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  1. Article ; Online: Mucormycosis in COVID-19 patients.

    Sundaram, Natarajan / Bhende, Tejas / Yashwant, Runali / Jadhav, Siddhita / Jain, Astha

    Indian journal of ophthalmology

    2021  Volume 69, Issue 12, Page(s) 3728–3733

    Abstract: Mucormycosis, commonly known as 'Black Fungus' which was then a rare fungal infection, has suddenly come to light post the COVID-19- pandemic, more so during the second wave in India. It thus becomes important not only for the medical fraternity but also ...

    Abstract Mucormycosis, commonly known as 'Black Fungus' which was then a rare fungal infection, has suddenly come to light post the COVID-19- pandemic, more so during the second wave in India. It thus becomes important not only for the medical fraternity but also the general population to build awareness about the same. The present review will focus on the pathophysiology, etiology, outcomes of some case studies, and current treatment methods of mucormycosis infection. Major focus of the current article is on rhino-orbital-cerebral mucormycosis. All the studies included in the present review article was extracted from the PubMed database.
    MeSH term(s) COVID-19 ; Humans ; Mucormycosis/diagnosis ; Mucormycosis/epidemiology ; Nose ; Orbital Diseases ; SARS-CoV-2
    Language English
    Publishing date 2021-12-15
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_1316_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development of integrated microfluidic platform coupled with Surface-enhanced Raman Spectroscopy for diagnosis of COVID-19.

    Jadhav, Siddhita A / Biji, Pullithadathil / Panthalingal, Manoj Kumar / Murali Krishna, C / Rajkumar, S / Joshi, Dattatraya S / Sundaram, Natarajan

    Medical hypotheses

    2020  Volume 146, Page(s) 110356

    Abstract: Corona Virus Disease 19 (COVID-19) pandemic has created an alarming situation across the globe. Varieties of diagnostic protocols are being developed for the diagnosis of COVID-19. Many of these diagnostic protocols however, have limitations such as for ... ...

    Abstract Corona Virus Disease 19 (COVID-19) pandemic has created an alarming situation across the globe. Varieties of diagnostic protocols are being developed for the diagnosis of COVID-19. Many of these diagnostic protocols however, have limitations such as for example unacceptable no of false-positive and false-negative cases, particularly during the early stages of infection. At present, the real-time (quantitative) reverse transcriptase-polymerase chain reaction (RT-PCR) is considered the gold standard for COVID-19 diagnosis. However, RT-PCR based tests are complex, expensive, time consuming and involve pre-processing of samples. A swift, sensitive, inexpensive protocol for mass screening is urgently needed to contain this pandemic. There is urgent need to harness new powerful technologies for accurate detection not only of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) but also combating the emergence of pandemics of new viruses as well. To overcome the current challenges, the authors propose a diagnostic protocol based on Surface-enhanced Raman Spectroscopy (SERS) coupled with microfluidic devices containing integrated microchannels functionalized either with vertically aligned Au/Ag coated carbon nanotubes or with disposable electrospun micro/nano-filter membranes. These devices have the potential to successfully trap viruses from diverse biological fluids/secretions including saliva, nasopharyngeal, tear etc. These can thus enrich the viral titre and enable accurate identification of the viruses from their respective Raman signatures. If the device is successfully developed and proven to detect target viruses, it would facilitate rapid screening of symptomatic as well as asymptomatic individuals of COVID-19. This would be a valuable diagnostic tool not only for mass screening of current COVID-19 pandemic but also in viral pandemic outbreaks of future.
    MeSH term(s) COVID-19/diagnosis ; COVID-19 Testing/instrumentation ; COVID-19 Testing/methods ; Dimethylpolysiloxanes ; Equipment Design ; Humans ; Lab-On-A-Chip Devices ; Metal Nanoparticles ; Nanotubes, Carbon ; Pandemics ; SARS-CoV-2/isolation & purification ; Spectrum Analysis, Raman/methods
    Chemical Substances Dimethylpolysiloxanes ; Nanotubes, Carbon ; baysilon (63148-62-9)
    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110356
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  3. Article ; Online: Development of Integrated Microfluidic Platform Coupled with Surface-Enhanced Raman Spectroscopy for Diagnosis of COVID-19

    Amit Jadhav, Siddhita / Biji, Pullithadathil. / Kumar Panthalingal, Manoj / Murali, Chilakapati / Kulkarni, Anjali / Rajkumar, Sankaranarayanan / Joshi, Dattatraya S. / Natarajan, Sundaram

    Medical Hypotheses

    2020  , Page(s) 110356

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110356
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