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  1. Article ; Online: A Tangled Web of Metabolism and Transcription Controls SMC Phenotype.

    Majesky, Mark W

    Circulation research

    2020  Volume 126, Issue 1, Page(s) 57–59

    MeSH term(s) Acetylglucosamine ; Humans ; Mitochondrial Proteins ; Muscle, Smooth, Vascular ; Myocytes, Smooth Muscle ; Neointima ; Phenotype ; Proteasome Endopeptidase Complex ; Transferases ; Ubiquitin
    Chemical Substances Mitochondrial Proteins ; Ubiquitin ; Transferases (EC 2.-) ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Acetylglucosamine (V956696549)
    Language English
    Publishing date 2020-01-02
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.119.316281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Vascular Development.

    Majesky, Mark W

    Arteriosclerosis, thrombosis, and vascular biology

    2018  Volume 38, Issue 3, Page(s) e17–e24

    Abstract: The vascular system forms as a branching network of endothelial cells that acquire identity as arterial, venous, hemogenic, or lymphatic. Endothelial specification depends on gene targets transcribed by Ets domain-containing factors, including Ets ... ...

    Abstract The vascular system forms as a branching network of endothelial cells that acquire identity as arterial, venous, hemogenic, or lymphatic. Endothelial specification depends on gene targets transcribed by Ets domain-containing factors, including Ets variant gene 2 (Etv2), together with the activity of chromatin-remodeling complexes containing Brahma-related gene-1 (Brg1). Once specified and assembled into vessels, mechanisms regulating lumen diameter and axial growth ensure that the structure of the branching vascular network matches the need for perfusion of target tissues. In addition, blood vessels provide important morphogenic cues that guide or direct the development of organs forming around them. As the embryo grows and lumen diameters increase, smooth muscle cells wrap around the nascent vessel walls to provide mechanical strength and vasomotor control of the circulation. Increasing mechanical stretch and wall strain promote smooth muscle cell differentiation via coupling of actin cytoskeletal remodeling to myocardin and serum response factor-dependent transcription. Remodeling of artery walls by developmental signaling pathways reappears in postnatal blood vessels during physiological and pathological adaptation to vessel wall injury, inflammation, or chronic hypoxia. Recent reports providing insights into major steps in vascular development are reviewed here with a particular emphasis on studies that have been recently published in
    MeSH term(s) Animals ; Arteries/embryology ; Arteries/metabolism ; Cell Communication ; Cell Differentiation ; Cell Lineage ; Endothelial Cells/metabolism ; Endothelial Cells/physiology ; Gene Expression Regulation, Developmental ; Humans ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/physiology ; Neovascularization, Physiologic ; Phenotype ; Signal Transduction
    Language English
    Publishing date 2018-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.118.310223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The adventitia in arterial development, remodeling, and hypertension.

    Majesky, Mark W / Weiser-Evans, Mary C M

    Biochemical pharmacology

    2022  Volume 205, Page(s) 115259

    Abstract: The adventitia receives input signals from the vessel wall, the immune system, perivascular nerves and from surrounding tissues to generate effector responses that regulate structural and mechanical properties of blood vessels. It is a complex and ... ...

    Abstract The adventitia receives input signals from the vessel wall, the immune system, perivascular nerves and from surrounding tissues to generate effector responses that regulate structural and mechanical properties of blood vessels. It is a complex and dynamic tissue that orchestrates multiple functions for vascular development, homeostasis, repair, and disease. The purpose of this review is to highlight recent advances in our understanding of the origins, phenotypes, and functions of adventitial and perivascular cells with particular emphasis on hypertensive vascular remodeling.
    MeSH term(s) Humans ; Adventitia/physiology ; Arteries ; Hypertension
    Language English
    Publishing date 2022-09-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2022.115259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Vascular Smooth Muscle Cells.

    Majesky, Mark W

    Arteriosclerosis, thrombosis, and vascular biology

    2016  Volume 36, Issue 10, Page(s) e82–6

    MeSH term(s) Actins/metabolism ; Animals ; Aortic Aneurysm/physiopathology ; Atherosclerosis/physiopathology ; Humans ; Inflammation/physiopathology ; Muscle, Smooth, Vascular/embryology ; Muscle, Smooth, Vascular/physiology ; Myocytes, Smooth Muscle/physiology ; Phenotype ; Polymerization ; Transforming Growth Factor beta/metabolism ; Vascular Remodeling/physiology
    Chemical Substances Actins ; Transforming Growth Factor beta
    Language English
    Publishing date 2016-09-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.116.308261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Wound healing and regeneration in spiny mice (Acomys cahirinus).

    Okamura, Daryl M / Nguyen, Elizabeth D / Beier, David R / Majesky, Mark W

    Current topics in developmental biology

    2022  Volume 148, Page(s) 139–164

    Abstract: The winds of Patagonia are referred to by locals as "The Broom of God" because they sweep away the less fit species that cannot survive there. Fitness as an evolutionary trait has been considered as fundamental for many aspects of morphogenesis and ... ...

    Abstract The winds of Patagonia are referred to by locals as "The Broom of God" because they sweep away the less fit species that cannot survive there. Fitness as an evolutionary trait has been considered as fundamental for many aspects of morphogenesis and behavior in metazoans. Yet, it has not received much attention in the area of wound healing, despite the obvious relevance of this polygenic trait to an organism's survival in nature. In this chapter, we review the evidence that the rodent species Acomys cahirinus is an emerging mammalian model system that has evolved a non-typical (for mammals) wound healing response that offers unique opportunities for the study of organ regeneration without fibrosis in an adult mammalian species.
    MeSH term(s) Animals ; Murinae/physiology ; Wound Healing
    Language English
    Publishing date 2022-03-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/bs.ctdb.2022.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis.

    Miano, Joseph M / Fisher, Edward A / Majesky, Mark W

    Circulation

    2021  Volume 143, Issue 21, Page(s) 2110–2116

    Abstract: Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing, single-cell RNA sequencing, and human genomics have been integrated to gain ... ...

    Abstract Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing, single-cell RNA sequencing, and human genomics have been integrated to gain unprecedented insights into the molecular reprogramming of VSMCs to other cell phenotypes in experimental and clinical atherosclerosis. The current thinking is that an apparently small subset of contractile VSMCs undergoes a fate switch to transitional, multipotential cells that can adopt plaque-destabilizing (inflammation, ossification) or plaque-stabilizing (collagen matrix deposition) cell states. Several candidate mediators of such VSMC fate and state changes are coming to light with intriguing implications for understanding coronary artery disease risk and the development of new treatment modalities. Here, we briefly summarize some technical and conceptual advancements derived from 2 publications in
    MeSH term(s) Atherosclerosis/physiopathology ; Cell Proliferation ; Humans ; Muscle, Smooth, Vascular/metabolism
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.049922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Adventitia and perivascular cells.

    Majesky, Mark W

    Arteriosclerosis, thrombosis, and vascular biology

    2015  Volume 35, Issue 8, Page(s) e31–5

    MeSH term(s) Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Adipose Tissue/physiopathology ; Adventitia/metabolism ; Adventitia/pathology ; Adventitia/physiopathology ; Animals ; Arteries/metabolism ; Arteries/pathology ; Arteries/physiopathology ; Cell Communication ; Humans ; Signal Transduction ; Stem Cells/metabolism ; Stem Cells/pathology ; Vascular Diseases/metabolism ; Vascular Diseases/pathology ; Vascular Diseases/physiopathology ; Vascular Diseases/therapy ; Vascular Remodeling
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.115.306088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Branch Point Smooth Muscle Cells Highlighted by Novel Lineage Tracking Approach.

    Brewer, Chris M / Majesky, Mark W

    Circulation research

    2018  Volume 122, Issue 2, Page(s) 194–196

    MeSH term(s) Muscle, Smooth, Vascular ; Myocytes, Smooth Muscle
    Language English
    Publishing date 2018-01-18
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.117.312444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Choosing Smads: smooth muscle origin-specific transforming growth factor-β signaling.

    Majesky, Mark W

    Circulation research

    2013  Volume 113, Issue 8, Page(s) 946–948

    MeSH term(s) Animals ; Cell Differentiation ; Male ; Muscle Development ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; Neural Crest/metabolism ; Smad2 Protein/metabolism ; Stem Cells/metabolism ; Transcription Factors/metabolism
    Chemical Substances Smad2 Protein ; Smad2 protein, mouse ; Transcription Factors ; myocardin-related transcription factor B, mouse
    Language English
    Publishing date 2013-09-27
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.113.302123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Origins of Smooth Muscle Progenitor Cells in Transplant Arteriosclerosis.

    Dong, Xiu Rong / Brewer, Chris M / Majesky, Mark W

    Circulation research

    2019  Volume 125, Issue 2, Page(s) 242–244

    MeSH term(s) Animals ; Arteriosclerosis ; Mice ; Muscle, Smooth ; Myocytes, Smooth Muscle ; Stem Cells
    Language English
    Publishing date 2019-07-03
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.119.315379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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