LIVIVO - Search results -

Search results

Result 1 - 10 of total 256

Search options

Article: Towards Ready-to-Use Iron-Crosslinked Alginate Beads as Mesenchymal Stem Cell Carriers.

Baudequin, Timothée / Wee, Hazel / Cui, Zhanfeng / Ye, Hua

2023 Volume 10, Issue 2

Abstract: Micro-carriers, thanks to high surface/volume ratio, are widely studied as mesenchymal stem cell (MSCs) in vitro substrate for proliferation at clinical rate. In particular, Ca-alginate-based biomaterials (sodium alginate crosslinked with ... ...

Abstract	Micro-carriers, thanks to high surface/volume ratio, are widely studied as mesenchymal stem cell (MSCs) in vitro substrate for proliferation at clinical rate. In particular, Ca-alginate-based biomaterials (sodium alginate crosslinked with CaCl
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering10020163
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Impact of fast-track regulatory designations on strategic commercialization decisions for autologous cell therapies.

Lam, Ching / Meinert, Edward / Yang, Aidong / Cui, Zhanfeng

Regenerative medicine

2022 Volume 17, Issue 3, Page(s) 155–174

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Investments
Language	English
Publishing date	2022-01-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2274500-2
ISSN	1746-076X ; 1746-0751
ISSN (online)	1746-076X
ISSN	1746-0751
DOI	10.2217/rme-2021-0061
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6627: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 629: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Stochastic neuro-fuzzy system implemented in memristor crossbar arrays.

Shi, Tuo / Zhang, Hui / Cui, Shiyu / Liu, Jinchang / Gu, Zixi / Wang, Zhanfeng / Yan, Xiaobing / Liu, Qi

Science advances

2024 Volume 10, Issue 12, Page(s) eadl3135

Abstract: Neuro-symbolic artificial intelligence has garnered considerable attention amid increasing industry demands for high-performance neural networks that are interpretable and adaptable to previously unknown problem domains with minimal reconfiguration. ... ...

Abstract	Neuro-symbolic artificial intelligence has garnered considerable attention amid increasing industry demands for high-performance neural networks that are interpretable and adaptable to previously unknown problem domains with minimal reconfiguration. However, implementing neuro-symbolic hardware is challenging due to the complexity in symbolic knowledge representation and calculation. We experimentally demonstrated a memristor-based neuro-fuzzy hardware based on TiN/TaO
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adl3135
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770-5p axis in PDAC.

Huang, Wenjie / Hu, Xiaojun / He, Xiang / Pan, Dongyue / Huang, Zhaorong / Gu, Zhanfeng / Huang, Guobing / Wang, Ping / Cui, Chunhui / Fan, Yingfang

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

2024 Volume 74, Page(s) 101079

Abstract: Aims: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease. Chemotherapy based on gemcitabine (GEM) remains the first-line drug for patients with advanced PDAC. However, GEM resistance impairs its therapeutic effectiveness. Therefore, ... ...

Abstract	Aims: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease. Chemotherapy based on gemcitabine (GEM) remains the first-line drug for patients with advanced PDAC. However, GEM resistance impairs its therapeutic effectiveness. Therefore, identifying effective therapeutic targets are urgently needed to overcome GEM resistance. Methods: The clinical significance of Tripartite Motif Containing 29 (TRIM29) was identified by exploring GEO datasets and TCGA database and its potential biological functions were predicted by GSEA analysis. The regulatory axis was established by bioinformatics analysis and validated by mechanical experiments. Then, in vitro and in vivo assays were performed to validate the roles of TRIM29 in PDAC GEM resistance. Results: High TRIM29 expression was associated with poor prognosis of PDAC and functional experiments demonstrated that TRIM29 promoted GEM resistance in PDAC GEM-resistant (GR) cells. Furthermore, we revealed that circRPS29 promoted TRIM29 expression via competitive interaction with miR-770-5p and then activated MEK/ERK signaling pathway. Additionally, both in vitro and in vivo functional experiments demonstrated that circRPS29/miR-770-5p/TRIM29 axis promoted PDAC GEM resistance via activating MEK/ERK signaling pathway. Conclusion: Our results identify the significance of the signaling axis, circRPS29/miR-770-5p/TRIM29-MEK/ERK, in PDAC GEM resistance, which will provide novel therapeutic targets for PDAC treatment.
Language	English
Publishing date	2024-03-12
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1474513-6
ISSN	1532-2084 ; 1368-7646
ISSN (online)	1532-2084
ISSN	1368-7646
DOI	10.1016/j.drup.2024.101079
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5099: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Radar Phase-Coded Waveform Design with Local Low Range Sidelobes Based on Particle Swarm-Assisted Projection Optimization

Xiang Feng / Zhanfeng Zhao / Fengcong Li / Wenqing Cui / Yinan Zhao

Remote Sensing, Vol 14, Iss 4186, p

2022 Volume 4186

Abstract: In modern electronic warfare, cognitive radar with knowledge-aided waveforms would show significant flexibility in anti-interference. In this paper, a novel method, named particle swarm-assisted projection optimization (PSAP), is introduced to design ... ...

Abstract	In modern electronic warfare, cognitive radar with knowledge-aided waveforms would show significant flexibility in anti-interference. In this paper, a novel method, named particle swarm-assisted projection optimization (PSAP), is introduced to design phase-coded waveforms with multi-level low range sidelobes, which mainly considers the stability for randomized initialization under the unimodular constraint. Firstly, the mathematical problem corresponding to avoid the range sidelobe masking from multiple non-cooperative targets or interference is formulated by giving different threat levels. Then, based on the alternating direction decomposition idea, the original problem is divided into triple-variable ones where these non-linear approximations can be solved via alternating projections along with FFT. Furthermore, the PSAP method with swarm intelligence, learning factor, and particle-assisted projection could ensure the optimization convergence in a parallel way, which could relax the non-convex constraint and enhance the global exploiting performance. Finally, simulations for several typical scenarios and numerical results are all provided to assess the waveforms generated by PSAP and other prevalent ones.
Keywords	cognitive radar ; waveform design ; range sidelobe suppression ; particle swarm-assisted projection ; FFT ; Science ; Q
Subject code	620
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Validation and scalability of homemade polycaprolactone macrobeads grafted with thermo-responsive poly(N-isopropylacrylamide) for mesenchymal stem cell expansion and harvesting.

Nguyen, Linh T B / Baudequin, Timothée / Cui, Zhanfeng / Ye, Hua

Biotechnology and bioengineering

2022 Volume 119, Issue 9, Page(s) 2345–2358

Abstract: In this study, polycaprolactone (PCL) macrobeads were prepared by an oil-in-water (o/w) emulsion solvent evaporation method with poly(vinyl alcohol) (PVA) as an emulsifier and conjugated to poly(N-isopropylacrylamide) (PNIPAAm) to be used as cell ... ...

Abstract	In this study, polycaprolactone (PCL) macrobeads were prepared by an oil-in-water (o/w) emulsion solvent evaporation method with poly(vinyl alcohol) (PVA) as an emulsifier and conjugated to poly(N-isopropylacrylamide) (PNIPAAm) to be used as cell carriers with noninvasive cell detachment properties (thermo-response). Following previous studies with PCL-PNIPAAm carriers, our objectives were to confirm the successful conjugation on homemade macrobeads and to show the advantages of homemade production over commercial beads to control morphological, biological, and fluidization properties. The effects of PCL concentration on the droplet formation and of flow rate and PVA concentration on the size of the beads were demonstrated. The size of the beads, all spherical, ranged from 0.5 to 3.7 mm with four bead categories based on production parameters. The morphology and size of the beads were observed by scanning electron microscopy to show surface roughness enhancing cell attachment and proliferation compared to commercial beads. The functionalization steps with PNIPAAm were then characterized and confirmed by Fourier transform infrared spectroscopy, scanning electron microscopy, and energy dispersion spectroscopy. PNIPAAm-grafted macrobeads allowed mesenchymal stem cells (MSCs) to spread and grow for up to 21 days. By reducing the temperature to 25°C, the MSCs were successfully detached from the PCL-PNIPAAm beads as observed with fluorescence microscopy. Furthermore, we validated the scalability potential of both macrobeads production and conjugation with PCL, to produce easily kilograms of thermo-responsive macrocarriers in a lab environment. This could help moving such approaches towards clinically and industrially relevant processes were cell expansion is needed at very large scale.
MeSH term(s)	Acrylic Resins/chemistry ; Cell Proliferation ; Mesenchymal Stem Cells ; Polyesters ; Temperature
Chemical Substances	Acrylic Resins ; Polyesters ; polycaprolactone (24980-41-4) ; poly-N-isopropylacrylamide (25189-55-3)
Language	English
Publishing date	2022-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280318-5
ISSN	1097-0290 ; 0006-3592
ISSN (online)	1097-0290
ISSN	0006-3592
DOI	10.1002/bit.28133
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 960: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Comparison between centralized and decentralized supply chains of autologous chimeric antigen receptor T-cell therapies: a UK case study based on discrete event simulation.

Lam, Ching / Meinert, Edward / Yang, Aidong / Cui, Zhanfeng

Cytotherapy

2021 Volume 23, Issue 5, Page(s) 433–451

Abstract: Background aims: Decentralized, or distributed, manufacturing that takes place close to the point of care has been a manufacturing paradigm of heightened interest within the cell therapy domain because of the product's being living cell material as well ...

Abstract	Background aims: Decentralized, or distributed, manufacturing that takes place close to the point of care has been a manufacturing paradigm of heightened interest within the cell therapy domain because of the product's being living cell material as well as the need for a highly monitored and temperature-controlled supply chain that has the potential to benefit from close proximity between manufacturing and application. Methods: To compare the operational feasibility and cost implications of manufacturing autologous chimeric antigen receptor T (CAR T)-cell products between centralized and decentralized schemes, a discrete event simulation model was built using ExtendSIM 9 for simulating the patient-to-patient supply chain, from the collection of patient cells to the final administration of CAR T therapy in hospitals. Simulations were carried out for hypothetical systems in the UK using three demand levels-low (100 patients per annum), anticipated (200 patients per annum) and high (500 patients per annum)-to assess resource allocation, cost per treatment and system resilience to demand changes and to quantify the risks of mix-ups within the supply chain for the delivery of CAR T treatments. Results: The simulation results show that although centralized manufacturing offers better economies of scale, individual facilities in a decentralized system can spread facility costs across a greater number of treatments and better utilize resources at high demand levels (annual demand of 500 patients), allowing for an overall more comparable cost per treatment. In general, raw material and consumable costs have been shown to be one of the greatest cost drivers, and genetic modification-associated costs have been shown to account for over one third of raw material and consumable costs. Turnaround time per treatment for the decentralized scheme is shown to be consistently lower than its centralized counterpart, as there is no need for product freeze-thaw, packaging and transportation, although the time savings is shown to be insignificant in the UK case study because of its rather compact geographical setting with well-established transportation networks. In both schemes, sterility testing lies on the critical path for treatment delivery and is shown to be critical for treatment turnaround time reduction. Conclusions: Considering both cost and treatment turnaround time, point-of-care manufacturing within the UK does not show great advantages over centralized manufacturing. However, further simulations using this model can be used to understand the feasibility of decentralized manufacturing in a larger geographical setting.
MeSH term(s)	Cell- and Tissue-Based Therapy ; Humans ; Immunotherapy, Adoptive ; Receptors, Chimeric Antigen ; T-Lymphocytes ; United Kingdom
Chemical Substances	Receptors, Chimeric Antigen
Language	English
Publishing date	2021-03-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2039821-9
ISSN	1477-2566 ; 1465-3249
ISSN (online)	1477-2566
ISSN	1465-3249
DOI	10.1016/j.jcyt.2020.08.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5601: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Reprogramming Synthetic Cells for Targeted Cancer Therapy.

Lim, Boon / Yin, Yutong / Ye, Hua / Cui, Zhanfeng / Papachristodoulou, Antonis / Huang, Wei E

ACS synthetic biology

2022 Volume 11, Issue 3, Page(s) 1349–1360

Abstract: Advances in synthetic biology enable the reprogramming of bacteria as smart agents to specifically target tumors and locally release anticancer drugs in a highly controlled manner. However, the bench-to-bedside translation of engineered bacteria is often ...

Abstract	Advances in synthetic biology enable the reprogramming of bacteria as smart agents to specifically target tumors and locally release anticancer drugs in a highly controlled manner. However, the bench-to-bedside translation of engineered bacteria is often impeded by genetic instability and the potential risk of uncontrollable replication of engineered bacteria inside the patient. SimCells (simple cells) are chromosome-free bacteria controlled by designed gene circuits, which can bypass the interference of the native gene network in bacteria and eliminate the risk of bacterial uncontrolled growth. Here, we describe the reprogramming of SimCells and mini-SimCells to serve as "safe and live drugs" for targeted cancer therapy. We engineer SimCells to display nanobodies on the surface for the binding of carcinoembryonic antigen (CEA), which is an important biomarker found commonly in colorectal cancer cells. We show that SimCells and mini-SimCells with surface display of anti-CEA nanobody can specifically bind CEA-expressing Caco2 cancer cells
MeSH term(s)	Artificial Cells ; Caco-2 Cells ; Carcinoembryonic Antigen/genetics ; Carcinoembryonic Antigen/metabolism ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Salicylates ; Synthetic Biology
Chemical Substances	Carcinoembryonic Antigen ; Salicylates
Language	English
Publishing date	2022-03-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2161-5063
ISSN (online)	2161-5063
DOI	10.1021/acssynbio.1c00631
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Membrane Applications in Autologous Cell Therapy.

Martin, Risto / Lei, Rui / Zeng, Yida / Zhu, Jiachen / Chang, Hong / Ye, Hua / Cui, Zhanfeng

Membranes

2022 Volume 12, Issue 12

Abstract: Stem cell and cell therapies, particularly autologous cell therapies, are becoming a common practice. However, in order for these technologies to achieve wide-scale clinical application, the prohibitively high cost associated with these therapies must be ...

Abstract	Stem cell and cell therapies, particularly autologous cell therapies, are becoming a common practice. However, in order for these technologies to achieve wide-scale clinical application, the prohibitively high cost associated with these therapies must be addressed through creative engineering. Membranes can be a disruptive technology to reshape the bioprocessing and manufacture of cellular products and significantly reduce the cost of autologous cell therapies. Examples of successful membrane applications include expansions of CAR-T cells, various human stem cells, and production of extracellular vesicles (EVs) using hollow fibre membrane bioreactors. Novel membranes with tailored functions and surface properties and novel membrane modules that can accommodate the changing needs for surface area and transport properties are to be developed to fulfil this key role.
Language	English
Publishing date	2022-11-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2614641-1
ISSN	2077-0375
ISSN	2077-0375
DOI	10.3390/membranes12121182
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Update of ultrasound-assembling fabrication and biomedical applications for heterogeneous polymer composites.

Dong, Jun / Wang, Zonghua / Yang, Fangfang / Wang, Huiqi / Cui, Xuejun / Li, Zhanfeng

Advances in colloid and interface science

2022 Volume 305, Page(s) 102683

Abstract: As a power-driving approach, ultrasound irradiation is very appealing to the preparation or modification of new materials. In the review, we overviewed the latest development of ultrasound-mediated effects or reactions in polymer composites, and ... ...

Abstract	As a power-driving approach, ultrasound irradiation is very appealing to the preparation or modification of new materials. In the review, we overviewed the latest development of ultrasound-mediated effects or reactions in polymer composites, and demonstrated its unique and powerful aspects on the polymerization or aggregation. The review generalized the different categories of heterogeneous polymer composites by defining the constituents, and described the shapes, sizes and basic properties of various purpose-specific or site-specific products. Importantly, the review paid more attention to the main biomedicine applications of heterogeneous polymer composites, such as drug or bioactive substance entrapment, delivery, release, imaging, and therapy, and emphasized many advantages of ultrasound-assembling approaches and heterogeneous polymer composites in biology and medicine fields. In addition, the review also indicated the prospective challenges of heterogeneous polymer composites both in ultrasound-assembling designs and in biomedical applications.
MeSH term(s)	Polymerization ; Polymers ; Prospective Studies
Chemical Substances	Polymers
Language	English
Publishing date	2022-05-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	210507-x
ISSN	1873-3727 ; 0001-8686
ISSN (online)	1873-3727
ISSN	0001-8686
DOI	10.1016/j.cis.2022.102683
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2716: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito