0%) surviving to discharge, both with poor neurological outcomes and no improvement at 90 days. Deviations occurred at every event with intra-arrest care deviations occurring mostly in medication delivery and defibrillation (98%). Post-arrest deviations occurred mostly in temperature monitoring (60%). Data missingness was 15.9% in the intra-arrest and 1.7% in the post-arrest group. Discussion: Deviations commonly occurred in both in-hospital arrest and post-arrest care. The study was under-powered to identify associations between DEVs and outcomes. Future work includes addressing specific deviations in intra-arrest and post-arrest care of POHCA patients and standardizing electronic documentation.
Language	English
Publishing date	2023-07-27
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2023.100433
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