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Article: Giant Cell Reparative Granuloma in the Thumb Distal Phalanx: A Case Report.

Arvind, Varun / Konigsberg, Matthew W / Strauch, Robert J

2023 Volume 15, Issue 8, Page(s) e43564

Abstract: Giant cell reparative granulomas (GCRG) often affect the bones of the hands and the feet. Treatment of this lesion depends on the exact location and amount of localized bony destruction. Ours is the first case report to discuss the nuances of treating ... ...

Abstract	Giant cell reparative granulomas (GCRG) often affect the bones of the hands and the feet. Treatment of this lesion depends on the exact location and amount of localized bony destruction. Ours is the first case report to discuss the nuances of treating this lesion in the thumb distal phalanx. A 19-year-old male presented with lytic, destructive expansion of his left thumb distal phalanx; imaging was suggestive of an aneurysmal bone cyst. Open biopsy was interpreted as giant cell reparative granuloma. Curettage and bone grafting resulted in complete healing of the distal phalanx with an excellent range of motion and interphalangeal joint stability. GCRG is a rare, benign entity typically presenting as a lytic bone lesion. Despite the initial massive bony destruction, this lesion nevertheless healed with curettage and bone grafting with maintained flexor pollicis longus and extensor pollicis longus function, permitting excellent active motion postoperatively.
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.43564
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Article ; Online: Antecubital Burn Resulting From Antenna Coupling: A Case Report.

Paskey, Taylor L / Ren, Mark / Arvind, Varun / Tyler, Wakenda K / Bogue, Jarrod T / Strauch, Robert J

JBJS case connector

2024 Volume 14, Issue 1

Abstract: Case: We present the case of a 54-year-old man who underwent elective hip disarticulation complicated by third-degree burn of the left antecubital fossa requiring skin graft. After careful review, it was determined that "antenna coupling" as a result of ...

Abstract	Case: We present the case of a 54-year-old man who underwent elective hip disarticulation complicated by third-degree burn of the left antecubital fossa requiring skin graft. After careful review, it was determined that "antenna coupling" as a result of electrosurgery was the likely cause. We present an experiment demonstrating this phenomenon. Conclusion: Antenna coupling is a real but rare cause of intraoperative burns not previously described in the orthopaedic literature. Care should be taken to avoid coiling or running bovie or other electrosurgical device cords with other metallic cords or corded devices.
MeSH term(s)	Male ; Humans ; Middle Aged ; Burns/etiology ; Electrosurgery/adverse effects ; Skin ; Skin Transplantation
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2160-3251
ISSN (online)	2160-3251
DOI	e24.00028
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Article: Reparative and Maladaptive Inflammation in Tendon Healing.

Arvind, Varun / Huang, Alice H

Frontiers in bioengineering and biotechnology

2021 Volume 9, Page(s) 719047

Abstract: Tendon injuries are common and debilitating, with non-regenerative healing often resulting in chronic disease. While there has been considerable progress in identifying the cellular and molecular regulators of tendon healing, the role of inflammation in ... ...

Abstract	Tendon injuries are common and debilitating, with non-regenerative healing often resulting in chronic disease. While there has been considerable progress in identifying the cellular and molecular regulators of tendon healing, the role of inflammation in tendon healing is less well understood. While inflammation underlies chronic tendinopathy, it also aids debris clearance and signals tissue repair. Here, we highlight recent findings in this area, focusing on the cells and cytokines involved in reparative inflammation. We also discuss findings from other model systems when research in tendon is minimal, and explore recent studies in the treatment of human tendinopathy to glean further insights into the immunobiology of tendon healing.
Language	English
Publishing date	2021-07-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2021.719047
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Article ; Online: Assessment of health risks for criteria air pollutants present in 11 non-attainment cities of Uttar Pradesh, India

Sharma, Khyati / Garg, Anchal / Joshi, Varun / Kumar, Arvind

Human and Ecological Risk Assessment: An International Journal. 2023 Feb. 1, v. 29, no. 1, p. 103-122

2023 , Page(s) 103–122

Abstract: Uttar Pradesh (UP), one of the most populous state of India is facing the highest mortality rate due to ambient air exposure. In this study, the Relative Risk (RR) and Excess Risk (ER) due to six criteria air pollutants namely PM₁₀, PM₂.₅, SO₂, NO₂, O₃, ... ...

Abstract	Uttar Pradesh (UP), one of the most populous state of India is facing the highest mortality rate due to ambient air exposure. In this study, the Relative Risk (RR) and Excess Risk (ER) due to six criteria air pollutants namely PM₁₀, PM₂.₅, SO₂, NO₂, O₃, and CO have been estimated for 11 non-attainment cities (NAC) of this State. Results indicated that the estimated total ER was 2.62 times higher when calculated using WHO 2021 Air Quality standards (AQS) and compared with estimates using India’s CPCB 2009 AQS. Ghaziabad faces the highest ERs for both PM₁₀ (6.20%) and PM₂.₅ (3.9%) as per WHO 2021 AQS. ER due to NO₂ was observed highest for Kanpur. The ERs obtained for CO, SO₂, and O₃ were found negative mainly because the estimated pollutant concentration was observed less than AQS and therefore possess no health risks. The study concludes that the present AQS of India’s CPCB for air pollutants PM₁₀, PM₂.₅, and NO₂ are underestimating the excess health risks and need to be revised urgently for better action plans in saving lives. PM₁₀ followed by PM₂.₅ are the major contributors to air pollution in almost all the 11 NAC of UP. Ghaziabad has the highest total ER among the 11 NAC. Aggregated ER was 2.62 times higher when estimated using WHO 2021 AQS than CPCB 2009 AQS CPCB 2009 AQS underestimate the health risks posed by PM₁₀, PM₂.₅, and NO₂. The study shows an urgent need to revise India’s CPCB air quality standards.
Keywords	air ; air quality ; environmental assessment ; humans ; mortality ; pollutants ; relative risk ; India ; non-attainment cities ; ambient air pollution ; human health ; health risks ; Uttar Pradesh
Language	English
Dates of publication	2023-0201
Size	p. 103-122
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	1549-7860
DOI	10.1080/10807039.2022.2157242
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Incidental FAPI Localization in Benign Bone Lesions in a Case of Carcinoma Stomach.

Manda, Divya / M V, Manikandan / Suresh, Arvind / Shukla, Varun

Clinical nuclear medicine

2023 Volume 48, Issue 12, Page(s) e572–e573

Abstract: Abstract: Recently developed radiolabeled FAPI (fibroblast-activation protein inhibitors) have attracted researcher's attention in diagnosing various tumors because of its high specificity and better tumor-to-background ratio. Increasing use of 68 Ga- ... ...

Abstract	Abstract: Recently developed radiolabeled FAPI (fibroblast-activation protein inhibitors) have attracted researcher's attention in diagnosing various tumors because of its high specificity and better tumor-to-background ratio. Increasing use of 68 Ga-FAPI PET/CT has resulted in reporting of incidental benign findings as well. We hereby present a case of suspected carcinoma stomach showing increased uptake in primary tumor in stomach as well as incidental uptake in benign subchondral cysts in bilateral shoulder joints and right hip joint on 68 Ga-FAPI PET CT scan.
MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography ; Stomach Neoplasms ; Bone Diseases ; Gallium Radioisotopes ; Carcinoma ; Fluorodeoxyglucose F18
Chemical Substances	Gallium-68 (98B30EPP5S) ; Gallium Radioisotopes ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004837
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Article: Expression of human papillomavirus 16 and 18 DNA in oral lichen planus using polymerase chain reaction.

Vijayan, Aswathy K / Muthukrishnan, Arvind / Velayudhannair, Vivek / Varun, Jayanthi / Vidyadharan, Mathew / James, Joseena

Journal of oral and maxillofacial pathology : JOMFP

2022 Volume 26, Issue 4, Page(s) 495–500

Abstract: Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with cell-mediated immune dysregulation. The aetiology of OLP has been studied extensively for decades. Viruses like Hepatitis C Virus (HCV), human papillomavirus (HPV), herpes ... ...

Abstract	Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with cell-mediated immune dysregulation. The aetiology of OLP has been studied extensively for decades. Viruses like Hepatitis C Virus (HCV), human papillomavirus (HPV), herpes simplex virus (HSV), and stress have been hypothesized to play a role in the pathogenesis and malignant transformation of OLP. HPV has been proved to be an etiological agent in oropharyngeal cancers and non-tobacco-associated leukoplakia. The role of human papillomavirus in the pathogenesis of OLP has to be studied extensively. Aim: This study aims to detect the presence of HPV 16 and HPV 18 DNA in the biopsy samples of OLP and also to determine the role played by the virus in the pathogenesis and malignant transformation of OLP. Materials and methods: Biopsy samples comprising 30 OLP tissues were collected. The DNA was extracted by the cetyltrimethylammonium bromide method. Polymerase chain reaction was performed by using general primers to amplify the HPV E6 gene. Results: Twelve out of 30 (40%) OLP cases were positive for HPV DNA. A significant relation was found between HPV, site (buccal mucosa) and the type (reticular) of the lesion ( Conclusion: This study confirmed the presence of high-risk HPV 16 and HPV 18 DNA in OLP. The study showed a significantly higher expression of HPV in erosive OLP when compared to reticular OLP, suggesting a possible role of HPV in the malignant transformation of OLP.
Language	English
Publishing date	2022-12-22
Publishing country	India
Document type	Journal Article
ZDB-ID	2390999-7
ISSN	1998-393X ; 0973-029X
ISSN (online)	1998-393X
ISSN	0973-029X
DOI	10.4103/jomfp.jomfp_61_22
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Article ; Online: Alterations in plant anatomy and higher lignin synthesis provides drought tolerance in cluster bean [Cyamopsis tetragonoloba (L.) Taub.]

Narayan, Shiv / Sharma, Rakesh Kumar / Kumar, Varun / Sanyal, Indraneel / Shirke, Pramod Arvind

Plant Physiology and Biochemistry. 2023 Aug., v. 201 p.107905-

2023

Abstract: Four contrasting varieties of guar, RGC-1002 and RGC-1038, drought tolerant, while, Sarada and RGC-936, drought sensitive, were monitored in watered and drought. The water status, phenolics, plant anatomy and transcript level of genes related to ... ...

Abstract	Four contrasting varieties of guar, RGC-1002 and RGC-1038, drought tolerant, while, Sarada and RGC-936, drought sensitive, were monitored in watered and drought. The water status, phenolics, plant anatomy and transcript level of genes related to anatomical traits were assessed. The study aimed to decipher the anatomical adaptations of guar plants in response to water stress. The physiological determinants, relative water content (RWC), water potential (ψ), and leaf membrane damage, declined under drought in all four varieties although, the decrement was lesser in the tolerant varieties. Furthermore, the tolerant cultivars subjected to water stress recorded higher accumulation of total phenolic content, anthocyanin and lignin, which efficiently scavenge the reactive oxygen species. The results suggest that the cultivars RGC-1002 and RGC-1038 are better able to resist drought-induced oxidative stress than Sarada and RGC-936. Moreover, leaf, petiole, stem and root anatomical traits viz. size of epidermal cell, parenchyma, width of cortex layer, and diameter of xylem vessels were narrowed in all the varieties although, the decrement was lesser in the tolerant varieties under drought. The expression analysis of genes revealed that drought-tolerant varieties showed enhanced mechanical support for water conduction by up-regulation of genes, Phenylalanine ammonia-lyase1 (PAL1), cinnamate-4-hydroxylase (C4H), 4-coumarate-CoA ligase (4CL), cinnamoyl-CoA reductase (CCR), caffeoyl-CoA O-methyltransferase (CCOMT), and cinnamyl-alcohol dehydrogenase (CAD6) in water stress conditions. The alterations in physio-anatomical, biochemical and gene expression traits in tolerant guar varieties enabled them to maintain steady nutrient transport while reducing the risk of embolisms and increasing water-flow resistance for better survival in water stressed conditions.
Keywords	Cyamopsis tetragonoloba ; anthocyanins ; cinnamoyl-CoA reductase ; cortex ; coumarate-CoA ligase ; cultivars ; drought ; drought tolerance ; gene expression ; lignin ; methyltransferases ; nutrient transport ; oxidative stress ; petioles ; phenolic compounds ; phenylalanine ; plant physiology ; reactive oxygen species ; risk ; root anatomy ; water content ; water flow ; water potential ; water stress ; xylem ; Anatomy ; Anthocyanin ; Cluster bean ; Lignin biosynthesis pathway ; Lignin content ; Total phenolic content ; CCOMT ; C4H ; CCR ; CAD6 ; 4CL ; HCl ; LTGA ; PAL1 ; RWC ; NaOH ; TGA ; TPC ; ψ
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Masson SAS
Document type	Article ; Online
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2023.107905
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Article ; Online: Alterations in plant anatomy and higher lignin synthesis provides drought tolerance in cluster bean [Cyamopsis tetragonoloba (L.) Taub.].

Narayan, Shiv / Sharma, Rakesh Kumar / Kumar, Varun / Sanyal, Indraneel / Shirke, Pramod Arvind

Plant physiology and biochemistry : PPB

2023 Volume 201, Page(s) 107905

Abstract	Four contrasting varieties of guar, RGC-1002 and RGC-1038, drought tolerant, while, Sarada and RGC-936, drought sensitive, were monitored in watered and drought. The water status, phenolics, plant anatomy and transcript level of genes related to anatomical traits were assessed. The study aimed to decipher the anatomical adaptations of guar plants in response to water stress. The physiological determinants, relative water content (RWC), water potential (ψ), and leaf membrane damage, declined under drought in all four varieties although, the decrement was lesser in the tolerant varieties. Furthermore, the tolerant cultivars subjected to water stress recorded higher accumulation of total phenolic content, anthocyanin and lignin, which efficiently scavenge the reactive oxygen species. The results suggest that the cultivars RGC-1002 and RGC-1038 are better able to resist drought-induced oxidative stress than Sarada and RGC-936. Moreover, leaf, petiole, stem and root anatomical traits viz. size of epidermal cell, parenchyma, width of cortex layer, and diameter of xylem vessels were narrowed in all the varieties although, the decrement was lesser in the tolerant varieties under drought. The expression analysis of genes revealed that drought-tolerant varieties showed enhanced mechanical support for water conduction by up-regulation of genes, Phenylalanine ammonia-lyase1 (PAL1), cinnamate-4-hydroxylase (C4H), 4-coumarate-CoA ligase (4CL), cinnamoyl-CoA reductase (CCR), caffeoyl-CoA O-methyltransferase (CCOMT), and cinnamyl-alcohol dehydrogenase (CAD6) in water stress conditions. The alterations in physio-anatomical, biochemical and gene expression traits in tolerant guar varieties enabled them to maintain steady nutrient transport while reducing the risk of embolisms and increasing water-flow resistance for better survival in water stressed conditions.
MeSH term(s)	Drought Resistance ; Cyamopsis/metabolism ; Lignin/metabolism ; Dehydration ; Droughts
Chemical Substances	Lignin (9005-53-2)
Language	English
Publishing date	2023-07-26
Publishing country	France
Document type	Journal Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2023.107905
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Article: What Are Patients Saying About Minimally Invasive Spine Surgeons Online: A Sentiment Analysis of 2,235 Physician Review Website Reviews.

Tang, Justin / White, Christopher A / Arvind, Varun / Cho, Samuel / Kim, Jun S / Steinberger, Jeremy

Cureus

2022 Volume 14, Issue 4, Page(s) e24113

Abstract: Objective Physician review websites are becoming increasingly popular for patients to find and review healthcare providers. The goal of this study was to utilize quantitative analyses to understand trends in ratings and written comments on physician ... ...

Abstract	Objective Physician review websites are becoming increasingly popular for patients to find and review healthcare providers. The goal of this study was to utilize quantitative analyses to understand trends in ratings and written comments on physician review websites for Society of Minimally Invasive Spine Surgery (SMISS) members. Methods This is a cross-sectional study. The reviews of SMISS surgeons were obtained from healthgrades.com, and sentiment analysis was used to obtain compound scores of each physicians' reviews. SMISS surgeons who were international or had fewer than three written reviews, often consisting of residents and fellows, were excluded. Inferential statistics were utilized, and word frequency analysis reported the phrases used to characterize reviews. Results One hundred sixty-nine surgeons met the inclusion criteria. 98.6% were males and the mean age was 51.7 years old. A total of 2,235 written reviews were analyzed. Younger surgeons were significantly more likely to receive higher star ratings (p<0.01). Positive behavioral characteristics, such as "kind" and "bedside manner," conferred significantly improved odds of receiving positive reviews (p<0.01). Ancillary "staff" conferred a 2x greater odds of receiving a positive review whereas a comment on "wait" times halved a surgeon's odds (p<0.01). Sentences describing pain drove down the odds of positive reviews whereas those describing pain relief produced greater odds of positive reviews (p<0.01). Conclusion Physicians who were younger, personable, provided sufficient pain relief, and who worked in favorable offices received the most positive reviews. This study informs SMISS members on the traits deemed important by patients who ultimately review surgeons online.
Language	English
Publishing date	2022-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.24113
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Article ; Online: Scoliosis Surgery: A Social Media Analysis of Content, Tone, and Perspective.

Yeramosu, Teja / Dominy, Calista L / Arvind, Varun / Isleem, Ula N / Cho, Samuel K

The Journal of the American Academy of Orthopaedic Surgeons

2022 Volume 31, Issue 1, Page(s) 26–33

Abstract: Introduction: The purpose of this study was to analyze posts shared on social media sites, Twitter and Instagram, referencing scoliosis surgery for tone, content, and perspective of the posts.: Methods: Public Twitter and Instagram posts from ... ...

Abstract	Introduction: The purpose of this study was to analyze posts shared on social media sites, Twitter and Instagram, referencing scoliosis surgery for tone, content, and perspective of the posts. Methods: Public Twitter and Instagram posts from November 2020 to April 2021 were isolated using the hashtag #ScoliosisSurgery or the words "scoliosis surgery." A total of 5,022 Instagram and 1,414 Twitter posts were collected, of which 500 of each were randomly selected to be analyzed by the authors for the variables previously listed. Results: Of the Instagram posts, 91.8% were associated with an image, and 47.8% were postoperative. 96.9% of the posts had either a positive or neutral tone. 38% delivered a progress update, and 29.9% disseminated education or sought to provide awareness. 48.6% of the posts were from the perspective of the patient. Of the Twitter posts, 60.1% contained only words, and 37.8% were postoperative. 75% of the posts had either a negative or neutral tone. 38.4% described a personal story, and 19.3% provided a progress update. 42.3% of the posts were from the perspective of the patient. Conclusion: Patients reported a positive tone on Instagram, displaying their progress updates and demonstrating contentment with scoliosis surgery, and a negative tone on Twitter, showing discontentment toward inadequate access to surgery. Although both platforms were used to distribute information and provide awareness, only a small percentage of posts were from physicians and hospitals, indicating opportunities for surgeons to use social media to connect with patients.
MeSH term(s)	Humans ; Social Media ; Scoliosis/surgery ; Surgeons ; Patients ; Hospitals
Language	English
Publishing date	2022-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-22-00312
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