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  1. Article ; Online: Effect of anakinra in COVID-19.

    Kooistra, Emma J / Waalders, Nicole J B / Kox, Matthijs / Pickkers, Peter

    The Lancet Rheumatology

    2020  Volume 2, Issue 9, Page(s) e523–e524

    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(20)30235-6
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  2. Article ; Online: Exploring transdiagnostic stress and trauma-related symptoms across the world: a latent class analysis.

    Haering, Stephanie / Kooistra, Marike J / Bourey, Christine / Chimed-Ochir, Ulziimaa / Doubková, Nikola / Hoeboer, Chris M / Lathan, Emma C / Christie, Hope / de Haan, Anke

    European journal of psychotraumatology

    2024  Volume 15, Issue 1, Page(s) 2318190

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Stress Disorders, Post-Traumatic/diagnosis ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/psychology ; Latent Class Analysis ; Asia ; Risk Factors ; Social Support
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2586642-4
    ISSN 2000-8066 ; 2000-8066
    ISSN (online) 2000-8066
    ISSN 2000-8066
    DOI 10.1080/20008066.2024.2318190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Specific and Non-specific Aspects and Future Challenges of ICU Care Among COVID-19 Patients with Obesity: A Narrative Review.

    Beurton, Alexandra / Kooistra, Emma J / De Jong, Audrey / Schiffl, Helmut / Jourdain, Mercedes / Garcia, Bruno / Vimpère, Damien / Jaber, Samir / Pickkers, Peter / Papazian, Laurent

    Current obesity reports

    2024  

    Abstract: Purpose of review: Since the end of 2019, the coronavirus disease 2019 (COVID-19) pandemic has infected nearly 800 million people and caused almost seven million deaths. Obesity was quickly identified as a risk factor for severe COVID-19, ICU admission, ...

    Abstract Purpose of review: Since the end of 2019, the coronavirus disease 2019 (COVID-19) pandemic has infected nearly 800 million people and caused almost seven million deaths. Obesity was quickly identified as a risk factor for severe COVID-19, ICU admission, acute respiratory distress syndrome, organ support including mechanical ventilation and prolonged length of stay. The relationship among obesity; COVID-19; and respiratory, thrombotic, and renal complications upon admission to the ICU is unclear.
    Recent findings: The predominant effect of a hyperinflammatory status or a cytokine storm has been suggested in patients with obesity, but more recent studies have challenged this hypothesis. Numerous studies have also shown increased mortality among critically ill patients with obesity and COVID-19, casting doubt on the obesity paradox, with survival advantages with overweight and mild obesity being reported in other ICU syndromes. Finally, it is now clear that the increase in the global prevalence of overweight and obesity is a major public health issue that must be accompanied by a transformation of our ICUs, both in terms of equipment and human resources. Research must also focus more on these patients to improve their care. In this review, we focused on the central role of obesity in critically ill patients during this pandemic, highlighting its specificities during their stay in the ICU, identifying the lessons we have learned, and identifying areas for future research as well as the future challenges for ICU activity.
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2162-4968
    ISSN (online) 2162-4968
    DOI 10.1007/s13679-024-00562-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions.

    Kox, Matthijs / Waalders, Nicole J B / Kooistra, Emma J / Gerretsen, Jelle / Pickkers, Peter

    JAMA

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.17052
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  5. Article ; Online: Effect of anakinra in COVID-19

    Kooistra, Emma J / Waalders, Nicole J B / Kox, Matthijs / Pickkers, Peter

    The Lancet Rheumatology

    2020  Volume 2, Issue 9, Page(s) e523–e524

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2665-9913
    DOI 10.1016/s2665-9913(20)30235-6
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Body Mass Index and Mortality in Coronavirus Disease 2019 and Other Diseases: A Cohort Study in 35,506 ICU Patients.

    Kooistra, Emma J / Brinkman, Sylvia / van der Voort, Peter H J / de Keizer, Nicolette F / Dongelmans, Dave A / Kox, Matthijs / Pickkers, Peter

    Critical care medicine

    2022  Volume 50, Issue 1, Page(s) e1–e10

    Abstract: Objectives: Obesity is a risk factor for severe coronavirus disease 2019 and might play a role in its pathophysiology. It is unknown whether body mass index is related to clinical outcome following ICU admission, as observed in various other categories ... ...

    Abstract Objectives: Obesity is a risk factor for severe coronavirus disease 2019 and might play a role in its pathophysiology. It is unknown whether body mass index is related to clinical outcome following ICU admission, as observed in various other categories of critically ill patients. We investigated the relationship between body mass index and inhospital mortality in critically ill coronavirus disease 2019 patients and in cohorts of ICU patients with non-severe acute respiratory syndrome coronavirus 2 viral pneumonia, bacterial pneumonia, and multiple trauma.
    Design: Multicenter observational cohort study.
    Setting: Eighty-two Dutch ICUs participating in the Dutch National Intensive Care Evaluation quality registry.
    Patients: Thirty-five-thousand five-hundred six critically ill patients.
    Interventions: None.
    Measurements and main results: Patient characteristics and clinical outcomes were compared between four cohorts (coronavirus disease 2019, nonsevere acute respiratory syndrome coronavirus 2 viral pneumonia, bacterial pneumonia, and multiple trauma patients) and between body mass index categories within cohorts. Adjusted analyses of the relationship between body mass index and inhospital mortality within each cohort were performed using multivariable logistic regression. Coronavirus disease 2019 patients were more likely male, had a higher body mass index, lower Pao2/Fio2 ratio, and were more likely mechanically ventilated during the first 24 hours in the ICU compared with the other cohorts. Coronavirus disease 2019 patients had longer ICU and hospital length of stay, and higher inhospital mortality. Odds ratios for inhospital mortality for patients with body mass index greater than or equal to 35 kg/m2 compared with normal weight in the coronavirus disease 2019, nonsevere acute respiratory syndrome coronavirus 2 viral pneumonia, bacterial pneumonia, and trauma cohorts were 1.15 (0.79-1.67), 0.64 (0.43-0.95), 0.73 (0.61-0.87), and 0.81 (0.57-1.15), respectively.
    Conclusions: The obesity paradox, which is the inverse association between body mass index and mortality in critically ill patients, is not present in ICU patients with coronavirus disease 2019-related respiratory failure, in contrast to nonsevere acute respiratory syndrome coronavirus 2 viral and bacterial respiratory infections.
    MeSH term(s) Aged ; Body Mass Index ; COVID-19/epidemiology ; COVID-19/mortality ; Critical Illness ; Female ; Hospital Mortality/trends ; Humans ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; Multiple Trauma/epidemiology ; Netherlands/epidemiology ; Obesity/epidemiology ; Patient Acuity ; Pneumonia, Bacterial/epidemiology ; SARS-CoV-2
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article: Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

    Kox, Matthijs / Waalders, Nicole J B / Kooistra, Emma J / Gerretsen, Jelle / Pickkers, Peter

    JAMA

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #915080
    Database COVID19

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  9. Article ; Online: Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

    Kox, Matthijs / Waalders, Nicole J. B. / Kooistra, Emma J. / Gerretsen, Jelle / Pickkers, Peter

    JAMA

    2020  Volume 324, Issue 15, Page(s) 1565

    Keywords General Medicine ; covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.17052
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
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  10. Article ; Online: Effects of dalteparin on anti-Xa activities cannot be predicted in critically ill COVID-19 patients.

    van der Heijden, Charlotte D C C / Ter Heine, Rob / Kooistra, Emma J / Brüggemann, Roger J / Walburgh Schmidt, Jesper W J / de Grouw, Elke P L M / Frenzel, Tim / Pickkers, Peter / Leentjens, Jenneke

    British journal of clinical pharmacology

    2022  Volume 88, Issue 6, Page(s) 2982–2987

    Abstract: Critically ill COVID-19 patients are at high risk of thromboembolic events despite routine-dosed low-molecular-weight heparin thromboprophylaxis. However, in recent randomized trials increased-intensity thromboprophylaxis seemed futile and possibly even ... ...

    Abstract Critically ill COVID-19 patients are at high risk of thromboembolic events despite routine-dosed low-molecular-weight heparin thromboprophylaxis. However, in recent randomized trials increased-intensity thromboprophylaxis seemed futile and possibly even harmful. In this explorative pharmacokinetic (PK) study we measured anti-Xa activities on frequent timepoints in 15 critically ill COVID-19 patients receiving dalteparin and performed PK analysis by nonlinear mixed-effect modelling. A linear one-compartment model with first-order kinetics provided a good fit. However, wide interindividual variation in dalteparin absorption (variance 78%) and clearance (variance 34%) was observed, unexplained by routine clinical covariates. Using the final PK model for Monte Carlo simulations, we predicted increased-intensity dalteparin to result in anti-Xa activities well over prophylactic targets (0.2-0.4 IU/mL) in the majority of patients. Therapeutic-intensity dalteparin results in supratherapeutic anti-Xa levels (target 0.6-1.0 IU/mL) in 19% of patients and subtherapeutic levels in 22%. Therefore, anti-Xa measurements should guide high-intensity dalteparin in critically ill COVID-19 patients.
    MeSH term(s) Anticoagulants ; COVID-19/drug therapy ; Critical Illness/therapy ; Dalteparin/adverse effects ; Factor Xa Inhibitors/pharmacokinetics ; Heparin, Low-Molecular-Weight ; Humans ; Venous Thromboembolism/chemically induced ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants ; Factor Xa Inhibitors ; Heparin, Low-Molecular-Weight ; Dalteparin (S79O08V79F)
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15208
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