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  1. Article ; Online: Advancing equitable access to care and optimal medication practice. World Kidney Day 2024.

    McCarthy, Florencio A / Bonilla-Felix, Melvin

    Pediatric nephrology (Berlin, Germany)

    2024  

    Language English
    Publishing date 2024-03-26
    Publishing country Germany
    Document type Editorial
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-024-06353-1
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  2. Article ; Online: Effects of Prematurity and Growth Restriction on Adult Blood Pressure and Kidney Volume.

    Iyengar, Arpana / Bonilla-Félix, Melvin

    Advances in chronic kidney disease

    2022  Volume 29, Issue 3, Page(s) 243–250

    Abstract: Gaining insight into the complex cycle of renal programming and its early-life clinical associations is essential to understand the origins of kidney disease. Prematurity and intrauterine growth restriction are associated with low nephron endowment. This ...

    Abstract Gaining insight into the complex cycle of renal programming and its early-life clinical associations is essential to understand the origins of kidney disease. Prematurity and intrauterine growth restriction are associated with low nephron endowment. This increases the risk of developing hypertension and chronic kidney disease later in life. There is appreciable evidence to support mechanistic links between low nephron endowment secondary to intrauterine events and kidney size, kidney function, and blood pressure in postnatal life. A clear understanding of the cycle of developmental programming and consequences of fetal insults on the kidney is critical. In addition, the impact of events in the early postnatal period (accelerated postnatal growth, development of obesity, exposure to nephrotoxins) on the cardiovascular system and blood pressure of individuals born prematurely or with low birth weight is discussed. In summary, this review draws attention to the concepts of renal programming and nephron endowment and underscores the associations between intrauterine growth restriction, prematurity, and its clinical consequences in adult life.
    MeSH term(s) Adult ; Blood Pressure ; Female ; Fetal Growth Retardation/etiology ; Humans ; Infant, Low Birth Weight/physiology ; Infant, Newborn ; Kidney ; Renal Insufficiency, Chronic/etiology
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1548-5609 ; 1548-5595
    ISSN (online) 1548-5609
    ISSN 1548-5595
    DOI 10.1053/j.ackd.2022.02.002
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  3. Article ; Online: Mesoamerican Endemic Nephropathy (MeN): A Disease Reported in Adults That May Start Since Childhood?

    Lou-Meda, Randall / Alvarez-Elías, Ana Catalina / Bonilla-Félix, Melvin

    Seminars in nephrology

    2023  Volume 42, Issue 5, Page(s) 151337

    Abstract: Mesoamerican endemic nephropathy (MeN) is a type of chronic kidney disease (CKD) of uncertain etiology that occurs along the Pacific coast of the southern part of Mexico and Central America. During the past 20 years MeN has become a leading cause of ... ...

    Abstract Mesoamerican endemic nephropathy (MeN) is a type of chronic kidney disease (CKD) of uncertain etiology that occurs along the Pacific coast of the southern part of Mexico and Central America. During the past 20 years MeN has become a leading cause of death in the region, clamming close to 50,000 lives, with 40% of these deaths occurring in young people. The cause remains unknown, but most researchers believe in a multifactorial etiology that includes social determinants of poverty. Existing evidence suggests that subclinical kidney injury begins early in life and leads to a higher than expected prevalence of CKD among children in Central America. Access to health services in the region, specifically kidney replacement therapy, remains limited. We proposed a strategy to address the perceived needs and urge coordinated efforts of governments, academic organizations, and international bodies to develop a comprehensive plan of action to mitigate this situation among the vulnerable and economically disadvantaged population.
    MeSH term(s) Child ; Male ; Humans ; Adult ; Adolescent ; Balkan Nephropathy ; Central America/epidemiology ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/therapy ; Kidney ; Chronic Kidney Diseases of Uncertain Etiology
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2023.151337
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  4. Article ; Online: Pediatric nephrology in under-resourced areas: one pill will not cure all ills-economics and awareness are both important factors.

    Banerjee, Sushmita / Kamath, Nivedita / Antwi, Sampson / Bonilla-Felix, Melvin

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 38, Issue 8, Page(s) 2885

    MeSH term(s) Child ; Humans ; Nephrology ; Pediatrics ; Health Resources
    Language English
    Publishing date 2023-04-13
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-05961-7
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  5. Article ; Online: Potassium regulation in the neonate.

    Bonilla-Félix, Melvin

    Pediatric nephrology (Berlin, Germany)

    2017  Volume 32, Issue 11, Page(s) 2037–2049

    Abstract: Potassium, the major cation in intracelluar fluids, is essential for vital biological functions. Neonates maintain a net positive potassium balance, which is fundamental to ensure somatic growth but places these infants, especially those born prematurely, ...

    Abstract Potassium, the major cation in intracelluar fluids, is essential for vital biological functions. Neonates maintain a net positive potassium balance, which is fundamental to ensure somatic growth but places these infants, especially those born prematurely, at risk for life-threatening disturbances in potassium concentration [K
    Language English
    Publishing date 2017-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-017-3635-2
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  6. Article ; Online: World Kidney Day 2023: preparing for the unexpected, supporting the vulnerable!

    Daga, Ankana / Bjornstad, Erica C / McCarthy, Florencio / Bonilla-Felix, Melvin

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 38, Issue 6, Page(s) 1697–1699

    Language English
    Publishing date 2023-03-20
    Publishing country Germany
    Document type Editorial
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-05945-7
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  7. Article ; Online: Living well with kidney disease.

    McCarthy, Florencio / Cochat, Pierre / Alhasan, Khalid / Bonilla-Felix, Melvin

    Pediatric nephrology (Berlin, Germany)

    2021  Volume 36, Issue 5, Page(s) 1035–1036

    MeSH term(s) Humans ; Kidney Diseases/diagnosis ; Kidney Diseases/therapy ; Quality of Life
    Language English
    Publishing date 2021-03-01
    Publishing country Germany
    Document type Editorial
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-05011-0
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  8. Article ; Online: Peritoneal dialysis in the pediatric intensive care unit setting: techniques, quantitations and outcomes.

    Bonilla-Félix, Melvin

    Blood purification

    2013  Volume 35, Issue 1-3, Page(s) 77–80

    Abstract: Acute kidney injury (AKI) is a common complication in pediatric and neonatal intensive care units (ICU). Renal replacement therapy (RRT) is frequently needed in children in whom supportive therapy is not enough to satisfy their metabolic demands or to be ...

    Abstract Acute kidney injury (AKI) is a common complication in pediatric and neonatal intensive care units (ICU). Renal replacement therapy (RRT) is frequently needed in children in whom supportive therapy is not enough to satisfy their metabolic demands or to be able to provide adequate nutrition. The decision to begin dialysis should not be delayed since experience in infants shows that the shorter the time from the insult to the beginning of dialysis, the higher the survival rate. As the use of continuous RRT in pediatric patients in the ICU has almost tripled, the use of peritoneal dialysis (PD) and intermittent hemodialysis has markedly decreased. The patient's age seems to be the most important factor influencing the decision on the choice of dialysis modality. PD is still the most common modality used in patients younger than 6 years of age. The relatively low cost, technical simplicity, no need for anticoagulation or placement of central venous catheters, and excellent tolerance in hemodynamically unstable patients are among the most significant advantages of PD. Much controversy exists regarding the adequacy of PD in hypercatabolic patients in the ICU. Nonetheless, when Kt/V has been applied to acutely ill children, it has been shown that PD can provide adequate clearances for most infants. The outcomes of critically ill patients with AKI treated with PD are comparable to other dialysis modalities. Therefore, the decision about dialysis modality should be based on local expertise, resources available, and patient's clinical status.
    MeSH term(s) Acute Kidney Injury/mortality ; Acute Kidney Injury/therapy ; Child ; Child, Preschool ; Critical Illness/mortality ; Developed Countries ; Developing Countries ; Humans ; Infant ; Intensive Care Units, Pediatric ; Peritoneal Dialysis/economics ; Peritoneal Dialysis/mortality ; Peritoneal Dialysis/utilization ; Renal Dialysis/economics ; Renal Dialysis/mortality ; Renal Dialysis/utilization ; Survival Analysis ; Treatment Outcome ; Vascular Access Devices
    Language English
    Publishing date 2013
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000345186
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  9. Article ; Online: Disaster Management in a Nephrology Service: Lessons Learned from Hurricane Maria.

    Bonilla-Félix, Melvin / Suárez-Rivera, Marta

    Blood purification

    2018  Volume 47, Issue 1-3, Page(s) 199–204

    Abstract: Background: Puerto Rico suffered a major humanitarian -crisis after Hurricane Maria. We describe our experience with patients with renal disease in an academic medical center.: Summary: A comprehensive emergency response plan should be developed, ... ...

    Abstract Background: Puerto Rico suffered a major humanitarian -crisis after Hurricane Maria. We describe our experience with patients with renal disease in an academic medical center.
    Summary: A comprehensive emergency response plan should be developed, shared and discussed with the team and the patients prior to the hurricane. The needs of the staff should not be ignored to ensure their ability to participate as responders. Physical damage to facilities, lack of basic services, shortage of disposable products, and the inability to get to treatment centers are the most common threats. Preemptive dialysis can avoid serious complications. A contingency plan to move patients to another center should be prearranged in case the unit is rendered nonfunctional after the storm. Patients must receive preventive education about fluid and dietary restrictions and the possible use of potassium binding drugs if they cannot reach a dialysis unit. A list of alternative drugs that could be used if patients are not able to fill their medications is required. The Internet and social media proved to be an invaluable communication tool. A registry of patients with updated contact information, as well as contact information for relatives and a physical address where an emergency rescue team can be dispatched is essential. Water safety should be reinforced. Key Message: Our experience showed us that preparing for the worst is not enough. Advanced planning of a streamlined response is the best tactic to decrease harm.
    MeSH term(s) Cyclonic Storms ; Disaster Medicine/methods ; Disaster Medicine/organization & administration ; Disaster Medicine/standards ; Disaster Planning/methods ; Disaster Planning/organization & administration ; Disaster Planning/standards ; Humans ; Registries ; Renal Dialysis
    Language English
    Publishing date 2018-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000494580
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  10. Article ; Online: Paediatric nephrology in under-resourced areas.

    Banerjee, Sushmita / Kamath, Nivedita / Antwi, Sampson / Bonilla-Felix, Melvin

    Pediatric nephrology (Berlin, Germany)

    2021  Volume 37, Issue 5, Page(s) 959–972

    Abstract: Background: Nearly 50% of the world population and 60% of children aged 0 to 14 years live in low- or lower-middle-income countries. Paediatric nephrology (PN) in these countries is not a priority for allocation of limited health resources. This article ...

    Abstract Background: Nearly 50% of the world population and 60% of children aged 0 to 14 years live in low- or lower-middle-income countries. Paediatric nephrology (PN) in these countries is not a priority for allocation of limited health resources. This article explores advancements made and persisting limitations in providing optimal PN services to children in such under-resourced areas (URA).
    Methods: Medline, PubMed and Google Scholar online databases were searched for articles pertaining to PN disease epidemiology, outcome, availability of services and infrastructure in URA. The ISN and IPNA offices were contacted for data, and two online questionnaire surveys of IPNA membership performed. Regional IPNA members were contacted for further detailed information.
    Results: There is a scarcity of published data from URA; where available, prevalence of PN diseases, managements and outcomes are often reported to be different from high income regions. Deficiencies in human resources, fluoroscopy, nuclear imaging, immunofluorescence, electron microscopy and genetic studies were identified. Several drugs and maintenance kidney replacement therapy are inaccessible to the majority of patients. Despite these issues, regional efforts with support from international bodies have led to significant advances in PN services and infrastructure in many URA.
    Conclusions: Equitable distribution and affordability of PN services remain major challenges in URA. The drive towards acquisition of regional data, advocacy to local government and non-government agencies and partnership with international support bodies needs to be continued. The aim is to optimise and achieve global parity in PN training, investigations and treatments, initially focusing on preventable and reversible conditions.
    MeSH term(s) Child ; Costs and Cost Analysis ; Humans ; Income ; Nephrology ; Renal Replacement Therapy ; Workforce
    Language English
    Publishing date 2021-04-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-05059-y
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