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  1. Book ; Online ; E-Book: Handbook of microbiome and gut-brain-axis in Alzheimer's disease

    Pasinetti, Giulio Maria

    (Advances in Alzheimer's disease ; volume 9)

    2022  

    Author's details edited by Giulio Maria Pasinetti
    Series title Advances in Alzheimer's disease ; volume 9
    Keywords Gastrointestinal system/Microbiology ; Alzheimer's disease
    Subject code 612.3/601579
    Language English
    Size 1 online resource (732 pages)
    Publisher IOS Press
    Publishing place Amsterdam, Netherlands
    Document type Book ; Online ; E-Book
    Note Includes indexes.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9781643682891 ; 9781643682884 ; 164368289X ; 1643682881
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Human microbiome collection.

    Pasinetti, Giulio Maria / Turroni, Silvia / Palmieri, Joshua / De Filippo, Carlotta

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 3807

    MeSH term(s) Humans ; Microbiota ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-30625-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Towards prevention and therapy of Alzheimer's disease.

    Pasinetti, Giulio Maria

    Molecular aspects of medicine

    2015  Volume 43-44, Page(s) 1–2

    MeSH term(s) Alzheimer Disease/pathology ; Alzheimer Disease/prevention & control ; Alzheimer Disease/therapy ; Humans
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Editorial
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2015.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1189: Show issues Location:
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  4. Article ; Online: Role of Artificial Intelligence in Multinomial Decisions and Preventative Nutrition in Alzheimer's Disease.

    Soares Dias Portela, Ariana / Saxena, Vrinda / Rosenn, Eric / Wang, Shu-Han / Masieri, Sibilla / Palmieri, Joshua / Pasinetti, Giulio Maria

    Molecular nutrition & food research

    2024  , Page(s) e2300605

    Abstract: Alzheimer's disease (AD) affects 50 million people worldwide, an increase of 35 million since 2015, and it is known for memory loss and cognitive decline. Considering the morbidity associated with AD, it is important to explore lifestyle elements ... ...

    Abstract Alzheimer's disease (AD) affects 50 million people worldwide, an increase of 35 million since 2015, and it is known for memory loss and cognitive decline. Considering the morbidity associated with AD, it is important to explore lifestyle elements influencing the chances of developing AD, with special emphasis on nutritional aspects. This review will first discuss how dietary factors have an impact in AD development and the possible role of Artificial Intelligence (AI) and Machine Learning (ML) in preventative care of AD patients through nutrition. The Mediterranean-DASH diets provide individuals with many nutrient benefits which assists the prevention of neurodegeneration by having neuroprotective roles. Lack of micronutrients, protein-energy, and polyunsaturated fatty acids increase the chance of cognitive decline, loss of memory, and synaptic dysfunction among others. ML software has the ability to design models of algorithms from data introduced to present practical solutions that are accessible and easy to use. It can give predictions for a precise medicine approach to evaluate individuals as a whole. There is no doubt the future of nutritional science lies on customizing diets for individuals to reduce dementia risk factors, maintain overall health and brain function.
    Language English
    Publishing date 2024-01-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2160372-8
    ISSN 1613-4133 ; 1613-4125
    ISSN (online) 1613-4133
    ISSN 1613-4125
    DOI 10.1002/mnfr.202300605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Transient anxiety-and depression-like behaviors are linked to the depletion of Foxp3-expressing cells via inflammasome in the brain.

    Yang, Eun-Jeong / Rahim, Md Al / Griggs, Elizabeth / Iban-Arias, Ruth / Pasinetti, Giulio Maria

    PNAS nexus

    2023  Volume 2, Issue 8, Page(s) pgad251

    Abstract: Forkhead box P3 (Foxp3) is a transcription factor that influences functioning of regulatory T cells (Tregs) that modulate peripheral immune response. Treg-mediated innate immunity and Treg-mediated adaptive immunity are receiving considerable attention ... ...

    Abstract Forkhead box P3 (Foxp3) is a transcription factor that influences functioning of regulatory T cells (Tregs) that modulate peripheral immune response. Treg-mediated innate immunity and Treg-mediated adaptive immunity are receiving considerable attention for their implication in mechanisms associated with anxiety and depression. Here, we demonstrated that depletion of Foxp3-expressing cells causally promotes transient anxiety- and depression-like behaviors associated with inflammasome activation in "depletion of regulatory T cell" (DEREG) mice. We found that restoration of Foxp3-expressing cells causally reverses neurobehavioral changes through alteration of innate immune responses as assessed by caspase-1 activity and interleukin-1β (IL-1β) release in the hippocampal formation of DEREG mice. Moreover, we found that depletion of Foxp3-expressing cells induces a significant elevation of granulocytes, monocytes, and macrophages in the blood, which are associated with transient expression of the matrix metalloprotease-9. Similarly, we found that depletion of Foxp3-expressing cells in 5xFAD, a mouse model of Alzheimer's disease (AD), exhibits elevated activated caspase-1 and promotion of IL-1β secretion and increased the level of amyloid-beta (Aβ)
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article
    ISSN 2752-6542
    ISSN (online) 2752-6542
    DOI 10.1093/pnasnexus/pgad251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Gut Microbiota Links Dietary Polyphenols With Management of Psychiatric Mood Disorders.

    Westfall, Susan / Pasinetti, Giulio Maria

    Frontiers in neuroscience

    2019  Volume 13, Page(s) 1196

    Abstract: The pathophysiology of depression is multifactorial yet generally aggravated by stress and its associated physiological consequences. To effectively treat these diverse risk factors, a broad acting strategy is required and is has been suggested that gut- ... ...

    Abstract The pathophysiology of depression is multifactorial yet generally aggravated by stress and its associated physiological consequences. To effectively treat these diverse risk factors, a broad acting strategy is required and is has been suggested that gut-brain-axis signaling may play a pinnacle role in promoting resilience to several of these stress-induced changes including pathogenic load, inflammation, HPA-axis activation, oxidative stress and neurotransmitter imbalances. The gut microbiota also manages the bioaccessibility of phenolic metabolites from dietary polyphenols whose multiple beneficial properties have known therapeutic efficacy against depression. Although several potential therapeutic mechanisms of dietary polyphenols toward establishing cognitive resilience to neuropsychiatric disorders have been established, only a handful of studies have systematically identified how the interaction of the gut microbiota with dietary polyphenols can synergistically alleviate the biological signatures of depression. The current review investigates several of these potential mechanisms and how synbiotics, that combine probiotics with dietary polyphenols, may provide a novel therapeutic strategy for depression. In particular, synbiotics have the potential to alleviate neuroinflammation by modulating microglial and inflammasome activation, reduce oxidative stress and balance serotonin metabolism therefore simultaneously targeting several of the major pathological risk factors of depression. Overall, synbiotics may act as a novel therapeutic paradigm for neuropsychiatric disorders and further understanding the fundamental mechanisms of gut-brain-axis signaling will allow full utilization of the gut microbiota's as a therapeutic tool.
    Language English
    Publishing date 2019-11-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2019.01196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ad-derived bone marrow transplant induces proinflammatory immune peripheral mechanisms accompanied by decreased neuroplasticity and reduced gut microbiome diversity affecting AD-like phenotype in the absence of Aβ neuropathology.

    Iban-Arias, Ruth / Yang, Eun-Jeong / Griggs, Elizabeth / Soares Dias Portela, Ariana / Osman, Aya / Trageser, Kyle J / Shahed, Mahadi / Maria Pasinetti, Giulio

    Brain, behavior, and immunity

    2024  Volume 118, Page(s) 252–272

    Abstract: Immune system dysfunction is increasingly recognized as a significant feature that contributes to Alzheimer's disease (AD) pathogenesis, reflected by alterations in central and peripheral responses leading to detrimental mechanisms that can contribute to ...

    Abstract Immune system dysfunction is increasingly recognized as a significant feature that contributes to Alzheimer's disease (AD) pathogenesis, reflected by alterations in central and peripheral responses leading to detrimental mechanisms that can contribute to the worsening of the disease. The damaging alterations in the peripheral immune system may disrupt the peripheral-central immune crosstalk, implicating the gut microbiota in this complex interaction. The central hypothesis posits that the immune signature inherently harbored in bone marrow (BM) cells can be transferred through allogeneic transplantation, influencing the recipient's immune system and modulating peripheral, gut, and brain immune responses. Employing a genetically modified mouse model to develop AD-type pathology we found that recipient wild-type (WT) mice engrafted with AD-derived BM, recapitulated the peripheral immune inflammatory donor phenotype, associated with a significant acceleration of cognitive deterioration in the absence of any overt change in AD-type amyloid neuropathology. Moreover, transcriptomic and phylogenetic 16S microbiome analysis evidence on these animals revealed a significantly impaired expression of genes associated with synaptic plasticity and neurotransmission in the brain and reduced bacteria diversity, respectively, compared to mice engrafted with WT BM. This investigation sheds light on the pivotal role of the peripheral immune system in the brain-gut-periphery axis and its profound potential to shape the trajectory of AD. In summary, this study advances our understanding of the complex interplay among the peripheral immune system, brain functionality, and the gut microbiome, which collectively influence AD onset and progression.
    MeSH term(s) Mice ; Animals ; Alzheimer Disease/pathology ; Gastrointestinal Microbiome/physiology ; Bone Marrow Transplantation ; Phylogeny ; Nervous System Diseases ; Phenotype ; Neuronal Plasticity ; Mice, Transgenic
    Language English
    Publishing date 2024-03-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2024.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2276: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 327: Show issues

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  8. Article ; Online: The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process.

    Sebastian-Valverde, Maria / Pasinetti, Giulio M

    Cells

    2020  Volume 9, Issue 6

    Abstract: As a consequence of the considerable increase in the human lifespan over the last century, we are experiencing the appearance and impact of new age-related diseases. The causal relationships between aging and an enhanced susceptibility of suffering from ... ...

    Abstract As a consequence of the considerable increase in the human lifespan over the last century, we are experiencing the appearance and impact of new age-related diseases. The causal relationships between aging and an enhanced susceptibility of suffering from a broad spectrum of diseases need to be better understood. However, one specific shared feature seems to be of capital relevance for most of these conditions: the low-grade chronic inflammatory state inherently associated with aging, i.e., inflammaging. Here, we review the molecular and cellular mechanisms that link aging and inflammaging, focusing on the role of the innate immunity and more concretely on the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, as well as how the chronic activation of this inflammasome has a detrimental effect on different age-related disorders.
    MeSH term(s) Humans ; Immunity, Innate/immunology ; Inflammasomes/immunology ; Inflammation/immunology ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein
    Keywords covid19
    Language English
    Publishing date 2020-06-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9061552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Role of Personalized Medicine in the Identification and Characterization of Parkinson's Disease in Asymptomatic Subjects.

    Pasinetti, Giulio Maria

    Journal of Alzheimer's disease & Parkinsonism

    2012  Volume 2, Issue 3

    Language English
    Publishing date 2012-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2711981-6
    ISSN 2161-0460
    ISSN 2161-0460
    DOI 10.4172/2161-0460.1000e118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Investigation of Potential Brain Microbiome in Alzheimer's Disease: Implications of Study Bias.

    Westfall, Susan / Dinh, Duy M / Pasinetti, Giulio Maria

    Journal of Alzheimer's disease : JAD

    2020  Volume 75, Issue 2, Page(s) 559–570

    Abstract: Background: Dysbiotic microbiota in the gastrointestinal tract promotes and aggravates neurodegenerative disorders. Alzheimer's disease (AD) has been shown to correlate to dysbiotic bacteria and the immune, metabolic, and endocrine abnormalities ... ...

    Abstract Background: Dysbiotic microbiota in the gastrointestinal tract promotes and aggravates neurodegenerative disorders. Alzheimer's disease (AD) has been shown to correlate to dysbiotic bacteria and the immune, metabolic, and endocrine abnormalities associated with abnormal gut-brain-axis signaling. Recent reports also indicate that brain dysbacteriosis may play a role in AD pathogenesis.
    Objective: To evaluate the presence and differences of brain-region dependent microbiomes in control and AD subjects and the contribution of study bias.
    Methods: Two independent cohorts of postmortem AD brain samples were collected from separate locations, processed with different extraction protocols and investigated for the presence of bacterial DNA indicative of a brain microbiome with V4 16S next generation sequencing.
    Results: In both cohorts, few differences between the control and AD groups were observed in terms of alpha and beta diversities, phyla and genera proportions. Independent of study in both AD and control subjects the most abundant phyla were Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes. Variations in beta diversity between hippocampal and cerebellum samples were observed indicating an impact of brain region on the presence of microbial DNA. Importantly, differences in alpha and beta diversities between the two independent cohorts were found indicating a significant cohort- and processing-dependent effect on the microbiome. Finally, there were cohort-specific correlations between the gut microbiome and subject demographics indicate that postmortem interval may have a significant impact on brain microbiome determination.
    Conclusions: Regardless of the study bias, this study concludes that bacterial DNA can be isolated from the human brain suggesting that a brain microbiome may exist; however, more studies are required to understand the variation in AD.
    MeSH term(s) Alzheimer Disease/microbiology ; Brain/microbiology ; Dysbiosis/microbiology ; Female ; Humans ; Male ; Microbiota ; Nerve Degeneration/microbiology
    Language English
    Publishing date 2020-04-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-191328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
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