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Article ; Online: Ancient DNA reveals a migration of the ancient Di-qiang populations into Xinjiang as early as the early Bronze Age.

Gao, Shi-Zhu / Zhang, Ye / Wei, Dong / Li, Hong-Jie / Zhao, Yong-Bin / Cui, Yin-Qiu / Zhou, Hui

American journal of physical anthropology

2015 Volume 157, Issue 1, Page(s) 71–80

Abstract: ... studies revealed that the Di-qiang populations from the Hexi Corridor had migrated to eastern Xinjiang and ...

Abstract	Xinjiang is at the crossroads between East and West Eurasia, and it harbors a relatively complex genetic history. In order to better understand the population movements and interactions in this region, mitochondrial and Y chromosome analyses on 40 ancient human remains from the Tianshanbeilu site in eastern Xinjiang were performed. Twenty-nine samples were successfully assigned to specific mtDNA haplogroups, including the west Eurasian maternal lineages of U and W and the east Eurasian maternal lineages of A, C, D, F, G, Z, M7, and M10. In the male samples, two Y chromosome haplogroups, C* and N1 (xN1a, N1c), were successfully assigned. Our mitochondrial and Y-chromosomal DNA analyses combined with the archaeological studies revealed that the Di-qiang populations from the Hexi Corridor had migrated to eastern Xinjiang and admixed with the Eurasian steppe populations in the early Bronze Age.
MeSH term(s)	Anthropology, Physical ; Asian Continental Ancestry Group/genetics ; China ; Chromosomes, Human, Y/genetics ; DNA, Mitochondrial/genetics ; Female ; Human Migration ; Humans ; Male ; Microsatellite Repeats/genetics ; Polymorphism, Single Nucleotide/genetics
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219376-0
ISSN	1096-8644 ; 0002-9483
ISSN (online)	1096-8644
ISSN	0002-9483
DOI	10.1002/ajpa.22690
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Systematic screening and characterization of Qi-Li-Qiang-Xin capsule-related xenobiotics in rats by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.

Yun, Wei-Jing / Yao, Zhi-Hong / Fan, Cai-Lian / Qin, Zi-Fei / Tang, Xi-Yang / Gao, Meng-Xue / Dai, Yi / Yao, Xin-Sheng

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2018 Volume 1090, Page(s) 56–64

Abstract: Qi-Li-Qiang-Xin capsule (QLQX), a well-known traditional Chinese medicine prescription (TCMP), is ...

Abstract	Qi-Li-Qiang-Xin capsule (QLQX), a well-known traditional Chinese medicine prescription (TCMP), is consisted of eleven commonly used herbal medicines, has been widely used for the treatment of chronic heart failure (CHF). However, the absorbed components and related metabolites after oral administration of QLQX are still remaining unknown. In the present work, a reliable and effective method using ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS) was established to identify QLQX-related xenobiotics in rats. Based on a representative structure based homologous xenobiotics identification (RSBHXI) strategy, a total of eleven compounds (salvianolic acid B, formononetin, benzoylmesaconine, alisol A, sinapine thiocyanate, naringin, tanshinone IIA, ginsenoside Rg1, ginsenoside Rb1, astragaloside IV and periplocin), bearing different chemical core structures, were selected and investigated for their metabolism in vivo. And then, comprehensive metabolic profiles of the holistic multi-ingredients in QLQX were achieved. As a result, a total of 121 QLQX-related xenobiotics (47 prototypes and 74 metabolites) were identified or tentatively characterized, among them eight prototypes (mesaconine, hypaconine, songorine, fuziline, neoline, talatizamine formononetin, neocryptotanshinone) and two metabolites (calycosin-gluA, formononetin-guA) were relatively the main existing xenobiotics exposed in blood. All absorbed prototype constituents were mainly from six composed herbal medicines (Aconiti lateralis radix, Astragali radix, Ginseng radix, Alismatis rhizoma, Salvia miltiorrhiza radix, Periploca cortex). The main metabolic reactions were methylation, hydrogenation, hydroxylation, oxidization, sulfation and glucuronidation. This is the first study on in vivo metabolism of QLQX. These results enabled us to focus on several high exposure ingredients in the discovery of effective substances of QLQX, however further pharmacokinetic study on these QLQX-related xenobiotics are needed to be carried out.
MeSH term(s)	Animals ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/pharmacokinetics ; Feces/chemistry ; Male ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry/methods ; Xenobiotics/analysis ; Xenobiotics/chemistry ; Xenobiotics/metabolism ; Xenobiotics/pharmacokinetics
Chemical Substances	Drugs, Chinese Herbal ; Xenobiotics ; qiliqiangxin
Language	English
Publishing date	2018-07-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2018.05.014
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Article ; Online: Ancient DNA evidence supports the contribution of Di-Qiang people to the han Chinese gene pool.

Zhao, Yong-Bin / Li, Hong-Jie / Li, Sheng-Nan / Yu, Chang-Chun / Gao, Shi-Zhu / Xu, Zhi / Jin, Li / Zhu, Hong / Zhou, Hui

American journal of physical anthropology

2011 Volume 144, Issue 2, Page(s) 258–268

Abstract: ... in Qinghai province, northwest of China, where the Di-Qiang populations had previously lived. In this study ... populations (descendants of Di-Qiang populations) and Han Chinese, suggesting that the Di-Qiang populations ...

Abstract	Han Chinese is the largest ethnic group in the world. During its development, it gradually integrated with many neighboring populations. To uncover the origin of the Han Chinese, ancient DNA analysis was performed on the remains of 46 humans (1700 to 1900 years ago) excavated from the Taojiazhai site in Qinghai province, northwest of China, where the Di-Qiang populations had previously lived. In this study, eight mtDNA haplogroups (A, B, D, F, M*, M10, N9a, and Z) and one Y-chromosome haplogroup (O3) were identified. All analyses show that the Taojiazhai population presents close genetic affinity to Tibeto-Burman populations (descendants of Di-Qiang populations) and Han Chinese, suggesting that the Di-Qiang populations may have contributed to the Han Chinese genetic pool.
MeSH term(s)	Analysis of Variance ; Asian Continental Ancestry Group/genetics ; Base Sequence ; Bone and Bones/chemistry ; China ; Chromosomes, Human, Y ; Cluster Analysis ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/isolation & purification ; Female ; Fossils ; Gene Pool ; Humans ; Male ; Molecular Sequence Data ; Polymorphism, Single Nucleotide ; Principal Component Analysis ; Tooth/chemistry
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2011-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219376-0
ISSN	1096-8644 ; 0002-9483
ISSN (online)	1096-8644
ISSN	0002-9483
DOI	10.1002/ajpa.21399
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Systematic screening and characterization of Qi-Li-Qiang-Xin capsule-related xenobiotics in rats by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry

Yun, Wei-jing / Dai, Yi / Fan, Cai-lian / Gao, Meng-xue / Qin, Zi-fei / Tang, Xi-yang / Yao, Xin-sheng / Yao, Zhi-hong

Journal of chromatography. 2018 July 15, v. 1090

2018

Abstract: Qi-Li-Qiang-Xin capsule (QLQX), a well-known traditional Chinese medicine prescription (TCMP), is ...

Abstract	Qi-Li-Qiang-Xin capsule (QLQX), a well-known traditional Chinese medicine prescription (TCMP), is consisted of eleven commonly used herbal medicines, has been widely used for the treatment of chronic heart failure (CHF). However, the absorbed components and related metabolites after oral administration of QLQX are still remaining unknown. In the present work, a reliable and effective method using ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS) was established to identify QLQX-related xenobiotics in rats. Based on a representative structure based homologous xenobiotics identification (RSBHXI) strategy, a total of eleven compounds (salvianolic acid B, formononetin, benzoylmesaconine, alisol A, sinapine thiocyanate, naringin, tanshinone IIA, ginsenoside Rg1, ginsenoside Rb1, astragaloside IV and periplocin), bearing different chemical core structures, were selected and investigated for their metabolism in vivo. And then, comprehensive metabolic profiles of the holistic multi-ingredients in QLQX were achieved. As a result, a total of 121 QLQX-related xenobiotics (47 prototypes and 74 metabolites) were identified or tentatively characterized, among them eight prototypes (mesaconine, hypaconine, songorine, fuziline, neoline, talatizamine formononetin, neocryptotanshinone) and two metabolites (calycosin-gluA, formononetin-guA) were relatively the main existing xenobiotics exposed in blood. All absorbed prototype constituents were mainly from six composed herbal medicines (Aconiti lateralis radix, Astragali radix, Ginseng radix, Alismatis rhizoma, Salvia miltiorrhiza radix, Periploca cortex). The main metabolic reactions were methylation, hydrogenation, hydroxylation, oxidization, sulfation and glucuronidation. This is the first study on in vivo metabolism of QLQX. These results enabled us to focus on several high exposure ingredients in the discovery of effective substances of QLQX, however further pharmacokinetic study on these QLQX-related xenobiotics are needed to be carried out.
Keywords	Alisols ; astragalosides ; blood ; cortex ; formononetin ; ginsenosides ; heart failure ; herbal medicines ; hydrogenation ; hydroxylation ; ingredients ; metabolites ; methylation ; naringin ; oral administration ; Oriental traditional medicine ; Panax ; pharmacokinetics ; prototypes ; rats ; rhizomes ; Salvia miltiorrhiza ; salvianolic acid ; screening ; sinapine ; tandem mass spectrometry ; thiocyanates ; ultra-performance liquid chromatography ; xenobiotics
Language	English
Dates of publication	2018-0715
Size	p. 56-64.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	1570-0232
DOI	10.1016/j.jchromb.2018.05.014
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A rare reason of pleural effusion in children: T-cell lymphoblastic lymphoma.

Tang, Fu-Xian / Gao, Qiang

Asian journal of surgery

2024

Language	English
Publishing date	2024-03-26
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.03.132
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Article ; Online: Tumor-Host Cometabolism Collaborates to Shape Cancer Immunity.

Wu, Yingcheng / Zou, Qiang / Jiang, Peng / Gao, Qiang

Cancer discovery

2024 Volume 14, Issue 4, Page(s) 653–657

Abstract: Summary: Nutrients are essential for supporting tumor growth and immune cell function in the tumor microenvironment, but emerging evidence reveals a paradoxical competition and collaboration between the metabolic demands of proliferating cancer cells ... ...

Abstract	Summary: Nutrients are essential for supporting tumor growth and immune cell function in the tumor microenvironment, but emerging evidence reveals a paradoxical competition and collaboration between the metabolic demands of proliferating cancer cells and immune cell activation. Dietary interventions and metabolic immunoengineering offer promise to selectively modulate cancer and immune cell metabolism by targeting metabolic sensing processes rather than pathways directly, moving beyond conventional ideas and heralding an exciting new era of immunometabolism discovery and translation.
MeSH term(s)	Humans ; Neoplasms/metabolism ; Tumor Microenvironment
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625242-9
ISSN	2159-8290 ; 2159-8274
ISSN (online)	2159-8290
ISSN	2159-8274
DOI	10.1158/2159-8290.CD-23-1509
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Article ; Online: EBER-negative inflammatory pseudotumor-like follicular dendritic cell sarcoma of liver: A case report.

Zhang, Qiang / Gao, Jialin

Medicine

2024 Volume 103, Issue 14, Page(s) e37651

Abstract: Rationale: Inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) of the liver is rare. It was previously believed that Epstein-Barr virus (EBV) positivity was a necessary criterion for pathological diagnosis. However, we found ... ...

Abstract	Rationale: Inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) of the liver is rare. It was previously believed that Epstein-Barr virus (EBV) positivity was a necessary criterion for pathological diagnosis. However, we found that there were also cases of EBV negativity. Therefore, clinicians and pathologists are reminded that EBV positivity is not a necessary condition for diagnosis. Patient concerns: A 70-year-old female underwent computed tomography (CT) examination for upper abdominal discomfort, which revealed the presence of a liver tumor. Follow-up revealed that the tumor had progressively increased in size. Diagnosis: The final diagnosis was an IPT-like follicular cell sarcoma, based on CT, MRI, HE staining, and immunohistochemical staining. Interventions: The patient underwent a laparoscopic left hemihepatectomy. Outcomes: The patient has not undergone any special treatment, such as radiotherapy and chemotherapy, and has been followed up for over 3 years without experiencing any recurrence. Lessons: IPT-like FDCS is a rare tumor that lacks definitive criteria, and its diagnosis mainly relies on pathological findings. Previously, it was believed that being EBV-positive was an important condition for diagnosis. Primary IPT-like FDCS in the liver is even rarer, and the patient in this case tested negative for EBV. It may be necessary for pathologists to consider the role of EBV in the diagnosis of IPT-like FDCS.
MeSH term(s)	Female ; Humans ; Aged ; Dendritic Cell Sarcoma, Follicular/diagnosis ; Dendritic Cell Sarcoma, Follicular/surgery ; Dendritic Cell Sarcoma, Follicular/pathology ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Granuloma, Plasma Cell/diagnosis ; Granuloma, Plasma Cell/surgery ; Granuloma, Plasma Cell/pathology ; Herpesvirus 4, Human ; Liver/diagnostic imaging ; Liver/pathology
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037651
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Article: Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2.

Ma, Yujie / Gao, Qiang

Open medicine (Warsaw, Poland)

2024 Volume 19, Issue 1, Page(s) 20240953

Abstract: Purpose: The aim of this study is to describe the novel epidemiological and clinical characteristics of influenza A-induced severe pneumonia occurring after the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to further ... ...

Abstract	Purpose: The aim of this study is to describe the novel epidemiological and clinical characteristics of influenza A-induced severe pneumonia occurring after the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to further assess its potential risk factors for mortality. Methods: We retrospectively studied the consecutive case series of 30 patients with confirmed influenza A-induced severe pneumonia treated in the intensive care unit at Dazhou Central Hospital in Sichuan, China, from March 1 to April 30, 2023. Logistic regression was used to analyze the independent risk factors, and receiver operating characteristic (ROC) curves were applied to evaluate the predictive efficacy of associated risk factors for mortality. Results: The mortality rate was 33.3% in this study. Independent risk factors for mortality of patients were acute respiratory distress syndrome (ARDS) ( Conclusion: ARDS and septic shock were the independent risk factors for mortality in patients with influenza A-induced severe pneumonia following the end of the SARS-CoV-2 pandemic. But high level of next generation sequencing reads Aspergillus coinfection, and comorbidities did not increase death risk of the study population.
Language	English
Publishing date	2024-04-15
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2829380-0
ISSN	2391-5463
ISSN	2391-5463
DOI	10.1515/med-2024-0953
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Article ; Online: A novel approach to electroacupuncture for postoperative urinary retention following lumbar spinal stenosis treatment: A case report.

Wu, Minmin / Tang, Qiang / Gao, Weibin / Zhu, Luwen

Asian journal of surgery

2024

Language	English
Publishing date	2024-02-19
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.02.020
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Article ; Online: Traumatic rupture of nephroblastoma misdiagnosed as isolated renal rupture in children.

Gao, Qiang / Lv, Min-Li

Asian journal of surgery

2023 Volume 47, Issue 1, Page(s) 590–591

MeSH term(s)	Child ; Humans ; Wilms Tumor/diagnosis ; Wilms Tumor/surgery ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/surgery ; Kidney ; Diagnostic Errors
Language	English
Publishing date	2023-10-10
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.09.122
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