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  1. Article ; Online: A united vision for cardiovascular-kidney-metabolic health.

    Quaggin, Susan E / Magod, Benjamin

    Nature reviews. Nephrology

    2024  Volume 20, Issue 5, Page(s) 273–274

    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-024-00812-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6334: Show issues Location:
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  2. Article ; Online: Preparation of a Single Cell Suspension from the Murine Iridocorneal Angle.

    Thomson, Benjamin R / Quaggin, Susan E

    Bio-protocol

    2022  Volume 12, Issue 10

    Abstract: Single cell RNA sequencing is a powerful tool that can be used to identify distinct cell types and transcriptomic differences within complex tissues. It has proven to be especially useful in tissues of the eye, where investigators have identified novel ... ...

    Abstract Single cell RNA sequencing is a powerful tool that can be used to identify distinct cell types and transcriptomic differences within complex tissues. It has proven to be especially useful in tissues of the eye, where investigators have identified novel cell types within the retina, anterior chamber, and iridocorneal angle and explored transcriptomic contribution to disease phenotypes in age-related macular degeneration. However, to obtain high quality results, the technique requires isolation of healthy single cells from the tissue of interest, seeking complete tissue digestion while minimizing stress and transcriptomic changes in the isolated cells prior to library preparation. Here, we present a protocol developed in our laboratory for isolation of live single cells from the murine iridocorneal angle, which includes Schlemm's canal and the trabecular meshwork, suitable for single cell RNA sequencing, flow cytometry, or other downstream analysis. Graphical abstract.
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Removing Race from Kidney Disease Diagnosis.

    Quaggin, Susan E / Palevsky, Paul M

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 12, Page(s) 2987–2989

    MeSH term(s) Humans ; Kidney Diseases/diagnosis
    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021091284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
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  4. Article ; Online: Evolving Demographics of Nephrology Research Workforce in the United States.

    Quaggin, Susan E / Humphreys, Benjamin D

    Clinical journal of the American Society of Nephrology : CJASN

    2021  Volume 16, Issue 9, Page(s) 1312–1314

    MeSH term(s) Biomedical Research/statistics & numerical data ; Demography ; Nephrology ; United States ; Workforce
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.09950721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Removing Race from Kidney Disease Diagnosis.

    Quaggin, Susan E / Palevsky, Paul M

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2021  Volume 79, Issue 2, Page(s) 153–155

    MeSH term(s) Creatinine ; Glomerular Filtration Rate ; Humans ; Kidney Diseases/diagnosis
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2021.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1669: Show issues Location:
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    Zs.MO 468: Show issues

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  6. Article: VEGF-C overexpression in kidney progenitor cells is a model of renal lymphangiectasia.

    Donnan, Michael D / Deb, Dilip K / David, Valentin / Quaggin, Susan E

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Background: Lymphangiogenesis is believed to be a protective response in the setting of multiple forms of kidney injury and mitigates the progression of interstitial fibrosis. To augment this protective response, promoting kidney lymphangiogenesis is ... ...

    Abstract Background: Lymphangiogenesis is believed to be a protective response in the setting of multiple forms of kidney injury and mitigates the progression of interstitial fibrosis. To augment this protective response, promoting kidney lymphangiogenesis is being investigated as a potential treatment to slow the progression of kidney disease.As injury related lymphangiogenesis is driven by signaling from the receptor VEGFR-3 in response to the cognate growth factor VEGF-C released by tubular epithelial cells, this signaling pathway is a candidate for future kidney therapeutics. However, the consequences to kidney development and function to targeting this signaling pathway remains poorly defined.
    Methods: We generated a new mouse model expressing
    Results: Six2Vegf-C
    Conclusions: Kidney lymphangiogenesis was robustly induced in the
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.03.538868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Art and Science of Medicine … and Standardized Test Scores.

    Quaggin, Susan E / Safar-Boueri, Luisa

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 11, Page(s) 2694–2696

    MeSH term(s) Education, Medical, Graduate ; Internship and Residency
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021091245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
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  8. Article: The transcription factor Tcf21 is required for specifying Foxd1 cells to the juxtaglomerular cell lineage.

    Anjum, Hina / Yacu, George / Medrano, Silvia / Gomez, R Ariel / Sequeira-Lopez, Maria Luisa S / Quaggin, Susan E / Finer, Gal

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Renin is a crucial enzyme involved in the regulation of blood pressure and electrolyte balance. It has been shown that renin expressing cells arise from the Foxd1+ stromal progenitors, however the factors involved in guiding Foxd1+ cells towards the ... ...

    Abstract Renin is a crucial enzyme involved in the regulation of blood pressure and electrolyte balance. It has been shown that renin expressing cells arise from the Foxd1+ stromal progenitors, however the factors involved in guiding Foxd1+ cells towards the renin-secreting cell fate remain poorly understood. Tcf21, also known as Pod1 or Capsulin, is a bHLH transcription factor that is expressed in the metanephric mesenchyme and plays a crucial role in kidney development. We have previously shown that deletion of Tcf21 in Foxd1+ cells (
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.25.586641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Endothelial Tyrosine Kinase Tie1 Is Required for Normal Schlemm's Canal Development-Brief Report.

    Du, Jing / Thomson, Benjamin R / Onay, Tuncer / Quaggin, Susan E

    Arteriosclerosis, thrombosis, and vascular biology

    2022  Volume 42, Issue 3, Page(s) 348–351

    Abstract: Background: Schlemm's canal (SC) is a large vessel residing in the iridocorneal angle and is required to regulate aqueous humor outflow. Normal SC structure and function is indispensable for maintaining normal intraocular pressure, and elevated ... ...

    Abstract Background: Schlemm's canal (SC) is a large vessel residing in the iridocorneal angle and is required to regulate aqueous humor outflow. Normal SC structure and function is indispensable for maintaining normal intraocular pressure, and elevated intraocular pressure is a risk factor for development of glaucoma. Recent reports have identified a key role of the angiopoietin-Tie2 pathway for SC development and function; however, the role of the orphan receptor Tie1 has not been clarified.
    Methods: We used Tie1 knock out mice to study the function of Tie1 in SC development and function. Real-time quantitative polymerase chain reaction and Western blot analyses were used to verify Tie1 deletion. High-resolution microscopy of mouse SC whole mount and cross sections were used to study SC morphology. Measurement of intraocular pressure in live mice was used to study the impact of Tie1 on SC function.
    Results: Tie1 is highly expressed in both human and mouse SC. Tie1 knock out mice display hypomorphic SC and elevated intraocular pressure as a result of attenuated SC development.
    Conclusions: Tie1 is indispensable for SC development and function, supporting it as a novel target for future SC-targeted glaucoma therapies and a candidate gene for glaucoma in humans.
    MeSH term(s) Animals ; Anterior Chamber/enzymology ; Anterior Chamber/growth & development ; Aqueous Humor/physiology ; Endothelium, Corneal/enzymology ; Glaucoma/etiology ; Humans ; Intraocular Pressure/physiology ; Lymphatic Vessels/abnormalities ; Lymphatic Vessels/enzymology ; Lymphatic Vessels/physiology ; Mice ; Mice, Knockout ; Models, Animal ; Receptor, TIE-1/deficiency ; Receptor, TIE-1/genetics ; Receptor, TIE-1/metabolism
    Chemical Substances Receptor, TIE-1 (EC 2.7.10.1)
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.121.316692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1705: Show issues Location:
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  10. Article ; Online: Kindling the Kidney.

    Quaggin, Susan E

    The New England journal of medicine

    2015  Volume 374, Issue 3, Page(s) 281–283

    Abstract: Investigators have generated kidney-like organoids - complete with nephrons, collecting ducts, stroma, and vasculature - from induced pluripotent stem cells. ...

    Abstract Investigators have generated kidney-like organoids - complete with nephrons, collecting ducts, stroma, and vasculature - from induced pluripotent stem cells.
    MeSH term(s) Drug Evaluation/methods ; Humans ; Induced Pluripotent Stem Cells/cytology ; Nephrons/cytology ; Organogenesis ; Organoids/cytology ; Renal Insufficiency, Chronic/therapy ; Tissue Culture Techniques
    Language English
    Publishing date 2015-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr1514351
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