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Article ; Online: Dexamethasone and COVID-19: Strategies in Low- and Middle-Income Countries to Tackle Steroid-Related Strongyloides Hyperinfection.

Olivera, Mario J

The American journal of tropical medicine and hygiene

2021 Volume 104, Issue 5, Page(s) 1611–1612

Abstract: COVID-19 can trigger a systemic inflammatory response that in some cases leads to severe lung involvement, multisystem dysfunction, and death. Dexamethasone therapy, because of its potent anti-inflammatory effects, has been proposed for the management of ...

Abstract	COVID-19 can trigger a systemic inflammatory response that in some cases leads to severe lung involvement, multisystem dysfunction, and death. Dexamethasone therapy, because of its potent anti-inflammatory effects, has been proposed for the management of hospitalized patients with severe COVID-19. The subject of this article is to discuss potential strategies to tackle Strongyloides hyperinfection in hospitalized patients with COVID-19 receiving dexamethasone therapy in low- and middle-income countries. In this context, dexamethasone treatment has been found to be generally safe. However, its use in people coinfected with undetected Strongyloides stercoralis increases the risk for Strongyloides hyperinfection/dissemination a potentially fatal complication. Infection caused by S. stercoralis may remain asymptomatic or with mild symptoms in humans for several years. Early detection and specific treatment prevent a fatal evolution of this complication, but the challenge is to screen before corticosteroid therapy. In some cases, presumptive treatment may be justified. Ivermectin is the gold standard for treatment.
MeSH term(s)	Animals ; Developing Countries ; Dexamethasone/adverse effects ; SARS-CoV-2 ; Strongyloides stercoralis ; Strongyloidiasis/drug therapy ; Strongyloidiasis/etiology ; COVID-19 Drug Treatment
Chemical Substances	Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2021-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.20-1085
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Article: Opportunity cost and COVID-19: A perspective from health economics.

Olivera, Mario J

Medical journal of the Islamic Republic of Iran

2020 Volume 34, Page(s) 177

Abstract: The substantial increase in demand for medical care in intensive care units (ICUs) caused by the recent appearance of coronavirus disease 2019 (COVID-19) has placed severe pressure on hospital beds. Although countries have intensified efforts to contain ... ...

Abstract	The substantial increase in demand for medical care in intensive care units (ICUs) caused by the recent appearance of coronavirus disease 2019 (COVID-19) has placed severe pressure on hospital beds. Although countries have intensified efforts to contain or delay the spread of COVID-19, they must prepare to cope with the growing demand for critical care inpatient beds or risk being overwhelmed by the pandemic. The subject of this paper is the COVID-19 pandemic and the opportunity cost from the perspective of health economics using the supply and demand model of hospital bed days in ICUs. In this context, it has been seen that there is an excess demand for hospital beds that exceeds the supply of bed days provided by the health system, generating opportunity costs for patients who cannot be admitted to ICUs because beds are not available. Policymakers must take into account the notion of opportunity cost to ensure that scarce resources are used efficiently because patients with and without COVID-19 will be competing for the same ICU resources.
Language	English
Publishing date	2020-12-29
Publishing country	Iran
Document type	Editorial
ZDB-ID	1095990-7
ISSN	1016-1430
ISSN	1016-1430
DOI	10.47176/mjiri.34.177
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Article ; Online: Malaria in the eco-epidemiological region of the Colombian Caribbean, 1960-2019.

Acuña-Cantillo, Luis / Olivera, Mario J / Padilla-Rodríguez, Julio Cesar

Revista peruana de medicina experimental y salud publica

2023 Volume 39, Issue 4, Page(s) 463–468

Abstract: Objectives.: Motivation for the study: the information available on the epidemiology of malaria in the Colombian Caribbean region is incomplete, poorly systematized and its dissemination is limited. This has led to a lack of knowledge of its magnitude ... ...

Title translation	Malaria en la región eco-epidemiológica del Caribe Colombiano, 1960-2019.
Abstract	Objectives.: Motivation for the study: the information available on the epidemiology of malaria in the Colombian Caribbean region is incomplete, poorly systematized and its dissemination is limited. This has led to a lack of knowledge of its magnitude and a low perception of its importance as a public health problem. Main findings: the behavior of malaria is endemic-epidemic, with low to very low transmission, focused and with irregular outbreaks. Plasmodium vivax infections predominate. Implications: the results of this study contribute to improve evidence-based decision making for the implementation of malaria eradication plans. Malaria has a heterogeneous and variable behavior among Colombian regions. In order to establish its epidemiological behavior in the Colombian Caribbean region between 1960 and 2019, we carried out an observational, descriptive and retrospective study based on records from the Ministry of Health and other secondary sources. We defined epidemiological variables and used measures of frequency and central tendency. A total of 155,096 cases were registered. The decades with the highest number of cases were 1990-1999 (20.5%) and 1980-1989 (18.9%). The average number of cases per decade was 25,849.3. The highest parasite rates were recorded in 1970 (3.3 per 1000 population) and 1981 (3.9 per 1000 population). Plasmodium vivax was the most frequent species and most of the burden by age group was found in people under 29 years of age, between 2010-2019. Malaria showed an endemic-epidemic pattern of low and very low transmission intensity, with a decreasing trend.
MeSH term(s)	Humans ; Adult ; Colombia/epidemiology ; Retrospective Studies ; Malaria/epidemiology ; Malaria, Vivax/epidemiology ; Caribbean Region ; Malaria, Falciparum
Language	English
Publishing date	2023-03-06
Publishing country	Peru
Document type	Journal Article
ZDB-ID	2120092-0
ISSN	1726-4642 ; 1726-4642
ISSN (online)	1726-4642
ISSN	1726-4642
DOI	10.17843/rpmesp.2022.394.11359
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Article: New Diagnostic Algorithm for Chagas Disease: Impact on Access to Diagnosis and Out-of-Pocket Expenditures in Colombia.

Olivera, Mario J / Chaverra, Kevin A

Iranian journal of public health

2019 Volume 48, Issue 7, Page(s) 1379–1381

Language	English
Publishing date	2019-08-23
Publishing country	Iran
Document type	Journal Article
ISSN	2251-6085
ISSN	2251-6085
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Article: A Retrospective Review on Severe Malaria in Colombia, 2007-2020.

Carmona-Fonseca, Jaime / Olivera, Mario J / Yasnot-Acosta, María F

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 8

Abstract: Background: Knowledge of severe malaria (SM) or complicated malaria is insufficient in all its components. The least known type is the one associated with : Methods: A descriptive, retrospective, and cross-sectional study of secondary information was ...

Abstract	Background: Knowledge of severe malaria (SM) or complicated malaria is insufficient in all its components. The least known type is the one associated with Methods: A descriptive, retrospective, and cross-sectional study of secondary information was performed via SIVIGILA. Results: There were 9881 SM cases among 1,060,950 total malaria cases in Colombia in 2007-2020: 9.31 SM cases per 1000 malaria cases. During this period, there were 7145 SM cases due to the following species: Conclusions: There has been a reduction in malaria incidence in Colombia in the last 10-15 years, but there has also been a strong increase in SM incidence. We suggest emphasizing the prevention of the onset of severe malaria, with the early and accurate diagnosis of plasmodial infection.
Language	English
Publishing date	2022-08-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11080893
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Article: Gastro-allergic anisakiasis: The first case reported in Colombia and a literature review

Patiño, John A / Olivera, Mario J

Biomedica : revista del Instituto Nacional de Salud

2019 Volume 39, Issue 2, Page(s) 241–246

Title translation	Anisakiasis gastro-alérgica, primera descripción de un caso en Colombia y revisión bibliográfica
MeSH term(s)	Albendazole/therapeutic use ; Animals ; Anisakiasis/diagnosis ; Anisakiasis/drug therapy ; Anisakiasis/immunology ; Anisakiasis/surgery ; Anisakis/growth & development ; Anisakis/isolation & purification ; Anthelmintics/therapeutic use ; Colombia ; Combined Modality Therapy ; Female ; Fishes/parasitology ; Food Parasitology ; Gastroscopy ; Humans ; Larva ; Middle Aged ; Raw Foods/adverse effects ; Raw Foods/parasitology ; Stomach Diseases/diagnosis ; Stomach Diseases/immunology ; Stomach Diseases/parasitology ; Urticaria/etiology
Chemical Substances	Anthelmintics ; Albendazole (F4216019LN)
Language	Spanish
Publishing date	2019-06-15
Publishing country	Colombia
Document type	Case Reports ; Journal Article ; Review
ISSN	0120-4157
ISSN	0120-4157
DOI	10.7705/biomedica.v39i2.3936
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Article ; Online: Comparison of Health-Related Quality of Life in Outpatients with Chagas and Matched Non-Chagas Chronic Heart Failure in Colombia: A Cross-Sectional Analysis.

Olivera, Mario J / Fory, Johana A / Buitrago, Giancarlo

The American journal of tropical medicine and hygiene

2021 Volume 104, Issue 3, Page(s) 951–958

Abstract: Chagas disease represents an important cause of heart failure (HF) and affects health-related quality of life (HRQoL). The study aimed to evaluate and compare the HRQoL of patients with chagasic HF and matched non-Chagas controls to identify factors ... ...

Abstract	Chagas disease represents an important cause of heart failure (HF) and affects health-related quality of life (HRQoL). The study aimed to evaluate and compare the HRQoL of patients with chagasic HF and matched non-Chagas controls to identify factors associated with HRQoL. A cross-sectional study with pair-matched controls was conducted in Colombia. From October 2018 to December 2019, a total of 84 HF patients were screened for study subjects. Four were excluded, resulting in 80 patients for the analysis, among whom 40 patients with Chagas were enrolled as cases and 40 gender- and age-matched non-Chagas patients as controls. The Kansas City Cardiomyopathy Questionnaire (KCCQ) and the Minnesota Living with Heart Failure Questionnaire (MLWHFQ) were used to measure HRQoL. Demographic, clinical, and laboratory data were obtained from each subject. Health-related quality of life scores were significantly worse among the Chagas group than among the non-Chagas group in the KCCQ domains of physical functioning and symptoms and in the MLWHFQ scale. In the multivariate analysis, the variables associated with lower HRQoL scores were living alone, obesity, having less than 12 years of education, and an increase in left ventricular diameters in the systole and diastole. Health-related quality of life in patients with chronic HF is impaired across all domains. Chagas patients showed worse HRQoL scores than non-Chagas patients. Six variables, some potentially modifiable, were independently associated with worse HRQoL.
MeSH term(s)	Aged ; Chagas Disease/psychology ; Chronic Disease/psychology ; Colombia ; Cross-Sectional Studies ; Female ; Heart Failure/psychology ; Humans ; Male ; Middle Aged ; Outpatients/psychology ; Outpatients/statistics & numerical data ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2021-02-01
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.20-0335
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Article ; Online: Epidemiological evolution and historical anti-malarial control initiatives in Colombia, 1848-2019.

Padilla-Rodríguez, Julio Cesar / Olivera, Mario J / Padilla-Herrera, María Cristina

Le infezioni in medicina

2022 Volume 30, Issue 2, Page(s) 309–319

Abstract: The evolution of epidemiological transmission and the control measures implemented in Colombia have been the result of complex global and regional economic and political processes that occurred at different historical moments, since the dawn of the ... ...

Abstract	The evolution of epidemiological transmission and the control measures implemented in Colombia have been the result of complex global and regional economic and political processes that occurred at different historical moments, since the dawn of the country's republican life. The development of economic activities for the production, exploitation and export of agricultural products, minerals and raw materials demanded in the international market, favored the necessary conditions for the emergence, expansion, resurgence and persistence of the endemic epidemic of malaria in the different stages studied. A common and fundamental element in the different defined historical moments was the importance given to malaria as an economic problem due to the negative externalities it imposed on the labor force. In addition, due to the role it played as a barrier that limited the exploitation of natural resources and raw materials of interest; as well as the impact that it caused to the flow and commercial exchange. The previous situation was framed with the growth, consolidation and geostrategic expansion of the United States, as the main commercial partner of the region, and its interest in the exploitation of resources and raw materials, cheap labor, the need to create new markets, which coincided with the goals of modernization and economic strengthening of Colombia. Taking into account different relevant milestones that occurred in the 1848-2019 period, the following stages were defined: Epidemiological emergence and re-emergence of tropical fevers in places of economic exploitation, 1848-1899;Emergence of a new paradigm, control in enclaves of economic interest, ports and cities, 1900-1949;Control to eradication, intensified control-eradication, prevention and control, 1950-1999;Prevention, control and elimination of malaria, 2000-2019. Historically, antimalarial control initiatives in the country have been directed, restricted and prioritized in places of political and economic importance. The technical-scientific intervention measures implemented in the different stages studied have been uncritically replicated without adapting to the epidemiological scenarios existing in the country. Finally, the antimalarial control measures implemented in Colombia have been imported and adopted from international health initiatives as a result of commitments and obligations acquired in the global commercial context.
Language	English
Publishing date	2022-06-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2041081-5
ISSN	2532-8689 ; 1124-9390
ISSN (online)	2532-8689
ISSN	1124-9390
DOI	10.53854/liim-3002-19
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Zs.A 5576: Show issues

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Article ; Online: Economic costs of Chagas disease in Colombia in 2017: A social perspective.

Olivera, Mario J / Buitrago, Giancarlo

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2019 Volume 91, Page(s) 196–201

Abstract: Objective: To quantify the costs of Chagas disease in Colombia from a societal perspective in 2017.: Methods: A cost-of-illness analysis was carried out using a prevalence-based approach. Costs attributable to Chagas were estimated from a bottom-up ... ...

Abstract	Objective: To quantify the costs of Chagas disease in Colombia from a societal perspective in 2017. Methods: A cost-of-illness analysis was carried out using a prevalence-based approach. Costs attributable to Chagas were estimated from a bottom-up strategy, using population attributable fractions. Indirect costs were calculated using the human capital approach. Results: The estimated total cost of diagnosed Chagas disease was US $13.1 million and included $5.7 million in direct medical costs, $1.5 million in direct nonmedical costs, and $5.8 million in indirect costs: absenteeism ($2.2 million), presenteeism ($3.1 million), and premature deaths ($515228). On average, people diagnosed with Chagas disease incurred $594 in medical expenses, and more than half of that expense was directly attributable to Chagas. The annual cost to society for a person with chronic Chagas disease was $4226. Conclusions: Chagas disease imposes a substantial financial burden on healthcare system and society. Economic cost of illness-related productivity losses is much more significant. Our research suggests that a health policy framework addressing as many of the social determinants of health as possible may be pivotal in containing social costs. Therefore, reducing this burden is not only the responsibility of the health system.
MeSH term(s)	Absenteeism ; Adolescent ; Adult ; Aged ; Chagas Disease/economics ; Colombia ; Cost of Illness ; Efficiency ; Female ; Health Care Costs ; Humans ; Male ; Middle Aged ; Prevalence ; Young Adult
Language	English
Publishing date	2019-11-23
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2019.11.022
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Article: Comparison of 1-year healthcare resource utilization and related costs for patients with heart failure in the Chagas and non-Chagas matched cohorts.

Olivera, Mario J / Arévalo, Adriana / Muñoz, Lyda / Duque, Sofía / Bedoya, Juan / Parra-Henao, Gabriel

Therapeutic advances in infectious disease

2022 Volume 9, Page(s) 20499361221114270

Abstract: Background: Chagas disease is one of the leading causes of heart failure (HF) in Latin Americans, and there are limited data available that examine related costs of care for patients with HF. This study aimed to compare healthcare resource utilization ... ...

Abstract	Background: Chagas disease is one of the leading causes of heart failure (HF) in Latin Americans, and there are limited data available that examine related costs of care for patients with HF. This study aimed to compare healthcare resource utilization and related costs for patients with HF, with and without Chagas disease. Methods: A prospective matched-cohort study comparing the healthcare costs for patients with HF with Chagas disease and care costs for patients with HF without Chagas disease was conducted between January 2019 and December 2019. Only direct costs have been estimated, including hospitalization costs, medications and other cardiovascular interventions, and clinical and laboratory follow-up for up to 1 year. Results: A total of 80 patients with chronic HF were included in the study. Of the 80 patients, 40 patients in the Chagas cohort and 40 patients in the non-Chagas cohort were matched for age, insurer and sex. From a social security system perspective, the total costs for the two cohorts during the study period were U$970,136. Specifically, the healthcare costs for the Chagas cohort were greater than the total healthcare costs for the non-Chagas group (U$511,931 Conclusions: Over a 12-month follow-up period, patients with chronic HF and Chagas consume as many healthcare resources as those with chronic HF and without Chagas. These data highlight the considerable and growing economic burden of HF on the Colombian health system.
Language	English
Publishing date	2022-07-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2728410-4
ISSN	2049-937X ; 2049-9361
ISSN (online)	2049-937X
ISSN	2049-9361
DOI	10.1177/20499361221114270
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