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  1. Article ; Online: Reply to F. Tomao et al and E.A. De Jaeghere et al.

    Walker, Joan L

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2019  Volume 37, Issue 33, Page(s) 3170

    MeSH term(s) Bevacizumab ; Carcinoma ; Carcinoma, Ovarian Epithelial ; Female ; Humans ; Ovarian Neoplasms
    Chemical Substances Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2019-09-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.19.02091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  2. Article ; Online: Absolute configurations of Emycin D, E and F; mimicry of centrosymmetric space groups by mixtures of chiral stereoisomers.

    Walker / Pohl / Herbst-Irmer / Gerlitz / Rohr / Sheldrick

    Acta crystallographica. Section B, Structural science

    1999  Volume 55, Issue Pt 4, Page(s) 607–616

    Abstract: The crystal structures of Emycin E (1), di-o-bromobenzoyl-Emycin F (2) and o-bromobenzoyl-Emycin D ... 3) have been determined by X-ray analysis at low temperature. Emycin E and o-bromobenzoyl-Emycin D ... in both P1 refinements. Di-o-bromobenzoyl-Emycin F crystallizes in the monoclinic space group P2(1) with one ...

    Abstract The crystal structures of Emycin E (1), di-o-bromobenzoyl-Emycin F (2) and o-bromobenzoyl-Emycin D (3) have been determined by X-ray analysis at low temperature. Emycin E and o-bromobenzoyl-Emycin D both crystallize with two molecules in a triclinic unit cell. These two structures can be solved and refined either in the centrosymmetric space group P1;, with apparent disorder localized at or around the expected chiral centre, or in the non-centrosymmetric space group P1 as mixtures of two diastereomers without disorder. Only the latter interpretation is consistent with the chemical and spectroscopic evidence. Refinements in the centrosymmetric and non-centrosymmetric space groups are compared in this paper and are shown to favour the chemically correct interpretation, more decisively so in the case of the bromo derivative as a result of the anomalous dispersion of bromine. Structures (1) and (3) provide a dramatic warning of the dangers inherent in the conventional wisdom that if a structure can be refined satisfactorarily in both centrosymmetric and non-centrosymmetric space groups, the former should always be chosen. In these two cases, despite apparently acceptable intensity statistics and R factors (5.87 and 3.55%), the choice of the centrosymmetric space group leads to the serious chemical error that the triclinic unit cell contains a racemate rather than two chiral diastereomers! The weakest reflections are shown to be most sensitive to the correct choice of space group, underlining the importance of refining against all data rather than against intensities greater than a specified threshold. The use of similar-distance restraints is shown to be beneficial in both P1 refinements. Di-o-bromobenzoyl-Emycin F crystallizes in the monoclinic space group P2(1) with one molecule in the asymmetric unit and so does not give rise to these problems of interpretation. The absolute configuration of the two bromo derivatives, and hence the Emycins in general, was determined unambiguously as S at the chiral centre C3.
    Language English
    Publishing date 1999-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2020841-8
    ISSN 1600-5740 ; 2052-5206 ; 2052-5192 ; 0108-7681
    ISSN (online) 1600-5740 ; 2052-5206
    ISSN 2052-5192 ; 0108-7681
    DOI 10.1107/s0108768199003948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cardiovascular responses to intracoronary infusion of prostaglandin E-1, F-1 alpha and F-2 alpha.

    Hollenberg, M / Walker, R S / McCormick, D P

    Archives internationales de pharmacodynamie et de therapie

    1968  Volume 174, Issue 1, Page(s) 66–73

    MeSH term(s) Animals ; Coronary Vessels/drug effects ; Dogs ; Electrocardiography ; Heart/drug effects ; Infusions, Parenteral ; Norepinephrine/pharmacology ; Prostaglandins/administration & dosage ; Prostaglandins/pharmacology ; Regional Blood Flow/drug effects ; Vasodilator Agents/pharmacology
    Chemical Substances Prostaglandins ; Vasodilator Agents ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 1968-07
    Publishing country Belgium
    Document type Journal Article
    ZDB-ID 80060-0
    ISSN 0003-9780
    ISSN 0003-9780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.30: Show issues Location:
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  4. Article: Punctaporonins A, D, E, and F (antibiotics M95464, M167906, M171950, and M189122), isomeric allylic alcohols from the fungus Poronia punctata: X-ray crystal structures of D and of E acetonide.

    Poyser, J P / Edwards, R L / Anderson, J R / Hursthouse, M B / Walker, N P / Sheldrick, G M / Whalley, A J

    The Journal of antibiotics

    1986  Volume 39, Issue 1, Page(s) 167–169

    MeSH term(s) Antifungal Agents ; Ascomycota/analysis ; Bridged-Ring Compounds ; Crystallization ; Isomerism ; Magnetic Resonance Spectroscopy ; X-Ray Diffraction ; Xylariales/analysis
    Chemical Substances Antifungal Agents ; Bridged-Ring Compounds ; punctaporonin D (102734-12-3) ; punctaporonin F (106758-24-1) ; punctaporonin E (65522-91-0) ; punctaporonin A (91161-74-9)
    Language English
    Publishing date 1986-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390800-8
    ISSN 1881-1469 ; 0021-8820 ; 0368-3532
    ISSN (online) 1881-1469
    ISSN 0021-8820 ; 0368-3532
    DOI 10.7164/antibiotics.39.167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 207: Show issues Location:
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  5. Article ; Online: Boric acid and Molybdenum trioxide synergistically stimulate osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells.

    Scheurle, A / Kunisch, E / Boccaccini, A R / Walker, T / Renkawitz, T / Westhauser, F

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

    2024  Volume 83, Page(s) 127405

    Abstract: Introduction: Metals and their metal ions have been shown to exhibit certain biological functions that make them attractive for use in biomaterials, for example in bone tissue engineering (BTE) applications. Recent data shows that Molybdenum (Mo) is a ... ...

    Abstract Introduction: Metals and their metal ions have been shown to exhibit certain biological functions that make them attractive for use in biomaterials, for example in bone tissue engineering (BTE) applications. Recent data shows that Molybdenum (Mo) is a potent inducer of osteogenic differentiation in human bone marrow-derived mesenchymal stromal cells (BMSCs). On the other hand, while boron (B) has been shown to enhance vascularization in BTE applications, its impact on osteogenic differentiation is volatile: while improved osteogenic differentiation has been described, other data show that B might slow down osteogenic differentiation or reduce the calcification of the extracellular matrix (ECM) when applied in higher doses. Still, the combination of pro-osteogenic Mo and pro-angiogenic B is certainly attractive in the context of biomaterials intended for the use in BTE.
    Methods: Therefore, the combined effect of molybdenum trioxide and boric acid at different ratios was investigated in this study to evaluate the effects on the viability, proliferation, osteogenic differentiation, ECM production and maturation of BMSCs.
    Results: Mo ions proved to be stronger osteoinductive compared to B, in fact, while some osteogenic differentiation markers were downregulated in the presence of B, the presence of Mo provided compensation. The combined application of B and Mo indicated a combination of individual effects, partially even enhancing the expected combined performance of the single stimulations.
    Conclusions: The combination of B and Mo might be beneficial for BTE applications since the limited osteogenic properties of B can be compensated by Mo. Furthermore, since B is known to be pro-angiogenic, the combination of both substances may synergistically lead to improved vascularization and bone regeneration. Future studies should assess the angiogenic performance of this combination in greater detail.
    MeSH term(s) Humans ; Osteogenesis ; Molybdenum/pharmacology ; Bone Marrow ; Cells, Cultured ; Mesenchymal Stem Cells ; Cell Differentiation ; Oxides/pharmacology ; Biocompatible Materials/pharmacology ; Boric Acids
    Chemical Substances molybdenum trioxide (22FQ3F03YS) ; Molybdenum (81AH48963U) ; boric acid (R57ZHV85D4) ; Oxides ; Biocompatible Materials ; Boric Acids
    Language English
    Publishing date 2024-02-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1236267-0
    ISSN 1878-3252 ; 1611-602X ; 0946-672X
    ISSN (online) 1878-3252 ; 1611-602X
    ISSN 0946-672X
    DOI 10.1016/j.jtemb.2024.127405
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    Zs.A 2279: Show issues Location:
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  6. Article ; Online: Effects of workplace stress, perceived stress, and burnout on collegiate coach mental health outcomes.

    Wright, Simon A / Walker, Lauren F / Hall, Eric E

    Frontiers in sports and active living

    2023  Volume 5, Page(s) 974267

    Abstract: ... to differentiate feelings of burnout from those of other sub-clinical mental health indicators (e.g., anxiety ... as a partial mediator between workplace and perceived stress and mental health indicators (e.g., depression ...

    Abstract Introduction: Given the continuously changing job demands of coaches, coach burnout continues to be an important area of study. Coaching literature highlights the role occupational stressors play in the development and management of burnout. However, research highlights the potential need for the field to differentiate feelings of burnout from those of other sub-clinical mental health indicators (e.g., anxiety, depression). This study sought to examine the relationship between workplace stress, perceived stress, coach burnout, coach well-being, and sub-clinical health issues (anxiety, stress, depression).
    Methods: One hundred forty-four NCAA collegiate coaches completed online questionnaires measuring the proposed variables. Structural equation modeling was used to test the proposed hypothesis that burnout would serve as a partial mediator between workplace and perceived stress and mental health indicators (e.g., depression, anxiety, stress, and well-being).
    Results: Workplace stress and perceived stress were positively associated with both burnout subscales. Additionally, perceived stress alone exhibited a positive association with depression, anxiety, and stress and a negative association with well-being. While there was a positive significant relationship between disengagement and depression in the model and a negative significant relationship between disengagement and well-being, most relationships between the two burnout subscales and mental health outcomes were negligible.
    Discussion: It can be concluded that while workplace and perceived life stressors may impact feelings of burnout and mental health indicators directly, burnout does not appear to exhibit a strong effect on perceptions of mental health and well-being. In line with other research studies, it may be worth considering whether burnout should be considered another type of clinical mental health issue instead of as a direct contributor to coach mental health.
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2624-9367
    ISSN (online) 2624-9367
    DOI 10.3389/fspor.2023.974267
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  7. Article: A 9-Year-Old Female with an Abdominal Mass.

    E Anderson, Justin / Walker, Don / Norozian, Farnaz / Domanski, Kristina

    Turkish archives of pediatrics

    2024  Volume 59, Issue 2, Page(s) 232–233

    Language English
    Publishing date 2024-03-07
    Publishing country Turkey
    Document type Journal Article
    ISSN 2757-6256
    ISSN 2757-6256
    DOI 10.5152/TurkArchPediatr.2024.24025
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  8. Book ; Online: Selecting value chains for sustainable food value chain development

    Walker, Cassandra / DeMatteis, Laura / Lienert, Anja

    guidelines

    2021  

    Institution FAO
    Author's details edited by Cassandra Walker, Laura DeMatteis, Anja Lienert ; Food and Agriculture Organization of the United Nations
    Keywords food chains ; value chains ; agricultural products ; food security ; food supply ; Sustainable Development Goals ; guidelines
    Language English
    Size 1 Online-Ressource (circa 84 Seiten), Illustrationen
    Publisher FAO
    Publishing place Rome
    Publishing country Italy ; XP
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT021211881
    ISBN 978-92-5-135316-5 ; 92-5-135316-6
    DOI 10.4060/cb7623en
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article: Preclinical Mouse Models in Sepsis: Don't Throw the Baby Out with the Bathwater [Response to Letter].

    Walker, Wendy E / Garcia, Luiz F / Singh, Vishwajeet / Mireles, Blake / Dwivedi, Alok Kumar

    Journal of inflammation research

    2023  Volume 16, Page(s) 2021–2022

    Language English
    Publishing date 2023-05-11
    Publishing country New Zealand
    Document type Journal Article ; Comment
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S417208
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  10. Article ; Online: Eyes meet, hands greet: The art of timing in social interactions.

    Kingstone, Alan / Walker, Esther / Amin, Shahrazad / Bischof, Walter F

    Perception

    2024  Volume 53, Issue 4, Page(s) 287–290

    Abstract: Shaking hands is a fundamental form of social interaction. The current study used high-definition cameras during a university graduation ceremony to examine the temporal sequencing of eye contact and shaking hands. Analyses revealed that mutual gaze ... ...

    Abstract Shaking hands is a fundamental form of social interaction. The current study used high-definition cameras during a university graduation ceremony to examine the temporal sequencing of eye contact and shaking hands. Analyses revealed that mutual gaze always preceded shaking hands. A follow up investigation manipulated gaze when shaking hands, and found that participants take significantly longer to accept a handshake when an outstretched hand precedes eye contact. These findings demonstrate that the timing between a person's gaze and their offer to shake hands is critical to how their action is interpreted.
    MeSH term(s) Humans ; Social Interaction ; Attention ; Eye ; Eye Movements ; Eye Movement Measurements ; Fixation, Ocular
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185533-5
    ISSN 1468-4233 ; 0301-0066
    ISSN (online) 1468-4233
    ISSN 0301-0066
    DOI 10.1177/03010066231223440
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    Zs.A 4197: Show issues Location:
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