LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 419

Search options

  1. Article: The Effects of Wearing a Portable Media Armband on Muscle Activation of the Biceps Brachii.

    Tucker, W Steven / Allen, Melissa J / Patterson, Ashley E / Fotioo, Alex W

    International journal of exercise science

    2024  Volume 16, Issue 1, Page(s) 1461–1470

    Abstract: Portable media armbands are commonly used among the physically active population. Their effect on muscle function has not been established. The purpose of this study was to determine if muscle activation of the biceps brachii is influenced by wearing a ... ...

    Abstract Portable media armbands are commonly used among the physically active population. Their effect on muscle function has not been established. The purpose of this study was to determine if muscle activation of the biceps brachii is influenced by wearing a portable media armband during an elbow flexion exercise. Eighteen participants (11 males: age = 22.5 ± 2.1 years, height = 178.3 ± 5.2 cm, mass = 85.0 ± 6.5 kg; 7 females: age = 22.9 ± 2.5 years, height = 168.3 ± 5.7 cm, mass = 72.3 ± 12.2 kg) with no history of upper extremity injury volunteered for the study. Participants performed elbow flexion trials with a hand-held dumbbell with and without wearing a portable media armband. Dumbbell weight was determined by an 8-10 repetition maximum, and the condition was counterbalanced. The average concentric and eccentric phases for five trials for each condition were normalized to a maximum voluntary isometric contraction using electromyography. The independent variable was condition (with-PMAB and without-PMAB). The dependent variable was the muscle activation of the biceps brachii. Mean data for each condition were analyzed using separate paired-samples
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2411342-6
    ISSN 1939-795X
    ISSN 1939-795X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: Inpatient prescribing patterns of long-acting injectables and their oral or short-acting injectable equivalent formulations.

    Liu, Yifei / Patterson, Mark E / Sahil, Suman / Stoner, Steven C

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1140969

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1140969
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Community water fluoride cessation and rate of caries-related pediatric dental treatments under general anesthesia in Alberta, Canada.

    Yazdanbakhsh, Elnaz / Bohlouli, Babak / Patterson, Steven / Amin, Maryam

    Canadian journal of public health = Revue canadienne de sante publique

    2024  Volume 115, Issue 2, Page(s) 305–314

    Abstract: Objective: This study examined the rate of caries-related dental treatments under general anesthesia (GA) in fluoridated and non-fluoridated communities in Alberta, Canada, between 2010 and 2019.: Methods: This retrospective, population-based study ... ...

    Abstract Objective: This study examined the rate of caries-related dental treatments under general anesthesia (GA) in fluoridated and non-fluoridated communities in Alberta, Canada, between 2010 and 2019.
    Methods: This retrospective, population-based study included all children (
    Results: Among 2659 children receiving caries-related treatments under GA, the mean (SD) and median (IQR) age were 4.8 (2.3) and 4 (3-6) years, respectively, and 65% resided in the non-fluoridated area. The analysis revealed that the cessation of water fluoridation was significantly associated with an increased rate of caries-related GA events per 10,000 children in both age groups (0-5 and 6-11 years), with a more pronounced effect in 0-5-year-olds in non-fluoridated areas. The risk of dental treatments under GA was also positively associated with post-cessation time.
    Conclusion: Discontinuing water fluoridation appears to negatively affect young children's oral health, potentially leading to a significant increase in caries-related dental treatments under GA and oral health disparities in this pediatric population.
    MeSH term(s) Child ; Humans ; Child, Preschool ; Fluorides ; Alberta/epidemiology ; Retrospective Studies ; Dental Caries Susceptibility ; Fluoridation ; Anesthesia, General/adverse effects ; Prevalence ; Dental Care ; Dental Caries/epidemiology
    Chemical Substances Fluorides (Q80VPU408O)
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 417262-0
    ISSN 1920-7476 ; 0008-4263
    ISSN (online) 1920-7476
    ISSN 0008-4263
    DOI 10.17269/s41997-024-00858-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Temporally Stable Supramolecular Polymeric Salts Enabling High-Performance 3D All-Aromatic Polyimide Lattices.

    Weyhrich, Cody W / Will, John W / Nayyar, Garvit / Westover, Clarissa C / Patterson, Steven / Arrington, Clay B / Williams, Christopher B / Long, Timothy E

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 32, Page(s) e2303188

    Abstract: ... sulfone-containing monomer, e.g., 4,4'-diaminodiphenyl sulfone (DDS), prohibited the aza-Michael addition ...

    Abstract Vat photopolymerization (VP) Additive Manufacturing (AM), in which UV light is selectively applied to cure photo-active polymers into complex geometries with micron-scale resolution, has a limited selection of aliphatic thermoset materials that exhibit relatively poor thermal performance. Ring-opening dianhydrides with acrylate-containing nucleophiles yielded diacrylate ester-dicarboxylic acids that enabled photo-active polyimide (PI) precursors, termed polysalts, upon neutralization with an aromatic diamine in solution. In situ FTIR spectroscopy coupled with a solution and photo-rheological measurements revealed a previously unknown time-dependent instability of 4,4'-oxydianiline (ODA) polysalts due to an aza-Michael addition. Replacement of the electron-donating ether-containing diamine with an electron withdrawing sulfone-containing monomer, e.g., 4,4'-diaminodiphenyl sulfone (DDS), prohibited the aza-Michael addition of the aromatic amine to the activated acrylate double bond. Novel DDS polysalt photocurable solutions are similarly analyzed and validated long-term stability, which enabled reproducible printing of polyimide organogel intermediates. Subsequent VP AM afforded 3-dimensional (3D) structures of intricate complexity and excellent surface finish, as demonstrated with scanning electron microscopy. In addition, the novel PMDA-HEA/DDS solution enabled the production of the first beam latticed architecture comprised of all-aromatic polyimide. The versatility of a polysalt platform for multi-material printing is further demonstrated by printing parts with alternating polysalt compositions.
    Language English
    Publishing date 2023-05-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202303188
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Three trap designs evaluated for a deepwater lionfish fishery

    Holden E. Harris / Steven B. Garner / Joseph H. Tarnecki / Stephen R. Gittings / David D. Chagaris / William F. Patterson

    Frontiers in Marine Science, Vol

    2023  Volume 10

    Abstract: A deepwater (>40 m) fishery for invasive lionfish (Pterois volitans/miles) offers a potential means to control invasive lionfish densities and mitigate their impacts on reefs too deep for SCUBA removals. Trapping could provide a scalable solution—if an ... ...

    Abstract A deepwater (>40 m) fishery for invasive lionfish (Pterois volitans/miles) offers a potential means to control invasive lionfish densities and mitigate their impacts on reefs too deep for SCUBA removals. Trapping could provide a scalable solution—if an effective fishing gear with minimal environmental impacts could be permitted and adopted by fishers. We tested the efficacy of wooden slat lobster traps, wire sea bass traps, and experimental non-containment Gittings traps. One hundred deployments of each trap type were made at 120 mesophotic (38–78 m deep) natural reef sites in the northeastern Gulf of Mexico (29.6–30.1°N, 86.1–87.6°W). Reef sites were surveyed with remotely operated vehicles (ROV) before and after trap deployments, and remote time-lapse video cameras were affixed above 86 traps to sample in situ recruitment to the traps. The video data showed that lionfish were attracted to the vicinity of the three trap types at similar rates, but that lionfish rarely entered the lobster or sea bass traps. The high bycatch rates of sea bass traps suggested their use is likely unsuitable for targeting lionfish. Lobster traps had lower rates of bycatch, but their relatively high ratio of bycatch-to-lionfish catches suggests that modifications will be needed to make them more efficient. The Gittings traps had the highest lionfish catch rates and lowest bycatches of native fishes, but operational issues were also identified. They failed to open on 20% of deployments and one entangled a green sea turtle (Chelonia mydas). Even with the best-performing trap design, the average catch rate of lionfish was less than one lionfish per trap. A potential explanation could be the low biomass of lionfish observed during the ROV surveys, which averaged 0.3 kg lionfish per site. The time-lapse video data suggested that lionfish recruitment to Gittings traps could increase with higher densities of lionfish on the nearby reefs, if traps were retrieved after approximately two days of deployment, and if traps were retrieved ...
    Keywords deepwater lionfish ; gear testing ; fishing innovation ; Pterois volitans ; ocean solutions ; research development and testing ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Subject code 333
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  6. Article ; Online: Hip-focused physical therapy versus spine-focused physical therapy for older adults with chronic low back pain at risk for mobility decline (MASH): a multicentre, single-masked, randomised controlled trial.

    Hicks, Gregory E / George, Steven Z / Pugliese, Jenifer M / Coyle, Peter C / Sions, J Megan / Piva, Sara / Simon, Corey B / Kakyomya, Joseph / Patterson, Charity G

    The Lancet. Rheumatology

    2024  Volume 6, Issue 1, Page(s) e10–e20

    Abstract: Background: Previously, we identified a population of older adults with chronic low back pain, hip pain, and hip muscle weakness who had worse 12-month low back pain and functional outcomes than age-matched adults with only low back pain, indicating an ... ...

    Abstract Background: Previously, we identified a population of older adults with chronic low back pain, hip pain, and hip muscle weakness who had worse 12-month low back pain and functional outcomes than age-matched adults with only low back pain, indicating an increased risk for future mobility decline. We sought to determine whether tailored, hip-focused physical therapy reduced pain and functional limitations in this high-risk population compared with non-tailored, spine-focused physical therapy.
    Methods: We did a multicentre, single-masked, randomised controlled trial at three research-based sites in the USA. We recruited older adults (aged 60-85 years) with hip pain and weakness who reported moderate low back pain intensity at least half the days in the last 6 months. Patients were randomly assigned to hip-focused physical therapy or spine-focused physical therapy using permuted blocks with random block size, stratified by site and sex (ie, male or female). The primary outcomes were self-reported disability using the Quebec Back Pain Disability Scale (QBPDS) and performance-based 10-Meter Walk Test (10MWT) at 8 weeks. All analyses were done in the intention-to-treat population. Adverse events were collected by study staff via a possible adverse event reporting form and then adjudicated by site investigators. This trial was registered with ClinicalTrials.gov, NCT04009837.
    Findings: Between Nov 1, 2019, and April 30, 2022, 184 participants were randomly assigned to receive hip-focused (n=91) or spine-focused physical therapy (n=93) interventions. The mean age was 70·7 (SD 6·2) years. 121 (66%) of 184 participants were women, 63 (34%) were men, and 149 (81%) were White. At 8 weeks, the mean between-group difference on the QBPDS was 4·0 (95% CI 0·5 to 7·5), favouring hip-focused physical therapy. Both groups had similar, clinically meaningful gait speed improvements (10MWT) at 8 weeks (mean difference 0·004 m/s [95% CI -0·044 to 0·052]). No serious adverse events were related to study participation.
    Interpretation: Tailored hip-focused physical therapy demonstrated greater improvements in low back pain-related disability at 8 weeks. However, both hip-focused physical therapy and spine-focused physical therapy produced clinically meaningful improvements in disability and function for this high-risk population at 6 months. These findings warrant further investigation before clinical implementation.
    Funding: US National Institute on Aging of the National Institutes of Health.
    MeSH term(s) United States ; Female ; Humans ; Male ; Aged ; Low Back Pain/therapy ; Spine ; Arthralgia ; Intention ; Physical Therapy Modalities
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(23)00267-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Type III Collagen is Required for Adipogenesis and Actin Stress Fibre Formation in 3T3-L1 Preadipocytes.

    Al Hasan, Mohammad / Martin, Patricia E / Shu, Xinhua / Patterson, Steven / Bartholomew, Chris

    Biomolecules

    2021  Volume 11, Issue 2

    Abstract: GPR56 is required for the adipogenesis of preadipocytes, and the role of one of its ligands, type III collagen (ColIII), was investigated here. ColIII expression was examined by reverse transcription quantitative polymerase chain reaction, immunoblotting ...

    Abstract GPR56 is required for the adipogenesis of preadipocytes, and the role of one of its ligands, type III collagen (ColIII), was investigated here. ColIII expression was examined by reverse transcription quantitative polymerase chain reaction, immunoblotting and immunostaining, and its function investigated by knockdown and genome editing in 3T3-L1 cells. Adipogenesis was assessed by oil red O staining of neutral cell lipids and production of established marker and regulator proteins. siRNA-mediated knockdown significantly reduced
    MeSH term(s) 3T3-L1 Cells ; Actin Cytoskeleton/metabolism ; Actins/metabolism ; Adipocytes/cytology ; Adipogenesis/genetics ; Animals ; Cell Differentiation ; Collagen Type III/genetics ; Collagen Type III/metabolism ; Extracellular Matrix/metabolism ; Gene Editing ; Ligands ; Mice ; Phenotype ; Receptors, G-Protein-Coupled/genetics ; Stress Fibers/metabolism
    Chemical Substances Actins ; COL3A1 protein, mouse ; Collagen Type III ; GPR56 protein, mouse ; Ligands ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2021-01-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11020156
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Recruitment and baseline characteristics of young adults at risk of early-onset knee osteoarthritis after ACL reconstruction in the SUPER-Knee trial.

    Culvenor, Adam G / West, Thomas J / Bruder, Andrea M / Scholes, Mark J / Barton, Christian J / Roos, Ewa M / Oei, Edwin H G / McPhail, Steven M / Souza, Richard B / Lee, Jusuk / Patterson, Brooke E / Girdwood, Michael A / Couch, Jamon L / Crossley, Kay M

    BMJ open sport & exercise medicine

    2024  Volume 10, Issue 2, Page(s) e001909

    Abstract: Objectives: The study aims to (1) report the process of recruiting young adults into a secondary knee osteoarthritis prevention randomised controlled trial (RCT) after anterior cruciate ligament reconstruction (ACLR); (2) determine the number of ... ...

    Abstract Objectives: The study aims to (1) report the process of recruiting young adults into a secondary knee osteoarthritis prevention randomised controlled trial (RCT) after anterior cruciate ligament reconstruction (ACLR); (2) determine the number of individuals needed to be screened to include one participant (NNS) and (3) report baseline characteristics of randomised participants.
    Methods: The SUpervised exercise-therapy and Patient Education Rehabilitation (SUPER)-Knee RCT compares SUPER and minimal intervention for young adults (aged 18-40 years) with ongoing symptoms (ie, mean score of <80/100 from four Knee injury and Osteoarthritis Outcome Score subscales (KOOS
    Results: 1044 individuals were screened to identify 567 eligible people, from which 184 participants (63% male) enrolled. The sample of enrolled participants was multicultural (29% born outside Australia; 2% Indigenous Australians). The NNS was 5.7. For randomised participants, mean±SD age was 30±6 years. The mean body mass index was 27.3±5.2 kg/m
    Conclusion: Young adults post-ACLR were willing to participate in a secondary osteoarthritis prevention trial. Sample size calculations should be multiplied by at least 5.7 to provide an estimate of the NNS. The SUPER-Knee cohort is ideally positioned to monitor and intervene in the early development and trajectory of osteoarthritis.
    Trial registration number: ACTRN12620001164987.
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2817580-3
    ISSN 2055-7647
    ISSN 2055-7647
    DOI 10.1136/bmjsem-2024-001909
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Distinct dual antiviral mechanism that enhances hepatitis B virus mutagenesis and reduces viral DNA synthesis.

    McDaniel, Yumeng Z / Patterson, Steven E / Mansky, Louis M

    Antiviral research

    2019  Volume 170, Page(s) 104540

    Abstract: ... We observed that a viral mutagen (e.g., 5-aza-2'-deoxycytidine, 5-aza-dC or 5-azacytidine, 5-aza-C) severely ...

    Abstract Reverse transcriptase (RT) is an essential enzyme for the replication of retroviruses and hepadnaviruses. Current therapies do not eliminate the intracellular viral replication intermediate termed covalently closed circular (ccc) DNA, which has enhanced interest in hepatitis B virus (HBV) reverse transcription and cccDNA formation. The HBV cccDNA is generated as a plasmid-like episome in the host cell nucleus from the protein-linked relaxed circular (rc) DNA genome in incoming virions during HBV replication. The creation of the cccDNA via conversion from rcDNA remains not fully understood. Here, we sought to investigate whether viral mutagens can effect HBV replication. In particular, we investigated whether nucleoside analogs that act as viral mutagens with retroviruses could impact hepadnaviral DNA synthesis. We observed that a viral mutagen (e.g., 5-aza-2'-deoxycytidine, 5-aza-dC or 5-azacytidine, 5-aza-C) severely diminished the ability of a HBV vector to express a reporter gene following virus transfer and infection of target cells. As predicted, the treatment of 5-aza-dC or 5-aza-C elevated the HBV rcDNA mutation frequency, primarily by increasing the frequency of G-to-C transversion mutations. A reduction in rcDNA synthesis was also observed. Intriguingly, the cccDNA nick/gap region transcription was diminished by 5-aza-dC, but did not enhance viral mutagenesis. Taken together, our results demonstrate that viral mutagens can impact HBV reverse transcription, and propose a model in which viral mutagens can induce mutagenesis during rcDNA formation and diminish viral DNA synthesis during both rcDNA formation and the conversion of rcDNA to cccDNA.
    MeSH term(s) Antiviral Agents/pharmacology ; Cell Line ; DNA Replication/drug effects ; DNA, Circular/genetics ; DNA, Viral/genetics ; Hep G2 Cells ; Hepatitis B virus/drug effects ; Hepatitis B virus/genetics ; Hepatocytes/virology ; Humans ; Mutagenesis ; Mutagens/pharmacology ; Nucleosides/pharmacology ; Reverse Transcription/drug effects ; Virus Replication/drug effects ; Virus Replication/genetics
    Chemical Substances Antiviral Agents ; DNA, Circular ; DNA, Viral ; Mutagens ; Nucleosides
    Language English
    Publishing date 2019-06-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2019.104540
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: Early Functional Outcomes in Low Back Pain Subjects with a Novel Interspinous Fusion Device: REFINE Study 6-Month Results.

    Falowski, Steven M / Raso, Louis J / Mangal, Vipul / Nairizi, Ali / Patterson, Denis G / Danko, Michael D / Justiz, Rafael / Vogel, Rainer S / Koga, Sebastian / Josephson, Yousseff / Pope, Jason E / Raji, Oluwatodimu Richard

    Journal of pain research

    2023  Volume 16, Page(s) 4113–4126

    Abstract: Purpose: Lumbar interlaminar decompression with interspinous fixation is an established safe and effective treatment for spinal stenosis. Early maintenance of improvements in pain intensity and function are critical for durability of symptom relief. The ...

    Abstract Purpose: Lumbar interlaminar decompression with interspinous fixation is an established safe and effective treatment for spinal stenosis. Early maintenance of improvements in pain intensity and function are critical for durability of symptom relief. The purpose of this study was to investigate the efficacy of minimally invasive treatments for low back pain during the early period after treatment and their utility in setting the course for longer term success.
    Patients and methods: This study utilized patient evaluations at 3- and 6-months following treatment and is part of an actively enrolling, institutional review board (IRB) approved, single-arm, multicenter, prospective, open-label 12-month study. Clinical efficacy was assessed primarily using the change from baseline in Oswestry Disability Index (ODI), Visual Analog Scale (VAS) of the back and leg pain during walking and standing, and Zurich Claudication Questionnaire (ZCQ), and secondarily using the Patient Global Impression of Change (PGIC) and Patient-Reported Outcomes Measurement Information System (PROMIS) 29 v2.1. The safety endpoints were the adverse events and reoperations or revisions at the index level(s).
    Results: At 6-month post-op, 76%, 62%-64%, and 64% of patients demonstrated clinical meaningful, and statistically significant improvement in their pain as defined by ZCQ, VAS (back and leg), and ODI, respectively. In addition, 78% of patients noted improvement in PGIC. Two procedure-related adverse events were noted which fully resolved without surgical intervention.
    Conclusion: This 6-month interim analysis at 42% enrollment of patients was conducted to determine prolonged safety and efficacy of the interspinous fusion device. Our analysis showed a sustained improvement in clinical efficacy, and safety endpoints, when compared to the 3-months evaluations, across both interventional pain and neurosurgery specialties.
    Language English
    Publishing date 2023-12-01
    Publishing country New Zealand
    Document type Case Reports ; Clinical Trial
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S427407
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top