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Article: Psychosocial conditions and the progression of diabetic nephropathy in Japanese with type 2 diabetes mellitus.

Ninomiya, Hiroyo / Katakami, Naoto / Takahara, Mitsuyoshi / Matsuoka, Taka-Aki / Shimomura, Iichiro

2021 Volume 12, Issue 3, Page(s) 336–341

Abstract: We previously reported the association of positive psychosocial conditions with diabetic nephropathy (DN) in patients with type 2 diabetes in a cross-sectional setting. In the present study, we evaluated the association between six indicators related to ... ...

Abstract	We previously reported the association of positive psychosocial conditions with diabetic nephropathy (DN) in patients with type 2 diabetes in a cross-sectional setting. In the present study, we evaluated the association between six indicators related to psychosocial conditions and the progression of DN assessed by estimated glomerular filtration rate (eGFR) and albuminuria during 2-year observation period in 252 patients with type 2 diabetes. In unadjusted model, the subjects with higher happiness score attenuated reduced eGFR, and those with more social support attenuated increase in alubuminuria and decline eGFR. However, in adjusted model for happiness score and social support, only happiness score indicated the significant association with reduced eGFR. Gender-segregated analysis showed a significant association between happiness score and ΔeGFR in male but not in female subjects. On the other hand, decrease in eGFR was significantly attenuated in the subjects with more social support as compared to those with less social support in women but not in men. These results suggested that that psychosocial conditions could be related to the progression of DN, and that the psychosocial factors that influence in DN might differ between men and women, in Japanese patients with type 2 diabetes.
Language	English
Publishing date	2021-01-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2574501-3
ISSN	2190-1686 ; 2190-1678
ISSN (online)	2190-1686
ISSN	2190-1678
DOI	10.1007/s13340-020-00479-x
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Article ; Online: Diabetes due to Mitochondrial Adipopathy.

Ninomiya, Hiroyo / Hirata, Ayumu / Kozawa, Junji / Imagawa, Akihisa / Shimomura, Iichiro

Internal medicine (Tokyo, Japan)

2017 Volume 56, Issue 6, Page(s) 745

Language	English
Publishing date	2017
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.56.7950
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Article ; Online: Identification of Plasma Inositol and Indoxyl Sulfate as Novel Biomarker Candidates for Atherosclerosis in Patients with Type 2 Diabetes. -Findings from Metabolome Analysis Using GC/MS.

Omori, Kazuo / Katakami, Naoto / Arakawa, Shoya / Yamamoto, Yuichi / Ninomiya, Hiroyo / Takahara, Mitsuyoshi / Matsuoka, Taka-Aki / Tsugawa, Hiroshi / Furuno, Masahiro / Bamba, Takeshi / Fukusaki, Eiichiro / Shimomura, Iichiro

Journal of atherosclerosis and thrombosis

2020 Volume 27, Issue 10, Page(s) 1053–1067

Abstract: Aim: An identification of the high-risk group of atherosclerotic cardiovascular disease (CVD) is important in the management of patients with diabetes. Metabolomics is a potential tool for the discovery of new biomarkers. With this background, we aimed ... ...

Abstract	Aim: An identification of the high-risk group of atherosclerotic cardiovascular disease (CVD) is important in the management of patients with diabetes. Metabolomics is a potential tool for the discovery of new biomarkers. With this background, we aimed to identify metabolites associated with atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 176 patients with T2DM who have never had a CVD event and 40 who were survivors of coronary artery disease (CAD) events were enrolled. Non-targeted metabolome analysis of fasting plasma samples was performed using gas chromatography coupled with mass spectrometry (GC/MS) highly optimized for multiple measurement of blood samples. First, metabolites were screened by analyzing the association with the established markers of subclinical atherosclerosis (i.e., carotid maximal intima-media thickness (max-IMT) and flow-mediated vasodilation (FMD)) in the non-CVD subjects. Then, the associations between the metabolites detected and the history of CAD were investigated. Result: A total of 65 annotated metabolites were detected. Non-parametric univariate analysis identified inositol and indoxyl sulfate as significantly (p＜0.05) associated with both max-IMT and FMD. These metabolites were also significantly associated with CAD. Moreover, inositol remained to be associated with CAD even after adjustments for traditional coronary risk factors. Conclusions: We identified novel biomarker candidates for atherosclerosis in Japanese patients with T2DM using GC/MS-based non-targeted metabolomics.
MeSH term(s)	Aged ; Atherosclerosis/blood ; Atherosclerosis/complications ; Biomarkers/blood ; Carotid Intima-Media Thickness ; Coronary Artery Disease/blood ; Coronary Artery Disease/complications ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Indican/blood ; Inositol/blood ; Japan/epidemiology ; Male ; Metabolome ; Metabolomics ; Middle Aged ; Myocardial Ischemia/pathology ; Solvents
Chemical Substances	Biomarkers ; Solvents ; Inositol (4L6452S749) ; Indican (N187WK1Y1J)
Language	English
Publishing date	2020-01-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2011474-6
ISSN	1880-3873 ; 1340-3478
ISSN (online)	1880-3873
ISSN	1340-3478
DOI	10.5551/jat.52506
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Article ; Online: Identification of Metabolites Associated with Onset of CAD in Diabetic Patients Using CE-MS Analysis: A Pilot Study.

Omori, Kazuo / Katakami, Naoto / Yamamoto, Yuichi / Ninomiya, Hiroyo / Takahara, Mitsuyoshi / Matsuoka, Taka-Aki / Bamba, Takeshi / Fukusaki, Eiichiro / Shimomura, Iichiro

Journal of atherosclerosis and thrombosis

2018 Volume 26, Issue 3, Page(s) 233–245

Abstract: Aim: Coronary artery disease (CAD) is the result of a complex metabolic disorder caused by various environmental and genetic factors. Metabolomics is a potential tool for identifying biomarkers for better risk classification and for understanding the ... ...

Abstract	Aim: Coronary artery disease (CAD) is the result of a complex metabolic disorder caused by various environmental and genetic factors. Metabolomics is a potential tool for identifying biomarkers for better risk classification and for understanding the pathophysiological mechanisms of CAD. With this background, we performed a pilot study to identify metabolites associated with the future onset of CAD in patients with type 2 diabetes. Methods: Sixteen subjects who suffered from CAD event during the observation period and 39 non-CAD subjects who were matched to the CAD subjects for Framingham Coronary Heart Disease Risk Score, diabetes duration, and HbA1c were selected. Capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) was used to perform non-targeted metabolome analysis of serum samples collected in 2005. Results: A total of 104 metabolites were identified. Unsupervised principal component analysis (PCA) did not to reveal two distinct clusters of individuals. However, a significant association with CAD was found for 7 metabolites (pelargonic acid, glucosamine:galactosamine, thymine, 3-hydroxybutyric acid, creatine, 2-aminoisobutyric acid, hypoxanthine) and the levels of all these metabolites were significantly lower in the CAD group compared with the non-CAD group. Conclusions: We identified 7 metabolites related to long-term future onset of CAD in Japanese patients with diabetes. Further studies with large sample size would be necessary to confirm our findings, and future studies using in vivo or in vitro models would be necessary to elucidate whether direct relationships exist between the detected metabolites and CAD pathophysiology.
MeSH term(s)	Aged ; Biomarkers/metabolism ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Case-Control Studies ; Diabetes Mellitus, Type 2/complications ; Electrophoresis, Capillary/methods ; Female ; Follow-Up Studies ; Humans ; Male ; Mass Spectrometry/methods ; Metabolome ; Metabolomics/methods ; Middle Aged ; Pilot Projects ; Prognosis ; Prospective Studies ; Retrospective Studies
Chemical Substances	Biomarkers
Language	English
Publishing date	2018-08-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2011474-6
ISSN	1880-3873 ; 1340-3478
ISSN (online)	1880-3873
ISSN	1340-3478
DOI	10.5551/jat.42945
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Zs.A 5192: Show issues

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Article ; Online: Association between Subclinical Atherosclerosis Markers and the Level of Accumulated Advanced Glycation End-Products in the Skin of Patients with Diabetes.

Ninomiya, Hiroyo / Katakami, Naoto / Sato, Ihoko / Osawa, Saeko / Yamamoto, Yuichi / Takahara, Mitsuyoshi / Kawamori, Dan / Matsuoka, Taka-Aki / Shimomura, Iichiro

Journal of atherosclerosis and thrombosis

2018 Volume 25, Issue 12, Page(s) 1274–1284

Abstract: Aim: The level of accumulated advanced glycation end-products (AGEs) in the skin has been shown to predict the risk of complications in patients with diabetes mellitus (DM). Recently, the level of accumulated fluorescent AGEs in the skin has become ... ...

Abstract	Aim: The level of accumulated advanced glycation end-products (AGEs) in the skin has been shown to predict the risk of complications in patients with diabetes mellitus (DM). Recently, the level of accumulated fluorescent AGEs in the skin has become measurable as skin autofluorescence (skin AF) using a non-invasive apparatus, autofluorescence reader. The purpose of this study was to evaluate the association between skin AF and the subclinical atherosclerosis markers, especially endothelial dysfunction, in patients with DM. Methods: We enrolled 140 Japanese subjects with DM who attended Osaka University Hospital, and measured the skin level of AGEs by skin AF and three subclinical atherosclerosis markers: endothelial function by flow-mediated vasodilation, FMD; carotid intima-media thickness, IMT; and brachial-ankle pulse wave velocity, baPWV. Results: FMD was significantly associated with skin AF (r=－0.259, p=0.002). Furthermore, a stepwise multivariate regression analysis revealed that skin AF was an independent determinant of FMD (β=－0.180, p=0.038). Although there were significant associations between skin AF and maximum carotid intima-media thickness (max-IMT)(r=0.298, p＜0.001) as well as baPWV (r=0.284, p= 0.001) in univariate analysis, skin AF was not an independent determinant of either carotid max-IMT or baPWV after adjustment for conventional cardiovascular risk factors. Receiver-operating characteristic curve analysis revealed that skin AF can identify the subjects whose FMD, max-IMT, and baPWV were completely within the normal range (C-statistics, 0.73; 95% confidence interval, 0.61-0.84; p＜0.001). Conclusions: Skin AF was independently associated with FMD as an indicator of endothelial dysfunction, and can be utilized as a screening marker of atherosclerosis in Japanese patients with DM.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Atherosclerosis/blood ; Atherosclerosis/diagnosis ; Atherosclerosis/etiology ; Biomarkers/blood ; Carotid Intima-Media Thickness ; Diabetes Mellitus, Type 2/complications ; Diabetic Angiopathies/blood ; Diabetic Angiopathies/diagnosis ; Diabetic Angiopathies/etiology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Female ; Follow-Up Studies ; Glycation End Products, Advanced/blood ; Humans ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Skin/metabolism ; Skin/pathology ; Young Adult
Chemical Substances	Biomarkers ; Glycation End Products, Advanced
Language	English
Publishing date	2018-06-30
Publishing country	Japan
Document type	Journal Article ; Observational Study
ZDB-ID	2011474-6
ISSN	1880-3873 ; 1340-3478
ISSN (online)	1880-3873
ISSN	1340-3478
DOI	10.5551/jat.44859
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Zs.A 5192: Show issues

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Article ; Online: Skin autofluorescence is associated with vascular complications in patients with type 2 diabetes.

Osawa, Saeko / Katakami, Naoto / Sato, Ihoko / Ninomiya, Hiroyo / Omori, Kazuo / Yamamoto, Yuichi / Takahara, Mitsuyoshi / Miyashita, Kazuyuki / Sakamoto, Fumie / Kawamori, Dan / Matsuoka, Takaaki / Shimomura, Iichiro

Journal of diabetes and its complications

2018 Volume 32, Issue 9, Page(s) 839–844

Abstract: Aims: Tissue accumulatedadvanced glycation end products (AGEs) can be evaluated non-invasively by an autofluorescence reader as skin autofluorescence (skin AF)·The present study investigated whether skin AF is associated with diabetic micro- and ... ...

Abstract	Aims: Tissue accumulatedadvanced glycation end products (AGEs) can be evaluated non-invasively by an autofluorescence reader as skin autofluorescence (skin AF)·The present study investigated whether skin AF is associated with diabetic micro- and macroangiopathies in Japanese patients with type 2 diabetes mellitus (T2DM). Methods: Skin AF was measured in 193 enrolled Japanese patients with T2DM and 24 enrolled healthy non-diabetic subjects by using the AGE reader®. Diabetic micro- and macroangiopathies were evaluated in the T2DM patients. Results: Skin AF was significantly increased in patients with T2DM than in age- and sex-matched non-diabetic controls (2.35 ± 0.51 [mean ± SD] and 1.91 ± 0.29, respectively, p = 0.001). In subjects with T2DM, skin AF was associated with age, pack-years of smoking, and eGFR (estimated glomerular filtration rate) independently. Skin AF was significantly increased in patients with diabetic retinopathy, neuropathy, nephropathy, and macroangiopathy than in those without them, and significantly associated with the number of diabetic complications. Moreover, skin AF was an independent predictor for diabetic retinopathy, neuropathy, and nephropathy but not macroangiopathy, after adjusting for major traditional risk factors. Conclusions: Skin AF is an independent predictor for diabetic retinopathy, neuropathy and nephropathy in Japanese patients with T2DM.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Angiopathies/diagnosis ; Diabetic Angiopathies/physiopathology ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/physiopathology ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/metabolism ; Diabetic Retinopathy/physiopathology ; Fluorescence ; Glycation End Products, Advanced/metabolism ; Humans ; Middle Aged ; Optical Imaging ; Skin/diagnostic imaging ; Skin/metabolism ; Skin Physiological Phenomena ; Young Adult
Chemical Substances	Glycation End Products, Advanced
Language	English
Publishing date	2018-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2018.06.009
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Article ; Online: Association between poor psychosocial conditions and diabetic nephropathy in Japanese type 2 diabetes patients: A cross-sectional study.

Ninomiya, Hiroyo / Katakami, Naoto / Matsuoka, Taka-Aki / Takahara, Mitsuyoshi / Nishizawa, Hitoshi / Maeda, Norikazu / Otsuki, Michio / Imagawa, Akihisa / Iso, Hiroyasu / Ohira, Tetsuya / Shimomura, Iichiro

Journal of diabetes investigation

2017 Volume 9, Issue 1, Page(s) 162–172

Abstract: Aims/introduction: It is suggested that a positive psychosocial condition has a good effect on health and glycemic control. However, there has been no research to evaluate the association between positive psychosocial factors and diabetic nephropathy ( ... ...

Abstract	Aims/introduction: It is suggested that a positive psychosocial condition has a good effect on health and glycemic control. However, there has been no research to evaluate the association between positive psychosocial factors and diabetic nephropathy (DN). The aim of the present study was to evaluate the association between psychosocial factors and DN in patients with type 2 diabetes. Material and methods: To assess psychosocial condition, six indicators (happiness score, Life Orientation Test-revised score as an indicator of dispositional optimism, laughter frequency, self-awareness of stress, social network and social support) were assessed by a self-administered questionnaire, and associations between these psychosocial indicators and the presence of DN were examined. Results: A cross-sectional analysis of patients with (n = 123) and without DN (n = 220) showed that a high score for happiness (odds ratio [OR] per 1 standard deviation 0.71, 95% confidence interval [CI] 0.57-0.89, P = 0.003), high Life Orientation Test-revised score (OR per 1 standard deviation 0.77, 95% CI: 0.61-0.98, P = 0.035), less self-awareness of stress (OR 0.56, 95% CI: 0.34-0.90, P = 0.017), high connection of social network (OR 0.55, 95% CI: 0.35-0.87, P = 0.010) and high social support (OR 0.61, 95% CI: 0.38-0.96, P = 0.035) were associated with a reduced risk of prevalence of DN. Similar results were observed even after adjustment for the following conventional risk factors of DN: age, sex, duration of diabetes, hemoglobin A1c, hypertension, dyslipidemia and current smoking. Conclusions: The present study showed that five out of six prespecified indicators of psychosocial condition were significantly associated with the presence of DN in Japanese patients with type 2 diabetes.
MeSH term(s)	Aged ; Asians ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/psychology ; Diabetic Nephropathies/complications ; Diabetic Nephropathies/psychology ; Female ; Happiness ; Health Knowledge, Attitudes, Practice ; Humans ; Japan ; Male ; Middle Aged ; Social Support ; Surveys and Questionnaires
Language	English
Publishing date	2017-03-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2625840-7
ISSN	2040-1124 ; 2040-1116
ISSN (online)	2040-1124
ISSN	2040-1116
DOI	10.1111/jdi.12641
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Zs.A 6920: Show issues

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Article ; Online: Treatment of Mitochondrial Diabetes with a Peroxisome Proliferator-activated Receptor (PPAR)-gamma Agonist.

Ninomiya, Hiroyo / Hirata, Ayumu / Kozawa, Junji / Nakata, Shinsuke / Kimura, Takekazu / Kitamura, Tetsuhiro / Yasuda, Tetsuyuki / Otsuki, Michio / Imagawa, Akihisa / Kaneto, Hideaki / Funahashi, Tohru / Shimomura, Iichiro

Internal medicine (Tokyo, Japan)

2016 Volume 55, Issue 9, Page(s) 1143–1147

Abstract: The 3243 A>G mutation in mitochondrial DNA is the most common cause of monogenic diabetes mellitus in Japan. A 45-year-old woman with mitochondrial diabetes and significant insulin resistance presented with hypoadiponectinemia despite a normal amount of ... ...

Abstract	The 3243 A>G mutation in mitochondrial DNA is the most common cause of monogenic diabetes mellitus in Japan. A 45-year-old woman with mitochondrial diabetes and significant insulin resistance presented with hypoadiponectinemia despite a normal amount of visceral fat. Three months of treatment with pioglitazone (PIO) improved her blood glucose profile and response to the 75-g oral glucose tolerance test. These changes were accompanied by the amelioration of her insulin resistance and the impairment of early-phase insulin secretion. Her serum adiponectin levels increased to the normal range. In this case of mitochondrial diabetes, PIO was effective for glycemic control.
MeSH term(s)	Adiponectin/blood ; Adiponectin/deficiency ; Blood Glucose/metabolism ; DNA, Mitochondrial/genetics ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/genetics ; Female ; Glucose Tolerance Test ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/blood ; Insulin Resistance/physiology ; Metabolism, Inborn Errors/drug therapy ; Metabolism, Inborn Errors/etiology ; Middle Aged ; Mitochondria/drug effects ; PPAR gamma/agonists ; Pedigree ; Thiazolidinediones/therapeutic use
Chemical Substances	ADIPOQ protein, human ; Adiponectin ; Blood Glucose ; DNA, Mitochondrial ; Hypoglycemic Agents ; Insulin ; PPAR gamma ; Thiazolidinediones ; pioglitazone (X4OV71U42S)
Language	English
Publishing date	2016
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.55.4418
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Article ; Online: Association between new onset diabetic retinopathy and monocyte chemoattractant protein-1 (MCP-1) polymorphism in Japanese type 2 diabetes.

Ninomiya, Hiroyo / Katakami, Naoto / Osonoi, Takeshi / Saitou, Miyoko / Yamamoto, Yuichi / Takahara, Mitsuyoshi / Kawamori, Dan / Matsuoka, Taka-aki / Yamasaki, Yoshimitsu / Shimomura, Iichiro

Diabetes research and clinical practice

2015 Volume 108, Issue 3, Page(s) e35–7

Abstract: We longitudinally evaluated the association between monocyte chemoattractant protein-1 (MCP-1) A-2518G polymorphism and new onset of diabetic retinopathy in 758 type 2 diabetic patients. The new onset of retinopathy increased with the increase of the ... ...

Abstract	We longitudinally evaluated the association between monocyte chemoattractant protein-1 (MCP-1) A-2518G polymorphism and new onset of diabetic retinopathy in 758 type 2 diabetic patients. The new onset of retinopathy increased with the increase of the number of G alleles, even after adjustment for age, HbA1c levels, and duration of diabetes.
MeSH term(s)	Aged ; Asian Continental Ancestry Group/genetics ; Asian Continental Ancestry Group/statistics & numerical data ; Chemokine CCL2/genetics ; Cohort Studies ; Diabetes Mellitus, Type 2/complications ; Diabetic Retinopathy/genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Japan/epidemiology ; Longitudinal Studies ; Male ; Middle Aged ; Polymorphism, Single Nucleotide
Chemical Substances	CCL2 protein, human ; Chemokine CCL2
Language	English
Publishing date	2015-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2015.04.006
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Article: Complete sequencing and characterization of 21,243 full-length human cDNAs.

Ota, Toshio / Suzuki, Yutaka / Nishikawa, Tetsuo / Otsuki, Tetsuji / Sugiyama, Tomoyasu / Irie, Ryotaro / Wakamatsu, Ai / Hayashi, Koji / Sato, Hiroyuki / Nagai, Keiichi / Kimura, Kouichi / Makita, Hiroshi / Sekine, Mitsuo / Obayashi, Masaya / Nishi, Tatsunari / Shibahara, Toshikazu / Tanaka, Toshihiro / Ishii, Shizuko / Yamamoto, Jun-ichi /

Saito, Kaoru / Kawai, Yuri / Isono, Yuko / Nakamura, Yoshitaka / Nagahari, Kenji / Murakami, Katsuhiko / Yasuda, Tomohiro / Iwayanagi, Takao / Wagatsuma, Masako / Shiratori, Akiko / Sudo, Hiroaki / Hosoiri, Takehiko / Kaku, Yoshiko / Kodaira, Hiroyo / Kondo, Hiroshi / Sugawara, Masanori / Takahashi, Makiko / Kanda, Katsuhiro / Yokoi, Takahide / Furuya, Takako / Kikkawa, Emiko / Omura, Yuhi / Abe, Kumi / Kamihara, Kumiko / Katsuta, Naoko / Sato, Kazuomi / Tanikawa, Machiko / Yamazaki, Makoto / Ninomiya, Ken / Ishibashi, Tadashi / Yamashita, Hiromichi / Murakawa, Katsuji / Fujimori, Kiyoshi / Tanai, Hiroyuki / Kimata, Manabu / Watanabe, Motoji / Hiraoka, Susumu / Chiba, Yoshiyuki / Ishida, Shinichi / Ono, Yukio / Takiguchi, Sumiyo / Watanabe, Susumu / Yosida, Makoto / Hotuta, Tomoko / Kusano, Junko / Kanehori, Keiichi / Takahashi-Fujii, Asako / Hara, Hiroto / Tanase, Tomo-o / Nomura, Yoshiko / Togiya, Sakae / Komai, Fukuyo / Hara, Reiko / Takeuchi, Kazuha / Arita, Miho / Imose, Nobuyuki / Musashino, Kaoru / Yuuki, Hisatsugu / Oshima, Atsushi / Sasaki, Naokazu / Aotsuka, Satoshi / Yoshikawa, Yoko / Matsunawa, Hiroshi / Ichihara, Tatsuo / Shiohata, Namiko / Sano, Sanae / Moriya, Shogo / Momiyama, Hiroko / Satoh, Noriko / Takami, Sachiko / Terashima, Yuko / Suzuki, Osamu / Nakagawa, Satoshi / Senoh, Akihiro / Mizoguchi, Hiroshi / Goto, Yoshihiro / Shimizu, Fumio / Wakebe, Hirokazu / Hishigaki, Haretsugu / Watanabe, Takeshi / Sugiyama, Akio / Takemoto, Makoto / Kawakami, Bunsei / Yamazaki, Masaaki / Watanabe, Koji / Kumagai, Ayako / Itakura, Shoko / Fukuzumi, Yasuhito / Fujimori, Yoshifumi / Komiyama, Megumi / Tashiro, Hiroyuki / Tanigami, Akira / Fujiwara, Tsutomu / Ono, Toshihide / Yamada, Katsue / Fujii, Yuka / Ozaki, Kouichi / Hirao, Maasa / Ohmori, Yoshihiro / Kawabata, Ayako / Hikiji, Takeshi / Kobatake, Naoko / Inagaki, Hiromi / Ikema, Yasuko / Okamoto, Sachiko / Okitani, Rie / Kawakami, Takuma / Noguchi, Saori / Itoh, Tomoko / Shigeta, Keiko / Senba, Tadashi / Matsumura, Kyoka / Nakajima, Yoshie / Mizuno, Takae / Morinaga, Misato / Sasaki, Masahide / Togashi, Takushi / Oyama, Masaaki / Hata, Hiroko / Watanabe, Manabu / Komatsu, Takami / Mizushima-Sugano, Junko / Satoh, Tadashi / Shirai, Yuko / Takahashi, Yukiko / Nakagawa, Kiyomi / Okumura, Koji / Nagase, Takahiro / Nomura, Nobuo / Kikuchi, Hisashi / Masuho, Yasuhiko / Yamashita, Riu / Nakai, Kenta / Yada, Tetsushi / Nakamura, Yusuke / Ohara, Osamu / Isogai, Takao / Sugano, Sumio

Nature genetics

2004 Volume 36, Issue 1, Page(s) 40–45

Abstract: As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) were ... ...

Abstract	As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) were unique to the FLJ collection. About half of them (5,416) seemed to be protein-coding. Of those, 1,999 clusters had not been predicted by computational methods. The distribution of GC content of nonpredicted cDNAs had a peak at approximately 58% compared with a peak at approximately 42%for predicted cDNAs. Thus, there seems to be a slight bias against GC-rich transcripts in current gene prediction procedures. The rest of the cDNAs unique to the FLJ collection (5,481) contained no obvious open reading frames (ORFs) and thus are candidate noncoding RNAs. About one-fourth of them (1,378) showed a clear pattern of splicing. The distribution of GC content of noncoding cDNAs was narrow and had a peak at approximately 42%, relatively low compared with that of protein-coding cDNAs.
MeSH term(s)	Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, Pair 20 ; Computational Biology ; DNA, Complementary ; Humans ; Open Reading Frames ; RNA, Messenger ; Sequence Analysis, DNA
Chemical Substances	DNA, Complementary ; RNA, Messenger
Language	English
Publishing date	2004-01
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1108734-1
ISSN	1546-1718 ; 1061-4036
ISSN (online)	1546-1718
ISSN	1061-4036
DOI	10.1038/ng1285
Database	MEDical Literature Analysis and Retrieval System OnLINE

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