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  1. Article ; Online: Effect of Yuchang suppository on PPARγ/NF-KB signaling pathway in rats with ulcerative colitis

    Li-Hong Zheng / Hai-Qiang Wang

    Journal of Hainan Medical University, Vol 25, Iss 7, Pp 5-

    2019  Volume 9

    Abstract: Objective: To investigate the therapeutic effect of Yuchang suppository on experimental ... control group, model group, high-dose group of Yuchang suppository, middle dose group , Low-dose group and ... the middle-dose group were significantly better than the low-dose group. Conclusion: Yuchang suppository ...

    Abstract Objective: To investigate the therapeutic effect of Yuchang suppository on experimental ulcerative colitis rats and the effect of PPARγ/NF-KB signaling pathway. Methods: The UC rat model was replicated by 2.4.6-trinitrobenzenesulfonic acid (TNBS)/ethanol method and randomly divided into normal control group, model group, high-dose group of Yuchang suppository, middle dose group , Low-dose group and sulfasalazine group, 8 rats in each group. After 14 days of treatment, the general condition of the rats was observed and the disease activity index was scored. The changes of serum TNF-α, IL-1β and IL-6 levels were detected by ELISA. The colonic mucosal injury index (CMDI) score and colon were observed by colon specimens. Histopathological changes; RT-PCR and Western blot were used to detect the expression of PPARγ and NF-KB genes and proteins in colon tissue. Results: Compared with the normal control group, the DAI and CMDI scores in the model group and the levels of serum TNF-α, IL-1β, IL-6, NF-κB p65 mRNA and protein in colon tissue were significantly increased, PPAR. - γ mRNA and protein expression levels were significantly reduced. The levels of IL-1β, IL-6, TNF-α and the expression of NF-κB p65 mRNA and protein in colon tissue were lower than those in the model group, and the expression levels of PPARγ mRNA and protein were high. In the model group. In the improvement of NF- κBp65 and PPAR-γ gene and protein expression in rat colonic mucosa, the high-dose group and the middle-dose group were significantly better than the low-dose group. Conclusion: Yuchang suppository can significantly improve the symptoms and histopathology of UC model rats. The mechanism may be through activation of PPARγ, blocking the activation of NF-κB signaling pathway, and down-regulating inflammatory factors such as TNF-α and IL-1β. The expression is such that the inflammatory response is alleviated or eliminated, thereby achieving the therapeutic effect of UC.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Editorial Board of Journal of Hainan Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Interpreting polygenic score effects in sibling analysis.

    Fletcher, Jason / Wu, Yuchang / Li, Tianchang / Lu, Qiongshi

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0282212

    Abstract: Researchers often claim that sibling analysis can be used to separate causal genetic effects from the assortment of biases that contaminate most downstream genetic studies (e.g. polygenic score predictors). Indeed, typical results from sibling analysis ... ...

    Abstract Researchers often claim that sibling analysis can be used to separate causal genetic effects from the assortment of biases that contaminate most downstream genetic studies (e.g. polygenic score predictors). Indeed, typical results from sibling analysis show large (>50%) attenuations in the associations between polygenic scores and phenotypes compared to non-sibling analysis, consistent with researchers' expectations about bias reduction. This paper explores these expectations by using family (quad) data and simulations that include indirect genetic effect processes and evaluates the ability of sibling analysis to uncover direct genetic effects of polygenic scores. We find that sibling analysis, in general, fail to uncover direct genetic effects; indeed, these models have both upward and downward biases that are difficult to sign in typical data. When genetic nurture effects exist, sibling analysis creates "measurement error" that attenuates associations between polygenic scores and phenotypes. As the correlation between direct and indirect effect changes, this bias can increase or decrease. Our findings suggest that interpreting results from sibling analysis aimed at uncovering direct genetic effects should be treated with caution.
    MeSH term(s) Humans ; Siblings ; Phenotype ; Multifactorial Inheritance/genetics ; Bias
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0282212
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  3. Article ; Online: Dynamically tunable multi-band plasmon-induced absorption based on multi-layer borophene ribbon gratings.

    Pan, Yizhao / Li, Yuchang / Chen, Fang / Yang, Wenxing / Yi, Zao

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 17, Page(s) 13209–13218

    Abstract: In this paper, we propose a borophene-based grating structure (BBGS) to realize multi-band plasmon-induced absorption. The coupling of two resonance modes excited by upper borophene grating (UBG) and lower borophene grating (LBG) leads to plasmon-induced ...

    Abstract In this paper, we propose a borophene-based grating structure (BBGS) to realize multi-band plasmon-induced absorption. The coupling of two resonance modes excited by upper borophene grating (UBG) and lower borophene grating (LBG) leads to plasmon-induced absorption. The coupled-mode theory (CMT) is utilized to fit the absorption spectrum. The simulated spectrum fits well with the calculated result. We found the absorption peaks exhibit a blue shift with an increase in the carrier density of borophene grating. Further, as the coupling distance
    Language English
    Publishing date 2024-05-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d4cp01062k
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  4. Article ; Online: ATAD3A: A Key Regulator of Mitochondria-Associated Diseases.

    Chen, Liting / Li, Yuchang / Zambidis, Alexander / Papadopoulos, Vassilios

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Mitochondrial membrane protein ATAD3A is a member of the AAA-domain-containing ATPases superfamily. It is important for the maintenance of mitochondrial DNA, structure, and function. In recent years, an increasing number ... ...

    Abstract Mitochondrial membrane protein ATAD3A is a member of the AAA-domain-containing ATPases superfamily. It is important for the maintenance of mitochondrial DNA, structure, and function. In recent years, an increasing number of
    Language English
    Publishing date 2023-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512511
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  5. Article: Effects of Multi-Components on the Microwave Absorption and Dielectric Properties of Plasma-Sprayed Carbon Nanotube/Y

    Li, Rong / Qing, Yuchang

    Nanomaterials (Basel, Switzerland)

    2021  Volume 11, Issue 10

    Abstract: Carbon nanotube (CNT)-reinforced ... ...

    Abstract Carbon nanotube (CNT)-reinforced Y
    Language English
    Publishing date 2021-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano11102640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Simultaneously enhancing organic phosphorescence quantum yields and lifetimes for triphenylphosphine salt doped polymer films.

    Li, Jiangang / Wei, Kuanjian / Wu, Jilong / Wang, Yuchang / Liu, Shujuan / Ma, Yun / Zhao, Qiang

    Chemical science

    2024  Volume 15, Issue 13, Page(s) 4881–4889

    Abstract: Simultaneously enhancing the quantum yields and luminescence lifetimes of organic persistent room temperature phosphorescence (RTP) molecules is a priority in the organic photonic area, but it remains a formidable challenge. Here, an effective strategy ... ...

    Abstract Simultaneously enhancing the quantum yields and luminescence lifetimes of organic persistent room temperature phosphorescence (RTP) molecules is a priority in the organic photonic area, but it remains a formidable challenge. Here, an effective strategy was proposed to improve both quantum efficiencies and emission decay times for phosphorescent triphenylphosphine salts. This approach involves integrating an electron donor unit into a triphenylphosphine salt
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d4sc00161c
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  7. Article ; Online: A novel plasma-sprayed Ti

    Li, Yang / Qing, Yuchang / Yao, Haoyang / Xu, Hailong / Wu, Hongjing

    Journal of colloid and interface science

    2023  Volume 645, Page(s) 165–175

    Abstract: High-performance microwave absorption coatings are critically required in the stealth defense system of military platforms. Regrettably, just optimizing the property but neglecting the application feasibility seriously inhibits its practical application ... ...

    Abstract High-performance microwave absorption coatings are critically required in the stealth defense system of military platforms. Regrettably, just optimizing the property but neglecting the application feasibility seriously inhibits its practical application in the field of microwave absorption. To face this challenge, the Ti
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2023.04.145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  8. Article ; Online: Positive Charge Holes Revealed by Energy Band Theory in Multiphase Ti

    Li, Yang / Qing, Yuchang / Cao, Yaru / Luo, Fa / Wu, Hongjing

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 41, Page(s) e2302769

    Abstract: Although numerous experimental investigations have been carried out on the problem of defect engineering in semiconductor absorbers, the relationship among charge carrier, defects, heterointerfaces, and electromagnetic (EM) wave absorption has not been ... ...

    Abstract Although numerous experimental investigations have been carried out on the problem of defect engineering in semiconductor absorbers, the relationship among charge carrier, defects, heterointerfaces, and electromagnetic (EM) wave absorption has not been established systematically. Herein, the new thermodynamic and kinetic control strategy is proposed to establish multiphase Ti
    Language English
    Publishing date 2023-06-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202302769
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  9. Article ; Online: The mitochondrial translocator protein (TSPO, 18 kDa): A key multifunctional molecule in liver diseases.

    Li, Yuchang / Chen, Liting / Papadopoulos, Vassilios

    Biochimie

    2023  

    Abstract: Translocator protein (TSPO, 18 kDa), previously known as peripheral-type benzodiazepine receptor, is an evolutionarily conserved and tryptophan-rich 169-amino-acid protein located on the outer mitochondrial membrane. TSPO plays a crucial role in various ... ...

    Abstract Translocator protein (TSPO, 18 kDa), previously known as peripheral-type benzodiazepine receptor, is an evolutionarily conserved and tryptophan-rich 169-amino-acid protein located on the outer mitochondrial membrane. TSPO plays a crucial role in various fundamental physiological functions and cellular processes. Its expression is altered in pathological conditions, thus rendering TSPO a potential tool for diagnostic imaging and an appealing therapeutic target. The investigation of synthetic TSPO ligands as both agonists and antagonists has provided valuable insights into the regulatory mechanisms and functional properties of TSPO. Recently, accumulating evidence has highlighted the significance of TSPO in liver diseases. However, a comprehensive summary of TSPO function in the normal liver and diverse liver diseases is lacking. This review aims to provide an overview of recent advances in understanding TSPO function in both normal liver cells and various liver diseases, with a particular emphasis on its involvement in liver fibrosis and inflammation and addresses the existing knowledge gaps in the field that require further investigation.
    Language English
    Publishing date 2023-12-06
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 120345-9
    ISSN 1638-6183 ; 0300-9084
    ISSN (online) 1638-6183
    ISSN 0300-9084
    DOI 10.1016/j.biochi.2023.11.013
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.135: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Comparison of the long-term effects of atropine in combination with Orthokeratology and defocus incorporated multiple segment lenses for myopia control in Chinese children and adolescents.

    Tang, Tao / Lu, Yuchang / Li, Xuewei / Zhao, Heng / Wang, Kai / Li, Yan / Zhao, Mingwei

    Eye (London, England)

    2024  

    Abstract: Purpose: The aim of this study was to evaluate the efficacy of Orthokeratology (Ortho-K), defocus incorporated multiple segment (DIMS) lens, combined Ortho-K/atropine, and combined DIMS/atropine for myopia control in children.: Methods: A ... ...

    Abstract Purpose: The aim of this study was to evaluate the efficacy of Orthokeratology (Ortho-K), defocus incorporated multiple segment (DIMS) lens, combined Ortho-K/atropine, and combined DIMS/atropine for myopia control in children.
    Methods: A retrospective study included 167 myopic children aged 6-14 years with a spherical equivalent refraction (SER) of -0.75 to -4.00 diopter treated with Ortho-K (OK, n = 41), combined Ortho-K/atropine (OKA, n = 43), DIMS (n = 41), or combined DIMS/atropine (DIMSA, n = 42). Axial length (AL) was measured at baseline and at 3, 6, 9 and 12 months. Axial elongation over time and between groups were analysed.
    Results: After 12 months, the AL change was 0.20 ± 0.12 mm, 0.12 ± 0.14 mm, 0.22 ± 0.14 mm, and 0.15 ± 0.15 mm in the OK, OKA, DIMS, and DIMSA, respectively. There was no significant difference in AL change between OK and DIMS. OKA and DIMSA significantly slowed axial elongation compared to OK and DIMS monotherapy. After stratification by age, in the subgroup aged 6-10 years, there was significant difference in AL change between OKA and DIMS (p = 0.013), and no difference between other groups, while in the subgroup aged 10-14 years, the difference between OKA and DIMS became insignificant (p = 0.237), and the difference between OK and OKA, OK and DIMSA, DIMS and DIMSA became significant.
    Conclusions: Ortho-K and DIMS lenses show similar reductions in myopia progression among children with low initial myopia. Atropine can significantly improve the efficacy of myopia control of both Ortho-K and DIMS lenses, and this add-on effect is better in older children.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-024-02987-5
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    In stock of ZB MED Cologne/Königswinter

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