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  1. Book ; Online ; E-Book: Diagnoses without names

    Lockshin, Michael D. / Crow, Mary K. / Barbhaiya, Medha

    challenges for medical care, research, and policy

    2022  

    Author's details Michael D. Lockshin, Mary K. Crow, Medha Barbhaiya, editors
    Keywords Diagnosis
    Subject code 616.075
    Language English
    Size 1 online resource (230 pages)
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-04935-7 ; 9783031049347 ; 978-3-031-04935-4 ; 3031049349
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets.

    Crow, Mary K

    Annals of the rheumatic diseases

    2023  Volume 82, Issue 8, Page(s) 999–1014

    Abstract: Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic acids and nucleic acid-binding proteins, as fundamental ... ...

    Abstract Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic acids and nucleic acid-binding proteins, as fundamental contributors to the disease. On the fertile background of significant genetic risk, a triggering stimulus, perhaps microbial, induces IFN-I, autoantibody production or most likely both. When innate and adaptive immune system cells are engaged and collaborate in the autoimmune response, clinical SLE can develop. This review describes recent data from genetic analyses of patients with SLE, along with current studies of innate and adaptive immune function that contribute to sustained IFN-I pathway activation, immune activation and autoantibody production, generation of inflammatory mediators and tissue damage. The goal of these studies is to understand disease mechanisms, identify therapeutic targets and stimulate development of therapeutics that can achieve improved outcomes for patients.
    MeSH term(s) Humans ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/genetics ; Autoantibodies ; Interferon Type I/metabolism
    Chemical Substances Autoantibodies ; Interferon Type I
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2022-223741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Book Review: Immunology and Rheumatology in Questions.

    Mavragani, Clio P / Crow, Mary K

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2024  Volume 28, Issue 1, Page(s) e317

    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4815: Show issues Location:
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  4. Article ; Online: Advances in lupus therapeutics: Achieving sustained control of the type I interferon pathway.

    Crow, Mary K

    Current opinion in pharmacology

    2022  Volume 67, Page(s) 102291

    Abstract: Achieving sustained control of disease activity in patients with systemic lupus erythematosus has been impeded by the complexity of its immunopathogenesis as well its clinical heterogeneity. In spite of these challenges, gains in understanding disease ... ...

    Abstract Achieving sustained control of disease activity in patients with systemic lupus erythematosus has been impeded by the complexity of its immunopathogenesis as well its clinical heterogeneity. In spite of these challenges, gains in understanding disease mechanisms have identified immune targets that are currently under study in trials of candidate therapeutics. Defining the type I interferon (IFN-I) pathway and autoantibodies specific for nucleic acid binding proteins as core pathogenic mediators allows an analysis of approaches that could control production of those mediators and improve patient outcomes. This review describes therapeutic targets and agents that could achieve control of the IFN-I pathway. Toll-like receptor 7, involved in IFN-I production and differentiation of B cells, and long-lived plasma cells, the producers of autoantibodies specific for RNA-binding proteins, components of the immune complex drivers of IFN-I, are particularly attractive therapeutic targets.
    MeSH term(s) Humans ; Interferon Type I/metabolism ; Lupus Erythematosus, Systemic/drug therapy ; Autoantibodies ; B-Lymphocytes
    Chemical Substances Interferon Type I ; Autoantibodies
    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2022.102291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5608: Show issues Location:
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  5. Article ; Online: Charles L Christian: model physician scientist and mentor.

    Crow, Mary K

    Annals of the rheumatic diseases

    2021  Volume 80, Issue 6, Page(s) 685–688

    MeSH term(s) Arthritis, Rheumatoid ; Humans ; Lupus Erythematosus, Systemic ; Mentors ; Physicians
    Language English
    Publishing date 2021-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2019-216630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Charles L Christian: Model Physician Scientist and Mentor.

    Crow, Mary K / Smolen, Josef S

    Rheumatic diseases clinics of North America

    2023  Volume 50, Issue 1, Page(s) 47–55

    Abstract: Dr Charles L Christian arrived in New York City in 1953, having grown up in Wichita, Kansas, and graduating from medical school at Case Western Reserve in Cleveland, Ohio. In New York, Dr Christian embarked on training in internal medicine at Columbia's ... ...

    Abstract Dr Charles L Christian arrived in New York City in 1953, having grown up in Wichita, Kansas, and graduating from medical school at Case Western Reserve in Cleveland, Ohio. In New York, Dr Christian embarked on training in internal medicine at Columbia's Presbyterian Hospital where he met an individual who would shape the course of his career, Dr Charles Ragan, a founder of the Arthritis Foundation. Dr Christian, or Chuck as he was usually called, went on to shape the developing field of rheumatology, advancing understanding of our most complex diseases as an investigator, master clinician, mentor, and academic leader. During an era when the cellular and humoral features of the immune system were just coming into focus, Chuck performed laboratory experiments with precision and creativity to achieve new understanding of 3 significant diseases: rheumatoid arthritis, systemic lupus erythematosus, and vasculitis. Review of his publications from the 1950s and 1960s provides a window into a time when figures were hand drawn and papers often had a single author. While the tools of technology that we rely on today were not available to Chuck, his insights have had a sustained impact on how we understand and treat autoimmune rheumatic diseases. His talents and his dedication to patients, colleagues, science, and medicine supported a lifetime of remarkable contributions.
    MeSH term(s) Male ; Humans ; Mentors ; Physicians
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2023.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Standing on Shoulders: Interferon Research From Viral Interference to Lupus Pathogenesis and Treatment.

    Crow, Mary K / Olferiev, Mikhail / Kirou, Kyriakos A

    Arthritis & rheumatology (Hoboken, N.J.)

    2024  

    Abstract: The discovery of interferon in the 1950s represents much more than the identification of the first cytokine and the key mediator of antiviral host defense. Defining the molecular nature and complexity of the type I interferon family, as well as its ... ...

    Abstract The discovery of interferon in the 1950s represents much more than the identification of the first cytokine and the key mediator of antiviral host defense. Defining the molecular nature and complexity of the type I interferon family, as well as its inducers and molecular mechanisms of action, was the work of investigators working at the highest level and producing insights of great consequence. Current knowledge of receptor-ligand interactions, cell signaling, and transcriptional regulation derives from studies of type I interferon. It is on the shoulders of the giants who produced that knowledge that others stand and have revealed critical mechanisms of the pathogenesis of systemic lupus erythematosus and other autoimmune diseases. The design of novel therapeutics is informed by the advances in investigation of type I interferon, with the potential for important impact on patient management.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hydroxychloroquine and lupus flare: a good drug, but we need to do better.

    Crow, Mary K / Kirou, Kyriakos A

    Annals of the rheumatic diseases

    2022  Volume 81, Issue 3, Page(s) 303–305

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Humans ; Hydroxychloroquine/therapeutic use ; Lupus Erythematosus, Systemic/drug therapy ; Randomized Controlled Trials as Topic ; Symptom Flare Up ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Editorial
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2021-221590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mitochondrial DNA promotes autoimmunity.

    Crow, Mary K

    Science (New York, N.Y.)

    2019  Volume 366, Issue 6472, Page(s) 1445–1446

    MeSH term(s) Autoimmunity ; DNA, Mitochondrial ; Mitochondria/genetics
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2019-12-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aaz9308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 77: Show issues

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  10. Article ; Online: Reactivity of IgG With the p40 Protein Encoded by the Long Interspersed Nuclear Element 1 Retroelement: Comment on the Article by Carter et al.

    Crow, Mary K

    Arthritis & rheumatology (Hoboken, N.J.)

    2019  Volume 72, Issue 2, Page(s) 374–376

    MeSH term(s) Autoantibodies ; Humans ; Immunoglobulin G ; Long Interspersed Nucleotide Elements ; Lupus Erythematosus, Systemic ; Prevalence ; Retroelements
    Chemical Substances Autoantibodies ; Immunoglobulin G ; Retroelements
    Language English
    Publishing date 2019-12-27
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.41102
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