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  1. Article ; Online: Oxidative Stress: A Unifying Mechanism for Cell Damage Induced by Noise, (Water-Pipe) Smoking, and Emotional Stress-Therapeutic Strategies Targeting Redox Imbalance.

    Golbidi, Saeid / Li, Huige / Laher, Ismail

    Antioxidants & redox signaling

    2018  Volume 28, Issue 9, Page(s) 741–759

    Abstract: Significance: Modern technologies have eased our lives but these conveniences can impact our lifestyles in destructive ways. Noise pollution, mental stresses, and smoking (as a stress-relieving solution) are some environmental hazards that affect our ... ...

    Abstract Significance: Modern technologies have eased our lives but these conveniences can impact our lifestyles in destructive ways. Noise pollution, mental stresses, and smoking (as a stress-relieving solution) are some environmental hazards that affect our well-being and healthcare budgets. Scrutinizing their pathophysiology could lead to solutions to reduce their harmful effects. Recent Advances: Oxidative stress plays an important role in initiating local and systemic inflammation after noise pollution, mental stress, and smoking. Lipid peroxidation and release of lysolipid by-products, disturbance in activation and function of nuclear factor erythroid 2-related factor 2 (Nrf2), induction of stress hormones and their secondary effects on intracellular kinases, and dysregulation of intracellular Ca
    Critical issues: Indiscriminate manipulation of the cellular redox network could lead to a new series of ailments. An ideal approach requires meticulous scrutiny of redox balance mechanisms for individual pathologies so as to create new treatment strategies that target key pathways while minimizing side effects.
    Future directions: Extrapolating our understanding of redox balance to other debilitating conditions such as diabetes and the metabolic syndrome could potentially lead to devising a unifying therapeutic strategy. Antioxid. Redox Signal. 28, 741-759.
    MeSH term(s) Antioxidants/therapeutic use ; Humans ; Inflammation/epidemiology ; Inflammation/etiology ; Inflammation/physiopathology ; Lipid Peroxidation/genetics ; NF-E2-Related Factor 2/genetics ; Noise/adverse effects ; Oxidation-Reduction ; Oxidative Stress/genetics ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Smoking/adverse effects ; Stress, Psychological/epidemiology ; Stress, Psychological/pathology
    Chemical Substances Antioxidants ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; Reactive Oxygen Species
    Language English
    Publishing date 2018-01-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2017.7257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Smoking and Endothelial Dysfunction.

    Golbidi, Saeid / Edvinsson, Lars / Laher, Ismail

    Current vascular pharmacology

    2018  Volume 18, Issue 1, Page(s) 1–11

    Abstract: Cigarette smoking is one of the most important health concerns worldwide. Even though the rate of smoking is declining in developed countries, it is still experiencing growth in developing regions. Many studies have examined the relationship between ... ...

    Abstract Cigarette smoking is one of the most important health concerns worldwide. Even though the rate of smoking is declining in developed countries, it is still experiencing growth in developing regions. Many studies have examined the relationship between smoking, as an established risk factor, and cardiovascular diseases. We provide an updated review of the underlying mechanisms of smokinginduced cardiovascular diseases, with a focus on the relationship between smoking and oxidative stress, particularly from the perspective of endothelial cell dysfunction. We review smoking-induced oxidative stress as a trigger for a generalized vascular inflammation associated with cytokine release, adhesion of inflammatory cells and, ultimately, disruption of endothelial integrity as a protective barrier layer. We also briefly discuss the harms related to the vaping of electronic cigarettes, which many erroneously consider as a safe alternative to smoking. We conclude that even though e-cigarette could be a helpful device during the transition period of cigarette quitting, it is by no means a safe substitute.
    MeSH term(s) Animals ; Antioxidants/metabolism ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; E-Cigarette Vapor/adverse effects ; Electronic Nicotine Delivery Systems ; Endothelial Cells/metabolism ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Hemodynamics ; Humans ; Inflammation Mediators/metabolism ; Oxidative Stress ; Risk Assessment ; Risk Factors ; Signal Transduction ; Smoking/adverse effects ; Smoking/metabolism ; Smoking/physiopathology ; Vaping/adverse effects
    Chemical Substances Antioxidants ; E-Cigarette Vapor ; Inflammation Mediators
    Language English
    Publishing date 2018-09-25
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192362-0
    ISSN 1875-6212 ; 1570-1611
    ISSN (online) 1875-6212
    ISSN 1570-1611
    DOI 10.2174/1573403X14666180913120015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6282: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Alpha Lipoic Acid Improves Endothelial Function and Oxidative Stress in Mice Exposed to Chronic Intermittent Hypoxia.

    Badran, Mohammad / Abuyassin, Bisher / Golbidi, Saeid / Ayas, Najib / Laher, Ismail

    Oxidative medicine and cellular longevity

    2019  Volume 2019, Page(s) 4093018

    Abstract: Objective: Obstructive sleep apnea (OSA) is characterized by recurrent airway collapse that causes chronic intermittent hypoxia (CIH). OSA is associated with systemic inflammation and oxidative stress resulting in endothelial dysfunction and ... ...

    Abstract Objective: Obstructive sleep apnea (OSA) is characterized by recurrent airway collapse that causes chronic intermittent hypoxia (CIH). OSA is associated with systemic inflammation and oxidative stress resulting in endothelial dysfunction and cardiovascular disease (CVD). Alpha lipoic acid (ALA) is a potent antioxidant with anti-inflammatory properties. We hypothesized that dietary ALA can improve endothelial function of mice exposed to CIH.
    Methods: Mice were exposed to either CIH or intermittent air (IA) and treated with dietary ALA (0.2%
    Results: Mice exposed to CIH exhibited endothelial dysfunction accompanied by systemic oxidative stress and inflammation as well as increased aortic expression of inflammatory cytokines. Furthermore, CIH led to eNOS uncoupling. Treatment with dietary ALA reversed endothelial dysfunction in mice exposed to CIH, lowered systemic oxidative stress and inflammation, prevented the increases of inflammatory cytokine gene expression, increased the expression of antioxidant enzymes, and preserved eNOS in a coupled state.
    Conclusion: ALA attenuates endothelial dysfunction by preventing oxidative stress and inflammation and restoring nitric oxide bioavailability in mice exposed to CIH. Our data suggests the potential beneficial use of ALA as adjunctive therapy in OSA.
    MeSH term(s) Aldehyde Dehydrogenase/metabolism ; Aldehydes/metabolism ; Animals ; Arginine/analogs & derivatives ; Arginine/blood ; Biomarkers/blood ; Biomarkers/urine ; Chronic Disease ; Cytokines/genetics ; Cytokines/metabolism ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiopathology ; Hypoxia/blood ; Hypoxia/pathology ; Hypoxia/physiopathology ; Hypoxia/urine ; Inflammation/blood ; Inflammation/pathology ; Inflammation/urine ; Male ; Mice, Inbred C57BL ; Models, Biological ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase Type III/metabolism ; Oxidative Stress/drug effects ; Thioctic Acid/pharmacology ; Up-Regulation/drug effects ; Vasodilation/drug effects
    Chemical Substances Aldehydes ; Biomarkers ; Cytokines ; dimethylarginine ; Nitric Oxide (31C4KY9ESH) ; Thioctic Acid (73Y7P0K73Y) ; Arginine (94ZLA3W45F) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Aldehyde Dehydrogenase (EC 1.2.1.3) ; 4-hydroxy-2-nonenal (K1CVM13F96)
    Language English
    Publishing date 2019-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2019/4093018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exercise induced adipokine changes and the metabolic syndrome.

    Golbidi, Saeid / Laher, Ismail

    Journal of diabetes research

    2014  Volume 2014, Page(s) 726861

    Abstract: The lack of adequate physical activity and obesity created a worldwide pandemic. Obesity is characterized by the deposition of adipose tissue in various parts of the body; it is now evident that adipose tissue also acts as an endocrine organ capable of ... ...

    Abstract The lack of adequate physical activity and obesity created a worldwide pandemic. Obesity is characterized by the deposition of adipose tissue in various parts of the body; it is now evident that adipose tissue also acts as an endocrine organ capable of secreting many cytokines that are though to be involved in the pathophysiology of obesity, insulin resistance, and metabolic syndrome. Adipokines, or adipose tissue-derived proteins, play a pivotal role in this scenario. Increased secretion of proinflammatory adipokines leads to a chronic inflammatory state that is accompanied by insulin resistance and glucose intolerance. Lifestyle change in terms of increased physical activity and exercise is the best nonpharmacological treatment for obesity since these can reduce insulin resistance, counteract the inflammatory state, and improve the lipid profile. There is growing evidence that exercise exerts its beneficial effects partly through alterations in the adipokine profile; that is, exercise increases secretion of anti-inflammatory adipokines and reduces proinflammatory cytokines. In this paper we briefly describe the pathophysiologic role of four important adipokines (adiponectin, leptin, TNF-α, and IL-6) in the metabolic syndrome and review some of the clinical trials that monitored these adipokines as a clinical outcome before and after exercise.
    MeSH term(s) Adipokines/blood ; Adipokines/metabolism ; Adipose Tissue/immunology ; Adipose Tissue/metabolism ; Animals ; Cytokines/blood ; Cytokines/metabolism ; Down-Regulation ; Evidence-Based Medicine ; Exercise ; Humans ; Insulin Resistance ; Metabolic Syndrome/blood ; Metabolic Syndrome/immunology ; Metabolic Syndrome/physiopathology ; Metabolic Syndrome/therapy ; Motor Activity ; Up-Regulation
    Chemical Substances Adipokines ; Cytokines
    Language English
    Publishing date 2014-01-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6745
    ISSN (online) 2314-6753
    ISSN 2314-6745
    DOI 10.1155/2014/726861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exercise Induced Adipokine Changes and the Metabolic Syndrome

    Saeid Golbidi / Ismail Laher

    Journal of Diabetes Research, Vol

    2014  Volume 2014

    Keywords Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Potential mechanisms of exercise in gestational diabetes.

    Golbidi, Saeid / Laher, Ismail

    Journal of nutrition and metabolism

    2013  Volume 2013, Page(s) 285948

    Abstract: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first diagnosed during pregnancy. This condition shares same array of underlying abnormalities as occurs in diabetes outside of pregnancy, for example, genetic and environmental causes. ...

    Abstract Gestational diabetes mellitus (GDM) is defined as glucose intolerance first diagnosed during pregnancy. This condition shares same array of underlying abnormalities as occurs in diabetes outside of pregnancy, for example, genetic and environmental causes. However, the role of a sedentary lifestyle and/or excess energy intake is more prominent in GDM. Physically active women are less likely to develop GDM and other pregnancy-related diseases. Weight gain in pregnancy causes increased release of adipokines from adipose tissue; many adipokines increase oxidative stress and insulin resistance. Increased intramyocellular lipids also increase cellular oxidative stress with subsequent generation of reactive oxygen species. A well-planned program of exercise is an important component of a healthy lifestyle and, in spite of old myths, is also recommended during pregnancy. This paper briefly reviews the role of adipokines in gestational diabetes and attempts to shed some light on the mechanisms by which exercise can be beneficial as an adjuvant therapy in GDM. In this regard, we discuss the mechanisms by which exercise increases insulin sensitivity, changes adipokine profile levels, and boosts antioxidant mechanisms.
    Language English
    Publishing date 2013-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573563-9
    ISSN 2090-0732 ; 2090-0724
    ISSN (online) 2090-0732
    ISSN 2090-0724
    DOI 10.1155/2013/285948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Exercise and the aging endothelium.

    Golbidi, Saeid / Laher, Ismail

    Journal of diabetes research

    2013  Volume 2013, Page(s) 789607

    Abstract: The endothelium plays a critical role in the maintenance of cardiovascular health by producing nitric oxide and other vasoactive materials. Aging is associated with a gradual decline in this functional aspect of endothelial regulation of cardiovascular ... ...

    Abstract The endothelium plays a critical role in the maintenance of cardiovascular health by producing nitric oxide and other vasoactive materials. Aging is associated with a gradual decline in this functional aspect of endothelial regulation of cardiovascular homeostasis. Indeed, age is an independent risk factor for cardiovascular diseases and is in part an important factor in the increased exponential mortality rates from vascular disease such as myocardial infarction and stroke that occurs in the ageing population. There are a number of mechanisms suggested to explain age-related endothelial dysfunction. However, recent scientific studies have advanced the notion of oxidative stress and inflammation as the two major risk factors underlying aging and age-related diseases. Regular physical activity, known to have a favorable effect on cardiovascular health, can also improve the function of the ageing endothelium by modulating oxidative stress and inflammatory processes, as we discuss in this paper.
    MeSH term(s) Aging/metabolism ; Aging/physiology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiology ; Endothelium, Vascular/physiopathology ; Exercise/physiology ; Humans ; Inflammation/metabolism ; Inflammation/physiopathology ; Nitric Oxide/metabolism ; Oxidative Stress/physiology ; Vasodilation/physiology
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2013-08-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6745
    ISSN (online) 2314-6753
    ISSN 2314-6745
    DOI 10.1155/2013/789607
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  8. Article ; Online: Exercise and the cardiovascular system.

    Golbidi, Saeid / Laher, Ismail

    Cardiology research and practice

    2012  Volume 2012, Page(s) 210852

    Abstract: There are alarming increases in the incidence of obesity, insulin resistance, type II diabetes, and cardiovascular disease. The risk of these diseases is significantly reduced by appropriate lifestyle modifications such as increased physical activity. ... ...

    Abstract There are alarming increases in the incidence of obesity, insulin resistance, type II diabetes, and cardiovascular disease. The risk of these diseases is significantly reduced by appropriate lifestyle modifications such as increased physical activity. However, the exact mechanisms by which exercise influences the development and progression of cardiovascular disease are unclear. In this paper we review some important exercise-induced changes in cardiac, vascular, and blood tissues and discuss recent clinical trials related to the benefits of exercise. We also discuss the roles of boosting antioxidant levels, consequences of epicardial fat reduction, increases in expression of heat shock proteins and endoplasmic reticulum stress proteins, mitochondrial adaptation, and the role of sarcolemmal and mitochondrial potassium channels in the contributing to the cardioprotection offered by exercise. In terms of vascular benefits, the main effects discussed are changes in exercise-induced vascular remodeling and endothelial function. Exercise-induced fibrinolytic and rheological changes also underlie the hematological benefits of exercise.
    Language English
    Publishing date 2012-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2506187-2
    ISSN 2090-0597 ; 2090-8016
    ISSN (online) 2090-0597
    ISSN 2090-8016
    DOI 10.1155/2012/210852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Nitric Oxide Bioavailability in Obstructive Sleep Apnea: Interplay of Asymmetric Dimethylarginine and Free Radicals.

    Badran, Mohammad / Golbidi, Saeid / Ayas, Najib / Laher, Ismail

    Sleep disorders

    2015  Volume 2015, Page(s) 387801

    Abstract: Obstructive sleep apnea (OSA) occurs in 2% of middle-aged women and 4% of middle-aged men and is considered an independent risk factor for cerebrovascular and cardiovascular diseases. Nitric oxide (NO) is an important endothelium derived vasodilating ... ...

    Abstract Obstructive sleep apnea (OSA) occurs in 2% of middle-aged women and 4% of middle-aged men and is considered an independent risk factor for cerebrovascular and cardiovascular diseases. Nitric oxide (NO) is an important endothelium derived vasodilating substance that plays a critical role in maintaining vascular homeostasis. Low levels of NO are associated with impaired endothelial function. Asymmetric dimethylarginine (ADMA), an analogue of L-arginine, is a naturally occurring product of metabolism found in the human circulation. Elevated levels of ADMA inhibit NO synthesis while oxidative stress decreases its bioavailability, so impairing endothelial function and promoting atherosclerosis. Several clinical trials report increased oxidative stress and ADMA levels in patients with OSA. This review discusses the role of oxidative stress and increased ADMA levels in cardiovascular disease resulting from OSA.
    Language English
    Publishing date 2015-05-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2619778-9
    ISSN 2090-3553 ; 2090-3545
    ISSN (online) 2090-3553
    ISSN 2090-3545
    DOI 10.1155/2015/387801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Uncoupling of Vascular Nitric Oxide Synthase Caused by Intermittent Hypoxia.

    Badran, Mohammad / Abuyassin, Bisher / Golbidi, Saeid / Ayas, Najib / Laher, Ismail

    Oxidative medicine and cellular longevity

    2016  Volume 2016, Page(s) 2354870

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Animals ; Diabetes Mellitus, Experimental/enzymology ; Diabetes Mellitus, Experimental/metabolism ; Disease Models, Animal ; Hypoxia/enzymology ; Hypoxia/metabolism ; Male ; Mice ; Mice, Transgenic ; Nitric Oxide Synthase/metabolism ; Risk Factors ; Sleep Apnea, Obstructive/enzymology ; Sleep Apnea, Obstructive/metabolism
    Chemical Substances Nitric Oxide Synthase (EC 1.14.13.39)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2016/2354870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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