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Article ; Online: Ethosomes as a carrier for transdermal drug delivery system: methodology and recent developments.

Mahajan, Karishma / Sharma, Poonam / Abbot, Vikrant / Chauhan, Kalpana

2024 , Page(s) 1–18

Abstract: Transdermal drug delivery systems (TDDS) have received significant attention in recent years. TDDS are flexible systems that transport active components to the skin for either localized or systemic delivery of drugs through the skin. Among the three main ...

Abstract	Transdermal drug delivery systems (TDDS) have received significant attention in recent years. TDDS are flexible systems that transport active components to the skin for either localized or systemic delivery of drugs through the skin. Among the three main layers of skin, the outermost layer, called the stratum corneum (SC), prevents the entry of water-loving bacteria and drugs with a high molecular weight. The challenge lies in successfully delivering drugs through the skin, which crosses the stratum corneum. The popularity of lipid-based vesicular delivery systems has increased in recent years due to their ability to deliver both hydrophilic and hydrophobic drugs. Ethosomes are specialized vesicles made of phospholipids that can store large amounts of ethanol. Ethosome structure and substance promote skin permeability and bioavailability. This article covers ethosome compositions, types, medication delivery techniques, stability, and safety. In addition to this, an in-depth analysis of the employment of ethosomes in drug delivery applications for a wide range of diseases has also been discussed. This review article highlights different aspects of ethosomes, such as their synthesis, characterization, marketed formulation, recent advancements in TDDS, and applications.
Language	English
Publishing date	2024-04-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	645173-1
ISSN	1532-2394 ; 0898-2104
ISSN (online)	1532-2394
ISSN	0898-2104
DOI	10.1080/08982104.2024.2339896
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Article ; Online: Green synthesis of nanoparticles using botanicals and their application in management of fungal phytopathogens: a review.

Chauhan, Poonam / Tapwal, Ashwani

Archives of microbiology

2023 Volume 205, Issue 3, Page(s) 94

Abstract: Green synthesis of nanoparticles is an emerging aspect in plant disease management that blends nanotechnology and plant-derived ingredients to produce a biocontrol formulation. Different physical and chemical processes employed in the synthesis of ... ...

Abstract	Green synthesis of nanoparticles is an emerging aspect in plant disease management that blends nanotechnology and plant-derived ingredients to produce a biocontrol formulation. Different physical and chemical processes employed in the synthesis of nanoparticles are polluting, expensive, and also release hazardous by- products. The range of secondary metabolites present in plants makes them efficient reducing and stabilizing agent during the synthesis process. These metabolites serve a vital role in plant defense against the invasion of phytopathogens including fungi, bacteria, viruses, insect pests, etc. The plant metabolites, such as sugars, terpenoids, polyphenols, alkaloids, phenolic acids, and proteins, have been shown to be crucial in the reduction of metal ions into nanoparticles. In green synthesis of nanoparticles, the plant extracts are used as potential reducing and capping. This also restricts the formation of clusters or aggregates and improves the colloidal stability. The nanoparticles exhibit excellent antimycotic against a variety of phytopathogens and are very efficient in managing plant diseases. The aim of this review is to highlight plants, phytochemicals exhibiting antifungal properties, green synthesis of nanoparticles using plant material and their antimycotic activity.
MeSH term(s)	Metal Nanoparticles/chemistry ; Green Chemistry Technology/methods ; Plants/metabolism ; Plant Extracts/chemistry ; Antifungal Agents/pharmacology ; Antifungal Agents/metabolism
Chemical Substances	Plant Extracts ; Antifungal Agents
Language	English
Publishing date	2023-02-17
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03431-0
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Article ; Online: Antimicrobial activity of nanocellulose composite hydrogel isolated from an agricultural waste.

Nehra, Poonam / Chauhan, Rishi Pal

Archives of microbiology

2023 Volume 205, Issue 4, Page(s) 133

Abstract: Infectious diseases and antimicrobial resistance have become one of the extreme health threats of this century. Overuse of antibiotics leads to pollution. To overcome this threat, the current strategy is to develop a substitute for these antibiotics that ...

Abstract	Infectious diseases and antimicrobial resistance have become one of the extreme health threats of this century. Overuse of antibiotics leads to pollution. To overcome this threat, the current strategy is to develop a substitute for these antibiotics that are extracted from natural sources. In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC). Then, chitosan (Ch) and DA-NC are both crosslinked with each other in different weight ratios, to obtain NC/Ch composite hydrogels. The resulted hydrogel is also characterized to confirm its structure, morphology and composition. The hydrogel was also tested for antimicrobial activities against bacteria, algae as well as fungal species to check its applicability for biomedical applications. The six microbes used for the ananlysis are Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Candida albicans, Aspergillus niger and Fusarium solani. The antimicrobial assessment of the hydrogel is evaluated via inhibition zone and optical density analysis. The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties. Hydrogel serves excellent antimicrobial results which makes it a promising candidate for various biomedical applications.
MeSH term(s)	Hydrogels/pharmacology ; Hydrogels/chemistry ; Chitosan/pharmacology ; Anti-Infective Agents/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Candida albicans ; Escherichia coli
Chemical Substances	Hydrogels ; Chitosan (9012-76-4) ; Anti-Infective Agents ; Anti-Bacterial Agents
Language	English
Publishing date	2023-03-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03454-7
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Article ; Online: Use of Dermatoscopy in Diagnosing Vestibular Papillomatosis in Pregnancy: An Uncommon Differential of Genital Warts.

Dhattarwal, Niharika / Chauhan, Neha / Puri, Poonam

Skinmed

2023 Volume 21, Issue 3, Page(s) 212–213

MeSH term(s)	Female ; Pregnancy ; Humans ; Dermoscopy ; Condylomata Acuminata/diagnosis ; Papilloma/diagnosis
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171125-2
ISSN	1751-7125 ; 1540-9740
ISSN (online)	1751-7125
ISSN	1540-9740
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Article ; Online: Green synthesis of nanoparticles using botanicals and their application in management of fungal phytopathogens: a review

Chauhan, Poonam / Tapwal, Ashwani

Arch Microbiol. 2023 Mar., v. 205, no. 3 p.94-94

2023

Abstract	Green synthesis of nanoparticles is an emerging aspect in plant disease management that blends nanotechnology and plant-derived ingredients to produce a biocontrol formulation. Different physical and chemical processes employed in the synthesis of nanoparticles are polluting, expensive, and also release hazardous by- products. The range of secondary metabolites present in plants makes them efficient reducing and stabilizing agent during the synthesis process. These metabolites serve a vital role in plant defense against the invasion of phytopathogens including fungi, bacteria, viruses, insect pests, etc. The plant metabolites, such as sugars, terpenoids, polyphenols, alkaloids, phenolic acids, and proteins, have been shown to be crucial in the reduction of metal ions into nanoparticles. In green synthesis of nanoparticles, the plant extracts are used as potential reducing and capping. This also restricts the formation of clusters or aggregates and improves the colloidal stability. The nanoparticles exhibit excellent antimycotic against a variety of phytopathogens and are very efficient in managing plant diseases. The aim of this review is to highlight plants, phytochemicals exhibiting antifungal properties, green synthesis of nanoparticles using plant material and their antimycotic activity.
Keywords	antifungal properties ; biological control ; disease control ; insects ; nanoparticles ; phytochemicals ; plant pathogenic fungi ; polyphenols ; secondary metabolites ; terpenoids
Language	English
Dates of publication	2023-03
Size	p. 94.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
Note	Review
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03431-0
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Antimicrobial activity of nanocellulose composite hydrogel isolated from an agricultural waste

Nehra, Poonam / Chauhan, Rishi Pal

Arch Microbiol. 2023 Apr., v. 205, no. 4 p.133-133

2023

Abstract	Infectious diseases and antimicrobial resistance have become one of the extreme health threats of this century. Overuse of antibiotics leads to pollution. To overcome this threat, the current strategy is to develop a substitute for these antibiotics that are extracted from natural sources. In this study, nanocellulose (NC) was isolated from an agricultural waste (wheat straw) and then oxidized with the help of sodium periodate to obtain dialdehyde nanocellulose (DA-NC). Then, chitosan (Ch) and DA-NC are both crosslinked with each other in different weight ratios, to obtain NC/Ch composite hydrogels. The resulted hydrogel is also characterized to confirm its structure, morphology and composition. The hydrogel was also tested for antimicrobial activities against bacteria, algae as well as fungal species to check its applicability for biomedical applications. The six microbes used for the ananlysis are Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Candida albicans, Aspergillus niger and Fusarium solani. The antimicrobial assessment of the hydrogel is evaluated via inhibition zone and optical density analysis. The resulted nanocellulose/chitosan (NC/Ch) hydrogel shows the uniform distribution of nanocellulose in the composite and the synergistic effect of their properties. Hydrogel serves excellent antimicrobial results which makes it a promising candidate for various biomedical applications.
Keywords	Aspergillus niger ; Bacillus subtilis ; Candida albicans ; Escherichia coli ; Fusarium solani ; Pseudomonas aeruginosa ; absorbance ; agricultural wastes ; antibiotic resistance ; antimicrobial properties ; cellulose ; chitosan ; crosslinking ; fungi ; hydrogels ; pollution ; sodium ; synergism ; wheat straw
Language	English
Dates of publication	2023-04
Size	p. 133.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03454-7
Database	NAL-Catalogue (AGRICOLA)

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Article: Assessment of Carotid Plaque Enhancement on Contrast-Enhanced Ultrasound as a Predictor for Severe Coronary Artery Disease

Agarwal, Vanshika / Sherwani, Poonam / Chauhan, Udit / Kumar, Barun

Indian Journal of Radiology and Imaging

2024

Abstract: Background and Aim: Contrast-enhanced ultrasound (CEUS) can reliably identify vulnerable plaques. As atherosclerosis is a systemic disease, we evaluated whether contrast enhancement of carotid plaque (CECP) can predict severe coronary artery disease ( ... ...

Abstract	Background and Aim: Contrast-enhanced ultrasound (CEUS) can reliably identify vulnerable plaques. As atherosclerosis is a systemic disease, we evaluated whether contrast enhancement of carotid plaque (CECP) can predict severe coronary artery disease (CAD) by comparing CECP in patients who have had acute coronary syndromes (ACS) recently with asymptomatic individuals. Settings and Design: This case–control study was done at a tertiary care center during 2022. Materials and Methods: Fourteen participants were recruited in each group, after screening in-patients for carotid plaques and inclusion and exclusion criteria. Those who had history of ACS were enrolled as cases, while those who did not were enrolled as controls. All these patients underwent grayscale, Doppler, and CEUS examination for characterization of the carotid plaque. For cases, findings on CEUS were also compared with the severity of CAD on catheter coronary angiography. Statistical Analysis: Diagnostic parameters including sensitivity, specificity, and diagnostic accuracy were calculated and proportions were compared by using Fisher's exact test. Results: Eight out of 28 patients showed CECP. CECP and CAD were positively associated with p -Value of 0.033. Eighty-three percent patients with triple vessel disease and 50% patients with double vessel disease on coronary angiography showed CECP. Sensitivity and specificity of CECP for prediction of CAD were 50 and 92.9%, respectively. Conclusion: CECP on CEUS can predict CAD and is a more reliable indicator of severe CAD than plaque characteristics on grayscale and Doppler imaging; making it useful for screening of patients at risk of having CAD.
Keywords	coronary artery disease ; contrast-enhanced ultrasound ; intraplaque neovascularization ; contrast enhancement of carotid plaque
Language	English
Publishing date	2024-02-23
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	605869-3
ISSN	1998-3808 ; 0971-3026 ; 0970-2016
ISSN (online)	1998-3808
ISSN	0971-3026 ; 0970-2016
DOI	10.1055/s-0044-1779522
Database	Thieme publisher's database

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Article: Utility of MR lymphangiography in chylous ascites: A report of two cases.

Bhatia, Pratibha / Sherwani, Poonam / Ahmed, Intezar / Chauhan, Udit / Saxena, Sudhir

SA journal of radiology

2023 Volume 27, Issue 1, Page(s) 2703

Abstract: Dynamic contrast-enhanced (DCE) lymphangiography is a novel imaging technique with a potential role in suspected cases of lymphatic leaks. A 15-year-old male with a post operative chylous leak and an 8-year-old male who developed chylous ascites ... ...

Abstract	Dynamic contrast-enhanced (DCE) lymphangiography is a novel imaging technique with a potential role in suspected cases of lymphatic leaks. A 15-year-old male with a post operative chylous leak and an 8-year-old male who developed chylous ascites secondary to disseminated tuberculosis are presented. Both children underwent MR lymphangiography. Contribution: The role of DCE-MR lymphangiography in cases of chylous ascites to help guide appropriate management.
Language	English
Publishing date	2023-08-31
Publishing country	South Africa
Document type	Case Reports
ZDB-ID	2475950-8
ISSN	2078-6778 ; 1027-202X
ISSN (online)	2078-6778
ISSN	1027-202X
DOI	10.4102/sajr.v27i1.2703
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Article ; Online: Role of Regulatory Authorities on the Working of Contract Research Organization and Pharmaceutical Company’s Clinical Trials in India

Poonam Chauhan / Monica Mendonica

Asia Pacific Journal of Health Management, Vol 16, Iss

2021 Volume 3

Abstract: The evolution of the drug development process and testing its efficacy is a primary responsibility of pharmaceutical companies. The time cost investment involved in identifying a compound suitable to its target disease and making it available to the ... ...

Abstract	The evolution of the drug development process and testing its efficacy is a primary responsibility of pharmaceutical companies. The time cost investment involved in identifying a compound suitable to its target disease and making it available to the masses eventually led to the rise of the Contract Research Organization (CRO) in the domain of clinical research. Pharmaceutical companies outsource the research and clinical trials to CRO’s. A CRO has a vital role from drug discovery to the launch and marketing of drugs. India is emerging as attractive location for global clinical trial. It has cost advantage compared to other countries and a well-developed associated services like data management, medical writing and pharmacovigilance. The Central Drug Standard Control Organization (CDSCO) is the National Regulatory Authority in India that aims to bring safe drugs and standardize clinical research. Pharmaceutical Companies benefit by strategically working with CRO to gain speed and efficiency in drug discovery, generation and retention of clinical data integrity. The risk associated with CRO relates to delays and inferior quality of work, thereby making CRO a critical decision for Pharmaceutical Company.
Keywords	Contract Research Organization (CRO ; Drug Development ; Clinical Trials ; Regulatory Authorities ; Pharmaceutical Brand Reputation ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
Subject code	650
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	ACHSM
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bronchoscopic Electrocautery Versus Adrenaline and Cold Saline Instillation for Prophylactic Haemostasis Prior to Biopsy of Endobronchial Lesions (BEVACS): A Randomized Controlled Trial.

Shahul S, Aneesa / Chauhan, Nishant Kumar / Dutt, Naveen / Chakraborti, Amartya / Elhence, Poonam / Jalandra, Ramniwas

Journal of bronchology & interventional pulmonology

2024 Volume 31, Issue 2, Page(s) 199–204

Abstract: Background: Flexible bronchoscopy-guided endobronchial biopsy (EBB) is routinely performed as an outpatient daycare procedure. Bleeding after EBB is a common complication, that at times disrupts the procedure and can rarely lead to a catastrophe. We ... ...

Abstract	Background: Flexible bronchoscopy-guided endobronchial biopsy (EBB) is routinely performed as an outpatient daycare procedure. Bleeding after EBB is a common complication, that at times disrupts the procedure and can rarely lead to a catastrophe. We aimed to compare the efficacy of prebiopsy prophylactic bronchoscopic electrocautery with adrenaline and cold saline instillation in achieving hemostasis in patients with endobronchial lesions with a higher risk of bleeding during EBB. Methods: In this open-label, randomized controlled trial, 60 patients with endobronchial lesions were randomized to either the prophylactic electrocautery arm or the adrenaline and cold saline arm. Postbiopsy endobronchial bleed was quantified in millimeters using the Visual Analog Scale (VAS) and graded as per the British Thoracic Society grading system. Electrocautery-induced tissue damage was graded by the pathologist as "no damage," "mild," "moderate," and "severe." Results: The median VAS score of bleeding was 6.14 mm (interquartile range: 8 mm) in the electrocautery arm and 10.17 mm (interquartile range: 7 mm) in the adrenaline and cold saline arm. Though the difference in the VAS score of bleeding between the two groups was statistically significant, there was no significant difference in the proportion of grade 2 or higher bleeding. Conclusion: No difference in postbiopsy bleed was observed between the application of electrocautery or instillation of cold saline plus adrenaline before biopsy of those endobronchial lesions which were likely to bleed more after biopsy. Although controlled prophylactic electrocautery using 15 watts did not impair the quality of EBB specimens, a higher wattage may change this observation, as well as the bleeding quantity.
MeSH term(s)	Humans ; Epinephrine/therapeutic use ; Biopsy/adverse effects ; Biopsy/methods ; Bronchoscopy/adverse effects ; Hemorrhage/etiology ; Hemorrhage/prevention & control ; Electrocoagulation/adverse effects
Chemical Substances	Epinephrine (YKH834O4BH)
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2478320-1
ISSN	1948-8270 ; 1944-6586
ISSN (online)	1948-8270
ISSN	1944-6586
DOI	10.1097/LBR.0000000000000961
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