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Article ; Online: Elderly-onset severe parkinsonism in Wilson disease: Expert commentary.

Patil, Laxmi / Mehta, Gaurav / Aggarwal, Annu

2024 , Page(s) 106945

Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Editorial
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2024.106945
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Zs.A 4553: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Assessment of the efficacy of reduced-radiation noncontrast computed tomography scan compared with the standard noncontrast computed tomography scan for detecting urolithiasis: A prospective single-center study.

Aggarwal, Gaurav / Adhikary, Samiran Das

Current urology

2022 Volume 17, Issue 1, Page(s) 18–24

Abstract: Background: Noncontrast computed tomography (CT) scan of the kidneys, ureter and bladder is the standard investigative modality for diagnosing and following up patients with urolithiasis. With each scan, a patient receives radiation of 18-34 mGy. Dose ... ...

Abstract	Background: Noncontrast computed tomography (CT) scan of the kidneys, ureter and bladder is the standard investigative modality for diagnosing and following up patients with urolithiasis. With each scan, a patient receives radiation of 18-34 mGy. Dose considerations become pertinent because of a 10% lifetime incidence rate and higher than 50% risk of recurrence, necessitating repeated imaging in the lifetime of a stone former. Hence, this study aimed to assess the sensitivity of "reduced-radiation" CT imaging by altering scan settings to lower than the "standard" norms. Materials and methods: Altogether, 222 patients (255 "kidney-ureter" stone-bearing units or "renal units") with urolithiasis and patients undergoing CT for other reasons with incidental findings of renal/ureteric calculi between 2017 and 2019 were included. All patients were subjected to 3 sequential scans at tube current settings of 250 mA (CT-N/Standard), 100 mA (CT-100), and 50 mA (CT-50) at a constant voltage of 120 kV. Their clinicodemographic and radiological findings were recorded and assessed for significance. Results: Of the 255 renal units, 117 were between 30 and 44 years of age, 75% were men. Of the 255 patients, 178 (70.1%) reported a first stone episode and 77 had recurrence. Lower ureteric calculi were predominant (40.4%). All calculi were identified on CT-N; CT-100 failed to detect calculi in 1 patient, and CT-50 failed in 3 patients, where all calculi were <3 mm in size. Meanwhile, none were undetected among patients with obesity. The sensitivity was 99.61% for the CT-100 and 98.82% for the CT-50, which indicated a 2.5 and 5 times lower radiation and dose/length, respectively, than CT-N. Conclusions: The reduced-radiation CT scan is safe, sensitive, and accurate for the diagnosis and follow-up of patients with urolithiasis with significantly lower radiation exposures. Our study lays the foundation to accept low-dose CT in general and CT-50 in particular, as the new "standard of care," and attempt further dose reduction without loss of diagnostic efficacy.
Language	English
Publishing date	2022-11-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2253664-4
ISSN	1661-7657 ; 1661-7649
ISSN (online)	1661-7657
ISSN	1661-7649
DOI	10.1097/CU9.0000000000000162
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Zs.A 6628: Show issues

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Article ; Online: Evaluation of three different

Tiwari, Nidhi / Jaimini, Abhinav / Jain, Gaurav Kumar / Aggarwal, Geeta / Mittal, Gaurav

Journal of pharmacological and toxicological methods

2023 Volume 122, Page(s) 107280

Abstract: Snakebite envenomation is one of the major public health concerns across many countries; with the WHO designating it as a 'priority neglected tropical disease' and stressing for a need to develop novel therapeutic strategies to reduce death and ... ...

Abstract	Snakebite envenomation is one of the major public health concerns across many countries; with the WHO designating it as a 'priority neglected tropical disease' and stressing for a need to develop novel therapeutic strategies to reduce death and disability rate by end of 2030. Since a major component of venom; the high molecular weight (HMw) toxins enter the bloodstream through lymphatic system, research is focusing on modulating the lymphatic flow rate after topical application of suitable drug candidates. Present study compared the suitability of three radiopharmaceutical agents, namely
MeSH term(s)	Humans ; Animals ; Rats ; Lymphoscintigraphy ; Radiopharmaceuticals/pharmacology ; Technetium Tc 99m Sulfur Colloid ; Venoms ; Snake Bites/diagnostic imaging ; Rats, Sprague-Dawley ; Lymph Nodes ; Sulfur Compounds
Chemical Substances	Radiopharmaceuticals ; Technetium Tc 99m Sulfur Colloid (556Q0P6PB1) ; Venoms ; Sulfur Compounds
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1105919-9
ISSN	1873-488X ; 1056-8719
ISSN (online)	1873-488X
ISSN	1056-8719
DOI	10.1016/j.vascn.2023.107280
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Article ; Online: Clinical lesson to not overlook venous thrombosis: a case of primary antiphospholipid syndrome.

Punjadath, Sryla / Aggarwal, Mukul / Gupta, Gaurav / Baitha, Upendra

BMJ case reports

2023 Volume 16, Issue 5

Abstract: A man in his early 30s presented to us with progressive shortness of breath limiting activities of daily living. An important clue in history was the episode of a deep vein thrombosis 5 years ago treated with short-term anticoagulation. His ... ...

Abstract	A man in his early 30s presented to us with progressive shortness of breath limiting activities of daily living. An important clue in history was the episode of a deep vein thrombosis 5 years ago treated with short-term anticoagulation. His echocardiography revealed elevated estimated pulmonary artery systolic pressure. A CT pulmonary angiography confirmed chronic thromboembolic pulmonary hypertension. Blood investigations established primary antiphospholipid syndrome. He underwent pulmonary endarterectomy, relieving his symptoms and was started on indefinite oral anticoagulation with warfarin. He is currently under follow-up with no recurrence of thrombosis.We wish to highlight the importance of an appropriate workup of venous thrombosis in all patients. Antiphospholipid syndrome is a rare disease with important implications in the management of patients with thromboses. The delay in his diagnosis had several causes including the unclear distinction between provoked and unprovoked thrombosis and socioeconomic factors in a developing nation limiting referral and testing.
MeSH term(s)	Male ; Humans ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/drug therapy ; Activities of Daily Living ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/drug therapy ; Venous Thrombosis/etiology ; Thrombosis/drug therapy ; Anticoagulants/therapeutic use ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/etiology
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-254671
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Article: Bronchoscopic treatment of bronchopleural fistula due to COVID-19.

Aggarwal, Manish / Chaudhry, Gaurav / Sinha, Ashish / Mohan, Sruthi P / Goyal, Rajiv

Lung India : official organ of Indian Chest Society

2023 Volume 39, Issue 5, Page(s) 477–478

Language	English
Publishing date	2023-01-09
Publishing country	India
Document type	Letter
ZDB-ID	2410801-7
ISSN	0974-598X ; 0970-2113
ISSN (online)	0974-598X
ISSN	0970-2113
DOI	10.4103/lungindia.lungindia_79_22
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Article: Recurrent hypercalcaemia in a patient with dual urological malignancies: A rare life-threatening entity.

Haldar, Srimanta K / Sarkar, Anshuman / Gupta, Aditi / Aggarwal, Gaurav

Indian journal of anaesthesia

2022 Volume 66, Issue Suppl 4, Page(s) S228–S230

Language	English
Publishing date	2022-06-06
Publishing country	India
Document type	Journal Article
ZDB-ID	412570-8
ISSN	0019-5049
ISSN	0019-5049
DOI	10.4103/ija.ija_811_21
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Article: Hypercalcemia in Urological Malignancies: A Review.

Aggarwal, Gaurav / Gupta, Sujoy / Khwaunju, Pragyan

Turkish journal of urology

2022 Volume 48, Issue 4, Page(s) 243–253

Abstract: Hypercalcemia is an uncommon occurrence in urological malignancies except for renal cell carcinoma. However, when seen, it is usually associated with advanced disease and both the osteolytic as well as humoral mechanisms may be causative. Owing to its ... ...

Abstract	Hypercalcemia is an uncommon occurrence in urological malignancies except for renal cell carcinoma. However, when seen, it is usually associated with advanced disease and both the osteolytic as well as humoral mechanisms may be causative. Owing to its rarity, hypercalcemia can be easily missed during the initial evaluation of a patient with urologic malignancy. Our article aims to highlight the mechanisms associated with hypercalcemia in malignancy, in general, and review the available literature on hypercalcemia in urological malignancies. We also aim to discuss the management options in case of such an unusual occurrence in any urological cancer.
Language	English
Publishing date	2022-07-22
Publishing country	Turkey
Document type	Journal Article
ISSN	2149-3235
ISSN	2149-3235
DOI	10.5152/tud.2022.22006
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Article ; Online: Type 2 hyper-IgM syndrome with a rare variant of AICDA gene mutation in a young woman.

Prakash, Prithivi Raaj / Gupta, Gaurav / Aggarwal, Mukul / Baitha, Upendra

BMJ case reports

2023 Volume 16, Issue 3

Abstract: We report the case of a woman in her early 20s with a history of recurrent infection, atopic dermatitis, filariasis and bilateral purulent ear discharge since childhood with tonsillar enlargement on examination. She was started on supportive care and ... ...

Abstract	We report the case of a woman in her early 20s with a history of recurrent infection, atopic dermatitis, filariasis and bilateral purulent ear discharge since childhood with tonsillar enlargement on examination. She was started on supportive care and evaluated for primary immunodeficiency disease. Blood investigations revealed increased IgM levels with reduced IgG, IgA and IgE levels. Radiological imaging of the chest revealed bilateral bronchiectasis. Otoscopic examination showed features suggestive of chronic suppurative otitis media. Next-generation sequencing identified homozygous single base pair deletion in exon 2 of the activation-induced cytidine deaminase gene. Thus, a diagnosis of hyper-IgM syndrome type 2 was confirmed. The patient was started on monthly intravenous immunoglobulin replacement therapy and is currently symptomatically better, and she remains under regular follow-up.
MeSH term(s)	Female ; Humans ; Cytidine Deaminase/genetics ; Exons ; Homozygote ; Hyper-IgM Immunodeficiency Syndrome/complications ; Hyper-IgM Immunodeficiency Syndrome/diagnosis ; Hyper-IgM Immunodeficiency Syndrome/genetics ; Immunoglobulin M ; Immunoglobulins, Intravenous ; Mutation ; Young Adult
Chemical Substances	Cytidine Deaminase (EC 3.5.4.5) ; Immunoglobulin M ; Immunoglobulins, Intravenous
Language	English
Publishing date	2023-03-17
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-253878
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Machine Learning Approach to Classify Biomedical Acoustic Features for Baby Cries.

Aggarwal, Gaurav / Jhajharia, Kavita / Izhar, Jaweria / Kumar, Manoj / Abualigah, Laith

Journal of voice : official journal of the Voice Foundation

2023

Abstract: Communication is imperative for living beings for exchanging information. But for newborns, the only way of communicating with the world is through crying, and it is the only medium through which caregivers can know about the needs of their children. ... ...

Abstract	Communication is imperative for living beings for exchanging information. But for newborns, the only way of communicating with the world is through crying, and it is the only medium through which caregivers can know about the needs of their children. Timely addressing baby cries is very important so that the child is relieved at the earliest. It has been a challenge, especially for new parents. The literature says newborn babies use The Dustan Baby Language to communicate. According to this language, there are five words to understand a baby's needs, which are "Neh" (hungry), "Eh" (burp is needed), "Owh/Oah" (fatigue), "Eair/Eargghh" (cramps), "Heh" (feel hot or wet, physical discomfort). This research aims to develop a model for recognizing baby cries and distinguishing between different kinds of baby cries. Here we more broadly focus on whether the infant is in pain due to hunger or discomfort. The study proposes a comparative approach using four classification models: random forest, support vector machine, logistic regression, and decision tree. These algorithms learn from the spectral features: chroma_stft, spectral_centroid, bandwidth, spectral_rolloff, mel-frequency cepstral coefficients, linear predictive coding, res, zero_crossing_rate extracted from the infant cry. The support vector machine model outperforms other classifiers for correctly classifying infant cries.
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	17459-2
ISSN	1873-4588 ; 1557-8658 ; 0892-1997
ISSN (online)	1873-4588 ; 1557-8658
ISSN	0892-1997
DOI	10.1016/j.jvoice.2023.06.014
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Zs.A 4034: Show issues

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Article ; Online: Evaluation of three different 99mTc-based mock-venom agents for lymphoscintigraphy studies in preclinical models of peripheral snakebite envenomation

Tiwari, Nidhi / Jaimini, Abhinav / Jain, Gaurav Kumar / Aggarwal, Geeta / Mittal, Gaurav

Journal of Pharmacological and Toxicological Methods. 2023 July, Aug., v. 122 p.107280-

2023

Abstract: Snakebite envenomation is one of the major public health concerns across many countries; with the WHO designating it as a ‘priority neglected tropical disease’ and stressing for a need to develop novel therapeutic strategies to reduce death and ... ...

Abstract	Snakebite envenomation is one of the major public health concerns across many countries; with the WHO designating it as a ‘priority neglected tropical disease’ and stressing for a need to develop novel therapeutic strategies to reduce death and disability rate by end of 2030. Since a major component of venom; the high molecular weight (HMw) toxins enter the bloodstream through lymphatic system, research is focusing on modulating the lymphatic flow rate after topical application of suitable drug candidates. Present study compared the suitability of three radiopharmaceutical agents, namely ⁹⁹ᵐTc-Sulfur colloid (SC), ⁹⁹ᵐTc-Phytate (Phy) and ⁹⁹ᵐTc-Human serum albumin (HSA), to be used as mock-venom agent in studying modulation in lymphatic flow rate in preclinical models of peripheral snakebite envenomation using lymphoscintigraphy studies. The study was performed in 72 Sprague Dawley rats; divided into six groups of 12 rats each. Control groups were given intradermal injection (1.29–1.48 MBq in 100 μl normal saline) of either ⁹⁹ᵐTc-Phy/ ⁹⁹ᵐTc-SC/ ⁹⁹ᵐTc-HSA into the tail as ‘mock-venom’. In respective test groups, commercially available topical formulation (Anobliss® Cream) containing Nifedipine (Nif; 0.3% w/w) and Lidocaine (Lid; 1.5% w/w) was applied topically over the animals' lower body (tail and hind limbs) immediately within 20s of administering intradermal injection of the radiopharmaceutical. Any modulation in lymph transit time from periphery to systemic circulation was assessed using lymphoscintigraphy by taking dynamic gamma-scintigraphy images of 60s each till 1 h post-injection of the test radiopharmaceuticals. Significant difference in movement of the three radiopharmaceuticals was noted in terms of their lymphatic movement. ⁹⁹ᵐTc-Phy did not show significant travel through the lymphatics and the liver was faintly visualized in control as well as test intervention groups. In case of ⁹⁹ᵐTc-SC, significant changes in movement of the radiotracer after topical application of Nif/Lid in the test intervention groups were clearly noted in comparison to control (P < 0.05). Multiple numbers of lymph nodes (LNs) could be clearly visualized in control (5 ± 1 LNs) and test intervention groups (3 ± 1 LNs). Liver uptake was more prominent in control animals and it reduced significantly in test intervention groups. On the other hand, ⁹⁹ᵐTc-HSA showed lesser number of lymph nodes and higher accumulation in liver as compared to ⁹⁹ᵐTc-SC, suggesting very fast movement of this radiopharmaceutical. Results indicates that ⁹⁹ᵐTc-SC could be used as a suitable agent to mimic lymphatic transit behavior of HMw toxin components of snake venom and could therefore be used as a model in studying the effect of any test pharmacological intervention in modulating lymphatic transit rate. Additional advantage could be a significant reduction in the need for sacrificing large number of animals, particularly during initial screening phase of drug development cycle.
Keywords	blood flow ; death ; drug development ; drugs ; lidocaine ; liver ; lymph ; models ; molecular weight ; public health ; serum albumin ; snake bites ; snake venoms ; tail ; topical application ; toxicology ; toxins ; travel ; tropical diseases ; Peripheral snakebite envenomation ; Preclinical models ; Lymphoscintigraphy ; 99mTc-Sulfur colloid ; Lymphatic flow rate
Language	English
Dates of publication	2023-07
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	1105919-9
ISSN	1873-488X ; 1056-8719
ISSN (online)	1873-488X
ISSN	1056-8719
DOI	10.1016/j.vascn.2023.107280
Database	NAL-Catalogue (AGRICOLA)

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