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  1. Article: Transit Amplifying Cells (TACs): a still not fully understood cell population.

    Cancedda, Ranieri / Mastrogiacomo, Maddalena

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1189225

    Abstract: Maintenance of tissue homeostasis and tissue regeneration after an insult are essential functions of adult stem cells (SCs). In adult tissues, SCs proliferate at a very slow rate within "stem cell niches", but, during tissue development and regeneration, ...

    Abstract Maintenance of tissue homeostasis and tissue regeneration after an insult are essential functions of adult stem cells (SCs). In adult tissues, SCs proliferate at a very slow rate within "stem cell niches", but, during tissue development and regeneration, before giving rise to differentiated cells, they give rise to multipotent and highly proliferative cells, known as transit-amplifying cells (TACs). Although differences exist in diverse tissues, TACs are not only a transitory phase from SCs to post-mitotic cells, but they also actively control proliferation and number of their ancestor SCs and proliferation and differentiation of their progeny toward tissue specific functional cells. Autocrine signals and negative and positive feedback and feedforward paracrine signals play a major role in these controls. In the present review we will consider the generation and the role played by TACs during development and regeneration of lining epithelia characterized by a high turnover including epidermis and hair follicles, ocular epithelial surfaces, and intestinal mucosa. A comparison between these different tissues will be made. There are some genes and molecular pathways whose expression and activation are common to most TACs regardless their tissue of origin. These include, among others, Wnt, Notch, Hedgehog and BMP pathways. However, the response to these molecular signals can vary in TACs of different tissues. Secondly, we will consider cultured cells derived from tissues of mesodermal origin and widely adopted for cell therapy treatments. These include mesenchymal stem cells and dedifferentiated chondrocytes. The possible correlation between cell dedifferentiation and reversion to a transit amplifying cell stage will be discussed.
    Language English
    Publishing date 2023-05-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1189225
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  2. Article: Editorial: Insights in tissue engineering and regenerative medicine 2021: Novel developments, current challenges, and future perspectives.

    Cancedda, Ranieri / Murphy, J Mary / Van Griensven, Martijn

    Frontiers in bioengineering and biotechnology

    2023  Volume 10, Page(s) 1125027

    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.1125027
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  3. Article ; Online: Synchrotron radiation techniques boost the research in bone tissue engineering.

    Mastrogiacomo, Maddalena / Campi, Gaetano / Cancedda, Ranieri / Cedola, Alessia

    Acta biomaterialia

    2019  Volume 89, Page(s) 33–46

    Abstract: X-ray Synchrotron radiation-based techniques, in particular Micro-tomography and Micro-diffraction, were exploited to investigate the structure of bone deposited in vivo within a porous ceramic scaffold. Bone formation was studied by implanting ... ...

    Abstract X-ray Synchrotron radiation-based techniques, in particular Micro-tomography and Micro-diffraction, were exploited to investigate the structure of bone deposited in vivo within a porous ceramic scaffold. Bone formation was studied by implanting Mesenchymal Stem Cell (MSC) seeded ceramic scaffolds in a mouse model. Osteoblasts derived from the seeded MSC and from differentiation of cells migrated within the scaffold together with the blood vessels, deposited within the scaffold pores an organic collagenous matrix on which a precursor mineral amorphous liquid-phase, containing Ca++ and PO
    MeSH term(s) Animals ; Bone and Bones/metabolism ; Calcification, Physiologic ; Cell Differentiation ; Ceramics/chemistry ; Mesenchymal Stem Cells/metabolism ; Mice ; Osteoblasts/metabolism ; Porosity ; Synchrotrons ; Tissue Engineering ; Tissue Scaffolds/chemistry ; X-Ray Diffraction
    Language English
    Publishing date 2019-03-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2019.03.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Platelet Lysate Activates Human Subcutaneous Adipose Tissue Cells by Promoting Cell Proliferation and Their Paracrine Activity Toward Epidermal Keratinocytes.

    Romaldini, Alessio / Mastrogiacomo, Maddalena / Cancedda, Ranieri / Descalzi, Fiorella

    Frontiers in bioengineering and biotechnology

    2018  Volume 6, Page(s) 203

    Abstract: Skin chronic wounds are non-healing ulcerative defects, which arise in association with a morbidity state, such as diabetes and vascular insufficiency or as the consequence of systemic factors including advanced age. Platelet Rich Plasma, a platelet-rich ...

    Abstract Skin chronic wounds are non-healing ulcerative defects, which arise in association with a morbidity state, such as diabetes and vascular insufficiency or as the consequence of systemic factors including advanced age. Platelet Rich Plasma, a platelet-rich blood fraction, can significantly improve the healing of human skin chronic ulcers. Given that the subcutaneous adipose tissue is located beneath the skin and plays a role in the skin homeostasis, in this study, we investigated the
    Language English
    Publishing date 2018-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2018.00203
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  5. Article: Innovative Cell and Platelet Rich Plasma Therapies for Diabetic Foot Ulcer Treatment: The Allogeneic Approach.

    Mastrogiacomo, Maddalena / Nardini, Marta / Collina, Maria Chiara / Di Campli, Cristiana / Filaci, Gilberto / Cancedda, Ranieri / Odorisio, Teresa

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 869408

    Abstract: Cutaneous chronic wounds are a major global health burden in continuous growth, because of population aging and the higher incidence of chronic diseases, such as diabetes. Different treatments have been proposed: biological, surgical, and physical. ... ...

    Abstract Cutaneous chronic wounds are a major global health burden in continuous growth, because of population aging and the higher incidence of chronic diseases, such as diabetes. Different treatments have been proposed: biological, surgical, and physical. However, most of these treatments are palliative and none of them can be considered fully satisfactory. During a spontaneous wound healing, endogenous regeneration mechanisms and resident cell activity are triggered by the released platelet content. Activated stem and progenitor cells are key factors for ulcer healing, and they can be either recruited to the wound site from the tissue itself (resident cells) or from elsewhere. Transplant of skin substitutes, and of stem cells derived from tissues such as bone marrow or adipose tissue, together with platelet-rich plasma (PRP) treatments have been proposed as therapeutic options, and they represent the today most promising tools to promote ulcer healing in diabetes. Although stem cells can directly participate to skin repair, they primarily contribute to the tissue remodeling by releasing biomolecules and microvesicles able to stimulate the endogenous regeneration mechanisms. Stem cells and PRP can be obtained from patients as autologous preparations. However, in the diabetic condition, poor cell number, reduced cell activity or impaired PRP efficacy may limit their use. Administration of allogeneic preparations from healthy and/or younger donors is regarded with increasing interest to overcome such limitation. This review summarizes the results obtained when these innovative treatments were adopted in preclinical animal models of diabetes and in diabetic patients, with a focus on allogeneic preparations.
    Language English
    Publishing date 2022-05-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.869408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bone mechanobiology, gravity and tissue engineering: effects and insights.

    Ruggiu, Alessandra / Cancedda, Ranieri

    Journal of tissue engineering and regenerative medicine

    2015  Volume 9, Issue 12, Page(s) 1339–1351

    Abstract: Bone homeostasis strongly depends on fine tuned mechanosensitive regulation signals from environmental forces into biochemical responses. Similar to the ageing process, during spaceflights an altered mechanotransduction occurs as a result of the effects ... ...

    Abstract Bone homeostasis strongly depends on fine tuned mechanosensitive regulation signals from environmental forces into biochemical responses. Similar to the ageing process, during spaceflights an altered mechanotransduction occurs as a result of the effects of bone unloading, eventually leading to loss of functional tissue. Although spaceflights represent the best environment to investigate near-zero gravity effects, there are major limitations for setting up experimental analysis. A more feasible approach to analyse the effects of reduced mechanostimulation on the bone is represented by the 'simulated microgravity' experiments based on: (1) in vitro studies, involving cell cultures studies and the use of bioreactors with tissue engineering approaches; (2) in vivo studies, based on animal models; and (3) direct analysis on human beings, as in the case of the bed rest tests. At present, advanced tissue engineering methods allow investigators to recreate bone microenvironment in vitro for mechanobiology studies. This group and others have generated tissue 'organoids' to mimic in vitro the in vivo bone environment and to study the alteration cells can go through when subjected to unloading. Understanding the molecular mechanisms underlying the bone tissue response to mechanostimuli will help developing new strategies to prevent loss of tissue caused by altered mechanotransduction, as well as identifying new approaches for the treatment of diseases via drug testing. This review focuses on the effects of reduced gravity on bone mechanobiology by providing the up-to-date and state of the art on the available data by drawing a parallel with the suitable tissue engineering systems.
    MeSH term(s) Animals ; Bone and Bones/cytology ; Bone and Bones/metabolism ; Humans ; Mechanotransduction, Cellular ; Tissue Engineering/methods ; Weightlessness
    Language English
    Publishing date 2015-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1932-7005
    ISSN (online) 1932-7005
    DOI 10.1002/term.1942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Whole-Genome Sequencing of Two Canine Herpesvirus 1 (CaHV-1) Isolates and Clinicopathological Outcomes of Infection in French Bulldog Puppies.

    Rocchigiani, Angela Maria / Bertoldi, Loris / Coradduzza, Elisabetta / Lostia, Giada / Pintus, Davide / Scivoli, Rosario / Cancedda, Maria Giovanna / Fiori, Mariangela Stefania / Bechere, Roberto / Murtino, Anna Pina / Pala, Giovanni / Cardeti, Giusy / Macioccu, Simona / Dettori, Maria Antonietta / Pintore, Antonio / Ligios, Ciriaco / Puggioni, Giantonella

    Viruses

    2024  Volume 16, Issue 2

    Abstract: Canine herpesvirus ... ...

    Abstract Canine herpesvirus 1
    MeSH term(s) Animals ; Dogs ; Herpesvirus 1, Canid/genetics ; Herpesviridae Infections ; Phylogeny ; Dog Diseases ; DNA, Viral/genetics ; DNA, Viral/analysis
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16020209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: ORF virus causes tumor-promoting inflammation in sheep and goats.

    Pintus, Davide / Cancedda, Maria G / Puggioni, Giantonella / Scivoli, Rosario / Rocchigiani, Angela M / Maestrale, Caterina / Coradduzza, Elisabetta / Bechere, Roberto / Silva-Flannery, Luciana / Bullock, Hannah A / Macciocu, Simona / Montesu, Maria A / Marras, Vincenzo / Dore, Simone / Ritter, Jana M / Ligios, Ciriaco

    Veterinary pathology

    2024  , Page(s) 3009858241241794

    Abstract: ORF virus (ORFV) causes contagious ecthyma ("ORF"), a disease of sheep and goats characterized by lesions ranging from vesicles and pustules to atypical papilloma-like and angiomatous lesions in the skin and mucosae. The authors investigated the ... ...

    Abstract ORF virus (ORFV) causes contagious ecthyma ("ORF"), a disease of sheep and goats characterized by lesions ranging from vesicles and pustules to atypical papilloma-like and angiomatous lesions in the skin and mucosae. The authors investigated the molecular factors leading to the ORF-associated atypical tumor-like changes. Fifteen lambs, 15 kids, and an adult ram clinically affected by natural ORFV infection were enrolled in the study and examined by several methods. ORFV was detected by viral culture or real-time polymerase chain reaction (RT-PCR) in the lesioned tissues and in the blood of the clinically affected sheep and goats. Surprisingly, ORFV was also detected in the blood of healthy goats from an affected herd. Microscopically, they found a pseudo-papillomatous proliferation of the epithelium, while the dermis and lamina propria were expanded by a proliferating neovascular component that highly expressed the viral vascular endothelial growth factor (vVEGF) and its host receptor vascular endothelial growth factor receptor 2 (VEGFR2). Immunohistochemistry, immunofluorescence, and
    Language English
    Publishing date 2024-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/03009858241241794
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  9. Article ; Online: The effect of connectivity on information in neural networks.

    Onesto, V / Narducci, R / Amato, F / Cancedda, L / Gentile, F

    Integrative biology : quantitative biosciences from nano to macro

    2018  Volume 10, Issue 2, Page(s) 121–127

    Abstract: We present a mathematical model that quantifies the amount of information exchanged in bi-dimensional networks of nerve cells as a function of network connectivity Q. Upon varying Q over a significant range, we found that, from a certain cell density ... ...

    Abstract We present a mathematical model that quantifies the amount of information exchanged in bi-dimensional networks of nerve cells as a function of network connectivity Q. Upon varying Q over a significant range, we found that, from a certain cell density onwards, 90% of the maximal information transferred I(Q) in a random neuronal network is already reached with just 40% of the total possible connections Q among the cells. As a consequence, the system would not benefit from additional connections in terms of the amount of I(Q), in agreement with the tendency of brains to minimize Q because of its energetic costs. The model may reveal the circuits responsible for neurodegenerative disorders in that neurodegeneration can be regarded as a connective failure affecting information.
    MeSH term(s) Action Potentials ; Brain/anatomy & histology ; Brain/physiology ; Cluster Analysis ; Computer Simulation ; Humans ; Information Theory ; Models, Neurological ; Nerve Net/anatomy & histology ; Nerve Net/physiology ; Systems Biology
    Language English
    Publishing date 2018-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2480063-6
    ISSN 1757-9708 ; 1757-9694
    ISSN (online) 1757-9708
    ISSN 1757-9694
    DOI 10.1039/c7ib00190h
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  10. Article ; Online: Platelet Lysate Induces in Human Osteoblasts Resumption of Cell Proliferation and Activation of Pathways Relevant for Revascularization and Regeneration of Damaged Bone.

    Nguyen, Van Thi / Nardini, Marta / Ruggiu, Alessandra / Cancedda, Ranieri / Descalzi, Fiorella / Mastrogiacomo, Maddalena

    International journal of molecular sciences

    2020  Volume 21, Issue 14

    Abstract: To understand the regenerative effect of platelet-released molecules in bone repair one should investigate the cascade of events involving the resident osteoblast population during the reconstructive process. Here the in vitro response of human ... ...

    Abstract To understand the regenerative effect of platelet-released molecules in bone repair one should investigate the cascade of events involving the resident osteoblast population during the reconstructive process. Here the in vitro response of human osteoblasts to a platelet lysate (PL) stimulus is reported. Quiescent or very slow dividing osteoblasts showed a burst of proliferation after PL stimulation and returned to a none or very slow dividing condition when the PL was removed. PL stimulated osteoblasts maintained a differentiation capability in vitro and in vivo when tested in absence of PL. Since angiogenesis plays a crucial role in the bone healing process, we investigated in PL stimulated osteoblasts the activation of hypoxia-inducible factor 1-alpha (HIF-1α) and signal transducer and activator of transcription 3 (STAT3) pathways, involved in both angiogenesis and bone regeneration. We observed phosphorylation of STAT3 and a strong induction, nuclear translocation and DNA binding of HIF-1α. In agreement with the induction of HIF-1α an enhanced secretion of vascular endothelial growth factor (VEGF) occurred. The double effect of the PL on quiescent osteoblasts, i.e., resumption of proliferation and activation of pathways promoting both angiogenesis and bone formation, provides a rationale to the application of PL as therapeutic agent in post-traumatic bone repair.
    MeSH term(s) Adult ; Animals ; Blood Platelets/metabolism ; Bone Regeneration ; Bone and Bones/blood supply ; Bone and Bones/injuries ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mice ; Neovascularization, Physiologic ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Osteogenesis ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Hypoxia-Inducible Factor 1, alpha Subunit ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2020-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21145123
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