LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article: Urethro-cutaneous fistula repair using a combination of buccal mucosal graft and pedicled gracilis muscular flap for high risk patients.

    Voss, James N / Crick, Alexandra P / Rees, Rowland W

    Urology case reports

    2018  Volume 23, Page(s) 37–38

    Language English
    Publishing date 2018-12-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2018.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Occult deep vein thrombosis in lower limb trauma requiring microsurgical reconstruction-A retrospective cohort study.

    Bendon, Charlotte L / Crick, Alexandra

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2020  Volume 74, Issue 4, Page(s) 775–784

    Abstract: ... was identified intraoperatively in a further 7 cases. Bilateral lower limb injuries (p = 0.0002 ... the level of injury at or above the knee (p < 0.0001), multiple levels of injury within the affected limb (p ... 0.0008) and critical care admission (p = 0.0008) were significant risk factors for DVT. All 7 cases ...

    Abstract Background: Delayed microsurgical reconstruction of lower extremity trauma is associated with increased risk of free flap loss, frequently following failure of the venous anastomosis. This has been attributed to thrombocytosis, but occult deep vein thrombosis (DVT) may contribute to this risk.
    Methods: We performed a retrospective cohort study of consecutive patients presenting to our service with lower limb injuries requiring microsurgical reconstruction between 2013 and 2017, and examined venous Duplex ultrasound reports, operation notes and free flap outcomes.
    Results: A total of 165 free flap reconstructions for lower limb trauma were performed for 162 limbs in 158 patients. Seventy-two limbs (44.4%) underwent preoperative venous Duplex ultrasound identifying occult DVT in 14 (19.4%) patients. Occult DVT was identified intraoperatively in a further 7 cases. Bilateral lower limb injuries (p = 0.0002), the level of injury at or above the knee (p < 0.0001), multiple levels of injury within the affected limb (p = 0.0008) and critical care admission (p = 0.0008) were significant risk factors for DVT. All 7 cases of DVT diagnosed intraoperatively prompted a change in the surgical plan for the recipient vein; however, preoperative identification of occult DVT also lead to an adjustment in the microsurgical plan in 4 out of 14 cases.
    Conclusions: Prevalence of DVT is high in severe lower limb injury, potentially increasing the risk of free flap loss. Preoperative identification of occult DVT may influence the microsurgical plan and mitigate for this risk.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Female ; Free Tissue Flaps ; Humans ; Leg Injuries/complications ; Leg Injuries/diagnostic imaging ; Leg Injuries/surgery ; Lower Extremity/blood supply ; Male ; Microsurgery/methods ; Middle Aged ; Reconstructive Surgical Procedures/methods ; Retrospective Studies ; Ultrasonography, Doppler, Duplex ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/etiology ; Venous Thrombosis/surgery
    Language English
    Publishing date 2020-10-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2020.10.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.157: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: CD4+ and CD8+ T cell and antibody correlates of protection against Delta vaccine breakthrough infection: A nested case-control study within the PITCH study

    Neale, Isabel / Ali, Mohammad / Kronsteiner, Barbara / Longet, Stephanie / Abraham, Priyanka / Deeks, Alexandra S / Brown, Anthony / Moore, Shona C / Stafford, Lizzie / Dobson, Susan L / Plowright, Megan / Newman, Thomas A H / Wu, Mary Y / Crick COVID Immunity Pipeline / Carr, Edward J / Beale, Rupert / Otter, Ashley D / Hopkins, Susan / Hall, Victoria /
    Tomic, Adriana / Payne, Rebecca P / Barnes, Eleanor / Richter, Alex / Duncan, Christopher J A / Turtle, Lance / de Silva, Thushan I / Carroll, Miles / Lambe, Teresa / Klenerman, Paul / Dunachie, Susanna / PITCH Consortium

    medRxiv

    Abstract: T cell correlates of protection against SARS-CoV-2 infection after vaccination (9vaccine breakthrough9) are incompletely defined, especially the specific contributions of CD4+ and CD8+ T cells. We studied 279 volunteers in the Protective Immunity from T ... ...

    Abstract T cell correlates of protection against SARS-CoV-2 infection after vaccination (9vaccine breakthrough9) are incompletely defined, especially the specific contributions of CD4+ and CD8+ T cells. We studied 279 volunteers in the Protective Immunity from T Cells in Healthcare Workers (PITCH) UK study, including 32 cases (with SARS-CoV-2 positive testing after two vaccine doses during the Delta-dominant era) and 247 controls (no positive test nor anti-nucleocapsid seroconversion during this period). 28 days after second vaccination, before all breakthroughs occurred, cases had lower ancestral S- and RBD-specific immunoglobulin G titres and S1- and S2-specific T cell interferon gamma (IFNγ) responses compared with controls. In a subset of matched cases and controls, cases had lower CD4+ and CD8+ IFNγ and tumour necrosis factor responses to Delta S peptides with reduced CD8+ responses to Delta versus ancestral peptides compared with controls. Our findings support a protective role for T cells against Delta breakthrough infection.
    Keywords covid19
    Language English
    Publishing date 2023-02-17
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.02.16.23285748
    Database COVID19

    Full text online

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: A 5-year follow-up study of 633 cutaneous SCC excisions: Rates of local recurrence and lymph node metastasis.

    Khan, K / Mykula, R / Kerstein, R / Rabey, N / Bragg, T / Crick, A / Heppell, S / Budny, P / Potter, M

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2018  Volume 71, Issue 8, Page(s) 1153–1158

    Abstract: ... Alexandra Hospital, Portsmouth) assessing rates of LR and LN metastasis.: Results: We report 5-year ... recurred versus only 5.6% (n = 31) of the 551 SCCs without perineural invasion (p = 0.005).: Conclusions ...

    Abstract Background: A 5-year follow-up study of 633 cutaneous squamous cell cancer (SCC) excisions was performed by collecting data on rates of local recurrence (LR) and lymph node (LN) metastasis.
    Methods: A retrospective analysis of patients was performed across four regional plastic surgery centres (Stoke Mandeville Hospital, Aylesbury; John Radcliffe Hospital, Oxford; Salisbury District Hospital, Salisbury and Queen Alexandra Hospital, Portsmouth) assessing rates of LR and LN metastasis.
    Results: We report 5-year outcomes from 598 SCCs (95% follow-up rate). The total recurrence rate (LR and LN metastasis) was 6.7% (n = 40) at 5 years, with 96% of these occurring within 2 years. Median time to LR was 9 months (1-57), with 76.9% (n = 20) undergoing further wide local excision. Median time to LN metastasis was 5.5 months (1-18 months). There were two cases of disease-related death. Only 15% (n = 6) of incomplete excisions recurred. Interestingly, 19.1% (n = 9) of 47 SCCs with perineural invasion on original histopathology recurred versus only 5.6% (n = 31) of the 551 SCCs without perineural invasion (p = 0.005).
    Conclusions: This study is one of the largest studies to date following up 598 SCC excisions at 5 years with total recurrence rates comparable to those in current published literature. We report perineural invasion as a significant predictor of recurrence and that 96% of total recurrence occurred within 2 years. This is in contrast to current UK guidelines (75% at 2 years, 95% at 5 years), thus suggesting that shorter length of hospital follow-up may be reasonable.
    MeSH term(s) Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/secondary ; Carcinoma, Squamous Cell/surgery ; Follow-Up Studies ; Humans ; Incidence ; Lymph Node Excision ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Staging ; Retrospective Studies ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Time Factors ; United Kingdom/epidemiology
    Language English
    Publishing date 2018-05-02
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2018.03.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.157: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Developmental mechanisms underlying polydactyly in the mouse mutant Doublefoot.

    Crick, Alexandra P / Babbs, Christian / Brown, Jennifer M / Morriss-Kay, Gillian M

    Journal of anatomy

    2002  Volume 202, Issue 1, Page(s) 21–26

    Abstract: The pre-axial polydactylous mouse mutant Doublefoot has 6-9 digits per limb but lacks anteroposterior polarity (there is no biphalangeal digit 1). It differs from other polydactylous mutants in showing normal Shh expression, but polarizing activity ( ... ...

    Abstract The pre-axial polydactylous mouse mutant Doublefoot has 6-9 digits per limb but lacks anteroposterior polarity (there is no biphalangeal digit 1). It differs from other polydactylous mutants in showing normal Shh expression, but polarizing activity (shown by mouse-chick grafting experiments) and hedgehog signalling activity (shown by expression of Ptc1) are present throughout the distal mesenchyme. The Dbf mutation has not yet been identified. Here we review current understanding of this mutant, and briefly report new results indicating (1) that limb bud expansion is concomitant with ectopic lhh expression and with extension of the posterior high cell proliferation rate into the anterior region, and (2) that the Dbf mutation is epistatic to Shh in the limb.
    MeSH term(s) Animals ; Gene Expression ; Gene Expression Regulation, Developmental ; Hedgehog Proteins ; Limb Buds/physiology ; Mesoderm/physiology ; Mice ; Mice, Mutant Strains ; Models, Animal ; Morphogenesis/genetics ; Polydactyly/embryology ; Polydactyly/genetics ; Trans-Activators/genetics
    Chemical Substances Hedgehog Proteins ; Trans-Activators
    Language English
    Publishing date 2002-12-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2955-5
    ISSN 1469-7580 ; 0021-8782
    ISSN (online) 1469-7580
    ISSN 0021-8782
    DOI 10.1046/j.1469-7580.2003.00132.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.38: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top