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  1. Article: Mild obstructive sleep apnoea in females:

    Wimms, Alison J / Kelly, Julia L / Turnbull, Christopher D / McMillan, Alison / Craig, Sonya E / O'Reilly, John F / Nickol, Annabel H / Decker, Meredith D / Willes, Leslee A / Calverley, Peter M A / Benjafield, Adam V / Stradling, John R / Morrell, Mary J

    ERJ open research

    2024  Volume 10, Issue 1

    Abstract: Background: A : Methods: MERGE participants with mild OSA (apnoea-hypopnoea index 5-15 events·h: Results: 233 patients were included; 71 (30%) were female. Females were more symptomatic at baseline in all QoL questionnaires. Specifically, females ... ...

    Abstract Background: A
    Methods: MERGE participants with mild OSA (apnoea-hypopnoea index 5-15 events·h
    Results: 233 patients were included; 71 (30%) were female. Females were more symptomatic at baseline in all QoL questionnaires. Specifically, females had lower 36-item Short-Form Health Survey (SF-36) Vitality scores (mean±sd 39.1±10.1
    Conclusions: Sex differences are apparent in patients with mild OSA. Females experience worse QoL symptoms than males at presentation to the sleep clinic; however, these improve significantly with CPAP treatment.
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00574-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Residual sleepiness in patients with OSA on CPAP.

    Stradling, J R

    The European respiratory journal

    2009  Volume 34, Issue 5, Page(s) 1209

    MeSH term(s) Case-Control Studies ; Continuous Positive Airway Pressure ; Data Interpretation, Statistical ; Disorders of Excessive Somnolence/epidemiology ; Disorders of Excessive Somnolence/etiology ; Humans ; Models, Statistical ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/therapy ; Treatment Outcome
    Language English
    Publishing date 2009-11
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/09031936.00099609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  3. Article ; Online: Physical Activity and Sedentary Behaviour in Patients With Malignant Pleural Effusion Undergoing Therapeutic Pleural Interventions (The ASPIRE Study).

    Hassan, Maged / Banka, Radhika / Castro-Añón, Olalla / Mercer, Rachel M / Bedawi, Eihab O / Asciak, Rachelle / Stradling, John / Rahman, Najib M

    Archivos de bronconeumologia

    2021  Volume 57, Issue 10, Page(s) 656–658

    MeSH term(s) Exercise ; Humans ; Pleura ; Pleural Effusion/etiology ; Pleural Effusion/therapy ; Pleural Effusion, Malignant/drug therapy ; Pleurodesis ; Sedentary Behavior
    Language English
    Publishing date 2021-08-26
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbr.2020.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Paradoxical decrease in isoprostane and increase in superoxide dismutase following CPAP withdrawal in OSA.

    Antoniades, Charalambos / Lee, Regent / Kohler, Malcolm / Stradling, John

    The European respiratory journal

    2016  Volume 47, Issue 3, Page(s) 1014–1015

    MeSH term(s) Biomarkers/blood ; Biomarkers/urine ; Continuous Positive Airway Pressure ; Female ; Humans ; Male ; Oxidative Stress ; Sleep Apnea, Obstructive/therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016-03-21
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01725-2015
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    Zs.MO 292: Show issues

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  5. Article ; Online: BAY 2253651 for the treatment of obstructive sleep apnoea: a multicentre, double-blind, randomised controlled trial (SANDMAN).

    Gaisl, Thomas / Turnbull, Chris D / Weimann, Gerrit / Unger, Sigrun / Finger, Rudolf / Xing, Charles / Cistulli, Peter A / West, Sophie / Chiang, Alan K I / Eckert, Danny J / Stradling, John R / Kohler, Malcolm

    The European respiratory journal

    2021  Volume 58, Issue 5

    MeSH term(s) Continuous Positive Airway Pressure ; Double-Blind Method ; Humans ; Sleep Apnea, Obstructive/therapy
    Language English
    Publishing date 2021-11-18
    Publishing country England
    Document type Letter ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01937-2021
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  6. Article ; Online: Snoring and the role of the GDP: British Society of Dental Sleep Medicine (BSDSM) pre-treatment screening protocol.

    Stradling, J / Dookun, R

    British dental journal

    2009  Volume 206, Issue 6, Page(s) 307–312

    Abstract: Snoring is not necessarily a benign condition; it can be linked to the serious condition obstructive sleep apnoea (OSA). In some cases mandibular repositioning devices can be an effective treatment for simple snoring and mild to moderate sleep apnoea, ... ...

    Abstract Snoring is not necessarily a benign condition; it can be linked to the serious condition obstructive sleep apnoea (OSA). In some cases mandibular repositioning devices can be an effective treatment for simple snoring and mild to moderate sleep apnoea, and these devices can be provided by dentists (with appropriate training and in line with Dental Protection Ltd guidelines). Until now, the dental profession has not been given any guidance on how to differentiate between patients who may be treated without further reference to medical colleagues (ie simple snorers), and those who should be referred for specialist assessment. The aim of this paper is to facilitate safe treatment of snoring and OSA and to protect dentists by explaining an accepted method for screening patients for obstructive sleep apnoea.
    MeSH term(s) Algorithms ; Clinical Protocols ; General Practice, Dental ; Humans ; Mass Screening/instrumentation ; Mass Screening/methods ; Monitoring, Physiologic/instrumentation ; Occlusal Splints ; Pharynx/physiopathology ; Referral and Consultation ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/therapy ; Snoring/physiopathology ; Snoring/therapy ; Societies, Dental
    Language English
    Publishing date 2009-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/sj.bdj.2009.214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 447: Show issues

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  7. Article ; Online: Physical Activity and Sedentary Behaviour in Patients With Malignant Pleural Effusion Undergoing Therapeutic Pleural Interventions (The ASPIRE Study).

    Hassan, Maged / Banka, Radhika / Castro-Añón, Olalla / Mercer, Rachel M / Bedawi, Eihab O / Asciak, Rachelle / Stradling, John / Rahman, Najib M

    Archivos de bronconeumologia

    2020  

    Language Spanish
    Publishing date 2020-10-22
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2591346-3
    ISSN 2173-5751 ; 2173-5751
    ISSN (online) 2173-5751
    ISSN 2173-5751
    DOI 10.1016/j.arbres.2020.09.018
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  8. Article: The role of the dentist in sleep disorders.

    Stradling, John / Dookun, Roy

    Dental update

    2011  Volume 38, Issue 2, Page(s) 136; author reply 136

    MeSH term(s) Dentists ; Humans ; Mandibular Advancement/instrumentation ; Mass Screening ; Orthodontic Appliances ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/therapy ; Sleep Stages/physiology ; Snoring/diagnosis ; Snoring/therapy
    Language English
    Publishing date 2011-03
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 423728-6
    ISSN 0305-5000
    ISSN 0305-5000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Ketone Ester Drink Increases Postexercise Muscle Glycogen Synthesis in Humans.

    Holdsworth, David A / Cox, Peter J / Kirk, Tom / Stradling, Huw / Impey, Samuel G / Clarke, Kieran

    Medicine and science in sports and exercise

    2018  Volume 49, Issue 9, Page(s) 1789–1795

    Abstract: Introduction: Physical endurance can be limited by muscle glycogen stores, in that glycogen depletion markedly reduces external work. During carbohydrate restriction, the liver synthesizes the ketone bodies, D-β-hydroxybutyrate, and acetoacetate from ... ...

    Abstract Introduction: Physical endurance can be limited by muscle glycogen stores, in that glycogen depletion markedly reduces external work. During carbohydrate restriction, the liver synthesizes the ketone bodies, D-β-hydroxybutyrate, and acetoacetate from fatty acids. In animals and in the presence of glucose, D-β-hydroxybutyrate promotes insulin secretion and increases glycogen synthesis. Here we determined whether a dietary ketone ester, combined with plentiful glucose, can increase postexercise glycogen synthesis in human skeletal muscle.
    Methods: After an interval-based glycogen depletion exercise protocol, 12 well-trained male athletes completed a randomized, three-arm, blinded crossover recovery study that consisted of consumption of either a taste-matched, zero-calorie control or a ketone monoester drink, followed by a 10-mM glucose clamp or saline infusion for 2 h. The three postexercise conditions were control drink then saline infusion, control drink then hyperglycemic clamp, or ketone ester drink then hyperglycemic clamp. Skeletal muscle glycogen content was determined in muscle biopsies of vastus lateralis taken before and after the 2-h clamps.
    Results: The ketone ester drink increased blood D-β-hydroxybutyrate concentrations to a maximum of 5.3 versus 0.7 mM for the control drink (P < 0.0001). During the 2-h glucose clamps, insulin levels were twofold higher (31 vs 16 mU·L, P < 0.01) and glucose uptake 32% faster (1.66 vs 1.26 g·kg, P < 0.001). The ketone drink increased by 61 g, the total glucose infused for 2 h, from 197 to 258 g, and muscle glycogen was 50% higher (246 vs 164 mmol glycosyl units per kilogram dry weight, P < 0.05) than after the control drink.
    Conclusion: In the presence of constant high glucose concentrations, a ketone ester drink increased endogenous insulin levels, glucose uptake, and muscle glycogen synthesis.
    MeSH term(s) Adult ; Beverages ; Blood Glucose/metabolism ; Cross-Over Studies ; Exercise/physiology ; Glucose/administration & dosage ; Glucose Clamp Technique ; Glycogen/biosynthesis ; Humans ; Hydroxybutyrates/administration & dosage ; Hydroxybutyrates/blood ; Insulin/blood ; Male ; Muscle, Skeletal/metabolism
    Chemical Substances (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ; Blood Glucose ; Hydroxybutyrates ; Insulin ; Glycogen (9005-79-2) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2018-03-04
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 603994-7
    ISSN 1530-0315 ; 0195-9131 ; 0025-7990
    ISSN (online) 1530-0315
    ISSN 0195-9131 ; 0025-7990
    DOI 10.1249/MSS.0000000000001292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Medical approaches to snoring and sleep apnoea.

    Stradling, J R

    Transactions of the Medical Society of London

    1999  Volume 114, Page(s) 17–19

    MeSH term(s) Humans ; Positive-Pressure Respiration ; Sleep Apnea, Obstructive/therapy ; Snoring/diagnosis ; Snoring/therapy
    Language English
    Publishing date 1999-11-03
    Publishing country England
    Document type Address
    ZDB-ID 414727-3
    ISSN 0076-6011
    ISSN 0076-6011
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