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  1. Article ; Online: 256

    Damoiseaux, Jan / Mammen, Andrew L / Piette, Yves / Benveniste, Olivier / Allenbach, Yves

    Neuromuscular disorders : NMD

    2022  Volume 32, Issue 7, Page(s) 594–608

    MeSH term(s) Autoantibodies ; Humans ; Myositis/diagnosis ; Netherlands
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-05-20
    Publishing country England
    Document type Clinical Conference
    ZDB-ID 1077681-3
    ISSN 1873-2364 ; 0960-8966
    ISSN (online) 1873-2364
    ISSN 0960-8966
    DOI 10.1016/j.nmd.2022.05.011
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    Zs.A 3258: Show issues Location:
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  2. Article ; Online: Positioning of myositis-specific and associated autoantibody (MSA/MAA) testing in disease criteria and routine diagnostic work-up.

    Bonroy, Carolien / Piette, Yves / Allenbach, Yves / Bossuyt, Xavier / Damoiseaux, Jan

    Journal of translational autoimmunity

    2022  Volume 5, Page(s) 100148

    Abstract: Nowadays, the importance of detection of myositis-specific antibodies (MSA) and myositis-associated antibodies (MAA) in diagnosis and in delineating disease subsets of idiopathic inflammatory myopathy (IIM) is highly acknowledged by IIM experts. ... ...

    Abstract Nowadays, the importance of detection of myositis-specific antibodies (MSA) and myositis-associated antibodies (MAA) in diagnosis and in delineating disease subsets of idiopathic inflammatory myopathy (IIM) is highly acknowledged by IIM experts. Consequently, MSA/MAA are increasingly integrated in expert-based myositis (sub)classification criteria as well as in routine diagnostics. In contrast, MSA/MAA are under-represented in data-based (sub)classification criteria, mostly related to the lack of sufficient data on the wide spectrum of MSA/MAA in large multicenter cohorts. Unfortunately, the current commercially available assays to detect MSA/MAA show variable analytical and clinical performance characteristics. This challenges the design of prospective multicenter studies on MSA/MAA as well as the optimization of their routine clinical use. Additional validation studies and continuous harmonization initiatives on MSA/MAA detection from the pre-analytical to the post-analytical phase (e.g. from defining request criteria to guidelines for reporting), will be needed to overcome these hurdles. To speed up this process, we encourage close collaborations between IIM clinical experts, laboratory professionals and diagnostic companies.
    Language English
    Publishing date 2022-02-11
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2022.100148
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  3. Article ; Online: Effect of sirolimus on muscle in inclusion body myositis observed with magnetic resonance imaging and spectroscopy.

    Reyngoudt, Harmen / Baudin, Pierre-Yves / de Caldas de Almeida Araújo, Ericky / Bachasson, Damien / Boisserie, Jean-Marc / Mariampillai, Kubéraka / Annoussamy, Mélanie / Allenbach, Yves / Hogrel, Jean-Yves / Carlier, Pierre G / Marty, Benjamin / Benveniste, Olivier

    Journal of cachexia, sarcopenia and muscle

    2024  

    Abstract: Background: Finding sensitive clinical outcome measures has become crucial in natural history studies and therapeutic trials of neuromuscular disorders. Here, we focus on 1-year longitudinal data from quantitative magnetic resonance imaging (MRI) and ... ...

    Abstract Background: Finding sensitive clinical outcome measures has become crucial in natural history studies and therapeutic trials of neuromuscular disorders. Here, we focus on 1-year longitudinal data from quantitative magnetic resonance imaging (MRI) and phosphorus magnetic resonance spectroscopy (
    Methods: Quantitative MRI and
    Results: The quadriceps and gastrocnemius medialis muscles had the highest FF values, displaying notable heterogeneity and asymmetry, particularly in the quadriceps. In the placebo group, the median 1-year FF increase in the quadriceps was 3.2% (P < 0.001), whereas in the sirolimus group, it was 0.7% (P = 0.033). Both groups experienced a significant decrease in cCSA in the quadriceps after 1 year (P < 0.001), with median changes of 12.6% for the placebo group and 5.5% for the sirolimus group. Differences in FF and cCSA changes between the two groups were significant (P < 0.001). SRM values for FF and cCSA were 1.3 and 1.4 in the placebo group and 0.5 and 0.8 in the sirolimus group, respectively. Water T
    Conclusions: This study has demonstrated that quantitative MRI/
    Language English
    Publishing date 2024-04-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.13451
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  4. Article ; Online: Inclusion body myositis: accumulation of evidence for its autoimmune origin.

    Benveniste, Olivier / Allenbach, Yves

    Brain : a journal of neurology

    2019  Volume 142, Issue 9, Page(s) 2549–2551

    MeSH term(s) Cell Differentiation ; Humans ; Myositis, Inclusion Body ; T-Lymphocytes
    Language English
    Publishing date 2019-08-30
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awz229
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  5. Article: Cytomegalovirus-induced oral ulcers: A case report and literature review.

    Pinana, Margaux / Rapoport, Camille / Champtiaux, Nicolas / Lescaille, Géraldine / Allenbach, Yves / Rochefort, Juliette

    Clinical case reports

    2023  Volume 11, Issue 6, Page(s) e7459

    Abstract: Cytomegalovirus (CMV) ulcerations are rare clinical entities, but their occurrence is favored in immunocompromised patients who present a favorable environment for opportunistic infections. We describe the case of a patient treated for a systemic lupus ... ...

    Abstract Cytomegalovirus (CMV) ulcerations are rare clinical entities, but their occurrence is favored in immunocompromised patients who present a favorable environment for opportunistic infections. We describe the case of a patient treated for a systemic lupus erythematosus suffering from deep oral ulcerations. The case illustrates the complexity of establishing a precise etiological diagnosis of CMV lesions, as the diagnostic hypothesis can be varied: related to an immunodeficiency disorder or drug-induced toxidermia.
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7459
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  6. Article ; Online: Possible future avenues for myositis therapeutics: DM, IMNM and IBM.

    Connolly, Caoilfhionn M / Plomp, Lotta / Paik, Julie J / Allenbach, Yves

    Best practice & research. Clinical rheumatology

    2022  Volume 36, Issue 2, Page(s) 101762

    Abstract: Idiopathic inflammatory myopathies (IIMs) represent a heterogeneous group of systemic autoimmune diseases characterized by immune-mediated muscle injury. As insights into pathogenesis of IIM evolve, novel therapeutic strategies have become available to ... ...

    Abstract Idiopathic inflammatory myopathies (IIMs) represent a heterogeneous group of systemic autoimmune diseases characterized by immune-mediated muscle injury. As insights into pathogenesis of IIM evolve, novel therapeutic strategies have become available to optimize outcomes. Herein, we summarize novel and emerging strategies in the management of dermatomyositis (DM), immunemediated necrotizing myopathy (IMNM), and inclusion body myositis (IBM).
    MeSH term(s) Humans ; Myositis/drug therapy ; Myositis, Inclusion Body/therapy
    Language English
    Publishing date 2022-06-28
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2022.101762
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  7. Article ; Online: Cytomegalovirus‐induced oral ulcers

    Margaux Pinana / Camille Rapoport / Nicolas Champtiaux / Géraldine Lescaille / Yves Allenbach / Juliette Rochefort

    Clinical Case Reports, Vol 11, Iss 6, Pp n/a-n/a (2023)

    A case report and literature review

    2023  

    Abstract: Key Clinical Message Cytomegalovirus (CMV) ulcerations are rare clinical entities, but their occurrence is favored in immunocompromised patients who present a favorable environment for opportunistic infections. We describe the case of a patient treated ... ...

    Abstract Key Clinical Message Cytomegalovirus (CMV) ulcerations are rare clinical entities, but their occurrence is favored in immunocompromised patients who present a favorable environment for opportunistic infections. We describe the case of a patient treated for a systemic lupus erythematosus suffering from deep oral ulcerations. The case illustrates the complexity of establishing a precise etiological diagnosis of CMV lesions, as the diagnostic hypothesis can be varied: related to an immunodeficiency disorder or drug‐induced toxidermia.
    Keywords cytomegalovirus ; immunodepression ; infection ; systemic lupus erythematosus ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
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  8. Article ; Online: Peculiar clinicopathological features of immune-mediated necrotizing myopathies.

    Allenbach, Yves / Benveniste, Olivier

    Current opinion in rheumatology

    2018  Volume 30, Issue 6, Page(s) 655–663

    Abstract: Purpose of review: In the past decade, immune-mediated necrotizing myopathies have emerged as a separate entity in the heterogenous group of autoimmune myopathies. This group is characterized by clinical manifestations restricted to the muscle tissue, ... ...

    Abstract Purpose of review: In the past decade, immune-mediated necrotizing myopathies have emerged as a separate entity in the heterogenous group of autoimmune myopathies. This group is characterized by clinical manifestations restricted to the muscle tissue, and until recently, the definition was based on muscular pathological features.
    Recent findings: It was shown that they are the most severe autoimmune myopathies in term of muscle damages. They have been associated with two myositis-specific antibodies: either anti-signal recognition particle (anti-SRP) or anti-hydroxy-3-methylglutaryl-CoA reductase (anti-HMGCR) antibodies. These two antibodies are now considered as immune-mediated necrotizing myopathy (IMNM) diagnostic criteria. Each antibody delineates a homogenous subgroup of IMNM patients in terms of severity and IMNM without myositis-specific antibodies have a high risk of malignancy. In addition, pathological observations as well as in-vitro experiments suggest the pathogenic role of anti-SRP and anti-HMGCR antibodies.
    Summary: IMNM are muscle-specific autoimmune diseases associated with a severe weakness and a risk poor muscle strength recovery. Anti-SRP and anti-HMGCR antibodies are specifically associated with this condition and are crucial for the diagnosis and the prognosis. The muscle biopsy remains necessary for IMNM diagnosis in absence of myositis-specific antibodies.
    MeSH term(s) Autoantibodies/immunology ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmunity ; Biopsy ; Humans ; Muscle, Skeletal/immunology ; Muscle, Skeletal/pathology ; Myositis/immunology ; Myositis/pathology ; Necrosis/immunology ; Necrosis/pathology ; Prognosis
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2018-09-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000547
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  9. Article ; Online: Autoantibodies at the Center of (sub)Classification-Issues of Detection-Reply.

    Allenbach, Yves / Mariampillai, Kubéraka / Benveniste, Olivier

    JAMA neurology

    2019  Volume 76, Issue 7, Page(s) 868–869

    MeSH term(s) Autoantibodies ; Humans ; Myositis
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2019-04-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2019.0443
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  10. Article ; Online: Immune-mediated necrotizing myopathy: clinical features and pathogenesis.

    Allenbach, Yves / Benveniste, Olivier / Stenzel, Werner / Boyer, Olivier

    Nature reviews. Rheumatology

    2020  Volume 16, Issue 12, Page(s) 689–701

    Abstract: Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies that was distinguished from polymyositis in 2004. Most IMNMs are associated with anti-signal recognition particle (anti-SRP) or anti-3-hydroxy-3-methylglutaryl-coA ... ...

    Abstract Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies that was distinguished from polymyositis in 2004. Most IMNMs are associated with anti-signal recognition particle (anti-SRP) or anti-3-hydroxy-3-methylglutaryl-coA reductase (anti-HMGCR) myositis-specific autoantibodies, although ~20% of patients with IMNM remain seronegative. These associations have led to three subclasses of IMNM: anti-SRP-positive IMNM, anti-HMGCR-positive IMNM and seronegative IMNM. IMNMs are frequently rapidly progressive and severe, displaying high serum creatine kinase levels, and failure to treat IMNMs effectively may lead to severe muscle impairment. In patients with seronegative IMNM, disease can be concomitant with cancer. Research into IMNM pathogenesis has shown that anti-SRP and anti-HMGCR autoantibodies cause weakness and myofibre necrosis in mice, suggesting that, as well as being diagnostic biomarkers of IMNM, they may play a key role in disease pathogenesis. Therapeutically, treatments such as rituximab or intravenous immunoglobulins can now be discussed for IMNM, and targeted therapies, such as anticomplement therapeutics, may be a future option for patients with refractory disease.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Autoantibodies/immunology ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/physiopathology ; Autoimmune Diseases/therapy ; Biopsy ; Humans ; Hydroxymethylglutaryl CoA Reductases/immunology ; Immunologic Factors/therapeutic use ; Mice ; Muscle, Skeletal/immunology ; Muscle, Skeletal/pathology ; Myositis/diagnosis ; Myositis/epidemiology ; Myositis/physiopathology ; Myositis/therapy ; Necrosis/immunology ; Necrosis/pathology ; Prognosis ; Signal Recognition Particle/antagonists & inhibitors ; Signal Recognition Particle/immunology
    Chemical Substances Anti-Inflammatory Agents ; Autoantibodies ; Immunologic Factors ; Signal Recognition Particle ; HMGCR protein, human (EC 1.1.1.-) ; Hydroxymethylglutaryl CoA Reductases (EC 1.1.1.-)
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-020-00515-9
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